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The map label for this gene is pyrG

Identifier: 119716711

GI number: 119716711

Start: 2652492

End: 2654201

Strand: Direct

Name: pyrG

Synonym: Noca_2485

Alternate gene names: 119716711

Gene position: 2652492-2654201 (Clockwise)

Preceding gene: 119716710

Following gene: 119716712

Centisome position: 53.2

GC content: 69.77

Gene sequence:

>1710_bases
GTGAACCAGGCGACGCCCACCAAGCACGTGTTCGTGACCGGAGGCGTCGCCTCCTCGCTCGGGAAGGGCCTGACGGCTTC
CAGCCTCGGTAGCCTCCTGCGCTCGCGCGGTCTGCGCGTCACCATGCAGAAGCTGGACCCCTACCTCAACGTCGACCCGG
GGACGATGAACCCGTTCCAGCACGGCGAGGTGTTCGTCACCAACGACGGAGCCGAGACCGACCTCGACATCGGGCACTAC
GAGCGGTTCCTCGACACCGACCTGAGCCAGATCGCGAACGTCACCACCGGCCAGGTGTACTCCAGCGTGATCGCCAAGGA
GCGCCGCGGCGACTACCTGGGCGACACCGTGCAGGTGATCCCGCACATCACGAACGAGATCAAGGAGCGGATCCTCGCCA
TGGGCGGCACCGGCGAGGACGGCCGGAGCGTCGACGTGGTGATCACCGAGGTCGGCGGCACCGTGGGCGACATCGAGTCG
CTGCCGTTCCTCGAGGCCGCCCGTCAGGTGCGCCACGACATCGGGCGGGAGAACTGCTTCTTCCTGCACGTCTCCCTGGT
GCCCTACATCGGGCCGTCGGGTGAGCTGAAGACCAAGCCCACCCAGCACTCGGTGGCCGCGTTGCGTCAGGTCGGCATCC
AGCCCGACGCCGTCGTCTGCCGCGCCGATCGCGAGCTCCCGCCGTCGATCAAGAAGAAGATCTCGTTGATGTGCGACGTC
GACCAGGATGCGGTGGTCACGTGCGCGGACGCGCCGTCGATCTACGACATCCCCAAGGTGCTGCACCGCGAGGGCCTGGA
CGCGTACCTGGTGCGCCGGCTCGACCTGCCCTTCCGCGACGTGGACTGGACGGTGTGGGACGACCTGCTGCGCCGGGTGC
ACCATCCGAAGGAGGAGGTGACGGTCGCGCTGGTCGGCAAGTACGTCGACCTGCCCGACGCGTACCTGTCGGTCGCCGAG
GCACTGCGCGCCGGCGGCTTCGCCCATGAGGCCAAGGTCCAGCTGCGGTGGGTCGCCTCCGACGAGTGCCAGACGGCGGC
CGGAGCGGCGCGCAACCTGCAGGACGTCGACGCGATCTGCGTGCCCGGCGGATTCGGGGTACGCGGCATCGAGGGCAAGC
TGGGTGCGCTCACCTACGCCCGCACGCACGGCATCCCCACGCTGGGGCTGTGCCTGGGCCTGCAGTGCATGGTGATCGAG
TACGCCCGCAACGTGGTGGGGCTGGAGAAGGCGGGGTCCACGGAGTTCGACCCCGACACCCCGGAGCCGGTTATCGCGAC
CATGGCCGAGCAGAAGGCCTTCGTCGAGGGCGCCGGCGACCTCGGCGGGACGATGCGGCTGGGCCTGTACCCGGCGGCCC
TCAAGGACGGCTCGATCGCCCGGGAGGTCTACGGCAGCAGCCTCATCGAGGAGCGGCACCGGCACCGCTACGAGGTCAAC
AACGCCTACCGCGACCAGCTCGAGGAGGCCGGTCTGGTCTTCTCCGGCACCTCGCCGGACAACAGCCTGGTGGAGTACGT
CGAGCTGCCGCGAGACACGCACCCCTACTACATCTCCACGCAGGCGCACCCCGAGCTGCGCTCCCGCCCGACCCGGCCGC
ATCCGCTGTTCGCGGGCCTGGTCGGCGCGGCCATCGAGCGCCAGCGCGAGCTGCGGTTCCCCATCGACGAGACCGGGCTG
CGCCGCGAGCCCGAGCCCGACGAGGACTGA

Upstream 100 bases:

>100_bases
CCGCCGTGCTCGCCCTGATCCGGTCGATGTCGGTCCAGGGTGGGTCCTTCGGTGCGTCGGGGTCGGACGGAACCGTTCCT
CTGACGTAGGATGGAGTTCC

Downstream 100 bases:

>100_bases
GCCCGACGACGGAGGAACGGGTGCCCGAGCTCGCCGACCGGCCCGAGGCGTGGCCGGTCGAGGACAGCGGCTATCCCTAC
GACGGCGACGGTTGGGTCGT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MNQATPTKHVFVTGGVASSLGKGLTASSLGSLLRSRGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHY
ERFLDTDLSQIANVTTGQVYSSVIAKERRGDYLGDTVQVIPHITNEIKERILAMGGTGEDGRSVDVVITEVGGTVGDIES
LPFLEAARQVRHDIGRENCFFLHVSLVPYIGPSGELKTKPTQHSVAALRQVGIQPDAVVCRADRELPPSIKKKISLMCDV
DQDAVVTCADAPSIYDIPKVLHREGLDAYLVRRLDLPFRDVDWTVWDDLLRRVHHPKEEVTVALVGKYVDLPDAYLSVAE
ALRAGGFAHEAKVQLRWVASDECQTAAGAARNLQDVDAICVPGGFGVRGIEGKLGALTYARTHGIPTLGLCLGLQCMVIE
YARNVVGLEKAGSTEFDPDTPEPVIATMAEQKAFVEGAGDLGGTMRLGLYPAALKDGSIAREVYGSSLIEERHRHRYEVN
NAYRDQLEEAGLVFSGTSPDNSLVEYVELPRDTHPYYISTQAHPELRSRPTRPHPLFAGLVGAAIERQRELRFPIDETGL
RREPEPDED

Sequences:

>Translated_569_residues
MNQATPTKHVFVTGGVASSLGKGLTASSLGSLLRSRGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHY
ERFLDTDLSQIANVTTGQVYSSVIAKERRGDYLGDTVQVIPHITNEIKERILAMGGTGEDGRSVDVVITEVGGTVGDIES
LPFLEAARQVRHDIGRENCFFLHVSLVPYIGPSGELKTKPTQHSVAALRQVGIQPDAVVCRADRELPPSIKKKISLMCDV
DQDAVVTCADAPSIYDIPKVLHREGLDAYLVRRLDLPFRDVDWTVWDDLLRRVHHPKEEVTVALVGKYVDLPDAYLSVAE
ALRAGGFAHEAKVQLRWVASDECQTAAGAARNLQDVDAICVPGGFGVRGIEGKLGALTYARTHGIPTLGLCLGLQCMVIE
YARNVVGLEKAGSTEFDPDTPEPVIATMAEQKAFVEGAGDLGGTMRLGLYPAALKDGSIAREVYGSSLIEERHRHRYEVN
NAYRDQLEEAGLVFSGTSPDNSLVEYVELPRDTHPYYISTQAHPELRSRPTRPHPLFAGLVGAAIERQRELRFPIDETGL
RREPEPDED
>Mature_569_residues
MNQATPTKHVFVTGGVASSLGKGLTASSLGSLLRSRGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHY
ERFLDTDLSQIANVTTGQVYSSVIAKERRGDYLGDTVQVIPHITNEIKERILAMGGTGEDGRSVDVVITEVGGTVGDIES
LPFLEAARQVRHDIGRENCFFLHVSLVPYIGPSGELKTKPTQHSVAALRQVGIQPDAVVCRADRELPPSIKKKISLMCDV
DQDAVVTCADAPSIYDIPKVLHREGLDAYLVRRLDLPFRDVDWTVWDDLLRRVHHPKEEVTVALVGKYVDLPDAYLSVAE
ALRAGGFAHEAKVQLRWVASDECQTAAGAARNLQDVDAICVPGGFGVRGIEGKLGALTYARTHGIPTLGLCLGLQCMVIE
YARNVVGLEKAGSTEFDPDTPEPVIATMAEQKAFVEGAGDLGGTMRLGLYPAALKDGSIAREVYGSSLIEERHRHRYEVN
NAYRDQLEEAGLVFSGTSPDNSLVEYVELPRDTHPYYISTQAHPELRSRPTRPHPLFAGLVGAAIERQRELRFPIDETGL
RREPEPDED

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=556, Percent_Identity=45.6834532374101, Blast_Score=491, Evalue=1e-138,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=45.5696202531646, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=45.5696202531646, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=45.5696202531646, Blast_Score=487, Evalue=1e-137,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=53.0054644808743, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=606, Percent_Identity=38.1188118811881, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=43.9929328621908, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=564, Percent_Identity=43.6170212765958, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24664469, Length=556, Percent_Identity=46.5827338129496, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21357815, Length=501, Percent_Identity=45.3093812375249, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_NOCSJ (A1SJK4)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923676.1
- ProteinModelPortal:   A1SJK4
- SMR:   A1SJK4
- STRING:   A1SJK4
- GeneID:   4597110
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2485
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   A1SJK4
- ProtClustDB:   PRK05380
- BioCyc:   NSP35761:NOCA_2485-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 62263; Mature: 62263

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 391-391 ACT_SITE 523-523 ACT_SITE 525-525

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQATPTKHVFVTGGVASSLGKGLTASSLGSLLRSRGLRVTMQKLDPYLNVDPGTMNPFQ
CCCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCCC
HGEVFVTNDGAETDLDIGHYERFLDTDLSQIANVTTGQVYSSVIAKERRGDYLGDTVQVI
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHITNEIKERILAMGGTGEDGRSVDVVITEVGGTVGDIESLPFLEAARQVRHDIGRENCF
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
FLHVSLVPYIGPSGELKTKPTQHSVAALRQVGIQPDAVVCRADRELPPSIKKKISLMCDV
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHEEEEEEC
DQDAVVTCADAPSIYDIPKVLHREGLDAYLVRRLDLPFRDVDWTVWDDLLRRVHHPKEEV
CCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHE
TVALVGKYVDLPDAYLSVAEALRAGGFAHEAKVQLRWVASDECQTAAGAARNLQDVDAIC
EEEEEHHHCCCCHHHHHHHHHHHHCCCCEECEEEEEEEECCCHHHHHHHHCCCCCCCEEE
VPGGFGVRGIEGKLGALTYARTHGIPTLGLCLGLQCMVIEYARNVVGLEKAGSTEFDPDT
ECCCCCCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCC
PEPVIATMAEQKAFVEGAGDLGGTMRLGLYPAALKDGSIAREVYGSSLIEERHRHRYEVN
CCHHHHHHHHHHHHHHCCCCCCCEEEECEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
NAYRDQLEEAGLVFSGTSPDNSLVEYVELPRDTHPYYISTQAHPELRSRPTRPHPLFAGL
HHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCHHHHHH
VGAAIERQRELRFPIDETGLRREPEPDED
HHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNQATPTKHVFVTGGVASSLGKGLTASSLGSLLRSRGLRVTMQKLDPYLNVDPGTMNPFQ
CCCCCCCCEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCCC
HGEVFVTNDGAETDLDIGHYERFLDTDLSQIANVTTGQVYSSVIAKERRGDYLGDTVQVI
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHITNEIKERILAMGGTGEDGRSVDVVITEVGGTVGDIESLPFLEAARQVRHDIGRENCF
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
FLHVSLVPYIGPSGELKTKPTQHSVAALRQVGIQPDAVVCRADRELPPSIKKKISLMCDV
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHEEEEEEC
DQDAVVTCADAPSIYDIPKVLHREGLDAYLVRRLDLPFRDVDWTVWDDLLRRVHHPKEEV
CCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHE
TVALVGKYVDLPDAYLSVAEALRAGGFAHEAKVQLRWVASDECQTAAGAARNLQDVDAIC
EEEEEHHHCCCCHHHHHHHHHHHHCCCCEECEEEEEEEECCCHHHHHHHHCCCCCCCEEE
VPGGFGVRGIEGKLGALTYARTHGIPTLGLCLGLQCMVIEYARNVVGLEKAGSTEFDPDT
ECCCCCCCCCCCCHHHEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCC
PEPVIATMAEQKAFVEGAGDLGGTMRLGLYPAALKDGSIAREVYGSSLIEERHRHRYEVN
CCHHHHHHHHHHHHHHCCCCCCCEEEECEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
NAYRDQLEEAGLVFSGTSPDNSLVEYVELPRDTHPYYISTQAHPELRSRPTRPHPLFAGL
HHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCHHHHHH
VGAAIERQRELRFPIDETGLRREPEPDED
HHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA