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The map label for this gene is folC [H]

Identifier: 119717692

GI number: 119717692

Start: 3678132

End: 3679514

Strand: Reverse

Name: folC [H]

Synonym: Noca_3470

Alternate gene names: 119717692

Gene position: 3679514-3678132 (Counterclockwise)

Preceding gene: 119717694

Following gene: 119717691

Centisome position: 73.8

GC content: 73.83

Gene sequence:

>1383_bases
ATGAGCGACACTCCCGCGGGCCCCCGCCTCGCCGAGACCTTCGAGGAGGTGGAGGACGCCCTGCTGTCCCGCTGGCCGGA
GACGAGGCTGGAGCCGTCCCTCGACCGGATCCGCGCGTTCACCGAGGTGCTCGGCGACCCCCAGTCCGGCTATCCAGTCA
TCCACCTGACCGGCACCAACGGCAAGACCTCGACGTCGCGGATGATCGACACCCTGTTGCGCGCGCTGGACCTGCGCACC
GGCCGGTTCACCAGCCCGCACGTGGAGCGGATGACCGAGCGGATCTCGGTGGACGGCGAGCCGCTCAGCGACGAGGAGTT
CGTGCGCGCGTTCAACGACGTCGCGCCGTACACCCACCTCGTGGACTCGAGCGAGGACCACCCACTGTCGTTCTTCGAGA
CCGTGGTCGGCATGGCGTACGCCGCGTTCGCGGACGCGCCCGTCGACGTCGCCGTGGTCGAGGTCGGGATGGGTGGGTCG
TGGGACGCGACGAACGTCGCGGACGCGACGGTGGCGGTGGTGCTCCCCGTGGCGGTCGACCATGCGGCGTACCTCGGCGA
GACGCCGGCCGAGATCGCCGTCGAGAAGGCCGGCATCATCAAGCCCGGCTCGGTCGCGGTGCTCGCCCAGCAAGCGCCGG
ACGTCGCGCGGGTGCTCCTGGAGCGGGCCGCCGAGGTCGGCGCGAGCGTGGTCCGGGAGGGCGTGGAGTTCGGCGTCGTC
TCGCGGGTGCCGGCCGTCGGCGGCCAGGTGCTCGCGCTCCAGGGCCTCCGCGCCCGCTACGACGACGTCTTCCTCCCGCT
GCACGGCGCGCACCAGGCGCAGAACGCCGCGGTCGCCCTCGCCGCCGTGGAGGCGTTCCTGGGTGCCGGTGAGCACGGCC
AGGCCCTCGACGAGGACCTGGTGCGCTCCGCGTTCGCGGAGGCGACCTCGCCCGGGCGGCTCGAGATCGTCCGGCGCAGC
CCCACGATCGTGCTCGACGCGGCGCACAACCCGCACGGCGCCGCGGCGACGGCCGCGGCGATCCAGGACTCGTTCACGTT
CTCCCCGCTCATCGGTGTGGTCGGCGTGATGGGGGACAAGGACCACGAGGGCCTGCTCGCCGCGTTCGAGCCGGTCCTCG
CCCACGTCGTGTGCACCCAGAACTCCACCGCCCGGGCGCTGCCCGCCGAGCGGCTCGCGGCGGTCGCCCGTGAGGTGTTC
GGGCCGGACCGGGTCACGGTCGCACCCAGCGTCGCGGTCGCGCTCGAGCAGGCGGCCACGCTGGCCGAGGCAGGCGAGGC
GTTCGGCGACCCGCTCGGATCCGGCGCCGTGCTGGTCACCGGCTCGGTGGTGACCGCCGGCGAGGCCCGCTCCCTCCTGG
TCCGCCCGGAGCGGAAGAGATGA

Upstream 100 bases:

>100_bases
CGGGACCGTCGACGACCGCGACCGTGGTTCTCATGACGAGCAACCTAGAACCTGTTCCACTTTCTGTCAGCAGGTTGACG
GTCCCTAGACTCGTTGCACC

Downstream 100 bases:

>100_bases
GCGGCCCGGTCGGTGTCCCCGAGCGGTCGCCGCGGCGCGGGATGTGCGCGGCGATCCTGGCCCTGGAGGCCGTCACCCTC
GGCCTCACCACGCCGGTGAT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSDTPAGPRLAETFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTNGKTSTSRMIDTLLRALDLRT
GRFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHLVDSSEDHPLSFFETVVGMAYAAFADAPVDVAVVEVGMGGS
WDATNVADATVAVVLPVAVDHAAYLGETPAEIAVEKAGIIKPGSVAVLAQQAPDVARVLLERAAEVGASVVREGVEFGVV
SRVPAVGGQVLALQGLRARYDDVFLPLHGAHQAQNAAVALAAVEAFLGAGEHGQALDEDLVRSAFAEATSPGRLEIVRRS
PTIVLDAAHNPHGAAATAAAIQDSFTFSPLIGVVGVMGDKDHEGLLAAFEPVLAHVVCTQNSTARALPAERLAAVAREVF
GPDRVTVAPSVAVALEQAATLAEAGEAFGDPLGSGAVLVTGSVVTAGEARSLLVRPERKR

Sequences:

>Translated_460_residues
MSDTPAGPRLAETFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTNGKTSTSRMIDTLLRALDLRT
GRFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHLVDSSEDHPLSFFETVVGMAYAAFADAPVDVAVVEVGMGGS
WDATNVADATVAVVLPVAVDHAAYLGETPAEIAVEKAGIIKPGSVAVLAQQAPDVARVLLERAAEVGASVVREGVEFGVV
SRVPAVGGQVLALQGLRARYDDVFLPLHGAHQAQNAAVALAAVEAFLGAGEHGQALDEDLVRSAFAEATSPGRLEIVRRS
PTIVLDAAHNPHGAAATAAAIQDSFTFSPLIGVVGVMGDKDHEGLLAAFEPVLAHVVCTQNSTARALPAERLAAVAREVF
GPDRVTVAPSVAVALEQAATLAEAGEAFGDPLGSGAVLVTGSVVTAGEARSLLVRPERKR
>Mature_459_residues
SDTPAGPRLAETFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTNGKTSTSRMIDTLLRALDLRTG
RFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHLVDSSEDHPLSFFETVVGMAYAAFADAPVDVAVVEVGMGGSW
DATNVADATVAVVLPVAVDHAAYLGETPAEIAVEKAGIIKPGSVAVLAQQAPDVARVLLERAAEVGASVVREGVEFGVVS
RVPAVGGQVLALQGLRARYDDVFLPLHGAHQAQNAAVALAAVEAFLGAGEHGQALDEDLVRSAFAEATSPGRLEIVRRSP
TIVLDAAHNPHGAAATAAAIQDSFTFSPLIGVVGVMGDKDHEGLLAAFEPVLAHVVCTQNSTARALPAERLAAVAREVFG
PDRVTVAPSVAVALEQAATLAEAGEAFGDPLGSGAVLVTGSVVTAGEARSLLVRPERKR

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=353, Percent_Identity=30.3116147308782, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI66932990, Length=353, Percent_Identity=30.3116147308782, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1788654, Length=359, Percent_Identity=31.1977715877437, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71984923, Length=324, Percent_Identity=30.8641975308642, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553150, Length=324, Percent_Identity=30.8641975308642, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553148, Length=324, Percent_Identity=30.8641975308642, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323760, Length=376, Percent_Identity=27.3936170212766, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324815, Length=318, Percent_Identity=26.4150943396226, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641571, Length=180, Percent_Identity=38.3333333333333, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24581568, Length=183, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 48155; Mature: 48024

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPAGPRLAETFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
GKTSTSRMIDTLLRALDLRTGRFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHL
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
VDSSEDHPLSFFETVVGMAYAAFADAPVDVAVVEVGMGGSWDATNVADATVAVVLPVAVD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HAAYLGETPAEIAVEKAGIIKPGSVAVLAQQAPDVARVLLERAAEVGASVVREGVEFGVV
HHHHHCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRVPAVGGQVLALQGLRARYDDVFLPLHGAHQAQNAAVALAAVEAFLGAGEHGQALDEDL
HHCCCCCCCEEEHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VRSAFAEATSPGRLEIVRRSPTIVLDAAHNPHGAAATAAAIQDSFTFSPLIGVVGVMGDK
HHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
DHEGLLAAFEPVLAHVVCTQNSTARALPAERLAAVAREVFGPDRVTVAPSVAVALEQAAT
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
LAEAGEAFGDPLGSGAVLVTGSVVTAGEARSLLVRPERKR
HHHHHHHHCCCCCCCEEEEECCEEECCCCCCEECCCCCCC
>Mature Secondary Structure 
SDTPAGPRLAETFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTN
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCC
GKTSTSRMIDTLLRALDLRTGRFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHL
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
VDSSEDHPLSFFETVVGMAYAAFADAPVDVAVVEVGMGGSWDATNVADATVAVVLPVAVD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HAAYLGETPAEIAVEKAGIIKPGSVAVLAQQAPDVARVLLERAAEVGASVVREGVEFGVV
HHHHHCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRVPAVGGQVLALQGLRARYDDVFLPLHGAHQAQNAAVALAAVEAFLGAGEHGQALDEDL
HHCCCCCCCEEEHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VRSAFAEATSPGRLEIVRRSPTIVLDAAHNPHGAAATAAAIQDSFTFSPLIGVVGVMGDK
HHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
DHEGLLAAFEPVLAHVVCTQNSTARALPAERLAAVAREVFGPDRVTVAPSVAVALEQAAT
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
LAEAGEAFGDPLGSGAVLVTGSVVTAGEARSLLVRPERKR
HHHHHHHHCCCCCCCEEEEECCEEECCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8419299; 9384377; 2553669 [H]