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The map label for this gene is 119716229

Identifier: 119716229

GI number: 119716229

Start: 2136688

End: 2137848

Strand: Direct

Name: 119716229

Synonym: Noca_1997

Alternate gene names: NA

Gene position: 2136688-2137848 (Clockwise)

Preceding gene: 119716228

Following gene: 119716230

Centisome position: 42.85

GC content: 74.33

Gene sequence:

>1161_bases
ATGGAGAGCGAGACGATCCCGGGCGGGACCATCGTCGTGGGCGTCGACCAGACCCCCGCCGCGAGGGACGCGCTGGCCTG
GGCGATCCAGGAGGCCGTGCACGAGGAGACGCCGCTGACGCTGGTCCACGGCGTCGGTGCGGCGCTGTCCGCGTGGGTCG
ACTTCTCGACGATCGACTTCCGCGACGTGATCGACGCGACCACCGCGACCGGGCGGGAGGTCCTCGACGCCGCGCAGGCC
CAGGTCGACCGGGTCGCGCCCGCGGTCGAGGTGCACCACGTGCTCCGCCTGACCGACCCGCACCAGGCGCTGCTCGACCT
CTCCGAGGACGCGGCGATGCTGGTCGTGGGGTCCCGGACCGCGCCGCACGAGCGCGAGTCGCTGATGTCCTCGGCGCTCG
GCTTCGTCCGCGACCGTGCCGGCTGCCCGGTGGTGGTCCCGCGGCTGCGCCGCAGCCCCGGCGTCGGCGTGGTCGTGCTC
TGCGACGGCTCGCCGGAGTCCCAGTCGATCCTCGCCTACGCGTGGGGCCAGGCCGACCGCCGCGGCCTCCCGCTGACCGT
CGTGCACTGCCTGCCCGACCCGCCGGCCGACCTGCACCCCCGCGACATCAGCCTGATGGACGCAACGGCTCGCATGGAGG
CCAGCCTCGGGCCCTCGCTGCTCGGCTTCGAGCGGCTGCTGCTCAGCGACCTGGTCCGTGACATGCGGTCGCGCTGGCCG
GGCGTGGACGTCCGCCTGGTCGTCGAGGACGACGCGATCGACAGGTGGCTCGAGCGCGCCCGGCAGCAGGCCGACCTGCT
CGTGGTCGGCGCCAGGCACGCCCGCCGGCTGTCCGAGCTGGTCATCGGCAGCTCCACGCCGGAGGAGGTGGAGTGCGTCA
CCGTCGTCCTGCCGTTGGAGGACCGGCTCGATCCCGACGCGGACGCGGCGCGGGTGACCATCCAGCGGCTCCATGGCTGT
GCCCAGCGGCTGGTCCGGCTCAACATCCCCCTCGACCAAGCGGTGGCCGAGATCCGCTCGGTCACCATGGACACCGACCT
GCTCGCCGAGGCCGCCCTCACCGCGCTGCGCGGCTGGGGCGCCACGACCGCCAAGAGCTGGCAGACCCGCGAGGTCACCG
AGCTGCTGGTACGGGCCGGAGCCCGCCGCGTCTGGCCCTGA

Upstream 100 bases:

>100_bases
CGGCCTCGCCTCGGTCGGCCCGACGATTAAGGACCGGCTTCTGCTCGCCGAAGGGACCTTCGTCAGGAACCGACGACGAG
CGCGGCAGGAGGTGGCGGCC

Downstream 100 bases:

>100_bases
CGCAGGCGCGCCCCAGCGCACGGCTACTCGCCGGTACTCGCCGGACAGGGCACAATCCCTCGCGTGACGGTGGCATCGGT
GGCCGAACGACTCTCGGGAC

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MESETIPGGTIVVGVDQTPAARDALAWAIQEAVHEETPLTLVHGVGAALSAWVDFSTIDFRDVIDATTATGREVLDAAQA
QVDRVAPAVEVHHVLRLTDPHQALLDLSEDAAMLVVGSRTAPHERESLMSSALGFVRDRAGCPVVVPRLRRSPGVGVVVL
CDGSPESQSILAYAWGQADRRGLPLTVVHCLPDPPADLHPRDISLMDATARMEASLGPSLLGFERLLLSDLVRDMRSRWP
GVDVRLVVEDDAIDRWLERARQQADLLVVGARHARRLSELVIGSSTPEEVECVTVVLPLEDRLDPDADAARVTIQRLHGC
AQRLVRLNIPLDQAVAEIRSVTMDTDLLAEAALTALRGWGATTAKSWQTREVTELLVRAGARRVWP

Sequences:

>Translated_386_residues
MESETIPGGTIVVGVDQTPAARDALAWAIQEAVHEETPLTLVHGVGAALSAWVDFSTIDFRDVIDATTATGREVLDAAQA
QVDRVAPAVEVHHVLRLTDPHQALLDLSEDAAMLVVGSRTAPHERESLMSSALGFVRDRAGCPVVVPRLRRSPGVGVVVL
CDGSPESQSILAYAWGQADRRGLPLTVVHCLPDPPADLHPRDISLMDATARMEASLGPSLLGFERLLLSDLVRDMRSRWP
GVDVRLVVEDDAIDRWLERARQQADLLVVGARHARRLSELVIGSSTPEEVECVTVVLPLEDRLDPDADAARVTIQRLHGC
AQRLVRLNIPLDQAVAEIRSVTMDTDLLAEAALTALRGWGATTAKSWQTREVTELLVRAGARRVWP
>Mature_386_residues
MESETIPGGTIVVGVDQTPAARDALAWAIQEAVHEETPLTLVHGVGAALSAWVDFSTIDFRDVIDATTATGREVLDAAQA
QVDRVAPAVEVHHVLRLTDPHQALLDLSEDAAMLVVGSRTAPHERESLMSSALGFVRDRAGCPVVVPRLRRSPGVGVVVL
CDGSPESQSILAYAWGQADRRGLPLTVVHCLPDPPADLHPRDISLMDATARMEASLGPSLLGFERLLLSDLVRDMRSRWP
GVDVRLVVEDDAIDRWLERARQQADLLVVGARHARRLSELVIGSSTPEEVECVTVVLPLEDRLDPDADAARVTIQRLHGC
AQRLVRLNIPLDQAVAEIRSVTMDTDLLAEAALTALRGWGATTAKSWQTREVTELLVRAGARRVWP

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 41929; Mature: 41929

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESETIPGGTIVVGVDQTPAARDALAWAIQEAVHEETPLTLVHGVGAALSAWVDFSTIDF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCH
RDVIDATTATGREVLDAAQAQVDRVAPAVEVHHVLRLTDPHQALLDLSEDAAMLVVGSRT
HHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCC
APHERESLMSSALGFVRDRAGCPVVVPRLRRSPGVGVVVLCDGSPESQSILAYAWGQADR
CCHHHHHHHHHHHHHHHHCCCCCEECHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
RGLPLTVVHCLPDPPADLHPRDISLMDATARMEASLGPSLLGFERLLLSDLVRDMRSRWP
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GVDVRLVVEDDAIDRWLERARQQADLLVVGARHARRLSELVIGSSTPEEVECVTVVLPLE
CCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEEEHH
DRLDPDADAARVTIQRLHGCAQRLVRLNIPLDQAVAEIRSVTMDTDLLAEAALTALRGWG
HCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
ATTAKSWQTREVTELLVRAGARRVWP
CCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MESETIPGGTIVVGVDQTPAARDALAWAIQEAVHEETPLTLVHGVGAALSAWVDFSTIDF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCH
RDVIDATTATGREVLDAAQAQVDRVAPAVEVHHVLRLTDPHQALLDLSEDAAMLVVGSRT
HHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCC
APHERESLMSSALGFVRDRAGCPVVVPRLRRSPGVGVVVLCDGSPESQSILAYAWGQADR
CCHHHHHHHHHHHHHHHHCCCCCEECHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCC
RGLPLTVVHCLPDPPADLHPRDISLMDATARMEASLGPSLLGFERLLLSDLVRDMRSRWP
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GVDVRLVVEDDAIDRWLERARQQADLLVVGARHARRLSELVIGSSTPEEVECVTVVLPLE
CCEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEEEHH
DRLDPDADAARVTIQRLHGCAQRLVRLNIPLDQAVAEIRSVTMDTDLLAEAALTALRGWG
HCCCCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
ATTAKSWQTREVTELLVRAGARRVWP
CCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]