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The map label for this gene is livM [H]

Identifier: 119716343

GI number: 119716343

Start: 2257153

End: 2258283

Strand: Reverse

Name: livM [H]

Synonym: Noca_2112

Alternate gene names: 119716343

Gene position: 2258283-2257153 (Counterclockwise)

Preceding gene: 119716344

Following gene: 119716342

Centisome position: 45.29

GC content: 70.29

Gene sequence:

>1131_bases
ATGACCGCCGTGTCGGTGCCTGTCCACGAGCCGGTCGAGGTGGAGCCGGGGGGTCTGCACAAGGAGTTCCGCCCGGGCAC
GGCCGGCTGGCTGGCCCGGGGCACGGTGTGGGCCCTCCTCGCGTGGGTGGTGCTGGCGTACCCGGTCAACGCACTCTCGC
CGTTCCACGTCGGGGTGGCCGACATCGACATCGCATCGCTGGCCGCGATCTACGCCATCGGCGGACTCTCGCTCAACGTG
CTCCTCGGCTACTGCGGCCAGATCTCGCTCGGCCACCAGGCCTTCGTCGGGATCGGTGCCTTCGCCTCGGCGTACATCGT
CACCAACCTGGGCCTGAGCTTCTGGCTGGCCGTCGCCGCGGCCGCCGTGTTCGGCGGGCTCCAGGCCGTGCTGCTGGGGG
CGGTGTCGCTACGGCTGACCGGGCTCTACTTCGCCCTGGTGACCCTGGCGTACGGGACGTTCGCCCAGGAGACCCTGTTC
GGCATCACGGCGATCACCGGCGGCGAGGGTGGCAAGCCCGCGCCGCGCCCGGAGCTCTTCGCGAGCGGCTACCGCTTCTA
CTTCTTGTGCCTCGGCTTCCTCGCCCTGGTGCTGTGGCTCGACTGGCGGCTCACCTCGTCCAAGGCGGGACGGGCGATGG
CGGCGCTGCGCGAGAACCCGCGGGTCGCCGCGTCGTACGGAATCGCGGTGCGTTCCTACATCCTGCTCGCCTTCGCGGTC
TCGGGGATCTTCGCCGGGATCGCGGGCTCGCTGATCGCCCATCACGACGAGGTGATCGTCGGCAGCTCGTTCGACTTCCG
GCTGGCCCTGCTCTTCGTCCTGATGACCGTGGTCGGTGGCCTGCGCAACCGGGTGGGCGTGGTCATCGGGTCGGTGTTCT
TCGCGCTCCTCGAGGAGGGCGCCCTGGTGAGCATGCTCCACCTCGGAGGCTTCTTCGAGGGGACCCTGGGCCTGCCGACC
GAGTTCGTCTCGCTGGTGGTCGGACCGATCCTGCTGGTGCTCACGCTCACCCTCTATCCGGGCGGGATCGGACAGCAGGT
GGCGCCGATCCGGGGCTGGCTCGCGGGCCGGCGGTTCGACCGCCACGCCGGTTCGGCCCACGACGTGGAGGTGTCCGATG
TCCGTGCTTGA

Upstream 100 bases:

>100_bases
TCGAGGTCCCCGGCGCCAGGGCCATGTTGCTGTTCGGCTTCCTGCTGGCGGTGCTCCTGGTACGGCCGCAAGGGATCTTC
GTACGCCGAGGGGTGGCGAC

Downstream 100 bases:

>100_bases
GATCGACCGGCTGAGCATCTCGTTCGGGGGGATCCAGGCGCTGCGGGACGTCAGCATCCGCGCCGGGGAGTGGGAGATCG
TGGGGATCATCGGCCCCAAC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTAVSVPVHEPVEVEPGGLHKEFRPGTAGWLARGTVWALLAWVVLAYPVNALSPFHVGVADIDIASLAAIYAIGGLSLNV
LLGYCGQISLGHQAFVGIGAFASAYIVTNLGLSFWLAVAAAAVFGGLQAVLLGAVSLRLTGLYFALVTLAYGTFAQETLF
GITAITGGEGGKPAPRPELFASGYRFYFLCLGFLALVLWLDWRLTSSKAGRAMAALRENPRVAASYGIAVRSYILLAFAV
SGIFAGIAGSLIAHHDEVIVGSSFDFRLALLFVLMTVVGGLRNRVGVVIGSVFFALLEEGALVSMLHLGGFFEGTLGLPT
EFVSLVVGPILLVLTLTLYPGGIGQQVAPIRGWLAGRRFDRHAGSAHDVEVSDVRA

Sequences:

>Translated_376_residues
MTAVSVPVHEPVEVEPGGLHKEFRPGTAGWLARGTVWALLAWVVLAYPVNALSPFHVGVADIDIASLAAIYAIGGLSLNV
LLGYCGQISLGHQAFVGIGAFASAYIVTNLGLSFWLAVAAAAVFGGLQAVLLGAVSLRLTGLYFALVTLAYGTFAQETLF
GITAITGGEGGKPAPRPELFASGYRFYFLCLGFLALVLWLDWRLTSSKAGRAMAALRENPRVAASYGIAVRSYILLAFAV
SGIFAGIAGSLIAHHDEVIVGSSFDFRLALLFVLMTVVGGLRNRVGVVIGSVFFALLEEGALVSMLHLGGFFEGTLGLPT
EFVSLVVGPILLVLTLTLYPGGIGQQVAPIRGWLAGRRFDRHAGSAHDVEVSDVRA
>Mature_375_residues
TAVSVPVHEPVEVEPGGLHKEFRPGTAGWLARGTVWALLAWVVLAYPVNALSPFHVGVADIDIASLAAIYAIGGLSLNVL
LGYCGQISLGHQAFVGIGAFASAYIVTNLGLSFWLAVAAAAVFGGLQAVLLGAVSLRLTGLYFALVTLAYGTFAQETLFG
ITAITGGEGGKPAPRPELFASGYRFYFLCLGFLALVLWLDWRLTSSKAGRAMAALRENPRVAASYGIAVRSYILLAFAVS
GIFAGIAGSLIAHHDEVIVGSSFDFRLALLFVLMTVVGGLRNRVGVVIGSVFFALLEEGALVSMLHLGGFFEGTLGLPTE
FVSLVVGPILLVLTLTLYPGGIGQQVAPIRGWLAGRRFDRHAGSAHDVEVSDVRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=289, Percent_Identity=32.5259515570934, Blast_Score=111, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 39502; Mature: 39370

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVSVPVHEPVEVEPGGLHKEFRPGTAGWLARGTVWALLAWVVLAYPVNALSPFHVGVA
CCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCHH
DIDIASLAAIYAIGGLSLNVLLGYCGQISLGHQAFVGIGAFASAYIVTNLGLSFWLAVAA
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFGGLQAVLLGAVSLRLTGLYFALVTLAYGTFAQETLFGITAITGGEGGKPAPRPELF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHH
ASGYRFYFLCLGFLALVLWLDWRLTSSKAGRAMAALRENPRVAASYGIAVRSYILLAFAV
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SGIFAGIAGSLIAHHDEVIVGSSFDFRLALLFVLMTVVGGLRNRVGVVIGSVFFALLEEG
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALVSMLHLGGFFEGTLGLPTEFVSLVVGPILLVLTLTLYPGGIGQQVAPIRGWLAGRRFD
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHH
RHAGSAHDVEVSDVRA
HCCCCCCCCCHHCCCC
>Mature Secondary Structure 
TAVSVPVHEPVEVEPGGLHKEFRPGTAGWLARGTVWALLAWVVLAYPVNALSPFHVGVA
CEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCHH
DIDIASLAAIYAIGGLSLNVLLGYCGQISLGHQAFVGIGAFASAYIVTNLGLSFWLAVAA
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFGGLQAVLLGAVSLRLTGLYFALVTLAYGTFAQETLFGITAITGGEGGKPAPRPELF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHH
ASGYRFYFLCLGFLALVLWLDWRLTSSKAGRAMAALRENPRVAASYGIAVRSYILLAFAV
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SGIFAGIAGSLIAHHDEVIVGSSFDFRLALLFVLMTVVGGLRNRVGVVIGSVFFALLEEG
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ALVSMLHLGGFFEGTLGLPTEFVSLVVGPILLVLTLTLYPGGIGQQVAPIRGWLAGRRFD
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHH
RHAGSAHDVEVSDVRA
HCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]