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The map label for this gene is trpS1 [H]

Identifier: 119717779

GI number: 119717779

Start: 3772353

End: 3773411

Strand: Reverse

Name: trpS1 [H]

Synonym: Noca_3557

Alternate gene names: 119717779

Gene position: 3773411-3772353 (Counterclockwise)

Preceding gene: 119717780

Following gene: 119717778

Centisome position: 75.68

GC content: 69.22

Gene sequence:

>1059_bases
ATGTCCACCACGACCGCGCCCGAGGTCTCGGCGTCCCTCCAGGGCTCGGGGACGTCCCGTCCGCGGGTCCTCTCCGGGAT
CCAGCCGACCGCTGACTCGTTCCACTTCGGCAACTACCTGGGCGCGCTGCGGCAGTGGGTGGACCTGCAGGAGGACTACC
AGCCGTTCTTCTTCATCGCCGACCTGCACGCGATCACCGTGGAGCAGGACCCGAAGGTGCTGCGGGAGCGCACCCTCCGG
GCGGCCGCGCAGCTGATCGCGATGGGCATCGACCCCGACCGGTCGGCGATCTTCGTGCAGTCGCAGGTCCCTGAGCACGC
CCAGCTCGGTTGGGTGCTCCAGTGCCTGACCGGCTTCGGCGAGGCCCGCCGGATGACCCAGTTCAAGGACAAGTCCGCCA
AGGGCGGCGAAGGCGCGGCCAGCGTCGGTCTGTTCACCTACCCGATCCTCCAGGCGGCCGACATCTTGCTGTACCGGCCG
CACTACGTCCCCGTCGGCGAGGACCAGCGCCAGCACCTCGAGCTCACCCGCGACCTCGCGCAGCGCTTCAACAGCCGCTA
CAAGAAGACCTTCCGGCTCCCCGAGCCCTACATCCTCAAGGCGACCGCGAAGATCACCGACCTCCAGGACCCGACCTCGA
AGATGTCCAAGTCGGCGTCCTCGCCGTCCGGCATCGTGGAGATGCTCGACGACCCGCGGGTCTCGGCGAAGAAGATCCGT
TCCGCGGTGACCGACTCCGGCTCGGAGATCCGCTTCGACCCCGAGACCAAGCCCGGAGTCAGCAACCTGCTCACGATCTT
CTCGGCCCTCACCGGGCGCGCCGTGTCGGACCTCGAGGAGGAGTACGAGGGCCGTGGGTACGGCGACCTCAAGAAGGAGC
TGGCCGAGACAGTCGTGGACTTCGTGACCCCGTTCCGCGAGCGCACGCTCGAGCTGCTCGACGACCAGGCCTACCTGACC
GACGTACTCCGCCGGGGCGCGGAGCAGGCCGGCGCCGTGGCGGCCACGACCCTGCGCGACGTCTACCAGCGGGTCGGCTT
CGTCGCGGCGGGCCAGTAG

Upstream 100 bases:

>100_bases
TGCGCCTGGTCGTGCGGGGCCGGTGACCCCCGGCCGGACCCCGAGCCGGACCCAGGGCCCTGTGCCCGTCGGCCCCGGCC
GATCAGGAACAATGGACGCC

Downstream 100 bases:

>100_bases
GGTCTGCCACGTGTCGACGATTGGCGTAGCGCTCGCGATCCCGGAGCCCTGGGCCTCTGAGCTGCAGGACTACCGGAAGG
CCGTCGGCGACCACACCGCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase 1; TrpRS 1 [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSTTTAPEVSASLQGSGTSRPRVLSGIQPTADSFHFGNYLGALRQWVDLQEDYQPFFFIADLHAITVEQDPKVLRERTLR
AAAQLIAMGIDPDRSAIFVQSQVPEHAQLGWVLQCLTGFGEARRMTQFKDKSAKGGEGAASVGLFTYPILQAADILLYRP
HYVPVGEDQRQHLELTRDLAQRFNSRYKKTFRLPEPYILKATAKITDLQDPTSKMSKSASSPSGIVEMLDDPRVSAKKIR
SAVTDSGSEIRFDPETKPGVSNLLTIFSALTGRAVSDLEEEYEGRGYGDLKKELAETVVDFVTPFRERTLELLDDQAYLT
DVLRRGAEQAGAVAATTLRDVYQRVGFVAAGQ

