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The map label for this gene is pstP [H]

Identifier: 119716214

GI number: 119716214

Start: 2119928

End: 2120734

Strand: Direct

Name: pstP [H]

Synonym: Noca_1982

Alternate gene names: 119716214

Gene position: 2119928-2120734 (Clockwise)

Preceding gene: 119716213

Following gene: 119716215

Centisome position: 42.52

GC content: 74.6

Gene sequence:

>807_bases
ATGCTGCGATTCTCGGGTGCCGGCGTCAGTGACGTGGGGCTGGTGCGCCCTCAGAACGAGGACTCCGCCTTCGTCGGACC
CTACGTGGCCGTCGTCGCCGACGGAGTCGGTGGTGCCGCGGCCGGGGAGGTCGCGTCCGCGACCGCGGCGTACGCCGTGG
CGGCGACCGTGCTCGGGCGGCCGGGCGAGCAGCCGGAGGAGCTGCTCCTCGACGGCTTGGAGGCGGCTCGCGCCAACATC
CGCCGGGGCGTCCAGGGCGACCTGACCCGGCTCGGCATGGCCACCACCCTCACCGCGGTCGTCTGCGACGGCCGGCGGGC
GGTGCTCGCCCACATCGGCGACTCGCGGGCCTACGTGCTCCGTGGGGGCGAGCTCACCCGGCTCACCACCGACCACACCT
ATGTGCAGCGGCTGGTGTCGCAGGGCGAGCTGCGGCCCGAGGAGGTGATCCGGCACCCGTGGCGCAACGTCGTGCTGCGC
TCGCTCGACGGCGACCCCGTGCACGACGGTGTCGACCTGCTGCCGCTCGCGGTGCAGCCCGGCGATCGGCTGCTGCTGTG
CAGCGACGGGCTCTCGGACCTGGTTCCGGAGCCGGTCATCGGGGAGCTGCTCGCGGTCGCGGACCCGCACTCCGCCGCCG
CGGTGCTCACCCGCGCGGCGCTCGATGCCGGCGGCCGCGACAACGTCACAGCGGTCGTCCTGGACGTGGTGGAGGGTCCG
ATGGTCGTCGGCGACGGCCAGCTGCTCGGCGCGCTGCGCGAGGTCGCCAACATCGTCGACCCGGGTGCGGTCCGCCTGGC
GCAGTGA

Upstream 100 bases:

>100_bases
CCATCGACAGCGAGGAGCTGACCGACGCCGACGCGCGCGCCGAGGCCCTCGAGCGGAAGCTCGGTTAGACTCTCCGCACT
TCGCGAGGAGGACCTGCACG

Downstream 100 bases:

>100_bases
CGTGCGAGACTCCTGCGCGTGGGGAACGTCAGGAGACCGGCACTCGAGGGCACCGTCGCGGTCCGCGACGACCGCCGGCT
GAGCTTCGCCGAGTACGGCC

Product: protein phosphatase 2C domain-containing protein

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MLRFSGAGVSDVGLVRPQNEDSAFVGPYVAVVADGVGGAAAGEVASATAAYAVAATVLGRPGEQPEELLLDGLEAARANI
RRGVQGDLTRLGMATTLTAVVCDGRRAVLAHIGDSRAYVLRGGELTRLTTDHTYVQRLVSQGELRPEEVIRHPWRNVVLR
SLDGDPVHDGVDLLPLAVQPGDRLLLCSDGLSDLVPEPVIGELLAVADPHSAAAVLTRAALDAGGRDNVTAVVLDVVEGP
MVVGDGQLLGALREVANIVDPGAVRLAQ

Sequences:

>Translated_268_residues
MLRFSGAGVSDVGLVRPQNEDSAFVGPYVAVVADGVGGAAAGEVASATAAYAVAATVLGRPGEQPEELLLDGLEAARANI
RRGVQGDLTRLGMATTLTAVVCDGRRAVLAHIGDSRAYVLRGGELTRLTTDHTYVQRLVSQGELRPEEVIRHPWRNVVLR
SLDGDPVHDGVDLLPLAVQPGDRLLLCSDGLSDLVPEPVIGELLAVADPHSAAAVLTRAALDAGGRDNVTAVVLDVVEGP
MVVGDGQLLGALREVANIVDPGAVRLAQ
>Mature_268_residues
MLRFSGAGVSDVGLVRPQNEDSAFVGPYVAVVADGVGGAAAGEVASATAAYAVAATVLGRPGEQPEELLLDGLEAARANI
RRGVQGDLTRLGMATTLTAVVCDGRRAVLAHIGDSRAYVLRGGELTRLTTDHTYVQRLVSQGELRPEEVIRHPWRNVVLR
SLDGDPVHDGVDLLPLAVQPGDRLLLCSDGLSDLVPEPVIGELLAVADPHSAAAVLTRAALDAGGRDNVTAVVLDVVEGP
MVVGDGQLLGALREVANIVDPGAVRLAQ

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 27758; Mature: 27758

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFSGAGVSDVGLVRPQNEDSAFVGPYVAVVADGVGGAAAGEVASATAAYAVAATVLGR
CEEECCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
PGEQPEELLLDGLEAARANIRRGVQGDLTRLGMATTLTAVVCDGRRAVLAHIGDSRAYVL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
RGGELTRLTTDHTYVQRLVSQGELRPEEVIRHPWRNVVLRSLDGDPVHDGVDLLPLAVQP
ECCEEEEEECCHHHHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECC
GDRLLLCSDGLSDLVPEPVIGELLAVADPHSAAAVLTRAALDAGGRDNVTAVVLDVVEGP
CCEEEEECCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCC
MVVGDGQLLGALREVANIVDPGAVRLAQ
EEEECHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MLRFSGAGVSDVGLVRPQNEDSAFVGPYVAVVADGVGGAAAGEVASATAAYAVAATVLGR
CEEECCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
PGEQPEELLLDGLEAARANIRRGVQGDLTRLGMATTLTAVVCDGRRAVLAHIGDSRAYVL
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
RGGELTRLTTDHTYVQRLVSQGELRPEEVIRHPWRNVVLRSLDGDPVHDGVDLLPLAVQP
ECCEEEEEECCHHHHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECC
GDRLLLCSDGLSDLVPEPVIGELLAVADPHSAAAVLTRAALDAGGRDNVTAVVLDVVEGP
CCEEEEECCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHCCC
MVVGDGQLLGALREVANIVDPGAVRLAQ
EEEECHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]