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The map label for this gene is meaA [H]

Identifier: 119716007

GI number: 119716007

Start: 1881141

End: 1883183

Strand: Direct

Name: meaA [H]

Synonym: Noca_1772

Alternate gene names: 119716007

Gene position: 1881141-1883183 (Clockwise)

Preceding gene: 119716006

Following gene: 119716008

Centisome position: 37.73

GC content: 70.73

Gene sequence:

>2043_bases
ATGACTGAGAAGGACGGCGCTCCGACGGATCGTGGCCCCGAGGGTCGTGCCCCGAAGGACCGACCCTGGGTGATGCGCAC
CTACGCCGGGCACTCGACGGCGGCGGCGTCCAACGCGCTCTACCGGACCAACCTCGCGAAGGGGCAGACCGGGCTCTCGG
TCGCCTTCGACCTGCCGACCCAGACCGGCTACGACCCGGACTCGCCGCTCGCGCGCGGCGAGGTGGGGAAGGTCGGCGTC
CCGGTGCCGCACCTGGGCGAGATGCGCCGGCTGTTCGAGGACATCCCGCTGACCTCGATGAACACCTCGATGACGATCAA
TGCCACCGCGATGTGGCTGCTGGCGATGTACCAGGTGGTCGCCGAGGAGCAGAACCCGGAGCTGAGCCCCGAGGAGGTCG
CCGCCCAGCTCGCCGGCACCACCCAGAACGACATCATCAAGGAGTACCTCTCCCGCGGGACCTACGCGTTCCCTCCCGAG
CACTCGATGCGGCTGATCGCCGATGTCATCTCGTACACGGTCCACCAGATCCCGCAGTGGAACCCGATCAACATCTGCAG
CTACCACCTGCAGGAGGCCGGGGCGACGCCCACGCAGGAGCTCGCGTACGCGCTGTGCACCGCGATCGCCGTCCTCGACG
CGGTCAAGAGCTCGGGCCAGGTCGACGAGGCGGACTTCGGACGCGTCGTCGGCCGGATCTCCTTCTTCGTCAACGCCGGC
GTCCGCTTCGTCGAGGAGACCTGCAAGATGCGGGCCTTCGGCCGGCTCTGGGACGAGATCACCCGGGAACGGTACGGCGT
CGAGGACCCCAAGATGCGTCGGTTCCGGTACGGCGTGCAGGTCAACTCGCTGGGCCTCACCGAGGCCCAGCCTGAGAACA
ACGTGCAGCGGATCGTGCTCGAGATGCTCGGCGTCACGCTCTCCAAGAACGCTCGCGCGCGGGCGCTCCAGCTGCCGGCG
TGGAACGAGGCCCTGGGCCTGCCGCGGCCCTGGGACCAGCAGTGGTCGCTGCGTCTCCAGCAGGTGCTGGCCTATGAGTC
CGACCTGCTCGAGTACGACGACATCTTCGACGGCTCGCACGTGATCGAGGCGAAGGTCGCGGAGCTGGTCGCGGGCGCCC
GCGCCGAGATCGACCGGGTCCAGGCGATGGGCGGCGCGATCGCGGCAGTCGAGTACATGAAGCAGGAGCTGGTCTCCTCG
CACGCCGCGCGGCGCGCGCGGATCGAGTCCGGCGAGGAGATCGTCGTCGGCGTCAACAAGTTCGAGACCACCGAGCCGTC
GCCGCTGACCTCCGACCTCGACAGCGCGATCATGACGGCGGACCCCGACGCGGAGCAGGCCGCGATCGCCAGCGTCGAGG
CGTGGAAGGCGCAGCGCGACGAGGACGAGGTCGCCGCAGCGCTCGCCCAGCTGGCCGAGGCTGCCAAGACCGACACGAAC
CTGATGGGGCCGACCCTGGTGGCCGCTCGCGCCGGAGCGACCACGGGGGAGTGGTCCGCCACGCTGCGCGAGGTCTTCGG
CGAGTACCGGGGCCCGACGGGCGTCAGCGGTGCGGTCGGCGTCGCGGAGGCGGGCGCGGAGCTCGCAGCCGTGCGGGACC
GGGTGCGTGAGACGGCGCAGGAGCTGGGTGGCCGGCTGCGCCTGCTGGTCGGCAAGCCCGGTCTCGACGGCCACTCCAAC
GGCGCCGAGCAGATCGCGGTGCGCGCCCGGGACGCGGGGTTCGAGGTCGTCTACCAGGGCATCCGGCTGACCCCCGAGCA
GATCGTCGCCGCGGCCGTCGCCGAGGACGTCCACTGCGTCGGGCTGTCGATCCTCTCCGGATCACACATGGAGCTGGTCC
CGGCCGTGCTCGACGGGCTGCGTGAGGCGGGGATGGGGGACGTACCCGTCGTGGTCGGCGGCATCATCCCCGAGTCGGAC
GGCCGCCGCCTGGGCGAGCTCGGCGTCGCGGCGGTCTTCACGCCCAAGGACTTCGGCCTGACCGAGATCATGGGCGGGAT
CGTCGACGTGATCCGCGCGGCCAACGGGCTGGACGAAGGTTAG

Upstream 100 bases:

>100_bases
GTGCAGGTCGAGCGGGTCGCCGTCTCGGCGTGAGCCGTGTCGGATAACCCACACCGGTGGGCGGTTACCAAGCGGTAGAC
CGTCTCCTACCCTCGGACCC

Downstream 100 bases:

>100_bases
GCTACCCTCACAGTTCTGGTAGGGTGCCTGCGTGCCCAAGGCCCGGAAGCTCCCGAAGACGGAGTGCTGCGCGTCGAAGA
CGAAGTGCGCTCGCTGCCCG

Product: methylmalonyl-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTEKDGAPTDRGPEGRAPKDRPWVMRTYAGHSTAAASNALYRTNLAKGQTGLSVAFDLPTQTGYDPDSPLARGEVGKVGV
PVPHLGEMRRLFEDIPLTSMNTSMTINATAMWLLAMYQVVAEEQNPELSPEEVAAQLAGTTQNDIIKEYLSRGTYAFPPE
HSMRLIADVISYTVHQIPQWNPINICSYHLQEAGATPTQELAYALCTAIAVLDAVKSSGQVDEADFGRVVGRISFFVNAG
VRFVEETCKMRAFGRLWDEITRERYGVEDPKMRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLGVTLSKNARARALQLPA
WNEALGLPRPWDQQWSLRLQQVLAYESDLLEYDDIFDGSHVIEAKVAELVAGARAEIDRVQAMGGAIAAVEYMKQELVSS
HAARRARIESGEEIVVGVNKFETTEPSPLTSDLDSAIMTADPDAEQAAIASVEAWKAQRDEDEVAAALAQLAEAAKTDTN
LMGPTLVAARAGATTGEWSATLREVFGEYRGPTGVSGAVGVAEAGAELAAVRDRVRETAQELGGRLRLLVGKPGLDGHSN
GAEQIAVRARDAGFEVVYQGIRLTPEQIVAAAVAEDVHCVGLSILSGSHMELVPAVLDGLREAGMGDVPVVVGGIIPESD
GRRLGELGVAAVFTPKDFGLTEIMGGIVDVIRAANGLDEG

Sequences:

>Translated_680_residues
MTEKDGAPTDRGPEGRAPKDRPWVMRTYAGHSTAAASNALYRTNLAKGQTGLSVAFDLPTQTGYDPDSPLARGEVGKVGV
PVPHLGEMRRLFEDIPLTSMNTSMTINATAMWLLAMYQVVAEEQNPELSPEEVAAQLAGTTQNDIIKEYLSRGTYAFPPE
HSMRLIADVISYTVHQIPQWNPINICSYHLQEAGATPTQELAYALCTAIAVLDAVKSSGQVDEADFGRVVGRISFFVNAG
VRFVEETCKMRAFGRLWDEITRERYGVEDPKMRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLGVTLSKNARARALQLPA
WNEALGLPRPWDQQWSLRLQQVLAYESDLLEYDDIFDGSHVIEAKVAELVAGARAEIDRVQAMGGAIAAVEYMKQELVSS
HAARRARIESGEEIVVGVNKFETTEPSPLTSDLDSAIMTADPDAEQAAIASVEAWKAQRDEDEVAAALAQLAEAAKTDTN
LMGPTLVAARAGATTGEWSATLREVFGEYRGPTGVSGAVGVAEAGAELAAVRDRVRETAQELGGRLRLLVGKPGLDGHSN
GAEQIAVRARDAGFEVVYQGIRLTPEQIVAAAVAEDVHCVGLSILSGSHMELVPAVLDGLREAGMGDVPVVVGGIIPESD
GRRLGELGVAAVFTPKDFGLTEIMGGIVDVIRAANGLDEG
>Mature_679_residues
TEKDGAPTDRGPEGRAPKDRPWVMRTYAGHSTAAASNALYRTNLAKGQTGLSVAFDLPTQTGYDPDSPLARGEVGKVGVP
VPHLGEMRRLFEDIPLTSMNTSMTINATAMWLLAMYQVVAEEQNPELSPEEVAAQLAGTTQNDIIKEYLSRGTYAFPPEH
SMRLIADVISYTVHQIPQWNPINICSYHLQEAGATPTQELAYALCTAIAVLDAVKSSGQVDEADFGRVVGRISFFVNAGV
RFVEETCKMRAFGRLWDEITRERYGVEDPKMRRFRYGVQVNSLGLTEAQPENNVQRIVLEMLGVTLSKNARARALQLPAW
NEALGLPRPWDQQWSLRLQQVLAYESDLLEYDDIFDGSHVIEAKVAELVAGARAEIDRVQAMGGAIAAVEYMKQELVSSH
AARRARIESGEEIVVGVNKFETTEPSPLTSDLDSAIMTADPDAEQAAIASVEAWKAQRDEDEVAAALAQLAEAAKTDTNL
MGPTLVAARAGATTGEWSATLREVFGEYRGPTGVSGAVGVAEAGAELAAVRDRVRETAQELGGRLRLLVGKPGLDGHSNG
AEQIAVRARDAGFEVVYQGIRLTPEQIVAAAVAEDVHCVGLSILSGSHMELVPAVLDGLREAGMGDVPVVVGGIIPESDG
RRLGELGVAAVFTPKDFGLTEIMGGIVDVIRAANGLDEG

Specific function: Required for the assimilation of methanol and ethanol [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=654, Percent_Identity=36.697247706422, Blast_Score=382, Evalue=1e-106,
Organism=Escherichia coli, GI1789284, Length=674, Percent_Identity=37.9821958456973, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI25144500, Length=653, Percent_Identity=35.5283307810107, Blast_Score=383, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 73170; Mature: 73039

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKDGAPTDRGPEGRAPKDRPWVMRTYAGHSTAAASNALYRTNLAKGQTGLSVAFDLPT
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCHHHHHCCCCCCCCEEEEECCC
QTGYDPDSPLARGEVGKVGVPVPHLGEMRRLFEDIPLTSMNTSMTINATAMWLLAMYQVV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHH
AEEQNPELSPEEVAAQLAGTTQNDIIKEYLSRGTYAFPPEHSMRLIADVISYTVHQIPQW
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NPINICSYHLQEAGATPTQELAYALCTAIAVLDAVKSSGQVDEADFGRVVGRISFFVNAG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VRFVEETCKMRAFGRLWDEITRERYGVEDPKMRRFRYGVQVNSLGLTEAQPENNVQRIVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCCCCCCHHHHHHHH
EMLGVTLSKNARARALQLPAWNEALGLPRPWDQQWSLRLQQVLAYESDLLEYDDIFDGSH
HHHHHHHCCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VIEAKVAELVAGARAEIDRVQAMGGAIAAVEYMKQELVSSHAARRARIESGEEIVVGVNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FETTEPSPLTSDLDSAIMTADPDAEQAAIASVEAWKAQRDEDEVAAALAQLAEAAKTDTN
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LMGPTLVAARAGATTGEWSATLREVFGEYRGPTGVSGAVGVAEAGAELAAVRDRVRETAQ
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELGGRLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPEQIVAAAVAEDVHCV
HHCCEEEEEEECCCCCCCCCCHHHEEEHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
GLSILSGSHMELVPAVLDGLREAGMGDVPVVVGGIIPESDGRRLGELGVAAVFTPKDFGL
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHCCEEEEECCCCCCH
TEIMGGIVDVIRAANGLDEG
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TEKDGAPTDRGPEGRAPKDRPWVMRTYAGHSTAAASNALYRTNLAKGQTGLSVAFDLPT
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCHHHHHCCCCCCCCEEEEECCC
QTGYDPDSPLARGEVGKVGVPVPHLGEMRRLFEDIPLTSMNTSMTINATAMWLLAMYQVV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHH
AEEQNPELSPEEVAAQLAGTTQNDIIKEYLSRGTYAFPPEHSMRLIADVISYTVHQIPQW
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NPINICSYHLQEAGATPTQELAYALCTAIAVLDAVKSSGQVDEADFGRVVGRISFFVNAG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VRFVEETCKMRAFGRLWDEITRERYGVEDPKMRRFRYGVQVNSLGLTEAQPENNVQRIVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCCCCCCCCHHHHHHHH
EMLGVTLSKNARARALQLPAWNEALGLPRPWDQQWSLRLQQVLAYESDLLEYDDIFDGSH
HHHHHHHCCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VIEAKVAELVAGARAEIDRVQAMGGAIAAVEYMKQELVSSHAARRARIESGEEIVVGVNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
FETTEPSPLTSDLDSAIMTADPDAEQAAIASVEAWKAQRDEDEVAAALAQLAEAAKTDTN
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LMGPTLVAARAGATTGEWSATLREVFGEYRGPTGVSGAVGVAEAGAELAAVRDRVRETAQ
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELGGRLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVVYQGIRLTPEQIVAAAVAEDVHCV
HHCCEEEEEEECCCCCCCCCCHHHEEEHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
GLSILSGSHMELVPAVLDGLREAGMGDVPVVVGGIIPESDGRRLGELGVAAVFTPKDFGL
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHCCEEEEECCCCCCH
TEIMGGIVDVIRAANGLDEG
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]