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The map label for this gene is hemE

Identifier: 119717896

GI number: 119717896

Start: 3896816

End: 3897853

Strand: Reverse

Name: hemE

Synonym: Noca_3674

Alternate gene names: 119717896

Gene position: 3897853-3896816 (Counterclockwise)

Preceding gene: 119717901

Following gene: 119717894

Centisome position: 78.18

GC content: 73.12

Gene sequence:

>1038_bases
GTGACCCCCGATCCGCGACTCGCCGACAGCGCCTTCCTGAAGGCGGCCCGCGGCGAGCCGGTGCCGCACACGCCGGTGTG
GTACATGCGCCAGGCGGGCCGCTCGCTGCCGGAGTACCTCGCCGTCCGCGAGGGCATCGGCATGCTGGAGTCCTGCATGG
ACCCGGACCTGGTGGTGGAGATCACGCTCCAGCCGGTGCGGCGGTACGGCGTGGACGCGGCGATCTTCTTCTCCGACATC
GTGCTGCCGCTCAAGGCGGTCGGCGTCGACCTGGACATCAAGCCGGGTGTCGGGCCGGTCGTCGCCCACCCGGTGCGCAC
GCTGGCCGACGTCGAGGCGATCCCGGACCTGACCCCCGAGCACGTCCCGTTCATCACCGAGGCGGTCCGCGGGCTGGTCG
GCGAGCTGGGCGGCACCCCGCTCATCGGGTTCGCGGGTGCTCCGTTCACGGTCGCGTCGTACCTCGTCGAGGGCGGGCCC
TCCAAGGAGCACGCGCGGACCAAGGCGATGATGTTCGGCGCCCCCGACGTGTGGGACGCGCTGCTGCGCAAGATCGCCGG
CATCTCCGCCTCCTACCTCGAGGTCCAGGTCGCCGCCGGCGCCTCCGCCGTCCAGCTCTTCGACTCCTGGGCCGGCGCGC
TGACCCCGGCCGACTACCGGGCGTTCGTGATGCCGCACTCCGCGCGCGTGCTCGAGCGCGCCGGCGCGCTCGGGGTGCCG
CGTATCCACTTCGGCGTCGGTACGGCGAACCTGCTCGGCCTGATGGGCGAGGCGGGTGCCGACGTGGTCGGCGTCGACTG
GCGCACCCCGCTCGCGCACGCGATCGCGCTGGTCGGCGACCGTGGGGTGCAGGGCAACCTCGACCCCACGCTGGTCTTCG
CCCCGACCGAGGTGATGACCGCCCGCGCCGCCGAGATCGTCGAGGCCGGCCGGGCCGCGCGCGGTCACATCTTCAACCTC
GGCCACGGCGTCATCCCCTCCACCGACCCCGACCAGCTCAAGCGGCTCACCGAGTTCGTCCAGACCTACCCCCGCTGA

Upstream 100 bases:

>100_bases
CTCGGGTGCGTCTCCTGACCGACGACCATGAGGTCACAGTAGGTCGATCCTGACGATCCCGATGTGCGAACACGCCGGGT
GACCTGCGAGGCTTCGCCCC

Downstream 100 bases:

>100_bases
GCCCTCCGCGCGATACTCCCTGACGGTTGCGTGGCGTGGGCGCGCTCCCAGACCACACAAACGTCAGGGACTATCGCTCA
GATCTCGGTGGGCTCCGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTPDPRLADSAFLKAARGEPVPHTPVWYMRQAGRSLPEYLAVREGIGMLESCMDPDLVVEITLQPVRRYGVDAAIFFSDI
VLPLKAVGVDLDIKPGVGPVVAHPVRTLADVEAIPDLTPEHVPFITEAVRGLVGELGGTPLIGFAGAPFTVASYLVEGGP
SKEHARTKAMMFGAPDVWDALLRKIAGISASYLEVQVAAGASAVQLFDSWAGALTPADYRAFVMPHSARVLERAGALGVP
RIHFGVGTANLLGLMGEAGADVVGVDWRTPLAHAIALVGDRGVQGNLDPTLVFAPTEVMTARAAEIVEAGRAARGHIFNL
GHGVIPSTDPDQLKRLTEFVQTYPR

Sequences:

>Translated_345_residues
MTPDPRLADSAFLKAARGEPVPHTPVWYMRQAGRSLPEYLAVREGIGMLESCMDPDLVVEITLQPVRRYGVDAAIFFSDI
VLPLKAVGVDLDIKPGVGPVVAHPVRTLADVEAIPDLTPEHVPFITEAVRGLVGELGGTPLIGFAGAPFTVASYLVEGGP
SKEHARTKAMMFGAPDVWDALLRKIAGISASYLEVQVAAGASAVQLFDSWAGALTPADYRAFVMPHSARVLERAGALGVP
RIHFGVGTANLLGLMGEAGADVVGVDWRTPLAHAIALVGDRGVQGNLDPTLVFAPTEVMTARAAEIVEAGRAARGHIFNL
GHGVIPSTDPDQLKRLTEFVQTYPR
>Mature_344_residues
TPDPRLADSAFLKAARGEPVPHTPVWYMRQAGRSLPEYLAVREGIGMLESCMDPDLVVEITLQPVRRYGVDAAIFFSDIV
LPLKAVGVDLDIKPGVGPVVAHPVRTLADVEAIPDLTPEHVPFITEAVRGLVGELGGTPLIGFAGAPFTVASYLVEGGPS
KEHARTKAMMFGAPDVWDALLRKIAGISASYLEVQVAAGASAVQLFDSWAGALTPADYRAFVMPHSARVLERAGALGVPR
IHFGVGTANLLGLMGEAGADVVGVDWRTPLAHAIALVGDRGVQGNLDPTLVFAPTEVMTARAAEIVEAGRAARGHIFNLG
HGVIPSTDPDQLKRLTEFVQTYPR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=37.5, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI2367337, Length=343, Percent_Identity=40.8163265306122, Blast_Score=244, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=352, Percent_Identity=35.5113636363636, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI221330099, Length=349, Percent_Identity=35.5300859598854, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI19921920, Length=349, Percent_Identity=35.5300859598854, Blast_Score=207, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_NOCSJ (A1SMY9)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924861.1
- ProteinModelPortal:   A1SMY9
- SMR:   A1SMY9
- STRING:   A1SMY9
- GeneID:   4595786
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3674
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A1SMY9
- BioCyc:   NSP35761:NOCA_3674-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 36585; Mature: 36453

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 79-79 BINDING 154-154 BINDING 209-209 BINDING 322-322

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDPRLADSAFLKAARGEPVPHTPVWYMRQAGRSLPEYLAVREGIGMLESCMDPDLVVE
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEE
ITLQPVRRYGVDAAIFFSDIVLPLKAVGVDLDIKPGVGPVVAHPVRTLADVEAIPDLTPE
EEEHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
HVPFITEAVRGLVGELGGTPLIGFAGAPFTVASYLVEGGPSKEHARTKAMMFGAPDVWDA
CCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
LLRKIAGISASYLEVQVAAGASAVQLFDSWAGALTPADYRAFVMPHSARVLERAGALGVP
HHHHHHCCCCHHEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCCC
RIHFGVGTANLLGLMGEAGADVVGVDWRTPLAHAIALVGDRGVQGNLDPTLVFAPTEVMT
EEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHH
ARAAEIVEAGRAARGHIFNLGHGVIPSTDPDQLKRLTEFVQTYPR
HHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPDPRLADSAFLKAARGEPVPHTPVWYMRQAGRSLPEYLAVREGIGMLESCMDPDLVVE
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEE
ITLQPVRRYGVDAAIFFSDIVLPLKAVGVDLDIKPGVGPVVAHPVRTLADVEAIPDLTPE
EEEHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
HVPFITEAVRGLVGELGGTPLIGFAGAPFTVASYLVEGGPSKEHARTKAMMFGAPDVWDA
CCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHH
LLRKIAGISASYLEVQVAAGASAVQLFDSWAGALTPADYRAFVMPHSARVLERAGALGVP
HHHHHHCCCCHHEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCCC
RIHFGVGTANLLGLMGEAGADVVGVDWRTPLAHAIALVGDRGVQGNLDPTLVFAPTEVMT
EEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHH
ARAAEIVEAGRAARGHIFNLGHGVIPSTDPDQLKRLTEFVQTYPR
HHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA