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The map label for this gene is srrB [H]

Identifier: 119716165

GI number: 119716165

Start: 2062938

End: 2064545

Strand: Direct

Name: srrB [H]

Synonym: Noca_1933

Alternate gene names: 119716165

Gene position: 2062938-2064545 (Clockwise)

Preceding gene: 119716164

Following gene: 119716170

Centisome position: 41.38

GC content: 74.07

Gene sequence:

>1608_bases
ATGGGGAGGGTGGCGACGAGGCTCGCGGGGTTGCACCGCCGGCTGCTGTTCGCCGACGACCCGGATCCGGAGCTGCTCCA
GGGTGTCTTCGCCGCCCTGTTCCTCCTCGACTTCGTGCTGCGCGCGGCCGGCGGCTCGTCGCCGGCGCTGGCTTCTTGGC
CGGTCCTGGGGCTGCTCGTCATGGCGCTCGCCTCGGCGGCCGCGATCGCGGTGCCGTGGGAGCGGGCGCCCGTCTGGGCG
GTCGGCATCCTCCCGGCCGTCGACATCCTCGCCCTCGGCTTCTCCCGGATGGACCCCGCCGGCGGCGCGACCGGGACGCT
CGCAGTGGTGCCGGCGCTGTGGCTCGGCCGCCAGTACGGTCGGCGCGGCGCCGTCGTCGTCCTCCTGTCGACCGCGTTCC
TGCTCGCCGGGCCGGGGCTGCTCTACCTGGGGGCGTCGGGGGCGAACCTGACCCGCACCGTGATGATCCCGCTGGTCGCC
ACCTGGGCCGCCCTGGCCATCTCCTACGCGCTCGAGCGGGTCCGGGCCGGCATCGAGGTGATCGAGCACCAGCGTCGGGT
CTCCCAGGCGATCTTCGACACCGTCGACGTGGGCCTGGTGCTCCTGGACGAGTCAGGGGCCTACCAGGGGATCAACCGCC
GGCACGCCGACTTCATCCGCCTCGCCTTCCCCGAGGGGCACCAGGGGCGAGCAGGCCAGCTCGGCGCGGTGTACGACGCC
GACGGCACCCGGGAGCTGGCCGCGGAGGAGATGCCGACGCACCGCGCGAGCCTGGGCGAGCAGTTCGAGGACGTGCGGAT
CTGGGTCGGCCCGGACCCGCTGACCCGCCGGGCGCTGTCGGTCTCCGCGCGCCGGGTGGAGGACGAGGCCGGGGCCCTCG
CCGGCGCCTCGCTGGCCTACAAGGACGTCACCGACTTCATGCGGGCGCTGCGGGTCAAGGACGAGTTCGTCGCCTCGGTC
TCCCACGAGCTGCGCACCCCGCTGACCTCCATCGTCGGCTACACGCAGATGCTGCTCGAGCGCGACGACCTGCCGGCCGA
CGTCGTCGCCCAGCTCGAGGTGATGGCCCGCAACAGTGGGCGGCTGCACCGGCTGGTCGCCGACCTGCTGCACACCGCCC
GCCTCGACGAGGGCGGGGCGCCCCTGGTGCGGGCGCCCGTCGACCTGGCTGCGGTCGTGCGGGACTGCGTGGAGGCCGCC
GCCCCGGCGGCGCGTCGCTCTGGCGTCGAGCTCGTCCTCGAGCTGCCGCCGACGCTGGTGCTGCGGGCCGATCAGGAGCG
GCTGGCGCAGGTCGTCGACAACCTCGTCTCGAACGCCGTGAAGTACACCAGCGCCGGTGGCTGCGTGCAGGTGACCCTGC
TCCTCGACGGGGACCGGGCCGAGCTGTGCGTCGCCGACACCGGGATCGGGATCGCCGCGGCCGACCGGGACCGCCTGTTC
ACCCGCTTCTTCCGCGCCCGCCAGGCCGAGGAGCGCTCGATCCAGGGTGTCGGGCTCGGCTTGAGCATCACCAAGGCGAT
CGTCGAGAGCCACGGTGGCCGGATCGAGGTCGAGAGCGAGCTCGGCAGGGGCAGCGTGTTCCGCGTGCGGCTGCCCCTGG
ACGCCTGA

