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The map label for this gene is fadA [H]

Identifier: 119716062

GI number: 119716062

Start: 1948796

End: 1950016

Strand: Direct

Name: fadA [H]

Synonym: Noca_1828

Alternate gene names: 119716062

Gene position: 1948796-1950016 (Clockwise)

Preceding gene: 119716057

Following gene: 119716063

Centisome position: 39.09

GC content: 69.94

Gene sequence:

>1221_bases
GTGCCCGAAGCCGTTATCGTCGCCACCGCCCGGTCCCCCATCGGGCGCGCCGGCAAGGGCTCGCTGAAGGACCTCCGTCC
CGACGAGCTCGCCGCCCAGATGGTGCAGGCCGCGCTCGTCAAGGTCCCGGAGCTGGACCCCACCGAGATCGATGACCTGG
TCCTGGGGTGCGGCCAGCCGGCCGGCGAGTCCGGGTTCAACATGGGCCGCGTCGTCGCCGTCCGCGTCGGCCTCGACTCC
GTGCCCGGTACGACAGTGAACCGGTACTGCTCCTCAAGCCTGCAGAGCACCCGGATGGCGTTGCACGCGATCCGGGCGGG
TGAGGGCGACGTCTTCATCAGCGCCGGCGTCGAGACTGTGAGCCGGTTCTACAGGGGCAGTGCCGACGGACTGCCGGACA
CCATGAACCCGTTCTTCGACGTGGCGATGCGGAGTACCGAGAAGCGGGCGGCTGGTGGGGCGGAGACCTGGGTCGATCCA
CGCACGTCGGGCCACCTGCCTGACGTCTACATCACGATGGGGCAGACCGCCGAGAACGTCGCCCAGCACGCCGGCGTCAC
GCGCGCCGACCAAGACGCCTTCGCTGTCCGGAGCCAGAACCTCGCCGAGCAGGCGATCGCCGATGGGTTCTGGGCGCGGG
AGATCACCCCCGTCACGCTCCCGGACGGGACCGTCGTCTCCGCCGACGACGGCCCCCGTTCCGGGGTGACGCTAGAGAGC
GTGGCCGCCCTACAGCCGGTGTTTCGCCCCGACGGCACCGTCACCGCCGGCAACTGCTGCCCCCTCAATGACGGGGCTGC
CGCACTGGTGATCATGTCGGACGTCAAGGCCAGGCAACTTGGCCTCACTCCGCTGGCCCGGATCGTCTCTACCGGCGTCA
CCGGCCTCTCACCGGAGATCATGGGCCTCGGGCCGGTGGGGGCCAGCCGTCAGGCGCTGCGCCGTGCGGGCATGACGATC
GACGACGTCGACCTCGTCGAGATCAACGAAGCGTTCGCCGCGCAGGTCATCCCCTCCGCCCGCGAGCTCGGGATCGCGGA
GGACAAGCTCAACGTCAACGGCGGCGCGATCGCGGTCGGTCACCCGTTCGGCATGACCGGCGCGCGGATCACCACCACCC
TGATCAACTCGCTGCAGCACCACGACAGGCAGATCGGTCTCGAGACCATGTGCGTGGGCGGGGGCCAGGGCATGGCGATG
GTGCTGGAGCGGCTCTCGTGA

Upstream 100 bases:

>100_bases
GCAGAGTAAGGCGCCTGTGGGGTCTCCGGCGCTTGACGACTGGGCAGCGGTTCGAGCAATATCGCCTAAGCAAGCGCTTA
TTCAATTGTGGAGGTTCCTC

Downstream 100 bases:

>100_bases
CGAGGGCGTCCGGCCAGCGCGCCGGACAGGGCGTCGTCGTCACCGGGGCCGCGCGCGGGATCGGCCGCGCGCTCGCCCGG
CGACTCGCCGCCGGCGGTGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPEAVIVATARSPIGRAGKGSLKDLRPDELAAQMVQAALVKVPELDPTEIDDLVLGCGQPAGESGFNMGRVVAVRVGLDS
VPGTTVNRYCSSSLQSTRMALHAIRAGEGDVFISAGVETVSRFYRGSADGLPDTMNPFFDVAMRSTEKRAAGGAETWVDP
RTSGHLPDVYITMGQTAENVAQHAGVTRADQDAFAVRSQNLAEQAIADGFWAREITPVTLPDGTVVSADDGPRSGVTLES
VAALQPVFRPDGTVTAGNCCPLNDGAAALVIMSDVKARQLGLTPLARIVSTGVTGLSPEIMGLGPVGASRQALRRAGMTI
DDVDLVEINEAFAAQVIPSARELGIAEDKLNVNGGAIAVGHPFGMTGARITTTLINSLQHHDRQIGLETMCVGGGQGMAM
VLERLS

Sequences:

>Translated_406_residues
MPEAVIVATARSPIGRAGKGSLKDLRPDELAAQMVQAALVKVPELDPTEIDDLVLGCGQPAGESGFNMGRVVAVRVGLDS
VPGTTVNRYCSSSLQSTRMALHAIRAGEGDVFISAGVETVSRFYRGSADGLPDTMNPFFDVAMRSTEKRAAGGAETWVDP
RTSGHLPDVYITMGQTAENVAQHAGVTRADQDAFAVRSQNLAEQAIADGFWAREITPVTLPDGTVVSADDGPRSGVTLES
VAALQPVFRPDGTVTAGNCCPLNDGAAALVIMSDVKARQLGLTPLARIVSTGVTGLSPEIMGLGPVGASRQALRRAGMTI
DDVDLVEINEAFAAQVIPSARELGIAEDKLNVNGGAIAVGHPFGMTGARITTTLINSLQHHDRQIGLETMCVGGGQGMAM
VLERLS
>Mature_405_residues
PEAVIVATARSPIGRAGKGSLKDLRPDELAAQMVQAALVKVPELDPTEIDDLVLGCGQPAGESGFNMGRVVAVRVGLDSV
PGTTVNRYCSSSLQSTRMALHAIRAGEGDVFISAGVETVSRFYRGSADGLPDTMNPFFDVAMRSTEKRAAGGAETWVDPR
TSGHLPDVYITMGQTAENVAQHAGVTRADQDAFAVRSQNLAEQAIADGFWAREITPVTLPDGTVVSADDGPRSGVTLESV
AALQPVFRPDGTVTAGNCCPLNDGAAALVIMSDVKARQLGLTPLARIVSTGVTGLSPEIMGLGPVGASRQALRRAGMTID
DVDLVEINEAFAAQVIPSARELGIAEDKLNVNGGAIAVGHPFGMTGARITTTLINSLQHHDRQIGLETMCVGGGQGMAMV
LERLS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=412, Percent_Identity=39.3203883495146, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI148539872, Length=411, Percent_Identity=36.9829683698297, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI167614485, Length=404, Percent_Identity=34.9009900990099, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4557237, Length=420, Percent_Identity=34.5238095238095, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.6603773584906, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI194353979, Length=404, Percent_Identity=28.960396039604, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1787663, Length=414, Percent_Identity=43.4782608695652, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=39.3719806763285, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=41.4634146341463, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI87082165, Length=412, Percent_Identity=39.3203883495146, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=32.512315270936, Blast_Score=158, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=37.192118226601, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI25147385, Length=414, Percent_Identity=33.8164251207729, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=34.1523341523341, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=31.8807339449541, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=421, Percent_Identity=28.2660332541568, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=35.8024691358025, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6325229, Length=416, Percent_Identity=34.375, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24655093, Length=412, Percent_Identity=37.1359223300971, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=35.0617283950617, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24640423, Length=414, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.447963800905, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42309; Mature: 42177

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVATARSPIGRAGKGSLKDLRPDELAAQMVQAALVKVPELDPTEIDDLVLGCGQP
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
AGESGFNMGRVVAVRVGLDSVPGTTVNRYCSSSLQSTRMALHAIRAGEGDVFISAGVETV
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHH
SRFYRGSADGLPDTMNPFFDVAMRSTEKRAAGGAETWVDPRTSGHLPDVYITMGQTAENV
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
AQHAGVTRADQDAFAVRSQNLAEQAIADGFWAREITPVTLPDGTVVSADDGPRSGVTLES
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCEEECCCCCCCCCCHHH
VAALQPVFRPDGTVTAGNCCPLNDGAAALVIMSDVKARQLGLTPLARIVSTGVTGLSPEI
HHHHHHCCCCCCCEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHCCCCCCCCCC
MGLGPVGASRQALRRAGMTIDDVDLVEINEAFAAQVIPSARELGIAEDKLNVNGGAIAVG
EEECCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEC
HPFGMTGARITTTLINSLQHHDRQIGLETMCVGGGQGMAMVLERLS
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
PEAVIVATARSPIGRAGKGSLKDLRPDELAAQMVQAALVKVPELDPTEIDDLVLGCGQP
CCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
AGESGFNMGRVVAVRVGLDSVPGTTVNRYCSSSLQSTRMALHAIRAGEGDVFISAGVETV
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHH
SRFYRGSADGLPDTMNPFFDVAMRSTEKRAAGGAETWVDPRTSGHLPDVYITMGQTAENV
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
AQHAGVTRADQDAFAVRSQNLAEQAIADGFWAREITPVTLPDGTVVSADDGPRSGVTLES
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCEEECCCCCCCCCCHHH
VAALQPVFRPDGTVTAGNCCPLNDGAAALVIMSDVKARQLGLTPLARIVSTGVTGLSPEI
HHHHHHCCCCCCCEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHCCCCCCCCCC
MGLGPVGASRQALRRAGMTIDDVDLVEINEAFAAQVIPSARELGIAEDKLNVNGGAIAVG
EEECCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEC
HPFGMTGARITTTLINSLQHHDRQIGLETMCVGGGQGMAMVLERLS
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]