Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 119715607

GI number: 119715607

Start: 1448622

End: 1449836

Strand: Reverse

Name: fadA [H]

Synonym: Noca_1371

Alternate gene names: 119715607

Gene position: 1449836-1448622 (Counterclockwise)

Preceding gene: 119715608

Following gene: 119715606

Centisome position: 29.08

GC content: 69.71

Gene sequence:

>1215_bases
ATGCCCGAGGCAGTCATCGTTTCCGTCGCCCGCTCCCCCATCGGCCGGGCCAACAAGGGCTCGCTGAAGGACCTGCGGCC
CGACGACCTGAGCGCGTTCATCATCAAGACCGCGCTGGACAAGGTCGAGGGCCTCGACCCCCACACCGTCGACGACGTGT
ACCTCGGCTGCGGCCTGCCCGGAGGCGAGTCGGGCAACAACATGGCGCGGATCGTCAACGTGCTCAACGGCATGGACGAC
GTCCCGGGCGCCACCATCACCCGCTACTGTGCCTCCTCGGTGCAGACCACCCGGATGGCGTTCCACGCGATCAAGGCCGG
CGAGGGCGACATCTTCGTCTCCGCCGGCGTCGAGACCGTCTCCCGCTTCGCGAAGGGCACCTCCGACCACTGGCCGGACA
CCAAGAACCCGCTGTACGACGAGGCGATGGCGCGCACCGAGAAGACCGCGGAGGGCGGCGTCGACTGGCACGATCCCCGC
GAGGACGGGCTGCTCCCCGACGCCTACATCGCGATGGGGCAGACCGCTGAGAACGTGGCCCGGCTGCGCGGGCTGGACCG
CAAGGAGCTCGACGAGTTCGGTGTGCGCTCCCAGAACCTCGCCGAGAAGGCCATCAACGACGGCTTCTGGGCCCGCGAGA
TCACCCCCGTCACCACCCCCGACGGCACCGTCGTCAGCCAGGACGACGGCCCGCGTGCCGGCGTCACCTACGAGGCGATC
TCGCAGCTCAAGCCCGTCTTCCGCCCCGACGGCGTGGTCACCGCCGGCAACTGCTGCCCGCTCAACGACGGTGCTGCGGC
CGTGGTGATCATGTCCGACACCAAGGCCGCCGAGCTCGGCGTCACGCCGCTGGCGCGGATCGTCGCGACCGGCGTGAGCG
GCCTCTCCCCCGAGATCATGGGCCTCGGCCCGGTCGAGGCCACCAGGCGGGCCCTGGCCCACGCCAAGATGAGCATCGGC
GACATCGACCTGGTCGAGATCAACGAGGCGTTCGCGGCTCAGGTCGTGCCGTCCTACCAGGACCTCGGCATCGACCTCGA
CCGGCTCAACGTCAACGGTGGGGCGATCGCGGTCGGCCACCCGTTCGGCATGACCGGCGCCCGCCTCCAGAACACGATGC
TGAACTCGCTGGACTGGCACGACAAGACGACCGGCCTGATCACCATGTGCGTGGGCGGCGGCCAGGGCATGGCCCTGATC
CTCGAGCGGCTCTGA

Upstream 100 bases:

>100_bases
ACGAGCGTCTCGTCCACGCCAGGAGAACACGGTCTAATCTGGCCGGACACCTCGACCCACCCCTCCGATCGCCCGCGATC
GCAACCGAGATGGAGCTTGC

Downstream 100 bases:

>100_bases
CCCTCACCGCGACGCACACCGGACGCCCGGCCGCCCACCGCGGCCGGGCGTCCTCGCGCCCGGACCGAGGTCACACCACC
CATCCTCCGATGCCGCCACG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPEAVIVSVARSPIGRANKGSLKDLRPDDLSAFIIKTALDKVEGLDPHTVDDVYLGCGLPGGESGNNMARIVNVLNGMDD
VPGATITRYCASSVQTTRMAFHAIKAGEGDIFVSAGVETVSRFAKGTSDHWPDTKNPLYDEAMARTEKTAEGGVDWHDPR
EDGLLPDAYIAMGQTAENVARLRGLDRKELDEFGVRSQNLAEKAINDGFWAREITPVTTPDGTVVSQDDGPRAGVTYEAI
SQLKPVFRPDGVVTAGNCCPLNDGAAAVVIMSDTKAAELGVTPLARIVATGVSGLSPEIMGLGPVEATRRALAHAKMSIG
DIDLVEINEAFAAQVVPSYQDLGIDLDRLNVNGGAIAVGHPFGMTGARLQNTMLNSLDWHDKTTGLITMCVGGGQGMALI
LERL

Sequences:

>Translated_404_residues
MPEAVIVSVARSPIGRANKGSLKDLRPDDLSAFIIKTALDKVEGLDPHTVDDVYLGCGLPGGESGNNMARIVNVLNGMDD
VPGATITRYCASSVQTTRMAFHAIKAGEGDIFVSAGVETVSRFAKGTSDHWPDTKNPLYDEAMARTEKTAEGGVDWHDPR
EDGLLPDAYIAMGQTAENVARLRGLDRKELDEFGVRSQNLAEKAINDGFWAREITPVTTPDGTVVSQDDGPRAGVTYEAI
SQLKPVFRPDGVVTAGNCCPLNDGAAAVVIMSDTKAAELGVTPLARIVATGVSGLSPEIMGLGPVEATRRALAHAKMSIG
DIDLVEINEAFAAQVVPSYQDLGIDLDRLNVNGGAIAVGHPFGMTGARLQNTMLNSLDWHDKTTGLITMCVGGGQGMALI
LERL
>Mature_403_residues
PEAVIVSVARSPIGRANKGSLKDLRPDDLSAFIIKTALDKVEGLDPHTVDDVYLGCGLPGGESGNNMARIVNVLNGMDDV
PGATITRYCASSVQTTRMAFHAIKAGEGDIFVSAGVETVSRFAKGTSDHWPDTKNPLYDEAMARTEKTAEGGVDWHDPRE
DGLLPDAYIAMGQTAENVARLRGLDRKELDEFGVRSQNLAEKAINDGFWAREITPVTTPDGTVVSQDDGPRAGVTYEAIS
QLKPVFRPDGVVTAGNCCPLNDGAAAVVIMSDTKAAELGVTPLARIVATGVSGLSPEIMGLGPVEATRRALAHAKMSIGD
IDLVEINEAFAAQVVPSYQDLGIDLDRLNVNGGAIAVGHPFGMTGARLQNTMLNSLDWHDKTTGLITMCVGGGQGMALIL
ERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=410, Percent_Identity=36.0975609756098, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI148539872, Length=407, Percent_Identity=36.8550368550369, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=35.7142857142857, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4557237, Length=413, Percent_Identity=34.3825665859564, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=29.81220657277, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI194353979, Length=402, Percent_Identity=27.1144278606965, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1787663, Length=415, Percent_Identity=41.4457831325301, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=41.5647921760391, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=38.4057971014493, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI87082165, Length=410, Percent_Identity=37.3170731707317, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=29.7169811320755, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=35.9605911330049, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=32.4257425742574, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=407, Percent_Identity=29.97542997543, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=28.6697247706422, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=25.3071253071253, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322031, Length=408, Percent_Identity=34.3137254901961, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=33.3333333333333, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655093, Length=410, Percent_Identity=38.2926829268293, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=34.9009900990099, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24640423, Length=412, Percent_Identity=32.0388349514563, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=28.8056206088993, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42722; Mature: 42591

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVSVARSPIGRANKGSLKDLRPDDLSAFIIKTALDKVEGLDPHTVDDVYLGCGLP
CCCCEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
GGESGNNMARIVNVLNGMDDVPGATITRYCASSVQTTRMAFHAIKAGEGDIFVSAGVETV
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SRFAKGTSDHWPDTKNPLYDEAMARTEKTAEGGVDWHDPREDGLLPDAYIAMGQTAENVA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
RLRGLDRKELDEFGVRSQNLAEKAINDGFWAREITPVTTPDGTVVSQDDGPRAGVTYEAI
HHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
SQLKPVFRPDGVVTAGNCCPLNDGAAAVVIMSDTKAAELGVTPLARIVATGVSGLSPEIM
HHCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHCCCHHHHHHHHHCCCCCCCCCE
GLGPVEATRRALAHAKMSIGDIDLVEINEAFAAQVVPSYQDLGIDLDRLNVNGGAIAVGH
ECCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCHHHHCCEEEEEECCCCEEEECC
PFGMTGARLQNTMLNSLDWHDKTTGLITMCVGGGQGMALILERL
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHEECC
>Mature Secondary Structure 
PEAVIVSVARSPIGRANKGSLKDLRPDDLSAFIIKTALDKVEGLDPHTVDDVYLGCGLP
CCCEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
GGESGNNMARIVNVLNGMDDVPGATITRYCASSVQTTRMAFHAIKAGEGDIFVSAGVETV
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SRFAKGTSDHWPDTKNPLYDEAMARTEKTAEGGVDWHDPREDGLLPDAYIAMGQTAENVA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
RLRGLDRKELDEFGVRSQNLAEKAINDGFWAREITPVTTPDGTVVSQDDGPRAGVTYEAI
HHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
SQLKPVFRPDGVVTAGNCCPLNDGAAAVVIMSDTKAAELGVTPLARIVATGVSGLSPEIM
HHCCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCHHCCCHHHHHHHHHCCCCCCCCCE
GLGPVEATRRALAHAKMSIGDIDLVEINEAFAAQVVPSYQDLGIDLDRLNVNGGAIAVGH
ECCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCHHHHCCEEEEEECCCCEEEECC
PFGMTGARLQNTMLNSLDWHDKTTGLITMCVGGGQGMALILERL
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]