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The map label for this gene is mcrA [H]

Identifier: 119716002

GI number: 119716002

Start: 1876368

End: 1877822

Strand: Reverse

Name: mcrA [H]

Synonym: Noca_1767

Alternate gene names: 119716002

Gene position: 1877822-1876368 (Counterclockwise)

Preceding gene: 119716005

Following gene: 119716001

Centisome position: 37.66

GC content: 75.19

Gene sequence:

>1455_bases
ATGACCATCGAGCTCGACACGCAGCACGGCACCGGACCGACCACCGGGTCGGACACCGGCACCACCCCGGCCGCCGAGGC
CCTCCGCGGCCTCATCGGCGGCCGCGTCCACCTGCCCGGCGATCCCGGGTACGACGCCGCCCGGCTGCCGTGGAACGTTG
CCATCGACCAGCGCCCGGCCGCGGTCGCGATGCCCCGCACCGCCGCCGAGGTGGCGACCGTGGTCCGGGTCGCTGCCGAG
GCCGGCCTCCGGGTCGCCCCGCAGAGCACCGGCCACAACGCCGGCCCGCTCGCCGCGCAGGGCCTCGACGACGTCGTCCT
GGTCCGCACGTCGGAGTTGGGCACCGCGATCGCCGACCCGGTCCGGGGCATCGTCCGCGTCGAGGGCGGCGCGATCTGGG
AGCCCGCCGTCGACGCCGCGGCCGCCCACGGCAAGGCCGTGCTGCACGGCTCCTCCCCCGACGTCGGCATCGCCGGCTAC
TCCCTGGGCGGCGGCATCGGCTGGTACGCCCGCAAGCTCGGCCTGGCGACCAACAGCCTGACCGCCGTCGAGCTGGTCAT
CGGCGACGGGAGCCTGGTGCGCGCCGACGACACCACGAACCGCGAGCTGTTCTGGGCGATCCGCGGCGGCGGCGGCAGCT
TCGGCGTCGTCACCGCCCTGGAGTTCCGCATGTACGACATCGAGACGGCGTACGCCGGGATCCTGATGTGGGACCTCACC
CGGATCGAGCCGGTCCTGCGCGAGTGGGCGGCCTGGGCGCCCACGGCCCCCGACGAGATCACCACCTCGTTCCGCGCGAT
GCGGCTGCCGGAGATGCCCGACCTGCCGGACTTCCTGCGCGGCCGCGAGCTGGCCGTGATCGACGGCGCCGTGCTCGGCT
CCGACGAGCGCGGCGAGGAGCTGCTGGCCGGGCTCCGCGCGCTGCGGCCCGAGCTCGACACGTTCGCCCGGGTGCCGGCC
AAGTCGCTGGTCCGGCTGCACATGGACCCCGAGGGCGGCGCCCCGTTCGCCTCCGACAGCGCGATGCTCGCGTCCTTCCC
GGACGCCGCCGTCGACGCGTTCATCGCCGAGGCCGGCCCCGACGCCCGGACGTCCCTGCTGATGGCCGAGCTGCGACAGC
TCGGCGGGGCCCTCGGTCGCCCGCACGAGGGCGGCGGCGTGCTGAACCGGCTCGACGCGCAGTTCGTCACCTTCGGTGGC
GGCATCGCGGCGACCCCGGAGATCGGCGCCCAGGCCCACGCGGACGCGGTCCGGCTGACCGAGGCGCTCGCGCCGTTCGA
CAACGGCCGGCAGTACCTCAACTTCGCCGAGAACCCGGTCGACACCCGCTCGGCGTACGGGTCGGATGTGTGGACCCAGC
TCACCGGGATCCGCAGCGCGGTCGACCCGCACGGGATCTTCGCCGCGAACCACCCCGTGCCGCGCCTGTACGAGAACGGA
GCGCCCACTGCCTGA

Upstream 100 bases:

>100_bases
GCCCCTCGCGGGTCTCACCGGCTCCAAGTCGACTCGAAGCCGACTCCAAGTGGCGACCGGCATGGTCCTGCCACCGATCA
CCCACACAGGAGTCACCACC

Downstream 100 bases:

>100_bases
GCCACCCCGAGTCGGCGCGTCTTGCCCGCCCCCGCACGCCGAGTCGGCGCATCTTGCCCACCTCCGGCGGGCAACCCGGG
CAGGACGCGCCGACTCGGGC

Product: FAD linked oxidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTIELDTQHGTGPTTGSDTGTTPAAEALRGLIGGRVHLPGDPGYDAARLPWNVAIDQRPAAVAMPRTAAEVATVVRVAAE
AGLRVAPQSTGHNAGPLAAQGLDDVVLVRTSELGTAIADPVRGIVRVEGGAIWEPAVDAAAAHGKAVLHGSSPDVGIAGY
SLGGGIGWYARKLGLATNSLTAVELVIGDGSLVRADDTTNRELFWAIRGGGGSFGVVTALEFRMYDIETAYAGILMWDLT
RIEPVLREWAAWAPTAPDEITTSFRAMRLPEMPDLPDFLRGRELAVIDGAVLGSDERGEELLAGLRALRPELDTFARVPA
KSLVRLHMDPEGGAPFASDSAMLASFPDAAVDAFIAEAGPDARTSLLMAELRQLGGALGRPHEGGGVLNRLDAQFVTFGG
GIAATPEIGAQAHADAVRLTEALAPFDNGRQYLNFAENPVDTRSAYGSDVWTQLTGIRSAVDPHGIFAANHPVPRLYENG
APTA

Sequences:

>Translated_484_residues
MTIELDTQHGTGPTTGSDTGTTPAAEALRGLIGGRVHLPGDPGYDAARLPWNVAIDQRPAAVAMPRTAAEVATVVRVAAE
AGLRVAPQSTGHNAGPLAAQGLDDVVLVRTSELGTAIADPVRGIVRVEGGAIWEPAVDAAAAHGKAVLHGSSPDVGIAGY
SLGGGIGWYARKLGLATNSLTAVELVIGDGSLVRADDTTNRELFWAIRGGGGSFGVVTALEFRMYDIETAYAGILMWDLT
RIEPVLREWAAWAPTAPDEITTSFRAMRLPEMPDLPDFLRGRELAVIDGAVLGSDERGEELLAGLRALRPELDTFARVPA
KSLVRLHMDPEGGAPFASDSAMLASFPDAAVDAFIAEAGPDARTSLLMAELRQLGGALGRPHEGGGVLNRLDAQFVTFGG
GIAATPEIGAQAHADAVRLTEALAPFDNGRQYLNFAENPVDTRSAYGSDVWTQLTGIRSAVDPHGIFAANHPVPRLYENG
APTA
>Mature_483_residues
TIELDTQHGTGPTTGSDTGTTPAAEALRGLIGGRVHLPGDPGYDAARLPWNVAIDQRPAAVAMPRTAAEVATVVRVAAEA
GLRVAPQSTGHNAGPLAAQGLDDVVLVRTSELGTAIADPVRGIVRVEGGAIWEPAVDAAAAHGKAVLHGSSPDVGIAGYS
LGGGIGWYARKLGLATNSLTAVELVIGDGSLVRADDTTNRELFWAIRGGGGSFGVVTALEFRMYDIETAYAGILMWDLTR
IEPVLREWAAWAPTAPDEITTSFRAMRLPEMPDLPDFLRGRELAVIDGAVLGSDERGEELLAGLRALRPELDTFARVPAK
SLVRLHMDPEGGAPFASDSAMLASFPDAAVDAFIAEAGPDARTSLLMAELRQLGGALGRPHEGGGVLNRLDAQFVTFGGG
IAATPEIGAQAHADAVRLTEALAPFDNGRQYLNFAENPVDTRSAYGSDVWTQLTGIRSAVDPHGIFAANHPVPRLYENGA
PTA

Specific function: Involved in mitomycin resistance; oxidizes reduced form of mitomycins [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012951
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016168
- InterPro:   IPR006094
- InterPro:   IPR006093 [H]

Pfam domain/function: PF08031 BBE; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 50572; Mature: 50441

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00862 OX2_COVAL_FAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIELDTQHGTGPTTGSDTGTTPAAEALRGLIGGRVHLPGDPGYDAARLPWNVAIDQRPA
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCCCC
AVAMPRTAAEVATVVRVAAEAGLRVAPQSTGHNAGPLAAQGLDDVVLVRTSELGTAIADP
EEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHCCCCCEEEEEEHHHCHHHHHH
VRGIVRVEGGAIWEPAVDAAAAHGKAVLHGSSPDVGIAGYSLGGGIGWYARKLGLATNSL
HCEEEEECCCEEECHHHHHHHHCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCC
TAVELVIGDGSLVRADDTTNRELFWAIRGGGGSFGVVTALEFRMYDIETAYAGILMWDLT
EEEEEEECCCCEEECCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHH
RIEPVLREWAAWAPTAPDEITTSFRAMRLPEMPDLPDFLRGRELAVIDGAVLGSDERGEE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECEEECCCCCHHH
LLAGLRALRPELDTFARVPAKSLVRLHMDPEGGAPFASDSAMLASFPDAAVDAFIAEAGP
HHHHHHHHCHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
DARTSLLMAELRQLGGALGRPHEGGGVLNRLDAQFVTFGGGIAATPEIGAQAHADAVRLT
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCEECCCCCCCHHHHHHHHHH
EALAPFDNGRQYLNFAENPVDTRSAYGSDVWTQLTGIRSAVDPHGIFAANHPVPRLYENG
HHHCCCCCCHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCC
APTA
CCCC
>Mature Secondary Structure 
TIELDTQHGTGPTTGSDTGTTPAAEALRGLIGGRVHLPGDPGYDAARLPWNVAIDQRPA
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCCCEEEEECCCCC
AVAMPRTAAEVATVVRVAAEAGLRVAPQSTGHNAGPLAAQGLDDVVLVRTSELGTAIADP
EEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHCCCCCEEEEEEHHHCHHHHHH
VRGIVRVEGGAIWEPAVDAAAAHGKAVLHGSSPDVGIAGYSLGGGIGWYARKLGLATNSL
HCEEEEECCCEEECHHHHHHHHCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCC
TAVELVIGDGSLVRADDTTNRELFWAIRGGGGSFGVVTALEFRMYDIETAYAGILMWDLT
EEEEEEECCCCEEECCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHH
RIEPVLREWAAWAPTAPDEITTSFRAMRLPEMPDLPDFLRGRELAVIDGAVLGSDERGEE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEECEEECCCCCHHH
LLAGLRALRPELDTFARVPAKSLVRLHMDPEGGAPFASDSAMLASFPDAAVDAFIAEAGP
HHHHHHHHCHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
DARTSLLMAELRQLGGALGRPHEGGGVLNRLDAQFVTFGGGIAATPEIGAQAHADAVRLT
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCEECCCCCCCHHHHHHHHHH
EALAPFDNGRQYLNFAENPVDTRSAYGSDVWTQLTGIRSAVDPHGIFAANHPVPRLYENG
HHHCCCCCCHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHCCC
APTA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7517396 [H]