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The map label for this gene is arcB [H]

Identifier: 119716652

GI number: 119716652

Start: 2585553

End: 2586557

Strand: Direct

Name: arcB [H]

Synonym: Noca_2425

Alternate gene names: 119716652

Gene position: 2585553-2586557 (Clockwise)

Preceding gene: 119716651

Following gene: 161485634

Centisome position: 51.86

GC content: 67.76

Gene sequence:

>1005_bases
ATGCCTGTCAACCTTCGCGGGCGGCACCTGCTCAGCCTGCGCCACCACAGCGCCGACGAGATCCGCTACCTGCTCGACCT
CTCCCGCGACCTCAAGCGTGCGAAGTACGCCGGCAGCGAGCGGCAGCTCCTGCAGGGCCGCAACGTCGCGCTGATCTTCG
AGAAGACCTCCACCCGCACCCGCTGCGCCTTCGAGGTCGCGTCCTACGACCAGGGTGCGCACGTCACCTACATCGACCCC
GCGTCGTCCCAGCTGGGGCACAAGGAGTCGGTCAAGGACACCGCTCGCGTCCTCGGCCGCATGTACGACGCGATCGAGTA
CCGCGGCTTCTCCCAGCAGGTCGTCGAGGAGCTGGCCGAGTACGCCGGCGTCCCGGTCTTCAACGGCCTCACCGACGAGT
TCCACCCGACCCAGATGCTCGCCGACGTGCTCACCATGCGTGAGCACTGCGACAAGCCGCTGCACGAGATCGCGTTCGCG
TTCATGGGCGACGGCCGCAACAACGTGGCGAACTCGCTGCTGCTCGTGGCCGCCAAGCTCGGGATGGACGTCCGCATCGG
CGCCCCCAAGGAGCTCTGGCCCGAGGACGAGCTGGTCAAGCTCTGCCACGATCTCGCCGACGTCTCCGGTGCCCGGATCA
CGATCACCGACGACCCGACCCAGGCCGTGGCCGGCGTCGACTTCATCTACACGGACGTGTGGGTCTCGATGGGTGAGCCG
GTGGAGTCGTGGGCCGAGCGCGTCGAGCGCTGCCTGCCGTTCCAGGTGAACGCGGACCTGCTGCACGCCACCGGCAATGC
CAGGGTCAAGGTGCTGCACTGCCTGCCCGCGTTCCACAACACCGAGACGAAGGTCGGCCACCAGGTGGTGGCGCAGTACC
CGCAGCTCGCGAACGGCATCGAGGTCACCGAGGACGTCTTCGAGTCCGCGGCCAACATCTCCTTCGACCAGGCGGAGAAC
CGGATGCACACGATCAAGGCGCTCCTCGTGGCGTCGCTCGCGTGA

Upstream 100 bases:

>100_bases
GAGCTGGGCCGCGGCCGCGGCGGCGGGCGCTGCATGACCTGCCCGATCCTGCGCGACCCCGTCGACTACTGACCACCGAC
CAGAAACCGAGGAACAACCC

Downstream 100 bases:

>100_bases
GGGGGACGGACGACATGCGCATCGTGATCGCTCTGGGGGGCAATGCCCTCCTGCGCCGGGGTGAGCCGCTGACGGCGGAC
AACCAGCGCGCCAACATCCG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MPVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRTRCAFEVASYDQGAHVTYIDP
ASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAEYAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFA
FMGDGRNNVANSLLLVAAKLGMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEP
VESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGIEVTEDVFESAANISFDQAEN
RMHTIKALLVASLA

Sequences:

>Translated_334_residues
MPVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRTRCAFEVASYDQGAHVTYIDP
ASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAEYAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFA
FMGDGRNNVANSLLLVAAKLGMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEP
VESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGIEVTEDVFESAANISFDQAEN
RMHTIKALLVASLA
>Mature_333_residues
PVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRTRCAFEVASYDQGAHVTYIDPA
SSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAEYAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFAF
MGDGRNNVANSLLLVAAKLGMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEPV
ESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGIEVTEDVFESAANISFDQAENR
MHTIKALLVASLA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=333, Percent_Identity=36.9369369369369, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI18105007, Length=193, Percent_Identity=26.4248704663212, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=57.3170731707317, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=56.9277108433735, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI2367364, Length=304, Percent_Identity=30.9210526315789, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994908, Length=382, Percent_Identity=21.9895287958115, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322373, Length=330, Percent_Identity=30.9090909090909, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322331, Length=190, Percent_Identity=29.4736842105263, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24642586, Length=296, Percent_Identity=25.6756756756757, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37180; Mature: 37048

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRT
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCC
RCAFEVASYDQGAHVTYIDPASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAE
CEEEEECCCCCCCEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFAFMGDGRNNVANSLLLVAAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEP
CCEEEECCCHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGI
HHHHHHHHHHHCCCEECCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
EVTEDVFESAANISFDQAENRMHTIKALLVASLA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVNLRGRHLLSLRHHSADEIRYLLDLSRDLKRAKYAGSERQLLQGRNVALIFEKTSTRT
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCC
RCAFEVASYDQGAHVTYIDPASSQLGHKESVKDTARVLGRMYDAIEYRGFSQQVVEELAE
CEEEEECCCCCCCEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YAGVPVFNGLTDEFHPTQMLADVLTMREHCDKPLHEIAFAFMGDGRNNVANSLLLVAAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GMDVRIGAPKELWPEDELVKLCHDLADVSGARITITDDPTQAVAGVDFIYTDVWVSMGEP
CCEEEECCCHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCC
VESWAERVERCLPFQVNADLLHATGNARVKVLHCLPAFHNTETKVGHQVVAQYPQLANGI
HHHHHHHHHHHCCCEECCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
EVTEDVFESAANISFDQAENRMHTIKALLVASLA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3109911; 10984043; 2118516; 7479879 [H]