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The map label for this gene is bhbA [H]

Identifier: 119716036

GI number: 119716036

Start: 1913529

End: 1915217

Strand: Direct

Name: bhbA [H]

Synonym: Noca_1802

Alternate gene names: 119716036

Gene position: 1913529-1915217 (Clockwise)

Preceding gene: 119716035

Following gene: 119716037

Centisome position: 38.38

GC content: 70.81

Gene sequence:

>1689_bases
ATGACCGAGAGCGCACGTTCCCGCTGGCAGGCCAGGTACGACGCGGCGCGCACCCGCGACGCCGACTTCACGACCCTGAG
CGGGCTGGAGGTGGCGCCGGCGTACGGCACGGACGACTCCGAGTGGCCGGGCGCGTTCCCTTACACCCGCGGGCTGTACC
CGACCGGCTACCGCGGCCGTACCTGGACGATCCGCCAGTTCGCCGGCTTCGGCAACGCGCGCCAGACCAACGAGCGCTAC
CGGATGATCCTGGGCCGCGGCGGCGGCGGGCTCAGCGTGGCCTTCGACATGCCGACCCTGATGGGCCGCGACTCCGACGA
CCCGCGCTCGCTCGGCGAGGTCGGCCACTGCGGCGTCGCGGTCGACTCCGCCGCCGACATGGAGGTCCTCTTCGACGGCA
TCGACCTGGGCGACGTCACGACCTCGATGACGATCAGCGGGCCGGCCGTGCCGGTGTTCTGCATGATGCTGGTCGCGGCG
GAGCGCGCCGGCGTCGACACCAGCGTCCTCAACGGCACCCTGCAGACCGACATCTTCAAGGAGTACATCGCCCAGAAGGA
GTGGATCTTCGGGCCCGAGCCGCACCTGAAGCTGATCGGCGACCTGATGGAGTACTGCGCGGAGAAGATCCCCGCCTACA
AGCCGCTCTCGGTCTCCGGCTACCACATCCGCGAGGCCGGCTCGACGGCCGCGCAGGAGCTGGCGTTCACCCTCGCCGAC
GGGTTCGGGTACGTCGAGCTGGGGCTCTCCCGCGGCCTCGACGTCGACGTGTTCGCGCCGGGCCTGTCGTTCTTCTTCGA
CGCCCACGTGGACTTCTTCGAGGAGATCGCCAAGTTCCGCGCCGCGCGCCGGATCTGGGCCCGCTGGATGCGCGACGTGT
ACGGGGCCACCACGGAGAAGGCGCAGTGGCTCCGGTTCCACACCCAGACCGCCGGGGTGTCGCTGACCGCGCAACAGCCC
TACAACAACGTCGTACGCACGGGCATCGAGGCGCTCTCCGCCGTGCTCGGCGGCACCAACTCGCTGCACACCAACGCGCT
CGACGAGACACTCGCGCTGCCGAGCGAGCAGGCCGCCGAGATCGCGCTGCGCACCCAGCAGGTGATCATGGAGGAGACCG
GCGTCGTCAACGTCGCGGACCCGCTCGGCGGCTCGTGGTACGTCGAGGCGCTCACCGACCGGCTCGAGGAGGAGGCGGTC
GCGATCTTCGACAAGATCCTCGCGATGGGCGGCTCCGCGCTGACCTCCGACCAGCCCGAGGCGCTCGCCGCCGCGGTGCG
CCGCGGGGAGAACCCGATCACCCGCGGCCTGCTGCGTGGCATCGAGGAGGGCTGGTTCATGTCGGAGATCGCCGAGGCCG
CCTTCCAGTACCAGACCGCGCTGGAGAAGGGCGACAAGCGGATCGTCGGGGTGAACTGCCACGAGGAGTCGGTGACCCAC
GACCTGGAGATCCTGCGCGTCTCGCACGAGGTCGAGGTCGAGCAGGTCCGCGAGCTCGACGTACGTCGCCAGGGGCGCGA
CGACGCGGCCGTGCAGGCCGCGCTGGCCCGGATGGTCGAGGCGGCCCGCGCGGACGAGAACCTGATCGAGCCGATGCTCG
ACGCGGTGCGTGCGGAGGCGACCCTGGGCGAGATCTGCGACGCACTGCGCGCCGAGTGGGGGGAGTACCGCGAACCCGCC
CGGTTCTGA

Upstream 100 bases:

>100_bases
CCGAAGTTTCGGCCCAACAGTGGCAACTTCCCCGGCTAACCGGGGAAACCGATGGCGGCGCCCGCTTGGCGCATTTACTA
GGACGTCCTAGTATTTCTCC

Downstream 100 bases:

>100_bases
CGGCGCGCGGCGATCCCGAGACCGTCGGCCCGACGGTGCAGGACTTCCGGCCCGGGTGACGCGCTCGGACGCTCTGGTGG
AATCGGAGGCGTGGATCTCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTESARSRWQARYDAARTRDADFTTLSGLEVAPAYGTDDSEWPGAFPYTRGLYPTGYRGRTWTIRQFAGFGNARQTNERY
RMILGRGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVAVDSAADMEVLFDGIDLGDVTTSMTISGPAVPVFCMMLVAA
ERAGVDTSVLNGTLQTDIFKEYIAQKEWIFGPEPHLKLIGDLMEYCAEKIPAYKPLSVSGYHIREAGSTAAQELAFTLAD
GFGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWMRDVYGATTEKAQWLRFHTQTAGVSLTAQQP
YNNVVRTGIEALSAVLGGTNSLHTNALDETLALPSEQAAEIALRTQQVIMEETGVVNVADPLGGSWYVEALTDRLEEEAV
AIFDKILAMGGSALTSDQPEALAAAVRRGENPITRGLLRGIEEGWFMSEIAEAAFQYQTALEKGDKRIVGVNCHEESVTH
DLEILRVSHEVEVEQVRELDVRRQGRDDAAVQAALARMVEAARADENLIEPMLDAVRAEATLGEICDALRAEWGEYREPA
RF

Sequences:

>Translated_562_residues
MTESARSRWQARYDAARTRDADFTTLSGLEVAPAYGTDDSEWPGAFPYTRGLYPTGYRGRTWTIRQFAGFGNARQTNERY
RMILGRGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVAVDSAADMEVLFDGIDLGDVTTSMTISGPAVPVFCMMLVAA
ERAGVDTSVLNGTLQTDIFKEYIAQKEWIFGPEPHLKLIGDLMEYCAEKIPAYKPLSVSGYHIREAGSTAAQELAFTLAD
GFGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWMRDVYGATTEKAQWLRFHTQTAGVSLTAQQP
YNNVVRTGIEALSAVLGGTNSLHTNALDETLALPSEQAAEIALRTQQVIMEETGVVNVADPLGGSWYVEALTDRLEEEAV
AIFDKILAMGGSALTSDQPEALAAAVRRGENPITRGLLRGIEEGWFMSEIAEAAFQYQTALEKGDKRIVGVNCHEESVTH
DLEILRVSHEVEVEQVRELDVRRQGRDDAAVQAALARMVEAARADENLIEPMLDAVRAEATLGEICDALRAEWGEYREPA
RF
>Mature_561_residues
TESARSRWQARYDAARTRDADFTTLSGLEVAPAYGTDDSEWPGAFPYTRGLYPTGYRGRTWTIRQFAGFGNARQTNERYR
MILGRGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVAVDSAADMEVLFDGIDLGDVTTSMTISGPAVPVFCMMLVAAE
RAGVDTSVLNGTLQTDIFKEYIAQKEWIFGPEPHLKLIGDLMEYCAEKIPAYKPLSVSGYHIREAGSTAAQELAFTLADG
FGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWMRDVYGATTEKAQWLRFHTQTAGVSLTAQQPY
NNVVRTGIEALSAVLGGTNSLHTNALDETLALPSEQAAEIALRTQQVIMEETGVVNVADPLGGSWYVEALTDRLEEEAVA
IFDKILAMGGSALTSDQPEALAAAVRRGENPITRGLLRGIEEGWFMSEIAEAAFQYQTALEKGDKRIVGVNCHEESVTHD
LEILRVSHEVEVEQVRELDVRRQGRDDAAVQAALARMVEAARADENLIEPMLDAVRAEATLGEICDALRAEWGEYREPAR
F

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=550, Percent_Identity=41.8181818181818, Blast_Score=433, Evalue=1e-121,
Organism=Escherichia coli, GI1789284, Length=545, Percent_Identity=42.5688073394495, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI25144500, Length=555, Percent_Identity=43.4234234234234, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 61739; Mature: 61608

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESARSRWQARYDAARTRDADFTTLSGLEVAPAYGTDDSEWPGAFPYTRGLYPTGYRGR
CCCHHHHHHHHHHHHHHCCCCCCEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TWTIRQFAGFGNARQTNERYRMILGRGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVA
EEEHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCHHHHCCCCCCHHHHHHHCCCCEE
VDSAADMEVLFDGIDLGDVTTSMTISGPAVPVFCMMLVAAERAGVDTSVLNGTLQTDIFK
ECCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHH
EYIAQKEWIFGPEPHLKLIGDLMEYCAEKIPAYKPLSVSGYHIREAGSTAAQELAFTLAD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHCCCHHHHHHHHHHHC
GFGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWMRDVYGATTEK
CCCEEEEHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AQWLRFHTQTAGVSLTAQQPYNNVVRTGIEALSAVLGGTNSLHTNALDETLALPSEQAAE
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHH
IALRTQQVIMEETGVVNVADPLGGSWYVEALTDRLEEEAVAIFDKILAMGGSALTSDQPE
HHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ALAAAVRRGENPITRGLLRGIEEGWFMSEIAEAAFQYQTALEKGDKRIVGVNCHEESVTH
HHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
DLEILRVSHEVEVEQVRELDVRRQGRDDAAVQAALARMVEAARADENLIEPMLDAVRAEA
HHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLGEICDALRAEWGEYREPARF
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TESARSRWQARYDAARTRDADFTTLSGLEVAPAYGTDDSEWPGAFPYTRGLYPTGYRGR
CCHHHHHHHHHHHHHHCCCCCCEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TWTIRQFAGFGNARQTNERYRMILGRGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVA
EEEHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCHHHHCCCCCCHHHHHHHCCCCEE
VDSAADMEVLFDGIDLGDVTTSMTISGPAVPVFCMMLVAAERAGVDTSVLNGTLQTDIFK
ECCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHH
EYIAQKEWIFGPEPHLKLIGDLMEYCAEKIPAYKPLSVSGYHIREAGSTAAQELAFTLAD
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHCCCHHHHHHHHHHHC
GFGYVELGLSRGLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWMRDVYGATTEK
CCCEEEEHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AQWLRFHTQTAGVSLTAQQPYNNVVRTGIEALSAVLGGTNSLHTNALDETLALPSEQAAE
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHH
IALRTQQVIMEETGVVNVADPLGGSWYVEALTDRLEEEAVAIFDKILAMGGSALTSDQPE
HHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ALAAAVRRGENPITRGLLRGIEEGWFMSEIAEAAFQYQTALEKGDKRIVGVNCHEESVTH
HHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
DLEILRVSHEVEVEQVRELDVRRQGRDDAAVQAALARMVEAARADENLIEPMLDAVRAEA
HHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TLGEICDALRAEWGEYREPARF
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]