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The map label for this gene is coxA2 [H]

Identifier: 119715858

GI number: 119715858

Start: 1720885

End: 1722570

Strand: Direct

Name: coxA2 [H]

Synonym: Noca_1623

Alternate gene names: 119715858

Gene position: 1720885-1722570 (Clockwise)

Preceding gene: 119715857

Following gene: 119715860

Centisome position: 34.52

GC content: 66.01

Gene sequence:

>1686_bases
ATGAGCACGTTCACCGAGACCCTGGTCCACGGCAAGTCCGGCGCCTTCAAGCCGAAGTCGCTGACCCCGATGCAGAGCCT
GACGCTGAAGTACGTCGTGTTCGGGCTGGTCTACTACGGGTTCGCGGCGATCGAGGGCATGCTCCTGCGGATCAACGCGG
TGAGCCCGCAGGACCTGCTCTACCCCGAGCGCTACTACGCGATGCTCACCGCACACCCGCTGGTCGGCATCTTCGGATCG
AGCTACCTGCTCGTCTTCGGCGCGTTCACCTTCCTGGTGCCGTTCTTGATGAAGAAGCCGCTGTGGTCCTACAAGCTCGC
CAACTGGACGCTGTGGCTGATCGTGGTCGGCGTCTTCACCTTCTGGTTCGACGGCTTCTTGACCCACTACGCGCCGCTCT
ACACGCTCTACTGGCCGCTCCCGGCGGACTTCGACCAGTTCGAGCCGGTGGCCGGCGCGATCTTCATCACCGGCGTCGCC
CTGGTGATGGTCGGCACCCTCTTCTTCGTGCTCAACGTGCTCAAGACCATCACCTACACACCGGAGGGCTGGACCCGGCA
GCCGGCCGGCCGGCTGCTCGGTGACGCCCTCGGCCTGACCACGCTGAAGAAGTTCTTCACCGGTCAGCTGCGCCGGGACC
GCGAGCAGGACCACCTGGTGTCGCTGCCGGTCGCGGCGATCGCCCGCGGCAGCGTCGACGTGCTCTTCAACGCGGGGATC
ATCCTGTTCTCCGGGGTCTTGATCCTGATCTACATGGTGGCCGAGATCTCGGGGACCTCGCTCGAGACGACGAACATCGA
CGCGCTGCTGTACAAGAACTGGTACTGGTGGGGGCTCGACCTCGTCGCCGACGGTCTGGTGCTGATCTTCGTCGCCGGCA
CCTGGTACCTCCTGGCCCAGCTGATCACCGGCCGCGAGGTCTTCATGGCGCGCTGGGCACGCTTCGCGCTGGGGCTGGAG
CTGGTCGTCTCCTGGACGGTGTGGAGCCACCATCTGCTCTCGGACCAGTCGCAGCCGGCGGCGCTGAAGATGGGCTCCGG
TGAGTTCGTCACCGCGTTCGAGCTGATCACGCAGGGGCTGGCGTTCTTCATCACCCTCGCCACGTTGTGGATGGCCCGGC
CGCTGAAGATGACGAACCCGCTGAAGTTCCTGCTCGGTGGGCTCCTCGGGTTCGCCCTCGCGGTGCCAGCGGGCATCATG
CAGGCCGACGCGGGCCTCAACCGGATCCTGCACAACACCCAGTGGGTCGTCGGACCGCACGTCCACGTGGCGGTGCTGGT
GGGGCTCACGATGACCCTCTACGCGGCCGTCTACTTCCTGCTGCCGATCCTCACCAACGGTGCGGAGCTGTACAGCCAGC
GGCTGGCGAACGTGCACTTCTGGTGCCACCTGATCGGCGGCATCGGGATGGGTGCGTTCATGGGCATGGCCGGCCTGCAG
GGCATGCTGCGGCGCACGATCTACTACGACGACGAGTTCTTGCCCTACATGGTGCTCGCCGCGATCAGCGGCGCGCTCCT
GCTGGTCGCCTTCGTGGTGTTCCTCTACAACATCGTGATGACGCTGGGTCTCCAGGGCGCCGTCGGACTGTTCAAGAAGT
CCTCGGCACCGGCATCGGTCCTGGTCCCCGGGATGGACGTGTCGATCCAGCCCGGGCCGGAGCCGGCAGCACCCGCGGGC
GCCTGA

Upstream 100 bases:

>100_bases
GCTCGACCGAGTACTCCGGCCCCGAGGGCGACGGGATGATCGTCCCGGACGCCGTCGAGGTCACCGGATGCGACCAGGCC
GAGGCGGAAGGCGGAGCACG

Downstream 100 bases:

>100_bases
CGCCACCGGGTCGGCTGCGGTCCACGCCGAGGGGGCGGCGTGGACCGCAGGTCACGTCATGCCGTGCGACCGAGCGGCGC
GAACCTCGCGGTGAAGTGCC

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSTFTETLVHGKSGAFKPKSLTPMQSLTLKYVVFGLVYYGFAAIEGMLLRINAVSPQDLLYPERYYAMLTAHPLVGIFGS
SYLLVFGAFTFLVPFLMKKPLWSYKLANWTLWLIVVGVFTFWFDGFLTHYAPLYTLYWPLPADFDQFEPVAGAIFITGVA
LVMVGTLFFVLNVLKTITYTPEGWTRQPAGRLLGDALGLTTLKKFFTGQLRRDREQDHLVSLPVAAIARGSVDVLFNAGI
ILFSGVLILIYMVAEISGTSLETTNIDALLYKNWYWWGLDLVADGLVLIFVAGTWYLLAQLITGREVFMARWARFALGLE
LVVSWTVWSHHLLSDQSQPAALKMGSGEFVTAFELITQGLAFFITLATLWMARPLKMTNPLKFLLGGLLGFALAVPAGIM
QADAGLNRILHNTQWVVGPHVHVAVLVGLTMTLYAAVYFLLPILTNGAELYSQRLANVHFWCHLIGGIGMGAFMGMAGLQ
GMLRRTIYYDDEFLPYMVLAAISGALLLVAFVVFLYNIVMTLGLQGAVGLFKKSSAPASVLVPGMDVSIQPGPEPAAPAG
A

Sequences:

>Translated_561_residues
MSTFTETLVHGKSGAFKPKSLTPMQSLTLKYVVFGLVYYGFAAIEGMLLRINAVSPQDLLYPERYYAMLTAHPLVGIFGS
SYLLVFGAFTFLVPFLMKKPLWSYKLANWTLWLIVVGVFTFWFDGFLTHYAPLYTLYWPLPADFDQFEPVAGAIFITGVA
LVMVGTLFFVLNVLKTITYTPEGWTRQPAGRLLGDALGLTTLKKFFTGQLRRDREQDHLVSLPVAAIARGSVDVLFNAGI
ILFSGVLILIYMVAEISGTSLETTNIDALLYKNWYWWGLDLVADGLVLIFVAGTWYLLAQLITGREVFMARWARFALGLE
LVVSWTVWSHHLLSDQSQPAALKMGSGEFVTAFELITQGLAFFITLATLWMARPLKMTNPLKFLLGGLLGFALAVPAGIM
QADAGLNRILHNTQWVVGPHVHVAVLVGLTMTLYAAVYFLLPILTNGAELYSQRLANVHFWCHLIGGIGMGAFMGMAGLQ
GMLRRTIYYDDEFLPYMVLAAISGALLLVAFVVFLYNIVMTLGLQGAVGLFKKSSAPASVLVPGMDVSIQPGPEPAAPAG
A
>Mature_560_residues
STFTETLVHGKSGAFKPKSLTPMQSLTLKYVVFGLVYYGFAAIEGMLLRINAVSPQDLLYPERYYAMLTAHPLVGIFGSS
YLLVFGAFTFLVPFLMKKPLWSYKLANWTLWLIVVGVFTFWFDGFLTHYAPLYTLYWPLPADFDQFEPVAGAIFITGVAL
VMVGTLFFVLNVLKTITYTPEGWTRQPAGRLLGDALGLTTLKKFFTGQLRRDREQDHLVSLPVAAIARGSVDVLFNAGII
LFSGVLILIYMVAEISGTSLETTNIDALLYKNWYWWGLDLVADGLVLIFVAGTWYLLAQLITGREVFMARWARFALGLEL
VVSWTVWSHHLLSDQSQPAALKMGSGEFVTAFELITQGLAFFITLATLWMARPLKMTNPLKFLLGGLLGFALAVPAGIMQ
ADAGLNRILHNTQWVVGPHVHVAVLVGLTMTLYAAVYFLLPILTNGAELYSQRLANVHFWCHLIGGIGMGAFMGMAGLQG
MLRRTIYYDDEFLPYMVLAAISGALLLVAFVVFLYNIVMTLGLQGAVGLFKKSSAPASVLVPGMDVSIQPGPEPAAPAGA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226519, Length=256, Percent_Identity=23.828125, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61711; Mature: 61580

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS50855 COX1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCEEECCCCCCCCCCCC
>Mature Secondary Structure 
STFTETLVHGKSGAFKPKSLTPMQSLTLKYVVFGLVYYGFAAIEGMLLRINAVSPQDLL
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHC
YPERYYAMLTAHPLVGIFGSSYLLVFGAFTFLVPFLMKKPLWSYKLANWTLWLIVVGVFT
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
FWFDGFLTHYAPLYTLYWPLPADFDQFEPVAGAIFITGVALVMVGTLFFVLNVLKTITYT
HHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEGWTRQPAGRLLGDALGLTTLKKFFTGQLRRDREQDHLVSLPVAAIARGSVDVLFNAGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCHHHHHHCCH
ILFSGVLILIYMVAEISGTSLETTNIDALLYKNWYWWGLDLVADGLVLIFVAGTWYLLAQ
HHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCEEEEHHHHHHCCHHHHHHHHHHHHHHH
LITGREVFMARWARFALGLELVVSWTVWSHHLLSDQSQPAALKMGSGEFVTAFELITQGL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHH
AFFITLATLWMARPLKMTNPLKFLLGGLLGFALAVPAGIMQADAGLNRILHNTQWVVGPH
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCH
VHVAVLVGLTMTLYAAVYFLLPILTNGAELYSQRLANVHFWCHLIGGIGMGAFMGMAGLQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMLRRTIYYDDEFLPYMVLAAISGALLLVAFVVFLYNIVMTLGLQGAVGLFKKSSAPASV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEE
LVPGMDVSIQPGPEPAAPAGA
EECCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1659810; 11016950 [H]