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The map label for this gene is glyA [H]

Identifier: 119716579

GI number: 119716579

Start: 2505447

End: 2506895

Strand: Direct

Name: glyA [H]

Synonym: Noca_2352

Alternate gene names: 119716579

Gene position: 2505447-2506895 (Clockwise)

Preceding gene: 119716574

Following gene: 119716581

Centisome position: 50.25

GC content: 71.08

Gene sequence:

>1449_bases
ATGAGCGACGAGCGCATCAGTTCCCTCACCAGCAGCGCGTACCAGCAGGCTCTCGAGGTGATCGCCTCGGTCGAGCCGCG
GATCGCGGAGGCGACCCGGCAGGAGCTCGTCGACCAGCGAGGTTCGCTGAAGCTGATCGCGAGCGAGAACTACGCCTCGC
CGGCGGTGCTGCTGACCATGGGCACCTGGCTGAGCGACAAGTACGCCGAGGGCACCGTCGGCCACCGCTTCTACGCAGGC
TGCCAGAACGTCGACACCGTCGAGGCGCTGGCCGCCGAGCACGCGCGCGAGCTCTTCGGGGCGCCGTACGCGTATGCCCA
GCCGCACTCCGGCATCGACGCGAACCTGGTGGCGTTCTGGTCGATCCTGGCCCACCGGGTCGAGACCCCGGCGCTCGAGC
GGCTCGGCGCCAAGAACGTCAACGAGCTGACCGAGGCGGACTGGGAGTCGTTGCGCCACGAGCTCGGCAACCAGCGGCTG
CTCGGGATGGCCCTGGACGCCGGCGGCCACCTCACCCACGGCTTCCGCCCGAACATCAGCGGCAAGATGTTCCACCAGCA
GCAGTACGGCACCGATCCGGAGACCGGGCTGCTCGACTACGCCGCGGTCGCCGCCAAGGCCCGCGAGTTCAAGCCGCTGG
TGATCGTCGCCGGCTACTCCGCCTACCCGCGCCGGGTGGACTTCGCGAAGATGCGCGAGATCGCCGACGAGGTCGGCGCG
ACGCTGATGGTCGACATGGCGCACTTCGCGGGCCTGGTCGCCGGGAAGGTGTTCACCGGCGACGAGGACCCGATCCCGCA
CGCCCACATCACCACGACCACGACCCACAAGTCACTGCGTGGCCCGCGCGGCGGCCTGGTGCTGGCCCAGGAGGACTTCG
CCGCCGACGTCGACCGCGGCTGCCCGATGGTGCTCGGCGGCCCGCTGGGGCACGTGATGGCGGCCAAGGCCGTGGCCCTC
GCCGAGGCCCGCCGCCCGGAGTTCCGGACCTATGCGCAGAACATCGCCGACAACGCCCAGTCGCTGGCCGAGGGCTTCCT
GTCCCGCGGTGCCCGGCTCGTCACCGGTGGCACCGACAACCACCTGGTGCTGCTCGACGTCTCGGCGTTCGGGCTCACCG
GCCGGCAGGCCGAGTCGGCGCTCCTCGACTCCGGCGTGGTCACCAACCGCAACTCGATCCCGCAGGACCCGAACGGCGCC
TGGTACACCTCCGGCATCCGCCTCGGCACGCCGGCCCTGACGACCCGGGGCTTCGGCCACGACGAGTTCGACCGGGTCGC
CGAGCTGATCGTGGACGTGCTCAGCAACACCGAGCCCGGCACCACCAAGGACGGCAAGCCGTCGAAGGCGTCCTACCGGC
TCGGTGACGGCGTGGCCGACAAGGTCCACGCCGCCGCCGCGGAGCTGCTCGACAAGCACCCGCTCTACCCAGGCCTCGAC
CTGGCCTGA

Upstream 100 bases:

>100_bases
AACGAGAGTCCGCTATGCGAGACAACAGCCAGGCGCATCCGCCCCGCGGGCGCGTGGACTGCGACCCACGTCACACCACG
GCCACCACTAGGCTGGCCGC

Downstream 100 bases:

>100_bases
GCCTCGAGCGGCTCCGGTCAGAGCGTCGGCGTCGCCCGCTCGACGATCGCGCGCAGGTCGCCGCCGTCCAGGGTGCCGAA
GACGCCGTCGTACGACGTGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSDERISSLTSSAYQQALEVIASVEPRIAEATRQELVDQRGSLKLIASENYASPAVLLTMGTWLSDKYAEGTVGHRFYAG
CQNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAFWSILAHRVETPALERLGAKNVNELTEADWESLRHELGNQRL
LGMALDAGGHLTHGFRPNISGKMFHQQQYGTDPETGLLDYAAVAAKAREFKPLVIVAGYSAYPRRVDFAKMREIADEVGA
TLMVDMAHFAGLVAGKVFTGDEDPIPHAHITTTTTHKSLRGPRGGLVLAQEDFAADVDRGCPMVLGGPLGHVMAAKAVAL
AEARRPEFRTYAQNIADNAQSLAEGFLSRGARLVTGGTDNHLVLLDVSAFGLTGRQAESALLDSGVVTNRNSIPQDPNGA
WYTSGIRLGTPALTTRGFGHDEFDRVAELIVDVLSNTEPGTTKDGKPSKASYRLGDGVADKVHAAAAELLDKHPLYPGLD
LA

Sequences:

>Translated_482_residues
MSDERISSLTSSAYQQALEVIASVEPRIAEATRQELVDQRGSLKLIASENYASPAVLLTMGTWLSDKYAEGTVGHRFYAG
CQNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAFWSILAHRVETPALERLGAKNVNELTEADWESLRHELGNQRL
LGMALDAGGHLTHGFRPNISGKMFHQQQYGTDPETGLLDYAAVAAKAREFKPLVIVAGYSAYPRRVDFAKMREIADEVGA
TLMVDMAHFAGLVAGKVFTGDEDPIPHAHITTTTTHKSLRGPRGGLVLAQEDFAADVDRGCPMVLGGPLGHVMAAKAVAL
AEARRPEFRTYAQNIADNAQSLAEGFLSRGARLVTGGTDNHLVLLDVSAFGLTGRQAESALLDSGVVTNRNSIPQDPNGA
WYTSGIRLGTPALTTRGFGHDEFDRVAELIVDVLSNTEPGTTKDGKPSKASYRLGDGVADKVHAAAAELLDKHPLYPGLD
LA
>Mature_481_residues
SDERISSLTSSAYQQALEVIASVEPRIAEATRQELVDQRGSLKLIASENYASPAVLLTMGTWLSDKYAEGTVGHRFYAGC
QNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAFWSILAHRVETPALERLGAKNVNELTEADWESLRHELGNQRLL
GMALDAGGHLTHGFRPNISGKMFHQQQYGTDPETGLLDYAAVAAKAREFKPLVIVAGYSAYPRRVDFAKMREIADEVGAT
LMVDMAHFAGLVAGKVFTGDEDPIPHAHITTTTTHKSLRGPRGGLVLAQEDFAADVDRGCPMVLGGPLGHVMAAKAVALA
EARRPEFRTYAQNIADNAQSLAEGFLSRGARLVTGGTDNHLVLLDVSAFGLTGRQAESALLDSGVVTNRNSIPQDPNGAW
YTSGIRLGTPALTTRGFGHDEFDRVAELIVDVLSNTEPGTTKDGKPSKASYRLGDGVADKVHAAAAELLDKHPLYPGLDL
A

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=437, Percent_Identity=39.1304347826087, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI261862350, Length=437, Percent_Identity=39.1304347826087, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI261862348, Length=437, Percent_Identity=39.1304347826087, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI19923315, Length=437, Percent_Identity=39.1304347826087, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI261862346, Length=437, Percent_Identity=37.7574370709382, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI22547186, Length=423, Percent_Identity=37.1158392434988, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI22547189, Length=407, Percent_Identity=36.6093366093366, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1788902, Length=420, Percent_Identity=47.3809523809524, Blast_Score=344, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=434, Percent_Identity=35.9447004608295, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI25144732, Length=434, Percent_Identity=35.9447004608295, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319739, Length=500, Percent_Identity=36.2, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323087, Length=485, Percent_Identity=33.8144329896907, Blast_Score=256, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24640005, Length=511, Percent_Identity=36.0078277886497, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI221329721, Length=491, Percent_Identity=36.0488798370672, Blast_Score=292, Evalue=3e-79,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 51704; Mature: 51572

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00096 SHMT ; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDERISSLTSSAYQQALEVIASVEPRIAEATRQELVDQRGSLKLIASENYASPAVLLTM
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEE
GTWLSDKYAEGTVGHRFYAGCQNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAFW
CCHHCCHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
SILAHRVETPALERLGAKNVNELTEADWESLRHELGNQRLLGMALDAGGHLTHGFRPNIS
HHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCC
GKMFHQQQYGTDPETGLLDYAAVAAKAREFKPLVIVAGYSAYPRRVDFAKMREIADEVGA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCH
TLMVDMAHFAGLVAGKVFTGDEDPIPHAHITTTTTHKSLRGPRGGLVLAQEDFAADVDRG
HHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCHHHHCCCCCCEEEECCHHHHHHHCC
CPMVLGGPLGHVMAAKAVALAEARRPEFRTYAQNIADNAQSLAEGFLSRGARLVTGGTDN
CCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
HLVLLDVSAFGLTGRQAESALLDSGVVTNRNSIPQDPNGAWYTSGIRLGTPALTTRGFGH
EEEEEEEHHHCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEECCCCHHCCCCCC
DEFDRVAELIVDVLSNTEPGTTKDGKPSKASYRLGDGVADKVHAAAAELLDKHPLYPGLD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCC
LA
CC
>Mature Secondary Structure 
SDERISSLTSSAYQQALEVIASVEPRIAEATRQELVDQRGSLKLIASENYASPAVLLTM
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEE
GTWLSDKYAEGTVGHRFYAGCQNVDTVEALAAEHARELFGAPYAYAQPHSGIDANLVAFW
CCHHCCHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
SILAHRVETPALERLGAKNVNELTEADWESLRHELGNQRLLGMALDAGGHLTHGFRPNIS
HHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCC
GKMFHQQQYGTDPETGLLDYAAVAAKAREFKPLVIVAGYSAYPRRVDFAKMREIADEVGA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCH
TLMVDMAHFAGLVAGKVFTGDEDPIPHAHITTTTTHKSLRGPRGGLVLAQEDFAADVDRG
HHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCHHHHCCCCCCEEEECCHHHHHHHCC
CPMVLGGPLGHVMAAKAVALAEARRPEFRTYAQNIADNAQSLAEGFLSRGARLVTGGTDN
CCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
HLVLLDVSAFGLTGRQAESALLDSGVVTNRNSIPQDPNGAWYTSGIRLGTPALTTRGFGH
EEEEEEEHHHCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEECCCCHHCCCCCC
DEFDRVAELIVDVLSNTEPGTTKDGKPSKASYRLGDGVADKVHAAAAELLDKHPLYPGLD
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCC
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA