Click here to switch to the map view.

The map label for this gene is nhaA2

Identifier: 119716099

GI number: 119716099

Start: 1991291

End: 1993141

Strand: Reverse

Name: nhaA2

Synonym: Noca_1867

Alternate gene names: 119716099

Gene position: 1993141-1991291 (Counterclockwise)

Preceding gene: 119716100

Following gene: 119716098

Centisome position: 39.98

GC content: 74.12

Gene sequence:

>1851_bases
ATGCGCGCCGAAGGCCGCGGGCAGACGCGGGCCCGGCGCCGGTCCCTGGCCGCACAGCTCTCGGTCCCCGTACGTCGCTA
CCTGAACACCGAGGCCGGCAGCGCGGGCCTCCTGCTCGGCGCCACGGCCCTGGCCCTCCTCTGGGCGAACTCGCGGTGGT
CCGGCAGCTACGAGTCGCTGTGGAGCGCGCAGGCGGCCGTCTCCGTGTCCCGCTGGGACCTGTCGATGGACCTCGGGCAC
TGGGTCAACGACGGCCTGATGGCGCTGTTCTTCTTCGTGATCGGCCTGGAGGTCCGCCGCGAGTTCTCCGTCGGCGAGCT
CACCGATCCGCGCCGCGCGGCGATCCCCGTGCTCGCGGCGCTGGGCGGCCTGGCCGTCCCGGCGCTGCTCTACGTCGCGA
TCGCCCCTGGGTCGGCCGCGCACGGTTGGGGTGTGGTCATCGGCACCGACACGGCGTTCCTGCTGGGTGCCCTGGCCGTG
GTCGGCCCGACCTTCGCGACCCAGCTGCGGATCTTCCTGCTCACCGTCACCGTGATCGACGACATCGTCGCGGTCAGTGT
GATCGGCCTGTTCTACAGCGACTCCCTCGACCCCGCCGCGATCGGCGTGATGGCGGTGTTCCTCGTGCTGATGGCCGCGC
TGAGCCGGCTCGGCGTGTGGCGCGCGGCCCCCTATGTGCTCGCCGTCCTCGGGCTGTGGATCGCGACGGTCCAGTCGGGC
CTGCACGCCTCGATCGCGGGGATGCTCGGCGGGCTGCTCGTCGCCGCCCACTCCCCCACCCGCGAGGCCGTCGAGGGCGC
CGCGAGGCGGTTCCGGGCGTTCCGGCAGTCCCCCGACGTCCAGGTCGGCAGGTCCGCCCGCCTTGGGCTGGCCCAGGCGG
TGTCGGTCAACGAACGGCTGCAGGCCGCACTGCACCCGTGGACCAGCTACCTCGTCGTACCGCTCTTCGCCCTCGCGAAC
GCCGGCGTCGACCTGCGTGACGGCGTCCTGGGCGACGCCCTGGCCTCCCGCCTCACGTGGGCCGTGGTGGTGGCGCTGGT
CCTGGGCAAGCTGGCCGGCATCGGACTGGCCTCGGTGGCGGGCGTCCGTGCCGGTCTCGGTCGGCTCCCGCGCGGCGTCC
GGCTCGGCCACGTCTTCGGCGGCGGCGCGCTGTCGGGGATCGGCTTCACTGTCGCGCTGCTGATCGCCGGGCTCGCCTTC
GAGTCCGACCAGCGCGACCGGGCGACCGTCGGGATCCTGATCGCGGCGGTGCTGGCGACCGGTCTCGGCTGGGCGGTCTT
CCACGCCGCCGCCGTGCTCCGGGGCCAGACCGACGCCGACCTGCCGAGGTTCCTCGATCCGCCCGTCGACGCCCGGCACG
ACCACGTCCGCGGCCGGGAGGACGCGCCGCTGACGCTGGTCGAGTACGGCGACTTCGAGTGCCCGTTCTGCGCTCGGGCC
ACGGGCGTGACCACGGAGCTCCGGGAGCGCTTCGGTGACGACCTGCGCTACGTGTTCCGCCACCTCCCGCTGGTCGACGT
GCACCCGCACGCCGAGCTGGCCGCCCGAGCCGCCGTGGCCGCGGACCACCAGGGTCGCTTCTGGGAGCTGCACGACCTGC
TGTTCGAGCACCAGGGCGAGCTGGAGGTCGAGGACCTCGCGGGGTACGCCGCCGACCTCGGCCTCGACGTCGAGGCGTTC
CTGCGCGACCTGGAGGAGGACGACACGGCCGACCGGGTCCGGAGGGACGTGGCGAGTGCGGAGGCAAGCGGCGCCCGCGG
GACGCCGACCTTCTTCGTCGGCGGGGTGCGGCACACCGGACCGCACGACGCCGAGACCCTGGCCCGGGCGCTCGAGGAGT
CGCGCACGTGA

Upstream 100 bases:

>100_bases
CCCGACAAGTACCTCGACCTGGTACCGGTCCGCGACCGCGAGCGCTTCGACCTCCCGGCCGGCACCGAGCCAGGCGCGGC
CCGCTGACGTGGCGGCGCGC

Downstream 100 bases:

>100_bases
CCCGGTCGCGAGGACCGGCCTGGCTACAGTCGTCGTCGACGGCCCGCGCCGCCACGGCGCCGTCGTACCGGAGGGAGAGC
GATGCCCGCGAACGCCGCCT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESLWSAQAAVSVSRWDLSMDLGH
WVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAALGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAV
VGPTFATQLRIFLLTVTVIDDIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSG
LHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERLQAALHPWTSYLVVPLFALAN
AGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVAGVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAF
ESDQRDRATVGILIAAVLATGLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARA
TGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGELEVEDLAGYAADLGLDVEAF
LRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTGPHDAETLARALEESRT

Sequences:

>Translated_616_residues
MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESLWSAQAAVSVSRWDLSMDLGH
WVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAALGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAV
VGPTFATQLRIFLLTVTVIDDIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSG
LHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERLQAALHPWTSYLVVPLFALAN
AGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVAGVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAF
ESDQRDRATVGILIAAVLATGLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARA
TGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGELEVEDLAGYAADLGLDVEAF
LRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTGPHDAETLARALEESRT
>Mature_616_residues
MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESLWSAQAAVSVSRWDLSMDLGH
WVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAALGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAV
VGPTFATQLRIFLLTVTVIDDIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSG
LHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERLQAALHPWTSYLVVPLFALAN
AGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVAGVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAF
ESDQRDRATVGILIAAVLATGLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARA
TGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGELEVEDLAGYAADLGLDVEAF
LRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTGPHDAETLARALEESRT

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1786201, Length=377, Percent_Identity=37.1352785145889, Blast_Score=211, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA2_NOCSJ (A1SHU2)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923064.1
- ProteinModelPortal:   A1SHU2
- SMR:   A1SHU2
- STRING:   A1SHU2
- GeneID:   4597187
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_1867
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   EMHDLLL
- PhylomeDB:   A1SHU2
- ProtClustDB:   CLSK901892
- BioCyc:   NSP35761:NOCA_1867-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR001853
- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF01323 DSBA; PF06965 Na_H_antiport_1; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 65388; Mature: 65388

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14316f48)-; HASH(0x181ba7d4)-; HASH(0x155aee68)-; HASH(0x181c4f44)-; HASH(0x1457c0b8)-; HASH(0x17dd148c)-; HASH(0x17cd8778)-; HASH(0x181c4d34)-; HASH(0x17a7bbf4)-; HASH(0x166354f4)-; HASH(0x181b1470)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
WSAQAAVSVSRWDLSMDLGHWVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAVVGPTFATQLRIFLLTVTVID
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
DIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
QAALHPWTSYLVVPLFALANAGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVA
HHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAFESDQRDRATVGILIAAVLAT
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARA
HHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHCC
TGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGE
CCCHHHHHHHHCHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
LEVEDLAGYAADLGLDVEAFLRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTG
CCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
PHDAETLARALEESRT
CCCHHHHHHHHHHCCH
>Mature Secondary Structure
MRAEGRGQTRARRRSLAAQLSVPVRRYLNTEAGSAGLLLGATALALLWANSRWSGSYESL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
WSAQAAVSVSRWDLSMDLGHWVNDGLMALFFFVIGLEVRREFSVGELTDPRRAAIPVLAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LGGLAVPALLYVAIAPGSAAHGWGVVIGTDTAFLLGALAVVGPTFATQLRIFLLTVTVID
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
DIVAVSVIGLFYSDSLDPAAIGVMAVFLVLMAALSRLGVWRAAPYVLAVLGLWIATVQSG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHASIAGMLGGLLVAAHSPTREAVEGAARRFRAFRQSPDVQVGRSARLGLAQAVSVNERL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
QAALHPWTSYLVVPLFALANAGVDLRDGVLGDALASRLTWAVVVALVLGKLAGIGLASVA
HHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GVRAGLGRLPRGVRLGHVFGGGALSGIGFTVALLIAGLAFESDQRDRATVGILIAAVLAT
HHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLGWAVFHAAAVLRGQTDADLPRFLDPPVDARHDHVRGREDAPLTLVEYGDFECPFCARA
HHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHCC
TGVTTELRERFGDDLRYVFRHLPLVDVHPHAELAARAAVAADHQGRFWELHDLLFEHQGE
CCCHHHHHHHHCHHHHHHHHHCCCEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
LEVEDLAGYAADLGLDVEAFLRDLEEDDTADRVRRDVASAEASGARGTPTFFVGGVRHTG
CCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCC
PHDAETLARALEESRT
CCCHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA