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The map label for this gene is ddn [H]

Identifier: 119716724

GI number: 119716724

Start: 2666810

End: 2667331

Strand: Direct

Name: ddn [H]

Synonym: Noca_2498

Alternate gene names: 119716724

Gene position: 2666810-2667331 (Clockwise)

Preceding gene: 119716723

Following gene: 119716725

Centisome position: 53.49

GC content: 73.56

Gene sequence:

>522_bases
ATGAGCGTGGCCACCGACCTCTCCTATCAGCCGAGACCGGCGAACCCCGTGCAGCGCGCGGTCCAGGCGTTCGGTGCATC
CCGTCCCGGGGCGTGGCTGTTCTCCCGGATCCTGCCGCCGCTCGACACGGTGGTGCAGCGGCTCACCCGGCACCGGCACA
CCCTGCCGAGCCTGCTGGCCGGGCTCCCGGTGGTCGACCTGACGACGACCGGGAGGCGCAGCGGCCAGCCGCGGACGGCA
CACCTGATCGCGGTGCCGCACGGCGAGGCGCTGGCCGTCCTCGGCACCAACTTCGGCCAGGCCTCGACCCCGACCTGGGT
GCTCAACCTGGAAGCCGACCCGCACGCCCGCCTGAGCTACCGCGACCGGACGGTGGACGTGCTGGCGCGACCGCTCGTCG
GCGAGGAGGCCGAGGAGCTGCTCGGGCGCGCCGAACGACTCTATGCGGGCTACCGGAAGTACCAGGGCCGGATCACCGGA
CGGCGGCTGCGGATCTTCGCGCTCGAGACGGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
AGGAGCTCGGCGAGCTGCTGGACACCGCCCAGCTGTAGGCGCCCCCGAAGGCTTCGCCGGTTCGGCTCCGGGCCGGTGCC
GCGGTCGCTAGCGTCGTCGT

Downstream 100 bases:

>100_bases
TCGCGGCCCGAGCGGGTCGACGGGGGTGTCGGCGCGGGCGGGTAGCGTCGACACCGAGACCGGAGAGCCGGCCGGTCCGC
AACCGGACGGTGGTGGCCAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSVATDLSYQPRPANPVQRAVQAFGASRPGAWLFSRILPPLDTVVQRLTRHRHTLPSLLAGLPVVDLTTTGRRSGQPRTA
HLIAVPHGEALAVLGTNFGQASTPTWVLNLEADPHARLSYRDRTVDVLARPLVGEEAEELLGRAERLYAGYRKYQGRITG
RRLRIFALETAAR

Sequences:

>Translated_173_residues
MSVATDLSYQPRPANPVQRAVQAFGASRPGAWLFSRILPPLDTVVQRLTRHRHTLPSLLAGLPVVDLTTTGRRSGQPRTA
HLIAVPHGEALAVLGTNFGQASTPTWVLNLEADPHARLSYRDRTVDVLARPLVGEEAEELLGRAERLYAGYRKYQGRITG
RRLRIFALETAAR
>Mature_172_residues
SVATDLSYQPRPANPVQRAVQAFGASRPGAWLFSRILPPLDTVVQRLTRHRHTLPSLLAGLPVVDLTTTGRRSGQPRTAH
LIAVPHGEALAVLGTNFGQASTPTWVLNLEADPHARLSYRDRTVDVLARPLVGEEAEELLGRAERLYAGYRKYQGRITGR
RLRIFALETAAR

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 19092; Mature: 18961

Theoretical pI: Translated: 11.57; Mature: 11.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVATDLSYQPRPANPVQRAVQAFGASRPGAWLFSRILPPLDTVVQRLTRHRHTLPSLLA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GLPVVDLTTTGRRSGQPRTAHLIAVPHGEALAVLGTNFGQASTPTWVLNLEADPHARLSY
CCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEE
RDRTVDVLARPLVGEEAEELLGRAERLYAGYRKYQGRITGRRLRIFALETAAR
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
SVATDLSYQPRPANPVQRAVQAFGASRPGAWLFSRILPPLDTVVQRLTRHRHTLPSLLA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
GLPVVDLTTTGRRSGQPRTAHLIAVPHGEALAVLGTNFGQASTPTWVLNLEADPHARLSY
CCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEEE
RDRTVDVLARPLVGEEAEELLGRAERLYAGYRKYQGRITGRRLRIFALETAAR
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]