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The map label for this gene is uvrD [H]

Identifier: 119715752

GI number: 119715752

Start: 1610054

End: 1612120

Strand: Direct

Name: uvrD [H]

Synonym: Noca_1516

Alternate gene names: 119715752

Gene position: 1610054-1612120 (Clockwise)

Preceding gene: 119715750

Following gene: 119715753

Centisome position: 32.29

GC content: 74.89

Gene sequence:

>2067_bases
ATGGCCACGCCCGCCGACCTGCTGACCGCGCTCGATCCCGAGCAGCGCCAGGTCGCGGAGGCACTGCGCGGGCCGGTCCG
GGTGCTCGCCGGCGCGGGCACCGGCAAGACCCGCGCGATCACGCACCGGATCGCGTACGGCGTGGCCTCCGGGGTCTACG
CGCCCACCGAGGTGCTCGCGGTCACGTTCACCACGCGAGCGGCCGGCGAGATGCGCAGTCGGCTGCGCGCCCTGGGCGCC
GGCCCGGTCCAGGCCCGCACCTTCCACTCGGCCGCGCTGCGCCAGCTGCGCTACTTCTGGCCGACCTCCTATGGCACCGA
GCTGCCCACGCTCATCGAGTCCAAGATCGGCCTGCTGGCCACGGCCGCCCGGCGCCAGCGGCTCAACGCCGACCAGGCGC
TGCTGCGTGACCTGGCCTCGGAGGTCGAGTGGGCCAAGGTCAGCAACGTCCACCCGGACGAGTACCCCATCGTCGCCGCC
CAGCGGGGCCGCAGCGTCTCGGGCCACGACCCCGACACCGTCGCCCGGGTCTTCGGGAGCTACGAGGAGGTCAAGCGCGG
CCAGGGCCGGATGGACATGGAGGACGTCCTGCTGCTGACCGCCGGGCTGCTCGCCGAGGACGAGCGGGTCGCGGCCCAGG
TGCGCCGCCAGTACAAGTGGTTCGTCGTCGACGAGTTCCAGGACGTCTCGCCGATCCAGTCCGCGCTCCTCGACCTGTGG
CTCGGCGGCCGCGACGAGCTGTGCGTGGTCGGCGACCCGGCGCAGACCATCTACTCCTTCGCCGGGGCGAACGCCGCCTA
CCTGCGCGACTTCCCGACCCGCCACCCCGGCACGACCTCCATCGAGCTGGTCCGCAACTACCGCTCCACCCCCGAGGTCG
TCGGGGCCGCCAACGCGCTGCTCGGCGGGTCCGCGAGCGCCGGCGTCCAGCTCCGGGCACAGCGGCCCTCGGGGCCGCCG
GTCACCTACACGCCGCGGCCCGACGAGGTCGCCGAGGCCGAGTCGGTCGCCGCGCAGGTGCTCCGGCTGCGCGATGCCGG
CCGCTCGCTCGGTGAGGTGGCCGTGCTGTTCCGCATCAACGCCCAGTCCGAGGCGTTCGAGGAGGCCCTGGCCGCGCGCG
GCCTCCCGTACGTCGTGCGCGGCGCCGCTCGGTTCTTCGACCGGCCGGAGGTCCGCGAGGCGGTCACCCGGCTGCGTGGC
GCGGCCCGATCCGGCGAGGCCGCCCGAGCCGCCGAGAGCGGCGACGGCGACTGGGTCGACGTGGTGCGGGCGATCCTGGC
CGGCATGGGCTGGAGCCCGGAGGCACCCACGACCCGCGGCCAGACCCGCGACCGGTGGGAGTCCTGGCAGGCACTGGTGG
ACCAGGCCGCCCAGTTCGCCGCCGAGTCGGCACGCGACGGCGAGGCCGCCGACCTCGACGCGTTCGTCGACCACCTCGAC
CGGCGCGCCGCCGAGCAGCACGCCCCGGTCGCCGACGGGGTCACCCTCGCGACCTTCCACGCCGCCAAGGGCCTGGAGTG
GGACTCGGTGTTCCTCTGTGGCCTCCAGGACGGCACCCTGCCCATAACCTACGCCGACACCCCGGCCGCGGTCGAGGAGG
AGCGCCGGCTCCTCTACGTCGGCATCACCCGGGCCCGCGTCGACCTCACGCTGTCCTGGGCGCTCTCGCGCAACCCCGGC
GGCCGCGCCTCCCGCAAGCCCTCGCGCTTCCTCGAGCCGCTGCTGCCTGACGACGCGCGCGCCACGCGCGAGCGGCCGCG
CGGCCGCAAGGTCGCCAACTGTCGCGAGTGCGGGCGTCCGCTCGCCACCGGCCAGGAGCTCAAGCGCGGCCGCTGCGCGG
ACTGCCCGGCGTCGTACGACGAGGAGCTCTTCGAGCGACTGCGCGAGTGGCGCCGCGAGCGCGCCGGGGAGGAGAGCGTC
CCCGCGTTCGTGGTCTTCACCGACGCCACCCTCCAGCTGATCGCCGAGCACAAGCCGCGCACACCGGAAGCGCTGCTGCG
GATCAACGGGATCGGCCGGTCCAAGCTCGAGCGGTACGGCGACGAGGTGCTCACGGTCGTCGGCTGA

Upstream 100 bases:

>100_bases
GTGTACATCGTGAAGGAGCTCATCTGGGACTGTCGCCTCCGGCGTCTAGGGTTTGACTGCACCCGGTCCAACGCCCCGTC
CCTAGGAGATGTTCCCCCGA

Downstream 100 bases:

>100_bases
GGTGCCCCGCCGAGACGCCTGCCGAGACGTCGGTCGAGGCGTCGAAGGCCCCCTCGGCGGCAACTCCTCCAGAAATTTCG
CGAAATACCCACTAAATGGT

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MATPADLLTALDPEQRQVAEALRGPVRVLAGAGTGKTRAITHRIAYGVASGVYAPTEVLAVTFTTRAAGEMRSRLRALGA
GPVQARTFHSAALRQLRYFWPTSYGTELPTLIESKIGLLATAARRQRLNADQALLRDLASEVEWAKVSNVHPDEYPIVAA
QRGRSVSGHDPDTVARVFGSYEEVKRGQGRMDMEDVLLLTAGLLAEDERVAAQVRRQYKWFVVDEFQDVSPIQSALLDLW
LGGRDELCVVGDPAQTIYSFAGANAAYLRDFPTRHPGTTSIELVRNYRSTPEVVGAANALLGGSASAGVQLRAQRPSGPP
VTYTPRPDEVAEAESVAAQVLRLRDAGRSLGEVAVLFRINAQSEAFEEALAARGLPYVVRGAARFFDRPEVREAVTRLRG
AARSGEAARAAESGDGDWVDVVRAILAGMGWSPEAPTTRGQTRDRWESWQALVDQAAQFAAESARDGEAADLDAFVDHLD
RRAAEQHAPVADGVTLATFHAAKGLEWDSVFLCGLQDGTLPITYADTPAAVEEERRLLYVGITRARVDLTLSWALSRNPG
GRASRKPSRFLEPLLPDDARATRERPRGRKVANCRECGRPLATGQELKRGRCADCPASYDEELFERLREWRRERAGEESV
PAFVVFTDATLQLIAEHKPRTPEALLRINGIGRSKLERYGDEVLTVVG

Sequences:

>Translated_688_residues
MATPADLLTALDPEQRQVAEALRGPVRVLAGAGTGKTRAITHRIAYGVASGVYAPTEVLAVTFTTRAAGEMRSRLRALGA
GPVQARTFHSAALRQLRYFWPTSYGTELPTLIESKIGLLATAARRQRLNADQALLRDLASEVEWAKVSNVHPDEYPIVAA
QRGRSVSGHDPDTVARVFGSYEEVKRGQGRMDMEDVLLLTAGLLAEDERVAAQVRRQYKWFVVDEFQDVSPIQSALLDLW
LGGRDELCVVGDPAQTIYSFAGANAAYLRDFPTRHPGTTSIELVRNYRSTPEVVGAANALLGGSASAGVQLRAQRPSGPP
VTYTPRPDEVAEAESVAAQVLRLRDAGRSLGEVAVLFRINAQSEAFEEALAARGLPYVVRGAARFFDRPEVREAVTRLRG
AARSGEAARAAESGDGDWVDVVRAILAGMGWSPEAPTTRGQTRDRWESWQALVDQAAQFAAESARDGEAADLDAFVDHLD
RRAAEQHAPVADGVTLATFHAAKGLEWDSVFLCGLQDGTLPITYADTPAAVEEERRLLYVGITRARVDLTLSWALSRNPG
GRASRKPSRFLEPLLPDDARATRERPRGRKVANCRECGRPLATGQELKRGRCADCPASYDEELFERLREWRRERAGEESV
PAFVVFTDATLQLIAEHKPRTPEALLRINGIGRSKLERYGDEVLTVVG
>Mature_687_residues
ATPADLLTALDPEQRQVAEALRGPVRVLAGAGTGKTRAITHRIAYGVASGVYAPTEVLAVTFTTRAAGEMRSRLRALGAG
PVQARTFHSAALRQLRYFWPTSYGTELPTLIESKIGLLATAARRQRLNADQALLRDLASEVEWAKVSNVHPDEYPIVAAQ
RGRSVSGHDPDTVARVFGSYEEVKRGQGRMDMEDVLLLTAGLLAEDERVAAQVRRQYKWFVVDEFQDVSPIQSALLDLWL
GGRDELCVVGDPAQTIYSFAGANAAYLRDFPTRHPGTTSIELVRNYRSTPEVVGAANALLGGSASAGVQLRAQRPSGPPV
TYTPRPDEVAEAESVAAQVLRLRDAGRSLGEVAVLFRINAQSEAFEEALAARGLPYVVRGAARFFDRPEVREAVTRLRGA
ARSGEAARAAESGDGDWVDVVRAILAGMGWSPEAPTTRGQTRDRWESWQALVDQAAQFAAESARDGEAADLDAFVDHLDR
RAAEQHAPVADGVTLATFHAAKGLEWDSVFLCGLQDGTLPITYADTPAAVEEERRLLYVGITRARVDLTLSWALSRNPGG
RASRKPSRFLEPLLPDDARATRERPRGRKVANCRECGRPLATGQELKRGRCADCPASYDEELFERLREWRRERAGEESVP
AFVVFTDATLQLIAEHKPRTPEALLRINGIGRSKLERYGDEVLTVVG

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=487, Percent_Identity=31.4168377823409, Blast_Score=197, Evalue=3e-51,
Organism=Escherichia coli, GI48994965, Length=396, Percent_Identity=30.3030303030303, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI48994977, Length=70, Percent_Identity=44.2857142857143, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322369, Length=437, Percent_Identity=28.1464530892449, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324477, Length=464, Percent_Identity=20.9051724137931, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 75145; Mature: 75014

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50967 HRDC ; PS00605 ATPASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPADLLTALDPEQRQVAEALRGPVRVLAGAGTGKTRAITHRIAYGVASGVYAPTEVLA
CCCHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VTFTTRAAGEMRSRLRALGAGPVQARTFHSAALRQLRYFWPTSYGTELPTLIESKIGLLA
EEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TAARRQRLNADQALLRDLASEVEWAKVSNVHPDEYPIVAAQRGRSVSGHDPDTVARVFGS
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCC
YEEVKRGQGRMDMEDVLLLTAGLLAEDERVAAQVRRQYKWFVVDEFQDVSPIQSALLDLW
HHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHH
LGGRDELCVVGDPAQTIYSFAGANAAYLRDFPTRHPGTTSIELVRNYRSTPEVVGAANAL
CCCCCCEEEECCCHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
LGGSASAGVQLRAQRPSGPPVTYTPRPDEVAEAESVAAQVLRLRDAGRSLGEVAVLFRIN
HCCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
AQSEAFEEALAARGLPYVVRGAARFFDRPEVREAVTRLRGAARSGEAARAAESGDGDWVD
CHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHH
VVRAILAGMGWSPEAPTTRGQTRDRWESWQALVDQAAQFAAESARDGEAADLDAFVDHLD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RRAAEQHAPVADGVTLATFHAAKGLEWDSVFLCGLQDGTLPITYADTPAAVEEERRLLYV
HHHHHHCCCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHCCEEEEE
GITRARVDLTLSWALSRNPGGRASRKPSRFLEPLLPDDARATRERPRGRKVANCRECGRP
EEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCC
LATGQELKRGRCADCPASYDEELFERLREWRRERAGEESVPAFVVFTDATLQLIAEHKPR
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCC
TPEALLRINGIGRSKLERYGDEVLTVVG
CHHHHHEECCCCHHHHHHHCCCEEEECC
>Mature Secondary Structure 
ATPADLLTALDPEQRQVAEALRGPVRVLAGAGTGKTRAITHRIAYGVASGVYAPTEVLA
CCHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VTFTTRAAGEMRSRLRALGAGPVQARTFHSAALRQLRYFWPTSYGTELPTLIESKIGLLA
EEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
TAARRQRLNADQALLRDLASEVEWAKVSNVHPDEYPIVAAQRGRSVSGHDPDTVARVFGS
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCC
YEEVKRGQGRMDMEDVLLLTAGLLAEDERVAAQVRRQYKWFVVDEFQDVSPIQSALLDLW
HHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHH
LGGRDELCVVGDPAQTIYSFAGANAAYLRDFPTRHPGTTSIELVRNYRSTPEVVGAANAL
CCCCCCEEEECCCHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
LGGSASAGVQLRAQRPSGPPVTYTPRPDEVAEAESVAAQVLRLRDAGRSLGEVAVLFRIN
HCCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
AQSEAFEEALAARGLPYVVRGAARFFDRPEVREAVTRLRGAARSGEAARAAESGDGDWVD
CHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHH
VVRAILAGMGWSPEAPTTRGQTRDRWESWQALVDQAAQFAAESARDGEAADLDAFVDHLD
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
RRAAEQHAPVADGVTLATFHAAKGLEWDSVFLCGLQDGTLPITYADTPAAVEEERRLLYV
HHHHHHCCCCCCCCEEEEEHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHCCEEEEE
GITRARVDLTLSWALSRNPGGRASRKPSRFLEPLLPDDARATRERPRGRKVANCRECGRP
EEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCC
LATGQELKRGRCADCPASYDEELFERLREWRRERAGEESVPAFVVFTDATLQLIAEHKPR
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHCCCC
TPEALLRINGIGRSKLERYGDEVLTVVG
CHHHHHEECCCCHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]