Upstream 100 bases:

>100_bases
GCCGGGACCGCCGGTACGGCGGCGCCGCCCCGAACCCCGTGCCGGGACCGAGCCAGGGCCCCGTCGCCGCCCCGGCGCCG
GGCGAGGACTGAGCCGCGCC

Downstream 100 bases:

>100_bases
GCCCGGCGGTGTGAGTACGGCGCTCAGCCGCAGCGCGCGCAGGTGCCGAAGATCTCCAGTGTGTGGCTGACCTCGGCGTA
CCCGTGCTCGGCGGCGATCG

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MGRVATRLAGLHRRLLFADDPDPELLQGVFAALFLLDFVLRAAGGSSPALASWPVLGLLVMALASAAAIAVPWERAPVWA
VGILPAVDILALGFSRMDPAGGATGTLAVVPALWLGRQYGRRGAVVVLLSTAFLLAGPGLLYLGASGANLTRTVMIPLVA
TWAALAISYALERVRAGIEVIEHQRRVSQAIFDTVDVGLVLLDESGAYQGINRRHADFIRLAFPEGHQGRAGQLGAVYDA
DGTRELAAEEMPTHRASLGEQFEDVRIWVGPDPLTRRALSVSARRVEDEAGALAGASLAYKDVTDFMRALRVKDEFVASV
SHELRTPLTSIVGYTQMLLERDDLPADVVAQLEVMARNSGRLHRLVADLLHTARLDEGGAPLVRAPVDLAAVVRDCVEAA
APAARRSGVELVLELPPTLVLRADQERLAQVVDNLVSNAVKYTSAGGCVQVTLLLDGDRAELCVADTGIGIAAADRDRLF
TRFFRARQAEERSIQGVGLGLSITKAIVESHGGRIEVESELGRGSVFRVRLPLDA

Sequences:

>Translated_535_residues
MGRVATRLAGLHRRLLFADDPDPELLQGVFAALFLLDFVLRAAGGSSPALASWPVLGLLVMALASAAAIAVPWERAPVWA
VGILPAVDILALGFSRMDPAGGATGTLAVVPALWLGRQYGRRGAVVVLLSTAFLLAGPGLLYLGASGANLTRTVMIPLVA
TWAALAISYALERVRAGIEVIEHQRRVSQAIFDTVDVGLVLLDESGAYQGINRRHADFIRLAFPEGHQGRAGQLGAVYDA
DGTRELAAEEMPTHRASLGEQFEDVRIWVGPDPLTRRALSVSARRVEDEAGALAGASLAYKDVTDFMRALRVKDEFVASV
SHELRTPLTSIVGYTQMLLERDDLPADVVAQLEVMARNSGRLHRLVADLLHTARLDEGGAPLVRAPVDLAAVVRDCVEAA
APAARRSGVELVLELPPTLVLRADQERLAQVVDNLVSNAVKYTSAGGCVQVTLLLDGDRAELCVADTGIGIAAADRDRLF
TRFFRARQAEERSIQGVGLGLSITKAIVESHGGRIEVESELGRGSVFRVRLPLDA
>Mature_534_residues
GRVATRLAGLHRRLLFADDPDPELLQGVFAALFLLDFVLRAAGGSSPALASWPVLGLLVMALASAAAIAVPWERAPVWAV
GILPAVDILALGFSRMDPAGGATGTLAVVPALWLGRQYGRRGAVVVLLSTAFLLAGPGLLYLGASGANLTRTVMIPLVAT
WAALAISYALERVRAGIEVIEHQRRVSQAIFDTVDVGLVLLDESGAYQGINRRHADFIRLAFPEGHQGRAGQLGAVYDAD
GTRELAAEEMPTHRASLGEQFEDVRIWVGPDPLTRRALSVSARRVEDEAGALAGASLAYKDVTDFMRALRVKDEFVASVS
HELRTPLTSIVGYTQMLLERDDLPADVVAQLEVMARNSGRLHRLVADLLHTARLDEGGAPLVRAPVDLAAVVRDCVEAAA
PAARRSGVELVLELPPTLVLRADQERLAQVVDNLVSNAVKYTSAGGCVQVTLLLDGDRAELCVADTGIGIAAADRDRLFT
RFFRARQAEERSIQGVGLGLSITKAIVESHGGRIEVESELGRGSVFRVRLPLDA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=35.5263157894737, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=34.3220338983051, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=33.1896551724138, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788393, Length=259, Percent_Identity=33.5907335907336, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=33.4841628959276, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=33.6244541484716, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=28.5106382978723, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=28.4644194756554, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=285, Percent_Identity=31.2280701754386, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=29.4605809128631, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=31.1111111111111, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=29.0909090909091, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=31.7073170731707, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=30.7339449541284, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=26.9565217391304, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=28.0334728033473, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=31.1881188118812, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57141; Mature: 57009

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00018 EF_HAND_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVATRLAGLHRRLLFADDPDPELLQGVFAALFLLDFVLRAAGGSSPALASWPVLGLLV
CCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MALASAAAIAVPWERAPVWAVGILPAVDILALGFSRMDPAGGATGTLAVVPALWLGRQYG
HHHHHHHEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
RRGAVVVLLSTAFLLAGPGLLYLGASGANLTRTVMIPLVATWAALAISYALERVRAGIEV
CCCCEEHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEHQRRVSQAIFDTVDVGLVLLDESGAYQGINRRHADFIRLAFPEGHQGRAGQLGAVYDA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECC
DGTRELAAEEMPTHRASLGEQFEDVRIWVGPDPLTRRALSVSARRVEDEAGALAGASLAY
CCCHHHHHHHCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCHHHH
KDVTDFMRALRVKDEFVASVSHELRTPLTSIVGYTQMLLERDDLPADVVAQLEVMARNSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
RLHRLVADLLHTARLDEGGAPLVRAPVDLAAVVRDCVEAAAPAARRSGVELVLELPPTLV
HHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCEE
LRADQERLAQVVDNLVSNAVKYTSAGGCVQVTLLLDGDRAELCVADTGIGIAAADRDRLF
EECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEECCCCEEECCHHHHH
TRFFRARQAEERSIQGVGLGLSITKAIVESHGGRIEVESELGRGSVFRVRLPLDA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
GRVATRLAGLHRRLLFADDPDPELLQGVFAALFLLDFVLRAAGGSSPALASWPVLGLLV
CHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MALASAAAIAVPWERAPVWAVGILPAVDILALGFSRMDPAGGATGTLAVVPALWLGRQYG
HHHHHHHEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
RRGAVVVLLSTAFLLAGPGLLYLGASGANLTRTVMIPLVATWAALAISYALERVRAGIEV
CCCCEEHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEHQRRVSQAIFDTVDVGLVLLDESGAYQGINRRHADFIRLAFPEGHQGRAGQLGAVYDA
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECC
DGTRELAAEEMPTHRASLGEQFEDVRIWVGPDPLTRRALSVSARRVEDEAGALAGASLAY
CCCHHHHHHHCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCHHHH
KDVTDFMRALRVKDEFVASVSHELRTPLTSIVGYTQMLLERDDLPADVVAQLEVMARNSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
RLHRLVADLLHTARLDEGGAPLVRAPVDLAAVVRDCVEAAAPAARRSGVELVLELPPTLV
HHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCEE
LRADQERLAQVVDNLVSNAVKYTSAGGCVQVTLLLDGDRAELCVADTGIGIAAADRDRLF
EECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEECCCCEEECCHHHHH
TRFFRARQAEERSIQGVGLGLSITKAIVESHGGRIEVESELGRGSVFRVRLPLDA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA