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The map label for this gene is hbd [H]

Identifier: 119716018

GI number: 119716018

Start: 1895023

End: 1896849

Strand: Direct

Name: hbd [H]

Synonym: Noca_1784

Alternate gene names: 119716018

Gene position: 1895023-1896849 (Clockwise)

Preceding gene: 119716015

Following gene: 119716019

Centisome position: 38.01

GC content: 69.51

Gene sequence:

>1827_bases
ATGCCCCGCATGACCAGCACCTCCCCCGAGACAGCCGCTCCCGGAGCCGGGCGCGAGTTCCGCACGATCGGCGTCATCGG
CCTGGGCACCATGGGTGCCGGCATCGCCGAGGTCTTCGCCCGGGCCGGCCACGCCGTGGTCGGCGTCGAGAAGGACGACG
AGTCCCTGGCCCGTGGCCGCCAGTACCTCGAGCACTCGACCTCCCGCGCCGTCAAGCGCGAGAAGATGACCGAGGCGGAC
CAGGCCGAGCTGCTGGGGCGGATCACGTTCACCACCTCGCTCAAGGACCTCGCCGAGGCGGACTTCGTCGTCGAGGCGGT
GGTGGAGTCGCTCGAGACCAAGAAGGCGATCTTCCGCGACCTCGACGAGATCGTCTCGCCCGAGACGATCCTGGCCACGA
ACACGTCCTCGCTCTCGGTCACCGAGATCTCGACCGCCAACGGCAGCCCGGGCCGCGTGGTCGGCGTGCACTTCTTCAAC
CCGGCGCCGGTGCAGGCGCTGGTCGAGATCGTGCGCACCGTCGTGACCGAGCAGAGCGTCCTCGACGAGACCACCGCGCT
GGTCACCAGCCTCGGGAAGGCCCCGGTCGTCTGCGGCGACAAGGCGGGCTTCATCGCCAACACGCTGCTCTTCGGCTACC
TCAACCACGCGGTCGCCATGTACGAGGGCCACTACGCCTCGCGCGAGGACATCGACGCCGCGATGCGGTACGGCTGCGGC
TACCCGATGGGCCCGCTCGCGCTGCTCGACCTGATCGGCCTGGACACGGCGTACGAGATCCTCGAGACCATGTACCACCA
GGGCCGCGACCGGCTGCACGCGCCGCGCCCGATCCTCAAGCAGATGGTCACCGCGGGCATGCTCGGCCGCAAGACCGGCC
GTGGGTTCTACTCCTACGAGGCCGCGGACAGCCCGGTCGTCGTCGCCGACGAGCTGACCCCGTCGGTGGACCAGAAGCCC
CAGCTGCGACACGACATCAAGCTGGTCGGGGTGGTCGGCACCGGCACGATGGCCACCGGCATCGTCGAGGTCTTCGCCAA
GAGCGGGTACGACGTGCTCTACGTCGGCCGCTCCGCCGACAAGGTCGCGGGCGTCCGCGCCGCGATCGAGAAGTCGCTCG
ACAAGGCCATCCAGCGCGGCAAGCTCGAGGAGTCCGCCAAGGCGGAGGTGCTCGGCCGACTGACCGGCAGCACCTCGCTG
GACGACCTCGCGCCGGTCGACATCGTGGTCGAGGCGATCGCCGAGGACCTGGCGATCAAGTCCACGCTCTTCGCGAACCT
CGACGAGATCTGTCGACCGGGCGCGATCCTGGCGACCACCACCTCCTCGCTGCCGGTCATCGAGTGCGCCCAGGCCACCG
CGCGCCCGCACGACGTCATCGGGATACACTTCTTCAACCCGGCGCCGGTGATGAAGCTGGTCGAGGTCGTCTCGACGGTC
GTCACGTCCGACGAGGTCACCGAGACGACGCGGGCGCTGTGCGACCGGGTCGGCAAGGTCGCCGTCTCGTGCGGCGACCG
GGCCGGCTTCATCGTCAACGCGCTGCTGTTCCCCTACCTCAACGACGCGGTGAAGATGCTCGAGGCGCACTACGCCACCG
CCGACGACATCGACCTCGCGATGAAGCAGGGCTGCGCGCTGCCGATGGGCCCGTTCGAGCTGCTCGACGTGGTCGGCAAC
GACGTGTCCCTCGCGATCCAGCGCGAGCTCTACCTCGAGTTCCGCGAGCCCGGCTTCGCCCCCGCGCCGTTGCTGGAGCA
CCTGGTCACCGCCGGCTACCTCGGCCGCAAGACCAAGCGCGGGTTCCGCGACTACTCTGCTCGCTAG

Upstream 100 bases:

>100_bases
AGGAGCCTCGAGTTGAGCAGAAGGCACGGATTCGTGGCGCCGGTAAGTTACTGGCGGGTGAACTAAGTCACGGTGACCGG
CGCGAACCCCGCGTGGCACG

Downstream 100 bases:

>100_bases
CCGCGTCTGGCGTGTCGGCTTCGCCGCCACGCCGGCCGCGGGGTCGTTCCTGGGCTGATGGTCCGACGTCGTGGTTGCGG
TCCGCGCGTGGGCGGTGGGT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPRMTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGRQYLEHSTSRAVKREKMTEAD
QAELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRDLDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFN
PAPVQALVEIVRTVVTEQSVLDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCG
YPMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYEAADSPVVVADELTPSVDQKP
QLRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSADKVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSL
DDLAPVDIVVEAIAEDLAIKSTLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTV
VTSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLAMKQGCALPMGPFELLDVVGN
DVSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKRGFRDYSAR

Sequences:

>Translated_608_residues
MPRMTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGRQYLEHSTSRAVKREKMTEAD
QAELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRDLDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFN
PAPVQALVEIVRTVVTEQSVLDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCG
YPMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYEAADSPVVVADELTPSVDQKP
QLRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSADKVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSL
DDLAPVDIVVEAIAEDLAIKSTLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTV
VTSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLAMKQGCALPMGPFELLDVVGN
DVSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKRGFRDYSAR
>Mature_607_residues
PRMTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGRQYLEHSTSRAVKREKMTEADQ
AELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRDLDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFNP
APVQALVEIVRTVVTEQSVLDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCGY
PMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYEAADSPVVVADELTPSVDQKPQ
LRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSADKVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSLD
DLAPVDIVVEAIAEDLAIKSTLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTVV
TSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLAMKQGCALPMGPFELLDVVGND
VSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKRGFRDYSAR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.560553633218, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.1960784313725, Blast_Score=220, Evalue=4e-57,
Organism=Homo sapiens, GI261878539, Length=289, Percent_Identity=33.9100346020761, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI68989263, Length=289, Percent_Identity=33.9100346020761, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=28.7719298245614, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787661, Length=305, Percent_Identity=40.9836065573771, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI1788682, Length=230, Percent_Identity=35.6521739130435, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=31.9391634980989, Blast_Score=135, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=36.6782006920415, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=293, Percent_Identity=42.6621160409556, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17553560, Length=294, Percent_Identity=35.0340136054422, Blast_Score=192, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=32.7402135231317, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=32.0284697508897, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17558304, Length=295, Percent_Identity=29.4915254237288, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17508951, Length=299, Percent_Identity=29.7658862876254, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144276, Length=330, Percent_Identity=29.0909090909091, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508953, Length=299, Percent_Identity=29.7658862876254, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=29.4736842105263, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=29.4736842105263, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=29.4736842105263, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45549573, Length=262, Percent_Identity=30.9160305343511, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129993, Length=241, Percent_Identity=29.045643153527, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 65181; Mature: 65050

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRMTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGR
CCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
QYLEHSTSRAVKREKMTEADQAELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFNPAPVQALVEIVRTVVTEQSV
HHHHCCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
LDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCG
HHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
YPMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYE
CCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEC
AADSPVVVADELTPSVDQKPQLRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSAD
CCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCH
KVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSLDDLAPVDIVVEAIAEDLAIK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
STLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTV
HHHHHCHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHH
VTSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLA
HCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MKQGCALPMGPFELLDVVGNDVSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKR
HHCCCCCCCCHHHHHHHHCCCHHEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFRDYSAR
CCCCCCCC
>Mature Secondary Structure 
PRMTSTSPETAAPGAGREFRTIGVIGLGTMGAGIAEVFARAGHAVVGVEKDDESLARGR
CCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
QYLEHSTSRAVKREKMTEADQAELLGRITFTTSLKDLAEADFVVEAVVESLETKKAIFRD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDEIVSPETILATNTSSLSVTEISTANGSPGRVVGVHFFNPAPVQALVEIVRTVVTEQSV
HHHHCCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
LDETTALVTSLGKAPVVCGDKAGFIANTLLFGYLNHAVAMYEGHYASREDIDAAMRYGCG
HHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
YPMGPLALLDLIGLDTAYEILETMYHQGRDRLHAPRPILKQMVTAGMLGRKTGRGFYSYE
CCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEC
AADSPVVVADELTPSVDQKPQLRHDIKLVGVVGTGTMATGIVEVFAKSGYDVLYVGRSAD
CCCCCEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCH
KVAGVRAAIEKSLDKAIQRGKLEESAKAEVLGRLTGSTSLDDLAPVDIVVEAIAEDLAIK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
STLFANLDEICRPGAILATTTSSLPVIECAQATARPHDVIGIHFFNPAPVMKLVEVVSTV
HHHHHCHHHHHCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHH
VTSDEVTETTRALCDRVGKVAVSCGDRAGFIVNALLFPYLNDAVKMLEAHYATADDIDLA
HCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MKQGCALPMGPFELLDVVGNDVSLAIQRELYLEFREPGFAPAPLLEHLVTAGYLGRKTKR
HHCCCCCCCCHHHHHHHHCCCHHEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFRDYSAR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]