Sequences:

>Translated_352_residues
MSTTTAPEVSASLQGSGTSRPRVLSGIQPTADSFHFGNYLGALRQWVDLQEDYQPFFFIADLHAITVEQDPKVLRERTLR
AAAQLIAMGIDPDRSAIFVQSQVPEHAQLGWVLQCLTGFGEARRMTQFKDKSAKGGEGAASVGLFTYPILQAADILLYRP
HYVPVGEDQRQHLELTRDLAQRFNSRYKKTFRLPEPYILKATAKITDLQDPTSKMSKSASSPSGIVEMLDDPRVSAKKIR
SAVTDSGSEIRFDPETKPGVSNLLTIFSALTGRAVSDLEEEYEGRGYGDLKKELAETVVDFVTPFRERTLELLDDQAYLT
DVLRRGAEQAGAVAATTLRDVYQRVGFVAAGQ
>Mature_351_residues
STTTAPEVSASLQGSGTSRPRVLSGIQPTADSFHFGNYLGALRQWVDLQEDYQPFFFIADLHAITVEQDPKVLRERTLRA
AAQLIAMGIDPDRSAIFVQSQVPEHAQLGWVLQCLTGFGEARRMTQFKDKSAKGGEGAASVGLFTYPILQAADILLYRPH
YVPVGEDQRQHLELTRDLAQRFNSRYKKTFRLPEPYILKATAKITDLQDPTSKMSKSASSPSGIVEMLDDPRVSAKKIRS
AVTDSGSEIRFDPETKPGVSNLLTIFSALTGRAVSDLEEEYEGRGYGDLKKELAETVVDFVTPFRERTLELLDDQAYLTD
VLRRGAEQAGAVAATTLRDVYQRVGFVAAGQ

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=43.5045317220544, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI41352700, Length=178, Percent_Identity=52.8089887640449, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1789786, Length=333, Percent_Identity=52.5525525525526, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71982800, Length=340, Percent_Identity=35.2941176470588, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI71982793, Length=340, Percent_Identity=35.2941176470588, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=349, Percent_Identity=40.974212034384, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24666151, Length=342, Percent_Identity=40.6432748538012, Blast_Score=254, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38895; Mature: 38764

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTAPEVSASLQGSGTSRPRVLSGIQPTADSFHFGNYLGALRQWVDLQEDYQPFFFIA
CCCCCCCCCHHCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLHAITVEQDPKVLRERTLRAAAQLIAMGIDPDRSAIFVQSQVPEHAQLGWVLQCLTGFG
EHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
EARRMTQFKDKSAKGGEGAASVGLFTYPILQAADILLYRPHYVPVGEDQRQHLELTRDLA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
QRFNSRYKKTFRLPEPYILKATAKITDLQDPTSKMSKSASSPSGIVEMLDDPRVSAKKIR
HHHHHHHHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHH
SAVTDSGSEIRFDPETKPGVSNLLTIFSALTGRAVSDLEEEYEGRGYGDLKKELAETVVD
HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FVTPFRERTLELLDDQAYLTDVLRRGAEQAGAVAATTLRDVYQRVGFVAAGQ
HHHHHHHHHHHHHCCHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STTTAPEVSASLQGSGTSRPRVLSGIQPTADSFHFGNYLGALRQWVDLQEDYQPFFFIA
CCCCCCCCHHCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLHAITVEQDPKVLRERTLRAAAQLIAMGIDPDRSAIFVQSQVPEHAQLGWVLQCLTGFG
EHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
EARRMTQFKDKSAKGGEGAASVGLFTYPILQAADILLYRPHYVPVGEDQRQHLELTRDLA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHH
QRFNSRYKKTFRLPEPYILKATAKITDLQDPTSKMSKSASSPSGIVEMLDDPRVSAKKIR
HHHHHHHHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHH
SAVTDSGSEIRFDPETKPGVSNLLTIFSALTGRAVSDLEEEYEGRGYGDLKKELAETVVD
HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FVTPFRERTLELLDDQAYLTDVLRRGAEQAGAVAATTLRDVYQRVGFVAAGQ
HHHHHHHHHHHHHCCHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]