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The map label for this gene is lcfB [H]

Identifier: 119716251

GI number: 119716251

Start: 2162401

End: 2164926

Strand: Reverse

Name: lcfB [H]

Synonym: Noca_2019

Alternate gene names: 119716251

Gene position: 2164926-2162401 (Counterclockwise)

Preceding gene: 119716252

Following gene: 119716248

Centisome position: 43.42

GC content: 76.17

Gene sequence:

>2526_bases
GTGACCACGGACCAGTTCGCCCGGGTCGCCGTACCCGCTCGCGAGCTGGACCTGACCCTCCTCGGCGGCCACCCCGACGA
CCCCGCGCTCGTCACCGGCGACCGCACGGTGACCTACGCCGAGCTGGCCGCGCTCGTGCAGCGCCGCGCGCTCGAGCTCG
ACGACCCGGGCCGGCTGCTGCTGCTCGAGATGGCCAACGACCTGCCCAGCGTCGTGACCTACCTGGCCGCCCTCGCGCTC
CACCGCCCCGTGGTGATCGCCACCCCCGGCGCGCACGACGACATCGCCCGGACCTACCGGCCGGCGCTGGACGCCGACGC
CCCGCCGCCGCTGCACCCCGACCTGGCCGTGCTGCTGTCGACCTCGGGCTCCACTGGCTCACCCAAGCTGGTCCGGCTCT
CCCGCGCCAACGTGGTCGCCAACGCGCGGAGCATCGCCGACTACCTCGGCATCCGCCGCTCCGACCGGGCGCTCACCTCG
CTCCCCCTGCACTACTGCTACGGCCTCTCGGTGCTCAACAGCCACCTGGTCGCCGGGGCCGCGGTGGTGCTGACCGACCT
GTCGGTGGCCGACGAGTGCTTCTGGGACCTGGCCCGCACCCACCGGGCGACGACGTTCGCCGGCGTCCCCTACACGTTCG
ACCTGCTGGACGCGACCGGCTTCGCCGACCGCGACCTGCCGCACCTGCGCTACGTCACCCAGGCCGGCGGCCGGCTCGCG
CCCGAGACGGTGGTGCGGTACGCCGAGCTCGGGCAGCGCCGCGGCTGGGACCTGTTCGTGATGTACGGCCAGACCGAGGC
CACCGCCCGGATGGCGTACCTGCCGCCCACGCTGGCGCCGACCCGGCCGGAGGCGATCGGGGTCGCCGTACCGGGGGGGA
CGCTGCGGGTGGACCTGGACGGGCCCGGCCGCGAGGGCCTGCCCGCGGACGTCGGCGAGCTCGTCTACGGCGGCCCGAAC
GTGATGATGGGCTACGCCCACGGGCCCGCGGACCTGGCCCGGGGCGCCGAGCTGACCGAGCTGCGCACCGGCGACCTGGC
CCGGCGCGGTCCGGACGGGCTGTGGGAGGTCGTCGGCCGGCTGAACCGCACCGCCAAGGTGTTCGGCCTGCGGCTCGACC
TCGACCGGATCGAGCGCCGGCTGGCCACCGCGGGTGCCCCGGCGCGGGCAGTGGTCGTCGGCGAGGGCCTGCACCTGTTC
ACGACCCGGCCCCGCGACCGGCGCGTGCTGCCCACCCACCTGGCGCGGATCGCCGGCATCCCGGCCGGCACCGTGACCGC
CCACGTGGTCGAGACCGTGCCGACGACCGCGTCCGGCAAGTGCGACTACGCCGCGCTGCGCCGCCAGGCCGAGGCCGCGC
TCGCGCTGGCCGAGCCGGACGCCGGATCCGAGGCGGCGCCGGCGTACGGCGACGTCACCGGCCTGCGCGACCTGTACGCC
GTCCTCCTCGGCCGCCCGGACGCCACCGCGCAGGACACCTTCGTCGGGCTCGGCGGCGACTCGCTGTCCTTCGTCGAGCT
CTCGACCCGGCTCGCGGCCCGGATCGGACACCTGCCCGCGGACTGGCCGCACCGGTCGATCGAGTCACTGGCCCTGGAGT
CCCGGCCGGCCCGCCGGTTCACGACGCCGGTCGAGCTCGGCGTCGTGCTGCGGGCCGTGGCGATCATCCTGATCGTCGTC
ACGCACGTCGACGTCGTGCACCTGCTCGGCGGGGCGCACGTGCTGCTCGCGCTGGTCGGCTACCACCTGGCCCGGTTCGG
CCTGGCCGTCGACGGGCGGCGGACCCGGACCCGGCGGCTGCTCGTCGGCCTGGCCGGGGTCGCCGTTCCTGCCTCGCTGT
GGATCGGCGGCGCCGCCCTCCTCACCGGGGAGTACCGCCCGGCCACGGCGCTGTACCTCAACGGCGTGGTCGGCGAGAGC
CGGTGGAGCGACGACTGGCAGTTCTGGTTCCTCGACGTGCTGGTCTGGGGCACGCTCGCGGTCGCCCTGGCGCTCGCGGT
GCCGTGGGTGGACCGCCGCCAGCGGCGCTCGCCGTACGCCGTCGCGCTGGTGGCGCTCGTGGCCGCCCTGGGGCTGCGCT
ACGCCACCGTCGGGGTGAGCGCGGACCTGACCGAGAAGTACACCGTGGCCGGCAGCCTGTGGCTGATCGCGCTCGGGTGG
GCGGTCGCGGAGGCGCGCACCCGGACCCAGCGGCTGGTGGTCGCGGCGGTCGCGGCGCTCGGGCTGGTGGGGTTCTTCCC
CGGCGAGCCGAGTCGTACGGCGATCGTCGGCATCGGCGTGCTCCTGCTGCTGTGGGCCCGACCCGTGCCGGTCCCCACGG
TCCTGGCCGCGCCGCTGCGCGTGGTCGCGGGCGCGTCGCTGTGGATCTACCTGACGCAGTGGCAGGTCTACCCCGGGCTC
GAGGCGGCCGGGCGGCCCGCGCTCGCGATCGGCGCCTCGCTGGCGGTGGGCGTGGCGTGCTGCTGCGCCTACACCCGGCT
GGAGCGGGCGGTGCGGCCGCGGCTCAGCAGGAGACGCCGAGGCTGA

Upstream 100 bases:

>100_bases
TCATCGCCCGCACCCCGGCCGACACGCTGCCCCGGCCCGGCGACCACGTGCGCCTCGTCGTCACCGGCGAGGTGCGCTGC
TTCGCCCCAGGGGCGGGCGC

Downstream 100 bases:

>100_bases
CGGTGCCGGCCGCCGCCTGGGTGGTGAGGTGCCGGCTGAACCACTCGGTCGCGAGCTCGGCCACCCGCTCCAGCGAGTGC
GGCTCGGAGAACAGGTGGGT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 841; Mature: 840

Protein sequence:

>841_residues
MTTDQFARVAVPARELDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLLLLEMANDLPSVVTYLAALAL
HRPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLSTSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTS
LPLHYCYGLSVLNSHLVAGAAVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLA
PETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLDGPGREGLPADVGELVYGGPN
VMMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGRLNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLF
TTRPRDRRVLPTHLARIAGIPAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYA
VLLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRFTTPVELGVVLRAVAIILIVV
THVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRLLVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGES
RWSDDWQFWFLDVLVWGTLAVALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGW
AVAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLRVVAGASLWIYLTQWQVYPGL
EAAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRRG

Sequences:

>Translated_841_residues
MTTDQFARVAVPARELDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLLLLEMANDLPSVVTYLAALAL
HRPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLSTSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTS
LPLHYCYGLSVLNSHLVAGAAVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLA
PETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLDGPGREGLPADVGELVYGGPN
VMMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGRLNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLF
TTRPRDRRVLPTHLARIAGIPAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYA
VLLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRFTTPVELGVVLRAVAIILIVV
THVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRLLVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGES
RWSDDWQFWFLDVLVWGTLAVALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGW
AVAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLRVVAGASLWIYLTQWQVYPGL
EAAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRRG
>Mature_840_residues
TTDQFARVAVPARELDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLLLLEMANDLPSVVTYLAALALH
RPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLSTSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTSL
PLHYCYGLSVLNSHLVAGAAVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLAP
ETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLDGPGREGLPADVGELVYGGPNV
MMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGRLNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLFT
TRPRDRRVLPTHLARIAGIPAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYAV
LLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRFTTPVELGVVLRAVAIILIVVT
HVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRLLVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGESR
WSDDWQFWFLDVLVWGTLAVALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGWA
VAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLRVVAGASLWIYLTQWQVYPGLE
AAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRRG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=362, Percent_Identity=26.5193370165746, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1789201, Length=361, Percent_Identity=30.4709141274238, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI145693145, Length=364, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1788107, Length=339, Percent_Identity=28.023598820059, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786801, Length=436, Percent_Identity=25.2293577981651, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559526, Length=383, Percent_Identity=26.6318537859008, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=28.9772727272727, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 89744; Mature: 89612

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDQFARVAVPARELDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLL
CCCCHHHHHCCCHHHEEEEEECCCCCCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEE
LLEMANDLPSVVTYLAALALHRPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLS
EEEHHCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEE
TSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTSLPLHYCYGLSVLNSHLVAGA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
AVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLA
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
PETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLD
HHHHHHHHHHHCCCCCEEEEEECCCCHHEEEEECCCCCCCCCCCEEEEEECCCEEEEEEC
GPGREGLPADVGELVYGGPNVMMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGR
CCCCCCCCCCHHHHEECCCCEEEEECCCHHHHHCCCCHHHCCCCCHHHCCCCHHHHHHHH
LNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLFTTRPRDRRVLPTHLARIAGI
HCCCEEEEEEEECHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHCC
PAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYA
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHH
VLLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRF
HHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHC
TTPVELGVVLRAVAIILIVVTHVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHH
LVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGESRWSDDWQFWFLDVLVWGTLA
HHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
VALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGW
HHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEHHHHHHHHHHH
AVAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVAGASLWIYLTQWQVYPGLEAAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRR
HHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure 
TTDQFARVAVPARELDLTLLGGHPDDPALVTGDRTVTYAELAALVQRRALELDDPGRLL
CCCHHHHHCCCHHHEEEEEECCCCCCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEE
LLEMANDLPSVVTYLAALALHRPVVIATPGAHDDIARTYRPALDADAPPPLHPDLAVLLS
EEEHHCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEE
TSGSTGSPKLVRLSRANVVANARSIADYLGIRRSDRALTSLPLHYCYGLSVLNSHLVAGA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
AVVLTDLSVADECFWDLARTHRATTFAGVPYTFDLLDATGFADRDLPHLRYVTQAGGRLA
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
PETVVRYAELGQRRGWDLFVMYGQTEATARMAYLPPTLAPTRPEAIGVAVPGGTLRVDLD
HHHHHHHHHHHCCCCCEEEEEECCCCHHEEEEECCCCCCCCCCCEEEEEECCCEEEEEEC
GPGREGLPADVGELVYGGPNVMMGYAHGPADLARGAELTELRTGDLARRGPDGLWEVVGR
CCCCCCCCCCHHHHEECCCCEEEEECCCHHHHHCCCCHHHCCCCCHHHCCCCHHHHHHHH
LNRTAKVFGLRLDLDRIERRLATAGAPARAVVVGEGLHLFTTRPRDRRVLPTHLARIAGI
HCCCEEEEEEEECHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCHHHHHHHHHCC
PAGTVTAHVVETVPTTASGKCDYAALRRQAEAALALAEPDAGSEAAPAYGDVTGLRDLYA
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHH
VLLGRPDATAQDTFVGLGGDSLSFVELSTRLAARIGHLPADWPHRSIESLALESRPARRF
HHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHC
TTPVELGVVLRAVAIILIVVTHVDVVHLLGGAHVLLALVGYHLARFGLAVDGRRTRTRRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHH
LVGLAGVAVPASLWIGGAALLTGEYRPATALYLNGVVGESRWSDDWQFWFLDVLVWGTLA
HHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
VALALAVPWVDRRQRRSPYAVALVALVAALGLRYATVGVSADLTEKYTVAGSLWLIALGW
HHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEHHHHHHHHHHH
AVAEARTRTQRLVVAAVAALGLVGFFPGEPSRTAIVGIGVLLLLWARPVPVPTVLAAPLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVAGASLWIYLTQWQVYPGLEAAGRPALAIGASLAVGVACCCAYTRLERAVRPRLSRRRR
HHCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]