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The map label for this gene is czcD [H]

Identifier: 119716445

GI number: 119716445

Start: 2364138

End: 2365055

Strand: Direct

Name: czcD [H]

Synonym: Noca_2216

Alternate gene names: 119716445

Gene position: 2364138-2365055 (Clockwise)

Preceding gene: 119716444

Following gene: 119716446

Centisome position: 47.42

GC content: 68.08

Gene sequence:

>918_bases
ATGGGACACGGACATGGACATAGTCACTCCGCGGCGGCGGGGCACGCCGGCGGCAGGTACCGGTGGCGGCTCGCGGTCAC
GTTCGCCATGGTTGCCACCTTCCTGGTGGTCGAGCTCGTCGTCGGGTTGTGGTCGCATTCGCTGGCCCTGATCTCCGATG
CCGGCCACATGACCGCGGACGTCGTGGCGCTCGGGGCCGCGCTGGTCGCCACCCGGATCGCGACCCGCAAAGACACCAGC
GGGCGGCGTACCTATGGCTCCTACCGCGCCGAAGTGTTCGCCTCTGGACTCACCGTGCTCATCATGCTCGGCGTAGCGGT
CTACGTCGTAGTCGAGGCTGTCGGTCGGATTGGTGCGGAACCCGAGGTGCAGACCGGCGCGATGCTGGTCGTCGGCGCGA
TCGGACTCGCCGTCAACATCGCCTCGATGCTGCTCCTGCGCGAAGGGTCCACCGAGTCCCTCAACGTCAAGGGCGCCTAC
TTTGAGGTCGTCGCCGACGCAGTCGGCAGCGTCGGGGTCATCCTCGCTGGCCTGCTCGTCGCCACCACCGGCCAGACCTG
GTGGGACACCGGTGTCGCCGTCGCGATCGGACTCTTCGTCGCCGTCCGCGCCATCGTCCTGGGCCGTCAGGTGCTCGCTG
TGCTCGGCCAGCATGTCCCCGACGGCATGCAGGTCGATCAGGTTGTCGCCGACCTCGAAGCACTGCCGGGAATCGAGGAC
GTCCACGACCTCCACGTCTGGACCCTCACCTCCGGGATGAACGTCGCCACCGCCCACCTCGTTGTCGCCCCCGACGCTGA
CCCCCAGCGGGTCCTGACCGACGCCCAGGCATTGCTCTCATCGAGCCACCGCATCGAACACGCCACCCTCCAGACCGAGA
CAGCCCCCACCCGGCAATGTCACGAGGTCACCTGGTGA

Upstream 100 bases:

>100_bases
CCGATGCGCGGCTCGCCCACGCGCTGGCCGACCTGCACGACATCATCCTGGTGACCGATCCCGACGCCTGCACCGAGACT
GAAGAGCAGGAATGCTGCTG

Downstream 100 bases:

>100_bases
ACACCAACCTGCCCCTGGAGACCGGCGGCGCAACCTCTCCCGTGCTGCCCAAGCCGCCGACCTCAGGCCAGGGCCGCGCC
CGCCGCCCCGCCCCGTCCTG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGHGHGHSHSAAAGHAGGRYRWRLAVTFAMVATFLVVELVVGLWSHSLALISDAGHMTADVVALGAALVATRIATRKDTS
GRRTYGSYRAEVFASGLTVLIMLGVAVYVVVEAVGRIGAEPEVQTGAMLVVGAIGLAVNIASMLLLREGSTESLNVKGAY
FEVVADAVGSVGVILAGLLVATTGQTWWDTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQVDQVVADLEALPGIED
VHDLHVWTLTSGMNVATAHLVVAPDADPQRVLTDAQALLSSSHRIEHATLQTETAPTRQCHEVTW

Sequences:

