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The map label for this gene is hrcA

Identifier: 119716135

GI number: 119716135

Start: 2032442

End: 2033455

Strand: Direct

Name: hrcA

Synonym: Noca_1903

Alternate gene names: 119716135

Gene position: 2032442-2033455 (Clockwise)

Preceding gene: 119716131

Following gene: 119716136

Centisome position: 40.76

GC content: 73.08

Gene sequence:

>1014_bases
GTGCAGGAGGAGCGCAGGCTCGCCGTGCTCCGCGCGATCGTGGAGGACTACGTCGCCACCGAGGAGCCGGTGGGCTCCAA
GGCGCTGGTCGAGCGGCACGGCCTCGGGGTGTCCCCGGCCACGGTCCGCAACGACATGGCGGCCCTGGAGGACGAGGGCT
ACATCACCCAGCCGCACACGAGCGCCGGCCGGGTCCCGACCGACAAGGGCTACCGGCTGTTCGTGGACCGGCTGACGACC
ATCAAGCCGATGAGCACGGCGGAGAAGCGGGCGATCGCCACCATCCTCGACGGCGCGATCGACCTCGACGACGTCGTCCA
GCGCTCGGTGCGGCTGCTGGCCCAGCTGACCCGCCAGGTCGCGGTCGTGCAGTACCCCACCCTGTCCCGCTCCACGGTGC
GCCACATCGAGCTGGTCGCCTTGACCCCGACCCGCCTGCTGGTGGTGCTGATCCTCAGCACGGGCCGGGTCGAGCAGCGC
CTCGTGGACCTCGCCGCCGAGCTCGGCGAGGAGGACCTGGCGGACCTGCGCACCGTGGTCAACCGCGCCGCGCTCGGCGA
GATCATCGCCGATGCCGCGACCGCGCTGCGGGCCCTGGTGCCCGCCGAGGATGCCACCCCCACCGGGGCGGTCGTCGACG
TCCTGGTCGAGGCGATGTCCGACCACCGATCCGACGAGCGGATCGCGGTCGGTGGCGCCGCGAACCTGGCCCGCTTCGGC
GACAGCTTCGACTCGGCCGTCCGGCCTCTGCTGGAGGCCCTCGAGGAGCACGTCGTGCTGCTCAAGCTGCTCGGCGAGGC
CACGGCCGGCGAGATCCTGACCGTTCGGATCGGGCACGAGGGGCCCTACCAGGAGCTCTCCTCGACCAGCGTGGTCGCGA
CCGGCTACGGGCCCGGCGACGAGGCGCTCGCGCGCCTCGGCATCGTCGGGCCCACCCGGATGGACTACGCCGGCTCGATG
GCGGCGGTCCGCGCCGTGGCGCGCTACGTGTCGCGGATCCTCGACGAGGGCTAG

Upstream 100 bases:

>100_bases
CGTGCCTCGGCGGGGCGCCTAGTAGTCTTGGCACTCAGGACTTTCGAGTGCCAGCGCGCCGGGCGACCGGGGCGCGGTCG
GACGTGAGGAGGTGTGGCGA

Downstream 100 bases:

>100_bases
CCCCCGGCCCACACCCACAGTCAGGTCGAGATCGACCAAGCCAGATCACAGAAGGAACCACGTTGAGCCAGGACCTGTAC
GAGCTGCTCGGTGTCGGCCG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQEERRLAVLRAIVEDYVATEEPVGSKALVERHGLGVSPATVRNDMAALEDEGYITQPHTSAGRVPTDKGYRLFVDRLTT
IKPMSTAEKRAIATILDGAIDLDDVVQRSVRLLAQLTRQVAVVQYPTLSRSTVRHIELVALTPTRLLVVLILSTGRVEQR
LVDLAAELGEEDLADLRTVVNRAALGEIIADAATALRALVPAEDATPTGAVVDVLVEAMSDHRSDERIAVGGAANLARFG
DSFDSAVRPLLEALEEHVVLLKLLGEATAGEILTVRIGHEGPYQELSSTSVVATGYGPGDEALARLGIVGPTRMDYAGSM
AAVRAVARYVSRILDEG

Sequences:

>Translated_337_residues
MQEERRLAVLRAIVEDYVATEEPVGSKALVERHGLGVSPATVRNDMAALEDEGYITQPHTSAGRVPTDKGYRLFVDRLTT
IKPMSTAEKRAIATILDGAIDLDDVVQRSVRLLAQLTRQVAVVQYPTLSRSTVRHIELVALTPTRLLVVLILSTGRVEQR
LVDLAAELGEEDLADLRTVVNRAALGEIIADAATALRALVPAEDATPTGAVVDVLVEAMSDHRSDERIAVGGAANLARFG
DSFDSAVRPLLEALEEHVVLLKLLGEATAGEILTVRIGHEGPYQELSSTSVVATGYGPGDEALARLGIVGPTRMDYAGSM
AAVRAVARYVSRILDEG
>Mature_337_residues
MQEERRLAVLRAIVEDYVATEEPVGSKALVERHGLGVSPATVRNDMAALEDEGYITQPHTSAGRVPTDKGYRLFVDRLTT
IKPMSTAEKRAIATILDGAIDLDDVVQRSVRLLAQLTRQVAVVQYPTLSRSTVRHIELVALTPTRLLVVLILSTGRVEQR
LVDLAAELGEEDLADLRTVVNRAALGEIIADAATALRALVPAEDATPTGAVVDVLVEAMSDHRSDERIAVGGAANLARFG
DSFDSAVRPLLEALEEHVVLLKLLGEATAGEILTVRIGHEGPYQELSSTSVVATGYGPGDEALARLGIVGPTRMDYAGSM
AAVRAVARYVSRILDEG

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_NOCSJ (A1SHX8)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923100.1
- ProteinModelPortal:   A1SHX8
- SMR:   A1SHX8
- STRING:   A1SHX8
- GeneID:   4596404
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_1903
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   RYLTAFL
- ProtClustDB:   PRK00082
- BioCyc:   NSP35761:NOCA_1903-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00081
- InterPro:   IPR001034
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- SMART:   SM00420
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA; PF08220 HTH_DeoR

EC number: NA

Molecular weight: Translated: 36085; Mature: 36085

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEERRLAVLRAIVEDYVATEEPVGSKALVERHGLGVSPATVRNDMAALEDEGYITQPHT
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCC
SAGRVPTDKGYRLFVDRLTTIKPMSTAEKRAIATILDGAIDLDDVVQRSVRLLAQLTRQV
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVVQYPTLSRSTVRHIELVALTPTRLLVVLILSTGRVEQRLVDLAAELGEEDLADLRTVV
HHHCCCCCCHHHHHHEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHH
NRAALGEIIADAATALRALVPAEDATPTGAVVDVLVEAMSDHRSDERIAVGGAANLARFG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHC
DSFDSAVRPLLEALEEHVVLLKLLGEATAGEILTVRIGHEGPYQELSSTSVVATGYGPGD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCEEEEECCCCCH
EALARLGIVGPTRMDYAGSMAAVRAVARYVSRILDEG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQEERRLAVLRAIVEDYVATEEPVGSKALVERHGLGVSPATVRNDMAALEDEGYITQPHT
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCC
SAGRVPTDKGYRLFVDRLTTIKPMSTAEKRAIATILDGAIDLDDVVQRSVRLLAQLTRQV
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVVQYPTLSRSTVRHIELVALTPTRLLVVLILSTGRVEQRLVDLAAELGEEDLADLRTVV
HHHCCCCCCHHHHHHEEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHH
NRAALGEIIADAATALRALVPAEDATPTGAVVDVLVEAMSDHRSDERIAVGGAANLARFG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHC
DSFDSAVRPLLEALEEHVVLLKLLGEATAGEILTVRIGHEGPYQELSSTSVVATGYGPGD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCEEEEECCCCCH
EALARLGIVGPTRMDYAGSMAAVRAVARYVSRILDEG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA