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The map label for this gene is merA [H]

Identifier: 119716646

GI number: 119716646

Start: 2577702

End: 2579078

Strand: Direct

Name: merA [H]

Synonym: Noca_2419

Alternate gene names: 119716646

Gene position: 2577702-2579078 (Clockwise)

Preceding gene: 119716645

Following gene: 119716647

Centisome position: 51.7

GC content: 75.16

Gene sequence:

>1377_bases
ATGGACGCACACGAGGTGGACCTGGTCGTGATCGGCACCGGCCCCGGCGGCGAGGCGCTCGCCACCGGCGCCGCCCGGGC
GGGGCTGCGGGTCGTGGCCGTGGACAGGCACCTGGTCGGCGGGGAGTGCCCCTACTACGGGTGCATCCCCACCAAGATGA
TGGTCCGCGGCAGCGATGCGGTCGCCGAGGTCCGGCGGGCCGCCGGCGTCGCCGGCGAGGCCACCATCGCCCCGGCCTGG
TCCGTGGTGGCGCGGCGCATCGACGAGGAGGCGACCACCGGCTGGGACGACACGATCGCCGTCGACCGCCTCCGGGATGC
CGGGGTGACCTTCCACCACGGGGCGGGCCGGCTCGACGGCCCCGGCCGGGTGCGCGTCGAGGAGCCGGACGGCACGGCGA
CGACGTACGCCGCCACGCGGGGCGTGCTGGTCAACCCCGGCACCCGCCCGGCCGTGCCCCCGGTCGACGGCCTGGCGGAC
GCGCCGTACTGGACCAACCGCGAAGCGGTGCGGGTCACCGAGCTGCCCGGCTCCCTGGTCGTCCTCGGGGGCGGGCCGAT
CGGCTGCGAGCTCGCGCAGGTGTTCTCCCGGTTCGGCGTCCGGGTCGCGGTGGTCCAGCGCGGTCCCCGGCTGCTGCCCG
CGGACGAGCCCGAGGCCGCGGAGCTGGTGGCGGAGGTCTTCGCCGAGGAGGGGATCCGGGTGCTCACCGGCGCCGAGGCG
ACCCGCGTGGCGTACGACGAGGGCGGCTTCACGATCCGGCTCGACACAGGAGAGCAGCTGAGCGCCGACAAGCTGCTGGT
CGCCGCCGGGCGGACCCCCAACCTGGACGACCTCGGCCTGGATACGGTCGGCCTGGACCCGACCGCGCGGACCCTCGAGG
TCGACGAGCGCCTGCGGGCGGGGGACCGGCTGTGGGCGATCGGCGACGTGACCGGCAGAGGCGCCTTCACCCACGTCTCG
ATGTACCAGTCGGCGATCGCGCTGCGCGACATCCTGGGTGAGCCGGGAGCGCCGGCCCGCTACCACGCGGTGCCACACAC
GACGTTCACCGACCCGGAGGTCGGCGGGGTGGGGCTGACCGAGTCCCGGGCCCGGGAATCGGGACTGCGGGTCCGCACGG
GCGGCACCGACCTGGCGGGCTCGTCGCGAGGTTTCACCCACGGGCCCGGCGGGCACGGCCTGATCAAGGTCGTCGAGGAC
GCGGACCGCGGAGTCCTCGTCGGAGCCACCGCGGTGGGTCCGGCGGGTGGCGAGATCCTCGGCTTCCTGGCCGTCGCGGT
CCACGCGGAGGTCCCCGTCGAGACGCTGAGGAACATGATGTACGCCTACCCCACCTTCCACCGGGCCATCGAGTCCGCCA
TCGCCGACCTGTCATGA

Upstream 100 bases:

>100_bases
GTCGCCGCAGTTCGTCAACGGCATCCTCGGCAGCATCGTGCGCAACAAGCCGTCCCTCGCCTGAGCAGCCGCCGACTGCG
CCTGGGCCCATAGTGGACCC

Downstream 100 bases:

>100_bases
CAGTGTCGGGAGGGAGCACCGCCCGTCGGGCCGAGGGAGCGGCCCGCGAGGCGCAGCACAGCGAGTGGGTCGATCACGCC
GTTCGGGCCGGCCTGGTCGC

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDAVAEVRRAAGVAGEATIAPAW
SVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDGPGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLAD
APYWTNREAVRVTELPGSLVVLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEA
TRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRAGDRLWAIGDVTGRGAFTHVS
MYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLTESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVED
ADRGVLVGATAVGPAGGEILGFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS

Sequences:

>Translated_458_residues
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDAVAEVRRAAGVAGEATIAPAW
SVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDGPGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLAD
APYWTNREAVRVTELPGSLVVLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEA
TRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRAGDRLWAIGDVTGRGAFTHVS
MYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLTESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVED
ADRGVLVGATAVGPAGGEILGFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS
>Mature_458_residues
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDAVAEVRRAAGVAGEATIAPAW
SVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDGPGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLAD
APYWTNREAVRVTELPGSLVVLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEA
TRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRAGDRLWAIGDVTGRGAFTHVS
MYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLTESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVED
ADRGVLVGATAVGPAGGEILGFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=25.1626898047722, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI50301238, Length=455, Percent_Identity=25.4945054945055, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=23.6323851203501, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=23.6323851203501, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=23.6323851203501, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=23.6323851203501, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=23.6323851203501, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=22.7571115973742, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22035672, Length=372, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.9315673289183, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786307, Length=481, Percent_Identity=26.6112266112266, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=25.3218884120172, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1789915, Length=361, Percent_Identity=26.0387811634349, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=26.2365591397849, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=24.7379454926625, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=392, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71983429, Length=355, Percent_Identity=25.6338028169014, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983419, Length=355, Percent_Identity=25.6338028169014, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=26.338329764454, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=24.5243128964059, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=22.7083333333333, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=26.4516129032258, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=27.8481012658228, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=27.8481012658228, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=27.8481012658228, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=26.7932489451477, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 47729; Mature: 47729

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDA
CCCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCEEEEECCHH
VAEVRRAAGVAGEATIAPAWSVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDG
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCC
PGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLADAPYWTNREAVRVTELPGSLV
CCEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
VLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEA
EECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCE
TRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRA
EEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCEEEHHHHHCC
GDRLWAIGDVTGRGAFTHVSMYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLT
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC
ESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVEDADRGVLVGATAVGPAGGEIL
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHH
GFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDAHEVDLVVIGTGPGGEALATGAARAGLRVVAVDRHLVGGECPYYGCIPTKMMVRGSDA
CCCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCEEEEECCHH
VAEVRRAAGVAGEATIAPAWSVVARRIDEEATTGWDDTIAVDRLRDAGVTFHHGAGRLDG
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCC
PGRVRVEEPDGTATTYAATRGVLVNPGTRPAVPPVDGLADAPYWTNREAVRVTELPGSLV
CCEEEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
VLGGGPIGCELAQVFSRFGVRVAVVQRGPRLLPADEPEAAELVAEVFAEEGIRVLTGAEA
EECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCE
TRVAYDEGGFTIRLDTGEQLSADKLLVAAGRTPNLDDLGLDTVGLDPTARTLEVDERLRA
EEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCEEEHHHHHCC
GDRLWAIGDVTGRGAFTHVSMYQSAIALRDILGEPGAPARYHAVPHTTFTDPEVGGVGLT
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCC
ESRARESGLRVRTGGTDLAGSSRGFTHGPGGHGLIKVVEDADRGVLVGATAVGPAGGEIL
HHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHH
GFLAVAVHAEVPVETLRNMMYAYPTFHRAIESAIADLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2691338; 2265748 [H]