>Translated_305_residues
MGHGHGHSHSAAAGHAGGRYRWRLAVTFAMVATFLVVELVVGLWSHSLALISDAGHMTADVVALGAALVATRIATRKDTS
GRRTYGSYRAEVFASGLTVLIMLGVAVYVVVEAVGRIGAEPEVQTGAMLVVGAIGLAVNIASMLLLREGSTESLNVKGAY
FEVVADAVGSVGVILAGLLVATTGQTWWDTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQVDQVVADLEALPGIED
VHDLHVWTLTSGMNVATAHLVVAPDADPQRVLTDAQALLSSSHRIEHATLQTETAPTRQCHEVTW
>Mature_304_residues
GHGHGHSHSAAAGHAGGRYRWRLAVTFAMVATFLVVELVVGLWSHSLALISDAGHMTADVVALGAALVATRIATRKDTSG
RRTYGSYRAEVFASGLTVLIMLGVAVYVVVEAVGRIGAEPEVQTGAMLVVGAIGLAVNIASMLLLREGSTESLNVKGAYF
EVVADAVGSVGVILAGLLVATTGQTWWDTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQVDQVVADLEALPGIEDV
HDLHVWTLTSGMNVATAHLVVAPDADPQRVLTDAQALLSSSHRIEHATLQTETAPTRQCHEVTW

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=28.3387622149837, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI21361112, Length=304, Percent_Identity=28.9473684210526, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=27.5974025974026, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI64762489, Length=313, Percent_Identity=25.2396166134185, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI289803013, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI289803009, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI289803007, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI289803003, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI52351208, Length=192, Percent_Identity=26.0416666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI14210520, Length=211, Percent_Identity=28.9099526066351, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI222080086, Length=125, Percent_Identity=33.6, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI40255009, Length=125, Percent_Identity=33.6, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=36.9230769230769, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786966, Length=283, Percent_Identity=34.2756183745583, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17555794, Length=311, Percent_Identity=28.9389067524116, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=311, Percent_Identity=29.2604501607717, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=26.4331210191083, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=300, Percent_Identity=27.6666666666667, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550442, Length=124, Percent_Identity=37.0967741935484, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=124, Percent_Identity=37.0967741935484, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=146, Percent_Identity=33.5616438356164, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=152, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=174, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583858, Length=332, Percent_Identity=25.6024096385542, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585900, Length=150, Percent_Identity=32, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585898, Length=150, Percent_Identity=32, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585896, Length=150, Percent_Identity=32, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921672, Length=150, Percent_Identity=32, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645863, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656728, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656724, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656720, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656715, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357035, Length=129, Percent_Identity=31.0077519379845, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584409, Length=151, Percent_Identity=27.1523178807947, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28574430, Length=151, Percent_Identity=27.1523178807947, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31894; Mature: 31763

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHGHGHSHSAAAGHAGGRYRWRLAVTFAMVATFLVVELVVGLWSHSLALISDAGHMTAD
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VVALGAALVATRIATRKDTSGRRTYGSYRAEVFASGLTVLIMLGVAVYVVVEAVGRIGAE
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEVQTGAMLVVGAIGLAVNIASMLLLREGSTESLNVKGAYFEVVADAVGSVGVILAGLLV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
ATTGQTWWDTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQVDQVVADLEALPGIED
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCH
VHDLHVWTLTSGMNVATAHLVVAPDADPQRVLTDAQALLSSSHRIEHATLQTETAPTRQC
HHHEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHEEECCCCCCHHH
HEVTW
HCCCC
>Mature Secondary Structure 
GHGHGHSHSAAAGHAGGRYRWRLAVTFAMVATFLVVELVVGLWSHSLALISDAGHMTAD
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VVALGAALVATRIATRKDTSGRRTYGSYRAEVFASGLTVLIMLGVAVYVVVEAVGRIGAE
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEVQTGAMLVVGAIGLAVNIASMLLLREGSTESLNVKGAYFEVVADAVGSVGVILAGLLV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
ATTGQTWWDTGVAVAIGLFVAVRAIVLGRQVLAVLGQHVPDGMQVDQVVADLEALPGIED
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCH
VHDLHVWTLTSGMNVATAHLVVAPDADPQRVLTDAQALLSSSHRIEHATLQTETAPTRQC
HHHEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHEEECCCCCCHHH
HEVTW
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]