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The map label for this gene is mrdA [H]

Identifier: 119717684

GI number: 119717684

Start: 3670315

End: 3672441

Strand: Reverse

Name: mrdA [H]

Synonym: Noca_3462

Alternate gene names: 119717684

Gene position: 3672441-3670315 (Counterclockwise)

Preceding gene: 119717685

Following gene: 119717683

Centisome position: 73.66

GC content: 70.52

Gene sequence:

>2127_bases
GTGTCCACGAGCTCAGGTCGGCTGCGCCTGGTGGTGATCCAGGTGCTGGTGTTCTCGCTGTTCGCCACCCTGTTCGCGCG
CCTCTACTACCTCCAGGTCGTCGGCGGCGAGGAGTACCACGCCCAGGCGGCCGCCCAGTCGGTGCGCGAGATCGTCGTGC
AGCCCCAGCGCGGGCTGATCGTCGACGACCAGGGCCGCCCGCTGGTCGCCAACCGCACCTCGTGGGTGGTGTCGATCGAC
CGCACCGTGCTCGGCAGGATGACCGCCCACCAGCAGGAGGTGCTGGTCGGCCGGGTCGCCGACGCCGTGGTGGTGCCGGC
CCGGAAGATCGACCAGAAGCTGGTCACCTGCGGGGACGAGGGCGCCGTTCCCGGCACCTGCTGGAACGGCTCGCCGTACC
AGCCGGTCCCGGTCGCGATGGACGTCAAGCAGGCGGTGGCGCTGCGGATCCTGGAGCAGCCCGAGGACTACCCCGGCGTG
CTCGCCGAGCAGCAGAGCGTGCGCGCCTACCCGCGTCCGTACGGCGTGAACCTCGCGCACGTACTCGGCTACCTGAGCCC
GATCACCGAGGACGAGCTCGACCGCGCCGAGGAGAACGGCGACCGTTCGGTCAACGGCGCCTCCTCGGTCGGCCGGGCCG
GGGTCGAGAAGGAGTACGACCGCTGGCTGCGCGGCATGCCCGGCTACAAGAGCGTCGCCGTGGACTCGATGGGCCGGGTG
CTGGGCGACGACGGCGAGGTCGCCGGCCAGCCCGGGGACACCCTGGTCACCTCGATCGACGCGAAGGTGCAGGGCGTGGT
CGAGCGGCAGCTCGCCGACACGATCTCGACCGCGCGGCAGACCTACGACGAGGTCACCCGTCGCAACTACCGCGCCGACT
CCGGCGCGGTGGTCGTGATGGAGGCGCAGACCGGCCGGATCGTCGCGATGGCCAGCCAGCCGACGTACGACCCCGGCGTG
TGGGTCGGTGGCATCACCAAGAAGCAGCTCGCGCGGCTGTACTCCGACGCCGCCGGCAACCCCCTGCTCGGTCGCGCGAC
CCAGGGCCAGTTCGCGCCCGGGTCGACCTGGAAGCCGATCATGACCGTCGGGGCGCTGAACAACGGGTTCTCCACCGGCA
CCCGCCTGGACTGCTCCTCCGGCCTCCAGGTCGGCAACCGGTGGTTCAAGAACTACGAGTCCGCCTCCTACGGGATGATC
GGCTTCGACCAGGCGCTGCAGCTGTCCTGCGACACCTTCTTCTACCGCGTCGGCCTGCACTTCTGGCAGAAGTACGGCTC
CGACCCGACGAACGTGGACGCCAAGGACCCGCTGGTCCAGGAGGCCAAGAACTTCGGCTTCGGCAGCGAGACCGGCATCG
ACCTCCCCGGAGAGGCCAGTGGCCGGATCGCCGACCGGCACTGGAAGCTCGCCTACTGGAAGGCGATGAAGGGCTACTAC
TGCAAGCTCGACCGCGAGGGGAGCGCGAAGAGCAGCTTCCTGCGGGTCTTCGCCCACGAGTTCTGCCTCGAGGGCAGCTA
CTACCGCGCCGGCGACGCCGTGAACTACTCGATCGGCCAGGGCGACACGATGGTCACCCCGCTCCAGCTCGCGCGCGCGT
ACGCCGCGCTGTCGAACGGCGGGACGCTCTACGCCCCACGGGTTGCCAAGGCGGTCGTCAGCCCCGAGGGCACCGTGCTC
AAGCGGTTCGACCCGGTCGTCGAGGGCAAGGTGGACGCCACGCCTGCGAGCCTGCGCTACGTCGACCAGGCGCTCCAGGG
CACCCCGAAGGTCGGCACCCTGGCCTGGCGGTTCGGGGGCTTCCCGCTGGACCGGGTCCACATCCGCGGCAAGACCGGCT
CCGCCGAGGTCTACGGGAAGCAGTCGACCTCGTGGGTCGCGTCGTACGACGAGAACTATGTCGTGGTGATGATGGTCAGC
CAGGCCGGCACCGGCTCGGGCACCTCGGGCCCCGCGGTCCGCAAGATCTGGGAGGCCCTGTACGGCGTGGATGGGATGAC
CGTCGACCCGTCGAAGGCCGCGATCCCGGGCACCACGCCGCCCGAGCGGCTGCCGACGTTCATGAAGGACGGCACCATCC
TGCCGCCGGCCGAGCAGGGCTCCGAGCGCCGCGACGAGGAGGACTGA

Upstream 100 bases:

>100_bases
TGGGACCTGCTGCTCACCCCGCTCGTGCTGCCGGCGGTGATGGCGCTGTTGCGCCGGATCGAACCCGATCGCGCGGTCGC
GTAGGGCCGGGGTGTCTTCG

Downstream 100 bases:

>100_bases
CGTGCCGACCCCCCGCTCCGGGCTCCGGACGTCCGGCCTCAGGCCCCCCGGTCTCAGGCCCCCCGGTCTCAGGGCCCCGG
GCCTCGACTGGGTGCTGATG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 708; Mature: 707

Protein sequence:

>708_residues
MSTSSGRLRLVVIQVLVFSLFATLFARLYYLQVVGGEEYHAQAAAQSVREIVVQPQRGLIVDDQGRPLVANRTSWVVSID
RTVLGRMTAHQQEVLVGRVADAVVVPARKIDQKLVTCGDEGAVPGTCWNGSPYQPVPVAMDVKQAVALRILEQPEDYPGV
LAEQQSVRAYPRPYGVNLAHVLGYLSPITEDELDRAEENGDRSVNGASSVGRAGVEKEYDRWLRGMPGYKSVAVDSMGRV
LGDDGEVAGQPGDTLVTSIDAKVQGVVERQLADTISTARQTYDEVTRRNYRADSGAVVVMEAQTGRIVAMASQPTYDPGV
WVGGITKKQLARLYSDAAGNPLLGRATQGQFAPGSTWKPIMTVGALNNGFSTGTRLDCSSGLQVGNRWFKNYESASYGMI
GFDQALQLSCDTFFYRVGLHFWQKYGSDPTNVDAKDPLVQEAKNFGFGSETGIDLPGEASGRIADRHWKLAYWKAMKGYY
CKLDREGSAKSSFLRVFAHEFCLEGSYYRAGDAVNYSIGQGDTMVTPLQLARAYAALSNGGTLYAPRVAKAVVSPEGTVL
KRFDPVVEGKVDATPASLRYVDQALQGTPKVGTLAWRFGGFPLDRVHIRGKTGSAEVYGKQSTSWVASYDENYVVVMMVS
QAGTGSGTSGPAVRKIWEALYGVDGMTVDPSKAAIPGTTPPERLPTFMKDGTILPPAEQGSERRDEED

Sequences:

>Translated_708_residues
MSTSSGRLRLVVIQVLVFSLFATLFARLYYLQVVGGEEYHAQAAAQSVREIVVQPQRGLIVDDQGRPLVANRTSWVVSID
RTVLGRMTAHQQEVLVGRVADAVVVPARKIDQKLVTCGDEGAVPGTCWNGSPYQPVPVAMDVKQAVALRILEQPEDYPGV
LAEQQSVRAYPRPYGVNLAHVLGYLSPITEDELDRAEENGDRSVNGASSVGRAGVEKEYDRWLRGMPGYKSVAVDSMGRV
LGDDGEVAGQPGDTLVTSIDAKVQGVVERQLADTISTARQTYDEVTRRNYRADSGAVVVMEAQTGRIVAMASQPTYDPGV
WVGGITKKQLARLYSDAAGNPLLGRATQGQFAPGSTWKPIMTVGALNNGFSTGTRLDCSSGLQVGNRWFKNYESASYGMI
GFDQALQLSCDTFFYRVGLHFWQKYGSDPTNVDAKDPLVQEAKNFGFGSETGIDLPGEASGRIADRHWKLAYWKAMKGYY
CKLDREGSAKSSFLRVFAHEFCLEGSYYRAGDAVNYSIGQGDTMVTPLQLARAYAALSNGGTLYAPRVAKAVVSPEGTVL
KRFDPVVEGKVDATPASLRYVDQALQGTPKVGTLAWRFGGFPLDRVHIRGKTGSAEVYGKQSTSWVASYDENYVVVMMVS
QAGTGSGTSGPAVRKIWEALYGVDGMTVDPSKAAIPGTTPPERLPTFMKDGTILPPAEQGSERRDEED
>Mature_707_residues
STSSGRLRLVVIQVLVFSLFATLFARLYYLQVVGGEEYHAQAAAQSVREIVVQPQRGLIVDDQGRPLVANRTSWVVSIDR
TVLGRMTAHQQEVLVGRVADAVVVPARKIDQKLVTCGDEGAVPGTCWNGSPYQPVPVAMDVKQAVALRILEQPEDYPGVL
AEQQSVRAYPRPYGVNLAHVLGYLSPITEDELDRAEENGDRSVNGASSVGRAGVEKEYDRWLRGMPGYKSVAVDSMGRVL
GDDGEVAGQPGDTLVTSIDAKVQGVVERQLADTISTARQTYDEVTRRNYRADSGAVVVMEAQTGRIVAMASQPTYDPGVW
VGGITKKQLARLYSDAAGNPLLGRATQGQFAPGSTWKPIMTVGALNNGFSTGTRLDCSSGLQVGNRWFKNYESASYGMIG
FDQALQLSCDTFFYRVGLHFWQKYGSDPTNVDAKDPLVQEAKNFGFGSETGIDLPGEASGRIADRHWKLAYWKAMKGYYC
KLDREGSAKSSFLRVFAHEFCLEGSYYRAGDAVNYSIGQGDTMVTPLQLARAYAALSNGGTLYAPRVAKAVVSPEGTVLK
RFDPVVEGKVDATPASLRYVDQALQGTPKVGTLAWRFGGFPLDRVHIRGKTGSAEVYGKQSTSWVASYDENYVVVMMVSQ
AGTGSGTSGPAVRKIWEALYGVDGMTVDPSKAAIPGTTPPERLPTFMKDGTILPPAEQGSERRDEED

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=688, Percent_Identity=25.8720930232558, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786272, Length=541, Percent_Identity=24.2144177449168, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 76775; Mature: 76644

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSGRLRLVVIQVLVFSLFATLFARLYYLQVVGGEEYHAQAAAQSVREIVVQPQRGLI
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCEE
VDDQGRPLVANRTSWVVSIDRTVLGRMTAHQQEVLVGRVADAVVVPARKIDQKLVTCGDE
ECCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
GAVPGTCWNGSPYQPVPVAMDVKQAVALRILEQPEDYPGVLAEQQSVRAYPRPYGVNLAH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHCCCCCCCCCHHH
VLGYLSPITEDELDRAEENGDRSVNGASSVGRAGVEKEYDRWLRGMPGYKSVAVDSMGRV
HHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LGDDGEVAGQPGDTLVTSIDAKVQGVVERQLADTISTARQTYDEVTRRNYRADSGAVVVM
HCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EAQTGRIVAMASQPTYDPGVWVGGITKKQLARLYSDAAGNPLLGRATQGQFAPGSTWKPI
EECCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
MTVGALNNGFSTGTRLDCSSGLQVGNRWFKNYESASYGMIGFDQALQLSCDTFFYRVGLH
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FWQKYGSDPTNVDAKDPLVQEAKNFGFGSETGIDLPGEASGRIADRHWKLAYWKAMKGYY
HHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCEE
CKLDREGSAKSSFLRVFAHEFCLEGSYYRAGDAVNYSIGQGDTMVTPLQLARAYAALSNG
EEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCEEHHHHHHHHHHHHCCC
GTLYAPRVAKAVVSPEGTVLKRFDPVVEGKVDATPASLRYVDQALQGTPKVGTLAWRFGG
CEEECCHHHHHHCCCCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
FPLDRVHIRGKTGSAEVYGKQSTSWVASYDENYVVVMMVSQAGTGSGTSGPAVRKIWEAL
CCEEEEEEECCCCCCEEECCCCCCEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
YGVDGMTVDPSKAAIPGTTPPERLPTFMKDGTILPPAEQGSERRDEED
HCCCCCEECCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STSSGRLRLVVIQVLVFSLFATLFARLYYLQVVGGEEYHAQAAAQSVREIVVQPQRGLI
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCEE
VDDQGRPLVANRTSWVVSIDRTVLGRMTAHQQEVLVGRVADAVVVPARKIDQKLVTCGDE
ECCCCCEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
GAVPGTCWNGSPYQPVPVAMDVKQAVALRILEQPEDYPGVLAEQQSVRAYPRPYGVNLAH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHCCCCCCCCCHHH
VLGYLSPITEDELDRAEENGDRSVNGASSVGRAGVEKEYDRWLRGMPGYKSVAVDSMGRV
HHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LGDDGEVAGQPGDTLVTSIDAKVQGVVERQLADTISTARQTYDEVTRRNYRADSGAVVVM
HCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
EAQTGRIVAMASQPTYDPGVWVGGITKKQLARLYSDAAGNPLLGRATQGQFAPGSTWKPI
EECCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
MTVGALNNGFSTGTRLDCSSGLQVGNRWFKNYESASYGMIGFDQALQLSCDTFFYRVGLH
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FWQKYGSDPTNVDAKDPLVQEAKNFGFGSETGIDLPGEASGRIADRHWKLAYWKAMKGYY
HHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCEE
CKLDREGSAKSSFLRVFAHEFCLEGSYYRAGDAVNYSIGQGDTMVTPLQLARAYAALSNG
EEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCEEHHHHHHHHHHHHCCC
GTLYAPRVAKAVVSPEGTVLKRFDPVVEGKVDATPASLRYVDQALQGTPKVGTLAWRFGG
CEEECCHHHHHHCCCCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
FPLDRVHIRGKTGSAEVYGKQSTSWVASYDENYVVVMMVSQAGTGSGTSGPAVRKIWEAL
CCEEEEEEECCCCCCEEECCCCCCEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
YGVDGMTVDPSKAAIPGTTPPERLPTFMKDGTILPPAEQGSERRDEED
HCCCCCEECCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]