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The map label for this gene is gcvT [H]

Identifier: 119716534

GI number: 119716534

Start: 2457481

End: 2458596

Strand: Direct

Name: gcvT [H]

Synonym: Noca_2307

Alternate gene names: 119716534

Gene position: 2457481-2458596 (Clockwise)

Preceding gene: 119716532

Following gene: 119716535

Centisome position: 49.29

GC content: 72.31

Gene sequence:

>1116_bases
ATGGTGGACCTCCACGAACAGGAGCTGCGCTCCCCGCTCCACGCACGTCACGTGGCCCTCGGGGCCAAGTTCGCCGCTTT
CGGCGGCTGGTCGATGCCGTTGGAGTACTCCACCGGCATCGTCAAGGAGCACACCGCGGTGCGCGAGTCGGTCGGCATCT
TCGACGTCAGCCACCTCGGCAAGGCCGTGGTGGCGGGGCCGGGCGCCGCCGCGTTCGTCAACCGCACGCTGACCAACGAC
CTCGACCGGATCGGCCCCGGCCAGGCGCAGTACACGCTGTGCTGCGACGACGCGACCGGTGGCGTGGTCGACGACCTGAT
CGTCTACCTGCACGCCGAGGACCGGGTGCTGCTGGTGCCCAACGCCGCCAACACCGCCGAGGTGGTCCGCCGGCTCGCGG
CGGTGGCCCCGGACGGGGTCACGGTCACCGACCGGCACCGCGACTTCGTGGTGCTCGCCGTGCAGGGCACCCGATCGGAC
GAGGTGCTGGCCGAGGTGGGGCTGCCGACCGGCCACGACTACATGTCCTTCGTCGAGCAGACGTTCGCCGACGAGACCGT
CGTGGTCTGCCGCACCGGCTACACCGGCGAGCGCGGCTACGAGCTGATCGCACCGAACGCGGTCGCCGAGCCGCTCTGGG
ACGCGCTGCTCGCCGCCGGCGAGGAGTTCGGGATGCTGCCCTGCGGGCTCGGCGCCCGCGACACGCTGCGCACCGAGATG
GGCTACCCGCTGCACGGCCAGGACATCTCCCTCGACGTCACCCCGAACGAGGCGCGCCTGGGCTGGGCGGTCGGATGGCG
CAAGGACGCCTTCTGGGGCCGCGACAAGCTCACCGCCGAGAAGGCGGCCGGCCCGAAGCGCCAGCTGCGGGGCCTGGTCG
CCACCGGTCGCGGCATCCCGCGCCCGCACATGAGCGTGAGCCTCACCCCCGACGTGCTGCTCGGCGAGGTCACCTCCGGA
ACCTTCTCGCCCACCCTGCGCAAGGGCATCGGCCTGGCGCTGATCCCGTCGTTCGTCGACCCGGAGGCCGAGGTCGGCGT
CGACATCCGCGGCCGTCGCGAGGTCTTCCAGCTCGTGAAGCCGCCGTTCCTCGACCCGTCCGTGCGGGAGGGCTGA

Upstream 100 bases:

>100_bases
ACGACGGCGTCGCTGCGGGTCTTGGCGGGGCTGGCGCTGCGCATGGTGTACGACGTCACCGGGGCAGGATAGTCCGGGGT
GCTGCGGTAGGTTCGCGGCC

Downstream 100 bases:

>100_bases
GATGAACCTGCCCGACCAGCCCGCCACGTTCCGCCCACCGTCGCCGACCGAGCGGCCCTGGTGGTGGCGGCTCGAGAACG
CCGCCGGCGACGAGGTCACC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MVDLHEQELRSPLHARHVALGAKFAAFGGWSMPLEYSTGIVKEHTAVRESVGIFDVSHLGKAVVAGPGAAAFVNRTLTND
LDRIGPGQAQYTLCCDDATGGVVDDLIVYLHAEDRVLLVPNAANTAEVVRRLAAVAPDGVTVTDRHRDFVVLAVQGTRSD
EVLAEVGLPTGHDYMSFVEQTFADETVVVCRTGYTGERGYELIAPNAVAEPLWDALLAAGEEFGMLPCGLGARDTLRTEM
GYPLHGQDISLDVTPNEARLGWAVGWRKDAFWGRDKLTAEKAAGPKRQLRGLVATGRGIPRPHMSVSLTPDVLLGEVTSG
TFSPTLRKGIGLALIPSFVDPEAEVGVDIRGRREVFQLVKPPFLDPSVREG

Sequences:

>Translated_371_residues
MVDLHEQELRSPLHARHVALGAKFAAFGGWSMPLEYSTGIVKEHTAVRESVGIFDVSHLGKAVVAGPGAAAFVNRTLTND
LDRIGPGQAQYTLCCDDATGGVVDDLIVYLHAEDRVLLVPNAANTAEVVRRLAAVAPDGVTVTDRHRDFVVLAVQGTRSD
EVLAEVGLPTGHDYMSFVEQTFADETVVVCRTGYTGERGYELIAPNAVAEPLWDALLAAGEEFGMLPCGLGARDTLRTEM
GYPLHGQDISLDVTPNEARLGWAVGWRKDAFWGRDKLTAEKAAGPKRQLRGLVATGRGIPRPHMSVSLTPDVLLGEVTSG
TFSPTLRKGIGLALIPSFVDPEAEVGVDIRGRREVFQLVKPPFLDPSVREG
>Mature_371_residues
MVDLHEQELRSPLHARHVALGAKFAAFGGWSMPLEYSTGIVKEHTAVRESVGIFDVSHLGKAVVAGPGAAAFVNRTLTND
LDRIGPGQAQYTLCCDDATGGVVDDLIVYLHAEDRVLLVPNAANTAEVVRRLAAVAPDGVTVTDRHRDFVVLAVQGTRSD
EVLAEVGLPTGHDYMSFVEQTFADETVVVCRTGYTGERGYELIAPNAVAEPLWDALLAAGEEFGMLPCGLGARDTLRTEM
GYPLHGQDISLDVTPNEARLGWAVGWRKDAFWGRDKLTAEKAAGPKRQLRGLVATGRGIPRPHMSVSLTPDVLLGEVTSG
TFSPTLRKGIGLALIPSFVDPEAEVGVDIRGRREVFQLVKPPFLDPSVREG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=31.5363881401617, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI257796258, Length=343, Percent_Identity=32.3615160349854, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=28.099173553719, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=30.2839116719243, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24797151, Length=332, Percent_Identity=25.9036144578313, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI197927446, Length=281, Percent_Identity=28.1138790035587, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI21361378, Length=281, Percent_Identity=28.1138790035587, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789272, Length=364, Percent_Identity=36.8131868131868, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17560118, Length=371, Percent_Identity=30.9973045822102, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71994045, Length=390, Percent_Identity=24.6153846153846, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994052, Length=390, Percent_Identity=24.6153846153846, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32563613, Length=351, Percent_Identity=25.0712250712251, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320222, Length=380, Percent_Identity=28.4210526315789, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=31.0160427807487, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28571104, Length=266, Percent_Identity=24.812030075188, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39908; Mature: 39908

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLHEQELRSPLHARHVALGAKFAAFGGWSMPLEYSTGIVKEHTAVRESVGIFDVSHLG
CCCCCHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEHHHCC
KAVVAGPGAAAFVNRTLTNDLDRIGPGQAQYTLCCDDATGGVVDDLIVYLHAEDRVLLVP
CEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEEEEEECCCCEEEEC
NAANTAEVVRRLAAVAPDGVTVTDRHRDFVVLAVQGTRSDEVLAEVGLPTGHDYMSFVEQ
CCCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHH
TFADETVVVCRTGYTGERGYELIAPNAVAEPLWDALLAAGEEFGMLPCGLGARDTLRTEM
HHCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHC
GYPLHGQDISLDVTPNEARLGWAVGWRKDAFWGRDKLTAEKAAGPKRQLRGLVATGRGIP
CCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCC
RPHMSVSLTPDVLLGEVTSGTFSPTLRKGIGLALIPSFVDPEAEVGVDIRGRREVFQLVK
CCCCEEEECCCCEEECCCCCCCCHHHHHCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHC
PPFLDPSVREG
CCCCCCCCCCC
>Mature Secondary Structure
MVDLHEQELRSPLHARHVALGAKFAAFGGWSMPLEYSTGIVKEHTAVRESVGIFDVSHLG
CCCCCHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEHHHCC
KAVVAGPGAAAFVNRTLTNDLDRIGPGQAQYTLCCDDATGGVVDDLIVYLHAEDRVLLVP
CEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHEEEEEEECCCCEEEEC
NAANTAEVVRRLAAVAPDGVTVTDRHRDFVVLAVQGTRSDEVLAEVGLPTGHDYMSFVEQ
CCCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHH
TFADETVVVCRTGYTGERGYELIAPNAVAEPLWDALLAAGEEFGMLPCGLGARDTLRTEM
HHCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHC
GYPLHGQDISLDVTPNEARLGWAVGWRKDAFWGRDKLTAEKAAGPKRQLRGLVATGRGIP
CCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCC
RPHMSVSLTPDVLLGEVTSGTFSPTLRKGIGLALIPSFVDPEAEVGVDIRGRREVFQLVK
CCCCEEEECCCCEEECCCCCCCCHHHHHCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHC
PPFLDPSVREG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA