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The map label for this gene is ilvD

Identifier: 119717641

GI number: 119717641

Start: 3621708

End: 3623411

Strand: Reverse

Name: ilvD

Synonym: Noca_3419

Alternate gene names: 119717641

Gene position: 3623411-3621708 (Counterclockwise)

Preceding gene: 119717644

Following gene: 119717640

Centisome position: 72.67

GC content: 70.36

Gene sequence:

>1704_bases
ATGACCGAGCCCACCTCCCGCCCCGACATCAAGCCCCGCTCCCGCGACGTCACCGACGGCCTGGAGAAGGCCGCCGCGCG
CGGCATGCTGCGGGCGGTAGGCATGGGCGACGAGGACTTCGCGAAGCCGCAGATCGGCGTGGGCTCGAGCTGGAACGAGA
TCACCCCGTGCAACCTGTCCCTGGACCGGCTCGCCAAGGCCGTGAAGAACGGCGTGCACGCGGCCGGCGGCTACCCGCTG
GAGTTCGGCACCATCTCGGTCTCCGACGGCATCTCCATGGGCCACGAGGGCATGCACTTCTCGCTGGTCTCCCGCGAGGT
GATCGCCGACTCGGTCGAGACCGTGATGATGGCCGAGCGCCTGGACGGCTCGGTGCTGCTCGCCGGCTGCGACAAGTCGC
TGCCGGGCATGATGATGGCCGCCGCCCGCCTCGACCTGGCCAGCGTGTTCCTCTACGCCGGCTCGACGATGCCCGGGCAG
GTGGACGGCAACGACGTCACGATCATCGACGCGTTCGAGGCCGTCGGGGCGTGCCTGGCCGGCAAGATCAGCCGCGACGA
GGTGGACCGGATCGAGCGGGCCATCTGTCCGGGCGAGGGCGCCTGCGGCGGCATGTACACCGCGAACACGATGGCCTCCA
TCGCCGAGGCGATCGGCATGTCGCTCCCCGGCTCGGCGGCCCCGCCGGCGGTCGATCGCCGACGCGACGGCTTCGCGCAC
CGCTCGGGGGAGGCCGTGGTCAACCTGTTGCGCCAGGGCATCACGGCCCGCCAGATCATGACTCGCGCGGCGTTCGAGAA
CGCGATCACGGTCGCGATGGCGCTCGGCGGCTCGACCAACGCCGTGCTCCACCTGCTCGCGATGGCTCGTGAGGCCGACG
TCGACCTCACCATCGACGACTTCAACCGGATCGGTGACAAGGTGCCGCACCTCGGCGACCTCAAACCGTTCGGCAAGTAC
GTCATGAACGACGTCGACAAGATCGGCGGCATCCCCGTCGTGATGAAGGCACTGCTCGACGCCGGTCTGATGCACGGCGA
CGCGCTCACCGTCACCGGCAAGACCCTGGCCGAGAACCTCGCCGAGCTGGCCCCGCCGGAGCTCGATGACGAGGTGATCC
GCAAGCTGGACCGGCCGATCCACAAGACCGGTGGGCTCACGATCCTCAAGGGCTCGCTCGCTCCCGAGGGCGCCGTGGTC
AAGACGGCCGGCTTCGACGACTCCGTGTTCACCGGCACCGCCCGCGTCTTCGACGGCGAGCGGGCCGCGATGGACGCCCT
CGAGGCCGGGCAGATCCAGCCCCGCGACGTCGTGGTGATCCGCTACGAGGGCCCGAAGGGTGGCCCCGGCATGCGCGAGA
TGCTCGCGATCACCGGCGCGATCAAGGGCGCCGGCCTCGGCAAGGACGTCTTGCTGATCACCGACGGCAGGTTCTCCGGT
GGTACGACGGGCCTGTGCGTGGGCCACATCGCCCCCGAGGCCGTCGACGGCGGCCCGATCGCGTTCGTCCGCGACGGCGA
CCAGATCACCCTCGACGTCGCCAACCGGCTGCTCGAGGTGGAGGTCGTCGGTCCCGATGCCGAGGCCGAGTGGGAGCGCC
GCAAGGTCGGCTGGGAGCCGAATCCGCCCAAGTACACCCGCGGGGTGCTCGGCAAGTACGCCAAGATCGTCCAGTCCGCC
GCGCACGGCGCCATCACCGGCTGA

Upstream 100 bases:

>100_bases
GCCAGCTCACCGAACGCACGGGACTCACACGAGAAGGCTAGGGCTTCTCGGGAGTCGGGCCGGGCGGCGCCCCACCCCTT
CCGGCGAATACCCTGGGCCC

Downstream 100 bases:

>100_bases
GTCGCCCGCCGGGCAGACAGGGGACCGATGCCTCGGGCCGGCCCCGCGACATCGTGACCCCCGAACTCATGTCAGAGGTC
TTCGGCGTCGCCTGCCTGAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MTEPTSRPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKNGVHAAGGYPL
EFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMMAERLDGSVLLAGCDKSLPGMMMAAARLDLASVFLYAGSTMPGQ
VDGNDVTIIDAFEAVGACLAGKISRDEVDRIERAICPGEGACGGMYTANTMASIAEAIGMSLPGSAAPPAVDRRRDGFAH
RSGEAVVNLLRQGITARQIMTRAAFENAITVAMALGGSTNAVLHLLAMAREADVDLTIDDFNRIGDKVPHLGDLKPFGKY
VMNDVDKIGGIPVVMKALLDAGLMHGDALTVTGKTLAENLAELAPPELDDEVIRKLDRPIHKTGGLTILKGSLAPEGAVV
KTAGFDDSVFTGTARVFDGERAAMDALEAGQIQPRDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLITDGRFSG
GTTGLCVGHIAPEAVDGGPIAFVRDGDQITLDVANRLLEVEVVGPDAEAEWERRKVGWEPNPPKYTRGVLGKYAKIVQSA
AHGAITG

Sequences:

>Translated_567_residues
MTEPTSRPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKNGVHAAGGYPL
EFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMMAERLDGSVLLAGCDKSLPGMMMAAARLDLASVFLYAGSTMPGQ
VDGNDVTIIDAFEAVGACLAGKISRDEVDRIERAICPGEGACGGMYTANTMASIAEAIGMSLPGSAAPPAVDRRRDGFAH
RSGEAVVNLLRQGITARQIMTRAAFENAITVAMALGGSTNAVLHLLAMAREADVDLTIDDFNRIGDKVPHLGDLKPFGKY
VMNDVDKIGGIPVVMKALLDAGLMHGDALTVTGKTLAENLAELAPPELDDEVIRKLDRPIHKTGGLTILKGSLAPEGAVV
KTAGFDDSVFTGTARVFDGERAAMDALEAGQIQPRDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLITDGRFSG
GTTGLCVGHIAPEAVDGGPIAFVRDGDQITLDVANRLLEVEVVGPDAEAEWERRKVGWEPNPPKYTRGVLGKYAKIVQSA
AHGAITG
>Mature_566_residues
TEPTSRPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKNGVHAAGGYPLE
FGTISVSDGISMGHEGMHFSLVSREVIADSVETVMMAERLDGSVLLAGCDKSLPGMMMAAARLDLASVFLYAGSTMPGQV
DGNDVTIIDAFEAVGACLAGKISRDEVDRIERAICPGEGACGGMYTANTMASIAEAIGMSLPGSAAPPAVDRRRDGFAHR
SGEAVVNLLRQGITARQIMTRAAFENAITVAMALGGSTNAVLHLLAMAREADVDLTIDDFNRIGDKVPHLGDLKPFGKYV
MNDVDKIGGIPVVMKALLDAGLMHGDALTVTGKTLAENLAELAPPELDDEVIRKLDRPIHKTGGLTILKGSLAPEGAVVK
TAGFDDSVFTGTARVFDGERAAMDALEAGQIQPRDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLITDGRFSGG
TTGLCVGHIAPEAVDGGPIAFVRDGDQITLDVANRLLEVEVVGPDAEAEWERRKVGWEPNPPKYTRGVLGKYAKIVQSAA
HGAITG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=40.7590759075908, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI2367371, Length=503, Percent_Identity=35.9840954274354, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1788157, Length=513, Percent_Identity=31.7738791423002, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786464, Length=471, Percent_Identity=36.5180467091295, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=47.3309608540925, Blast_Score=513, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_NOCSJ (A1SM84)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924606.1
- ProteinModelPortal:   A1SM84
- SMR:   A1SM84
- STRING:   A1SM84
- GeneID:   4598217
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3419
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- PhylomeDB:   A1SM84
- ProtClustDB:   PRK00911
- BioCyc:   NSP35761:NOCA_3419-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59432; Mature: 59301

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPTSRPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVGSSWNEITPCNLS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
LDRLAKAVKNGVHAAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMMAER
HHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LDGSVLLAGCDKSLPGMMMAAARLDLASVFLYAGSTMPGQVDGNDVTIIDAFEAVGACLA
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHH
GKISRDEVDRIERAICPGEGACGGMYTANTMASIAEAIGMSLPGSAAPPAVDRRRDGFAH
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCC
RSGEAVVNLLRQGITARQIMTRAAFENAITVAMALGGSTNAVLHLLAMAREADVDLTIDD
CCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
FNRIGDKVPHLGDLKPFGKYVMNDVDKIGGIPVVMKALLDAGLMHGDALTVTGKTLAENL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
AELAPPELDDEVIRKLDRPIHKTGGLTILKGSLAPEGAVVKTAGFDDSVFTGTARVFDGE
HHHCCCCCCHHHHHHHCCCHHHCCCEEEEECCCCCCCCEEEECCCCCCCEECCCEEECCH
RAAMDALEAGQIQPRDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLITDGRFSG
HHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GTTGLCVGHIAPEAVDGGPIAFVRDGDQITLDVANRLLEVEVVGPDAEAEWERRKVGWEP
CCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCHHHHHCCCCC
NPPKYTRGVLGKYAKIVQSAAHGAITG
CCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TEPTSRPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVGSSWNEITPCNLS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
LDRLAKAVKNGVHAAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMMAER
HHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
LDGSVLLAGCDKSLPGMMMAAARLDLASVFLYAGSTMPGQVDGNDVTIIDAFEAVGACLA
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHH
GKISRDEVDRIERAICPGEGACGGMYTANTMASIAEAIGMSLPGSAAPPAVDRRRDGFAH
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCC
RSGEAVVNLLRQGITARQIMTRAAFENAITVAMALGGSTNAVLHLLAMAREADVDLTIDD
CCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
FNRIGDKVPHLGDLKPFGKYVMNDVDKIGGIPVVMKALLDAGLMHGDALTVTGKTLAENL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
AELAPPELDDEVIRKLDRPIHKTGGLTILKGSLAPEGAVVKTAGFDDSVFTGTARVFDGE
HHHCCCCCCHHHHHHHCCCHHHCCCEEEEECCCCCCCCEEEECCCCCCCEECCCEEECCH
RAAMDALEAGQIQPRDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLITDGRFSG
HHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GTTGLCVGHIAPEAVDGGPIAFVRDGDQITLDVANRLLEVEVVGPDAEAEWERRKVGWEP
CCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCHHHHHCCCCC
NPPKYTRGVLGKYAKIVQSAAHGAITG
CCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA