Click here to switch to the map view.

The map label for this gene is betA [H]

Identifier: 119718224

GI number: 119718224

Start: 4227158

End: 4228795

Strand: Reverse

Name: betA [H]

Synonym: Noca_4005

Alternate gene names: 119718224

Gene position: 4228795-4227158 (Counterclockwise)

Preceding gene: 119718226

Following gene: 119718223

Centisome position: 84.82

GC content: 69.54

Gene sequence:

>1638_bases
ATGGCCAAGACGCCGTACAAGAACGAGGCCGACTACGTGGTGGTCGGCTCCGGCAGCTCGGGCGCCGCGATCGCCGGCCG
GTTGGCCCAGTCCGGCGCGAGCGTGATCGTGCTCGAGGCCGGCAAGAGCGACGAGCAGTACCTGGTGAAGAAGCCCGGCA
TGATCGGCCCGATGCACTCGGTGCCCGAGATCAAGAAGCGCGTCGACTGGGGCTACTACTCCACGCCGCAGAAGCACCTC
CTGGAGCGCAAGATGCCGGTCCCGCGCGGCAAGGTGGTCGGCGGCTCGAGCTCGATCAACGGCATGGTCTACGTGCGCGG
CAACCGCGCCAACTACGACTCCTGGGCAGCCGAGGGCTGCACCGGCTGGTCGGCCGACGAGGTCAACGCGGCGTACCGGC
GCATGGAGGACTTCGAGGACGGCGCCAACGACTACCGCGGTGCGGGCGGGCCGATCAAGGTGACCCGCAACGCCGCGCCG
CAGGAGGGCTCCCTGCAGTTCATCCAGGCGACCTCGGACGTGCTGGGCGTGAAGGTCCTCGACGACTACAACGCCGAGTC
GCAGGAGGGGGTCAGCCGGATGCAGCAGAACGCCGCCGGCGGGCTGCGCTACAGCGCGTCGCGGGGCTACCTCCACCACC
TCGACGTACCCACCCTGCAGCTGCAGACCGAGGTGCTGGTGAGGAAGGTCGTCATCGAGAACGGGCGGGCGACGGGCGTC
GAGGTCACCGACAAGAGCGGCAGCCGGCGTACCGTCCGGGCCGGCAAGGAGGTCATCCTCTCGGCCGGCTTCGTCGGGTC
CGCGCAGCTCCTGATGCTCTCCGGCATCGGCCCCGCCCAGCACCTGCGCGACCACGGCATCGAGGTGCTCGCGGACCTGC
CGGTGGGCGACAACCTGCACGACCACATGTTCCACGCGCTGACCTTCCACGTGACCTCCTCGAAGATGCGCGGGAACGCC
TTCTTCTTCGGCAAGGGCGTCCTCAAGGAGGCGCTGCGCCCCGGCAGGACGTTCATGGCGAACTCGGTGTTCGAGGCCGT
CGCGTTCCTGCGTACGTCGCAGGCGACCGACGTGCCCGACCTGCAGCTGCACCTGCTGCCGTGGTCCTACGTCTCGCCCA
ACCAGGACGAGCCGATCCGCCACGACGTCGACCCGCGTACGTCGATCACGCTGCTCTCGACGCTGATCTACCCGCGCAGC
CGCGGCACGTTGCGGCTCGCGTCCGACGACCCGACCACCCCACCGCTGATCGACTTCCAGTACCTCGCCGACCCCGGCGA
CCTGGAGGTGCTCGCGGAGGGTTCGGAGATGGTCCGGGAGATCATGGCCGGCGCCGCGTTCGGCGGTGCGGTCAAGGAGG
AGATCCATCCGGGGGCCCGCCTGAAGGGGCAGGAGCTGCGCGACGCGATCCTCAACCGGGCGACCTCGGTCTACCACGGC
GTCGGCACCTGCCGGATGGGCACCGACGACCTGTCGGTCGTGACCCCCGACCTCAAGGTCCGCGGCGTCGAGAACCTCCG
GGTCTGCGACGCCTCGATCATGCCGTCGATCACCGGGGGCAACACCAACGCGCCCGCGATCATGATCGGTGAGCGCGGCG
CGGACCTCGTTCTCGGCACCGTTCTCGGAAGGGCGTGA

Upstream 100 bases:

>100_bases
CGGGAAGGCCCGACCCTCTGGCTCGGAAAACTAGAACGCGTTACAGTGTGGTCGCGCACACATTCCCGCGGTATGCCGCC
TGCCCAGCGAGGTAACACCC

Downstream 100 bases:

>100_bases
GCACGATGGCACTCCAGCGACCGGCGTCGATCACCGACGCGTTCCTCGAGCGGCTCGTGGCCCGCGTGCCGTCGACCAGC
GGCGGCACCTGGAAGCTCAC

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKTPYKNEADYVVVGSGSSGAAIAGRLAQSGASVIVLEAGKSDEQYLVKKPGMIGPMHSVPEIKKRVDWGYYSTPQKHL
LERKMPVPRGKVVGGSSSINGMVYVRGNRANYDSWAAEGCTGWSADEVNAAYRRMEDFEDGANDYRGAGGPIKVTRNAAP
QEGSLQFIQATSDVLGVKVLDDYNAESQEGVSRMQQNAAGGLRYSASRGYLHHLDVPTLQLQTEVLVRKVVIENGRATGV
EVTDKSGSRRTVRAGKEVILSAGFVGSAQLLMLSGIGPAQHLRDHGIEVLADLPVGDNLHDHMFHALTFHVTSSKMRGNA
FFFGKGVLKEALRPGRTFMANSVFEAVAFLRTSQATDVPDLQLHLLPWSYVSPNQDEPIRHDVDPRTSITLLSTLIYPRS
RGTLRLASDDPTTPPLIDFQYLADPGDLEVLAEGSEMVREIMAGAAFGGAVKEEIHPGARLKGQELRDAILNRATSVYHG
VGTCRMGTDDLSVVTPDLKVRGVENLRVCDASIMPSITGGNTNAPAIMIGERGADLVLGTVLGRA

Sequences:

>Translated_545_residues
MAKTPYKNEADYVVVGSGSSGAAIAGRLAQSGASVIVLEAGKSDEQYLVKKPGMIGPMHSVPEIKKRVDWGYYSTPQKHL
LERKMPVPRGKVVGGSSSINGMVYVRGNRANYDSWAAEGCTGWSADEVNAAYRRMEDFEDGANDYRGAGGPIKVTRNAAP
QEGSLQFIQATSDVLGVKVLDDYNAESQEGVSRMQQNAAGGLRYSASRGYLHHLDVPTLQLQTEVLVRKVVIENGRATGV
EVTDKSGSRRTVRAGKEVILSAGFVGSAQLLMLSGIGPAQHLRDHGIEVLADLPVGDNLHDHMFHALTFHVTSSKMRGNA
FFFGKGVLKEALRPGRTFMANSVFEAVAFLRTSQATDVPDLQLHLLPWSYVSPNQDEPIRHDVDPRTSITLLSTLIYPRS
RGTLRLASDDPTTPPLIDFQYLADPGDLEVLAEGSEMVREIMAGAAFGGAVKEEIHPGARLKGQELRDAILNRATSVYHG
VGTCRMGTDDLSVVTPDLKVRGVENLRVCDASIMPSITGGNTNAPAIMIGERGADLVLGTVLGRA
>Mature_544_residues
AKTPYKNEADYVVVGSGSSGAAIAGRLAQSGASVIVLEAGKSDEQYLVKKPGMIGPMHSVPEIKKRVDWGYYSTPQKHLL
ERKMPVPRGKVVGGSSSINGMVYVRGNRANYDSWAAEGCTGWSADEVNAAYRRMEDFEDGANDYRGAGGPIKVTRNAAPQ
EGSLQFIQATSDVLGVKVLDDYNAESQEGVSRMQQNAAGGLRYSASRGYLHHLDVPTLQLQTEVLVRKVVIENGRATGVE
VTDKSGSRRTVRAGKEVILSAGFVGSAQLLMLSGIGPAQHLRDHGIEVLADLPVGDNLHDHMFHALTFHVTSSKMRGNAF
FFGKGVLKEALRPGRTFMANSVFEAVAFLRTSQATDVPDLQLHLLPWSYVSPNQDEPIRHDVDPRTSITLLSTLIYPRSR
GTLRLASDDPTTPPLIDFQYLADPGDLEVLAEGSEMVREIMAGAAFGGAVKEEIHPGARLKGQELRDAILNRATSVYHGV
GTCRMGTDDLSVVTPDLKVRGVENLRVCDASIMPSITGGNTNAPAIMIGERGADLVLGTVLGRA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=563, Percent_Identity=36.7673179396092, Blast_Score=302, Evalue=4e-82,
Organism=Escherichia coli, GI1786503, Length=542, Percent_Identity=34.1328413284133, Blast_Score=276, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17532301, Length=562, Percent_Identity=33.0960854092527, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24642042, Length=568, Percent_Identity=35.5633802816901, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24642055, Length=576, Percent_Identity=34.5486111111111, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24650267, Length=572, Percent_Identity=32.8671328671329, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI45551458, Length=577, Percent_Identity=34.315424610052, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI45549471, Length=574, Percent_Identity=34.3205574912892, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642037, Length=591, Percent_Identity=35.1945854483926, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24642039, Length=565, Percent_Identity=32.212389380531, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI18859993, Length=579, Percent_Identity=32.2970639032815, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=32.5174825174825, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24642048, Length=569, Percent_Identity=32.688927943761, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24642059, Length=565, Percent_Identity=32.7433628318584, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24642035, Length=572, Percent_Identity=34.0909090909091, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=31.4647377938517, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24642051, Length=573, Percent_Identity=29.4938917975567, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24642057, Length=621, Percent_Identity=26.7310789049919, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24645930, Length=619, Percent_Identity=27.3021001615509, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58650; Mature: 58519

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00623 GMC_OXRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTPYKNEADYVVVGSGSSGAAIAGRLAQSGASVIVLEAGKSDEQYLVKKPGMIGPMHS
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCCCC
VPEIKKRVDWGYYSTPQKHLLERKMPVPRGKVVGGSSSINGMVYVRGNRANYDSWAAEGC
CHHHHHHCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCEEEEEECCCCCCCHHHCCCC
TGWSADEVNAAYRRMEDFEDGANDYRGAGGPIKVTRNAAPQEGSLQFIQATSDVLGVKVL
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCCCCCCCEEEEEECCCCEEEEEE
DDYNAESQEGVSRMQQNAAGGLRYSASRGYLHHLDVPTLQLQTEVLVRKVVIENGRATGV
ECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCE
EVTDKSGSRRTVRAGKEVILSAGFVGSAQLLMLSGIGPAQHLRDHGIEVLADLPVGDNLH
EEECCCCCCHHHHHCCEEEEECCCCCCCEEEEEECCCHHHHHHHCCCEEEEECCCCCCHH
DHMFHALTFHVTSSKMRGNAFFFGKGVLKEALRPGRTFMANSVFEAVAFLRTSQATDVPD
HHHHEEEEEEEECCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
LQLHLLPWSYVSPNQDEPIRHDVDPRTSITLLSTLIYPRSRGTLRLASDDPTTPPLIDFQ
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEE
YLADPGDLEVLAEGSEMVREIMAGAAFGGAVKEEIHPGARLKGQELRDAILNRATSVYHG
EECCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
VGTCRMGTDDLSVVTPDLKVRGVENLRVCDASIMPSITGGNTNAPAIMIGERGADLVLGT
CEEEEECCCCCEEECCCCEEECCCCEEEECHHHCCCCCCCCCCCCEEEECCCCCCEEHHH
VLGRA
HHCCC
>Mature Secondary Structure 
AKTPYKNEADYVVVGSGSSGAAIAGRLAQSGASVIVLEAGKSDEQYLVKKPGMIGPMHS
CCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCCCC
VPEIKKRVDWGYYSTPQKHLLERKMPVPRGKVVGGSSSINGMVYVRGNRANYDSWAAEGC
CHHHHHHCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCEEEEEECCCCCCCHHHCCCC
TGWSADEVNAAYRRMEDFEDGANDYRGAGGPIKVTRNAAPQEGSLQFIQATSDVLGVKVL
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCCCCCCCEEEEEECCCCEEEEEE
DDYNAESQEGVSRMQQNAAGGLRYSASRGYLHHLDVPTLQLQTEVLVRKVVIENGRATGV
ECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCE
EVTDKSGSRRTVRAGKEVILSAGFVGSAQLLMLSGIGPAQHLRDHGIEVLADLPVGDNLH
EEECCCCCCHHHHHCCEEEEECCCCCCCEEEEEECCCHHHHHHHCCCEEEEECCCCCCHH
DHMFHALTFHVTSSKMRGNAFFFGKGVLKEALRPGRTFMANSVFEAVAFLRTSQATDVPD
HHHHEEEEEEEECCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCC
LQLHLLPWSYVSPNQDEPIRHDVDPRTSITLLSTLIYPRSRGTLRLASDDPTTPPLIDFQ
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEE
YLADPGDLEVLAEGSEMVREIMAGAAFGGAVKEEIHPGARLKGQELRDAILNRATSVYHG
EECCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
VGTCRMGTDDLSVVTPDLKVRGVENLRVCDASIMPSITGGNTNAPAIMIGERGADLVLGT
CEEEEECCCCCEEECCCCEEECCCCEEEECHHHCCCCCCCCCCCCEEEECCCCCCEEHHH
VLGRA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]