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The map label for this gene is kynU [H]

Identifier: 119717619

GI number: 119717619

Start: 3598679

End: 3599884

Strand: Reverse

Name: kynU [H]

Synonym: Noca_3396

Alternate gene names: 119717619

Gene position: 3599884-3598679 (Counterclockwise)

Preceding gene: 119717620

Following gene: 119717617

Centisome position: 72.2

GC content: 75.21

Gene sequence:

>1206_bases
GTGACCGAGCCCCCCGAGCGGCTCGACGCCGCGGACCCGCTCGCGTCGTACCGCGCCCGCTTCGTCGGCGCCGCCGAGCC
GCTCGTCTACTTCGACGGCAACTCGCTGGGCCGGCCGCTGGCGGCGACCGGCCCGCGGCTCGCGGCGTTCGTGGAGCAGG
AGTGGGGTGGCCGACTGATCCGCGGGTGGGACGAGCGGTGGTTCGAGCTGCCGCAGATGATCGGGGACGACCTCGGCCGG
GTGGTCCTCGGCGCGGCCCCGGGCCAGACCGTCGTCGGCGACTCGACGACGGTGCTGCTCTACAAGCTGATGCGCGCGGC
CGTCGCCGACCGGCCGGGGCGCACCGAGATCGTCATCGACCGCGACAACTTCCCGACCGACCGGTACGTCGCCGCGGGGG
TCGCGCAGGAGTGCGGGCTGACGCTGCGGTGGATCGACGTGGACCCGGCCGCGGGCGTCACCGTCGACCTGCTCGCCGAG
GCCGTCGGACCGCAGACCGCGCTGGTCGTGCTCTCGCACGTCGCGTACCGCTCGGCCTGGCTCGCCGACCTGCCGGCGCT
GACCCGGATCGCCCAGGACGCGGGGGCACTGGTGCTGTGGGACCTGTGCCACTCGGTGGCGTCGGTGCCGTTGGCGCTGG
ACGCCGCCGGCGTGGACCTGGCGGTCGGCTGCACCTACAAGTACCTCAACGGCGGCCCCGGCTCCCCGGCGTTCGCCTAC
GTCGCGCAGCGGCACCTCGGCGAGCTGACCCAGCCGATCCAGGGCTGGATGGGCGCCGCGGACCCGTTCCTCATGGGGCC
GTCGTACGCCCCGGCCGCCGGGGTGCGCCGGTTCCTCTCCGGCACCCCGCCGATCGTCGGGATGCTGGCCCTCCAGGACA
TGCTCGGCCTGATCGCGGAGGTCGGCATGGACGCGGTGCGCGCCAAGTCGGTGGCGCTCACGTCGTACGCCGTCGACGTC
GCCGACGAGCTGCTCGCCCCGCTCGGCGTGGTGCTGGGCTCGCCGCGCGACCCCGCGCAGCGCGGCAGCCACGTGACGCT
CAACCACCCGCGGATGCGCGAGGTCACCGCCGCGCTGTGGGAGCGCGACGTGATCCCCGACTACCGCGACCCGCACGGGC
TGCGGATCGGGCTGTCGCCGCTGTCCACGTCGTTCGCCGAGGTGCGGGCCGGCCTCGAGGCGGTGCGCGAGGTCCTCGAG
GCCTGA

Upstream 100 bases:

>100_bases
CCGCGTGGCCGCTCGCTGACGTGGTCGCCACCGAGGTCGAGCCGACCCCACAGGTGCGGGCCCGGTATGCCGAGGTCCGC
GACCTGACAGCGACCCGGCC

Downstream 100 bases:

>100_bases
GCCCAGGACTTCTCAGGCAAAGCCGGAACCTCTCGGCCGAAGTTTCGGCCCAACAGTTCCGGTTTCCCCGGTTCACCGGG
GAAACCGCCGCCGCGAGCCG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTEPPERLDAADPLASYRARFVGAAEPLVYFDGNSLGRPLAATGPRLAAFVEQEWGGRLIRGWDERWFELPQMIGDDLGR
VVLGAAPGQTVVGDSTTVLLYKLMRAAVADRPGRTEIVIDRDNFPTDRYVAAGVAQECGLTLRWIDVDPAAGVTVDLLAE
AVGPQTALVVLSHVAYRSAWLADLPALTRIAQDAGALVLWDLCHSVASVPLALDAAGVDLAVGCTYKYLNGGPGSPAFAY
VAQRHLGELTQPIQGWMGAADPFLMGPSYAPAAGVRRFLSGTPPIVGMLALQDMLGLIAEVGMDAVRAKSVALTSYAVDV
ADELLAPLGVVLGSPRDPAQRGSHVTLNHPRMREVTAALWERDVIPDYRDPHGLRIGLSPLSTSFAEVRAGLEAVREVLE
A

Sequences:

>Translated_401_residues
MTEPPERLDAADPLASYRARFVGAAEPLVYFDGNSLGRPLAATGPRLAAFVEQEWGGRLIRGWDERWFELPQMIGDDLGR
VVLGAAPGQTVVGDSTTVLLYKLMRAAVADRPGRTEIVIDRDNFPTDRYVAAGVAQECGLTLRWIDVDPAAGVTVDLLAE
AVGPQTALVVLSHVAYRSAWLADLPALTRIAQDAGALVLWDLCHSVASVPLALDAAGVDLAVGCTYKYLNGGPGSPAFAY
VAQRHLGELTQPIQGWMGAADPFLMGPSYAPAAGVRRFLSGTPPIVGMLALQDMLGLIAEVGMDAVRAKSVALTSYAVDV
ADELLAPLGVVLGSPRDPAQRGSHVTLNHPRMREVTAALWERDVIPDYRDPHGLRIGLSPLSTSFAEVRAGLEAVREVLE
A
>Mature_400_residues
TEPPERLDAADPLASYRARFVGAAEPLVYFDGNSLGRPLAATGPRLAAFVEQEWGGRLIRGWDERWFELPQMIGDDLGRV
VLGAAPGQTVVGDSTTVLLYKLMRAAVADRPGRTEIVIDRDNFPTDRYVAAGVAQECGLTLRWIDVDPAAGVTVDLLAEA
VGPQTALVVLSHVAYRSAWLADLPALTRIAQDAGALVLWDLCHSVASVPLALDAAGVDLAVGCTYKYLNGGPGSPAFAYV
AQRHLGELTQPIQGWMGAADPFLMGPSYAPAAGVRRFLSGTPPIVGMLALQDMLGLIAEVGMDAVRAKSVALTSYAVDVA
DELLAPLGVVLGSPRDPAQRGSHVTLNHPRMREVTAALWERDVIPDYRDPHGLRIGLSPLSTSFAEVRAGLEAVREVLEA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=438, Percent_Identity=27.6255707762557, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI74101437, Length=270, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17550466, Length=392, Percent_Identity=25.765306122449, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323261, Length=447, Percent_Identity=26.8456375838926, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 42714; Mature: 42583

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPPERLDAADPLASYRARFVGAAEPLVYFDGNSLGRPLAATGPRLAAFVEQEWGGRLI
CCCCHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RGWDERWFELPQMIGDDLGRVVLGAAPGQTVVGDSTTVLLYKLMRAAVADRPGRTEIVID
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEE
RDNFPTDRYVAAGVAQECGLTLRWIDVDPAAGVTVDLLAEAVGPQTALVVLSHVAYRSAW
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LADLPALTRIAQDAGALVLWDLCHSVASVPLALDAAGVDLAVGCTYKYLNGGPGSPAFAY
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCEEEEECEEEECCCCCCCHHHHH
VAQRHLGELTQPIQGWMGAADPFLMGPSYAPAAGVRRFLSGTPPIVGMLALQDMLGLIAE
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VGMDAVRAKSVALTSYAVDVADELLAPLGVVLGSPRDPAQRGSHVTLNHPRMREVTAALW
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHH
ERDVIPDYRDPHGLRIGLSPLSTSFAEVRAGLEAVREVLEA
HHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEPPERLDAADPLASYRARFVGAAEPLVYFDGNSLGRPLAATGPRLAAFVEQEWGGRLI
CCCHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHH
RGWDERWFELPQMIGDDLGRVVLGAAPGQTVVGDSTTVLLYKLMRAAVADRPGRTEIVID
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEE
RDNFPTDRYVAAGVAQECGLTLRWIDVDPAAGVTVDLLAEAVGPQTALVVLSHVAYRSAW
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LADLPALTRIAQDAGALVLWDLCHSVASVPLALDAAGVDLAVGCTYKYLNGGPGSPAFAY
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCEEEEECEEEECCCCCCCHHHHH
VAQRHLGELTQPIQGWMGAADPFLMGPSYAPAAGVRRFLSGTPPIVGMLALQDMLGLIAE
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VGMDAVRAKSVALTSYAVDVADELLAPLGVVLGSPRDPAQRGSHVTLNHPRMREVTAALW
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHH
ERDVIPDYRDPHGLRIGLSPLSTSFAEVRAGLEAVREVLEA
HHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA