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The map label for this gene is ygeZ [C]

Identifier: 119715870

GI number: 119715870

Start: 1737070

End: 1738473

Strand: Direct

Name: ygeZ [C]

Synonym: Noca_1635

Alternate gene names: 119715870

Gene position: 1737070-1738473 (Clockwise)

Preceding gene: 119715869

Following gene: 119715871

Centisome position: 34.84

GC content: 76.28

Gene sequence:

>1404_bases
ATGTCGAACGACCTCGTGGTGCGGGGCGGCACCGTCGTCGACGGTGCCGGCACCCGCCGGGCCGACGTGCTCGTGCGGGC
CGGCCGGATCGTGGCGGTGGAGCCCGAGATCGCGCTCGACTCCGCCGCCGCTGCCGACATCGTGGACGCCGGCGGCGCCT
ACGTGGTCCCCGGCGGCATCGACGTCCACACCCACTTCGCCCTGCCGGTGGGGGCGGTCACGTCGGCGGACGACTTCGAG
TCGGGCACGCTGGCCGCGGCGTGCGGCGGGACCACCTGCGTCGTCGACTTCGCCGGGGCCGGTCGCGAGCCGTGGCAGGA
GGCCCTGGCCACCTGGCACGACCGCGCCCGGGACCGGGCGGTCGTCGACTACGGGTTCCACCTGACGGTCGCCGAGCTGC
CCGAGGACCCCGAGGCCGCCGTCGCCCGGTTCGGCGAGTTCGTCGAGCACGGCGTCACCAGTGTGAAGCTGTACCTCGCC
TACCCGGACCGCCTGATGGTCGACGACGACACGCTGGCGCGGGCGCTTGCCGCGGGTCGGCGTACCGGCGTCCGGGTCTG
CGTGCACGCCGAGGACGGCGCAACCGTCGAGTCCCTGGTCGTCGAAGCGCTCGCGGCGGGTCGAAAGGGCCCGGACGCGA
TCCCGGCCGTGCGACCCGACTCCGTCGAGGCCGAGGCGATCCGCCGCGCCGCGGTGCTGGCCGCTGCCGCGGACACGAGC
CTGTACGTCGTGCACCTCTCCAGCGCGGCCGGCCTGGAGGCCGTCCGCGCGGCCCGCGCCGTGGGGGCCGACGTCCACGC
CGAGACCTGCCCGCACTACCTCTACCTCGACCAGGCGCACCTCGAGGCCGGCGAGCCGGACTTCGTGTGCGCCCCACCCC
TGCGGGGGGCTGCCGACCGCGCGGCGCTGTGGGGTGCGATCGCCGCCGGTGAGGTCGAGGTCGTCGCCACCGACCACTGC
CCGTTCACGCGGGCCGACCGTCGGCGAGGGACCGGTGGGGACGGCTGGGCGGACTTCCGGCAGCTCCCCGGCGGGCTCAG
CGGGGTCGAGACCCGGCTCGCGCTGGCCTACCAGGGCGTCGTGTCGGGCCGGCTCACCCTCGGGCGCTGGGTCGAGGTGA
CGTCCGGAGCCCCGGCCCGGCTGTTCGGCCTGGCCGGCGTCAAGGGGTCGGTCCGGCCCGGGCTCGACGCGGACCTGGTC
GTGTTCGATCCGGGAGCGACCCGCGTCCTCGACGCCGCGACCCTGCACTCGCGCTGCGACCACAGCCCGTACGAGGGCCT
GGTCGTCACCGGCTGGCCGGCCCTGACCCTCAGCCGCGGCGAGGTGGTCGCGGCCGCCGGCGAGCCCGTGGAGCCGCGCC
CCGGACGCGGCCGGTTCGTCCGAAGATCGCCGATCGTCCACTGA

Upstream 100 bases:

>100_bases
CGCAACGCGATCCTCGACGCGACCGGGGCCACCGTCAACGAGCTGCCGCTCACCCCCGAACGGGTCTGGCGGGCGCTGCA
CGCCTGAAGACGCGACCGAG

Downstream 100 bases:

>100_bases
CGTCGGCCGCGGCGACCGGCCGCCCGGAACGTGCTCGCGGAGGCCGCCGGCCACGTAAAATGTTGTCGCGTTGCGTGCGT
GAGGAGAGCGGCATGGCAGC

Product: dihydropyrimidinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSNDLVVRGGTVVDGAGTRRADVLVRAGRIVAVEPEIALDSAAAADIVDAGGAYVVPGGIDVHTHFALPVGAVTSADDFE
SGTLAAACGGTTCVVDFAGAGREPWQEALATWHDRARDRAVVDYGFHLTVAELPEDPEAAVARFGEFVEHGVTSVKLYLA
YPDRLMVDDDTLARALAAGRRTGVRVCVHAEDGATVESLVVEALAAGRKGPDAIPAVRPDSVEAEAIRRAAVLAAAADTS
LYVVHLSSAAGLEAVRAARAVGADVHAETCPHYLYLDQAHLEAGEPDFVCAPPLRGAADRAALWGAIAAGEVEVVATDHC
PFTRADRRRGTGGDGWADFRQLPGGLSGVETRLALAYQGVVSGRLTLGRWVEVTSGAPARLFGLAGVKGSVRPGLDADLV
VFDPGATRVLDAATLHSRCDHSPYEGLVVTGWPALTLSRGEVVAAAGEPVEPRPGRGRFVRRSPIVH

Sequences:

>Translated_467_residues
MSNDLVVRGGTVVDGAGTRRADVLVRAGRIVAVEPEIALDSAAAADIVDAGGAYVVPGGIDVHTHFALPVGAVTSADDFE
SGTLAAACGGTTCVVDFAGAGREPWQEALATWHDRARDRAVVDYGFHLTVAELPEDPEAAVARFGEFVEHGVTSVKLYLA
YPDRLMVDDDTLARALAAGRRTGVRVCVHAEDGATVESLVVEALAAGRKGPDAIPAVRPDSVEAEAIRRAAVLAAAADTS
LYVVHLSSAAGLEAVRAARAVGADVHAETCPHYLYLDQAHLEAGEPDFVCAPPLRGAADRAALWGAIAAGEVEVVATDHC
PFTRADRRRGTGGDGWADFRQLPGGLSGVETRLALAYQGVVSGRLTLGRWVEVTSGAPARLFGLAGVKGSVRPGLDADLV
VFDPGATRVLDAATLHSRCDHSPYEGLVVTGWPALTLSRGEVVAAAGEPVEPRPGRGRFVRRSPIVH
>Mature_466_residues
SNDLVVRGGTVVDGAGTRRADVLVRAGRIVAVEPEIALDSAAAADIVDAGGAYVVPGGIDVHTHFALPVGAVTSADDFES
GTLAAACGGTTCVVDFAGAGREPWQEALATWHDRARDRAVVDYGFHLTVAELPEDPEAAVARFGEFVEHGVTSVKLYLAY
PDRLMVDDDTLARALAAGRRTGVRVCVHAEDGATVESLVVEALAAGRKGPDAIPAVRPDSVEAEAIRRAAVLAAAADTSL
YVVHLSSAAGLEAVRAARAVGADVHAETCPHYLYLDQAHLEAGEPDFVCAPPLRGAADRAALWGAIAAGEVEVVATDHCP
FTRADRRRGTGGDGWADFRQLPGGLSGVETRLALAYQGVVSGRLTLGRWVEVTSGAPARLFGLAGVKGSVRPGLDADLVV
FDPGATRVLDAATLHSRCDHSPYEGLVVTGWPALTLSRGEVVAAAGEPVEPRPGRGRFVRRSPIVH

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=470, Percent_Identity=34.8936170212766, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=33.9168490153173, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4503377, Length=477, Percent_Identity=31.0272536687631, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI190194363, Length=474, Percent_Identity=33.1223628691983, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4503379, Length=471, Percent_Identity=29.2993630573248, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4503051, Length=475, Percent_Identity=29.2631578947368, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI62422571, Length=476, Percent_Identity=29.2016806722689, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=27.0531400966184, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87082175, Length=467, Percent_Identity=40.2569593147752, Blast_Score=317, Evalue=9e-88,
Organism=Escherichia coli, GI1786722, Length=479, Percent_Identity=30.8977035490605, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71989490, Length=471, Percent_Identity=36.0934182590234, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17539558, Length=471, Percent_Identity=34.6072186836518, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI86575075, Length=467, Percent_Identity=30.406852248394, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI193204318, Length=451, Percent_Identity=25.9423503325942, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=418, Percent_Identity=28.7081339712919, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221377917, Length=489, Percent_Identity=33.7423312883436, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137462, Length=473, Percent_Identity=32.9809725158562, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24644287, Length=310, Percent_Identity=33.8709677419355, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24644289, Length=234, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24642586, Length=418, Percent_Identity=27.511961722488, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859883, Length=460, Percent_Identity=24.1304347826087, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 48561; Mature: 48430

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDLVVRGGTVVDGAGTRRADVLVRAGRIVAVEPEIALDSAAAADIVDAGGAYVVPGGI
CCCCEEEECCEEECCCCCCCCEEEEECCEEEEECCCCCCCCHHHHHHHCCCCCEEECCCE
DVHTHFALPVGAVTSADDFESGTLAAACGGTTCVVDFAGAGREPWQEALATWHDRARDRA
EEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCE
VVDYGFHLTVAELPEDPEAAVARFGEFVEHGVTSVKLYLAYPDRLMVDDDTLARALAAGR
EEEECEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHHHCC
RTGVRVCVHAEDGATVESLVVEALAAGRKGPDAIPAVRPDSVEAEAIRRAAVLAAAADTS
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCE
LYVVHLSSAAGLEAVRAARAVGADVHAETCPHYLYLDQAHLEAGEPDFVCAPPLRGAADR
EEEEEECCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEHHHCCCCCCCEEECCCCCCCCHH
AALWGAIAAGEVEVVATDHCPFTRADRRRGTGGDGWADFRQLPGGLSGVETRLALAYQGV
HHHHHEEECCEEEEEEECCCCCCCCHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
VSGRLTLGRWVEVTSGAPARLFGLAGVKGSVRPGLDADLVVFDPGATRVLDAATLHSRCD
HCCCEEECEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
HSPYEGLVVTGWPALTLSRGEVVAAAGEPVEPRPGRGRFVRRSPIVH
CCCCCCEEEECCCEEEECCCCEEEECCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
SNDLVVRGGTVVDGAGTRRADVLVRAGRIVAVEPEIALDSAAAADIVDAGGAYVVPGGI
CCCEEEECCEEECCCCCCCCEEEEECCEEEEECCCCCCCCHHHHHHHCCCCCEEECCCE
DVHTHFALPVGAVTSADDFESGTLAAACGGTTCVVDFAGAGREPWQEALATWHDRARDRA
EEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCE
VVDYGFHLTVAELPEDPEAAVARFGEFVEHGVTSVKLYLAYPDRLMVDDDTLARALAAGR
EEEECEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCHHHHHHHHHCC
RTGVRVCVHAEDGATVESLVVEALAAGRKGPDAIPAVRPDSVEAEAIRRAAVLAAAADTS
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCE
LYVVHLSSAAGLEAVRAARAVGADVHAETCPHYLYLDQAHLEAGEPDFVCAPPLRGAADR
EEEEEECCCCCHHHHHHHHHHCCCCCHHCCCCEEEEEHHHCCCCCCCEEECCCCCCCCHH
AALWGAIAAGEVEVVATDHCPFTRADRRRGTGGDGWADFRQLPGGLSGVETRLALAYQGV
HHHHHEEECCEEEEEEECCCCCCCCHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
VSGRLTLGRWVEVTSGAPARLFGLAGVKGSVRPGLDADLVVFDPGATRVLDAATLHSRCD
HCCCEEECEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
HSPYEGLVVTGWPALTLSRGEVVAAAGEPVEPRPGRGRFVRRSPIVH
CCCCCCEEEECCCEEEECCCCEEEECCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]