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The map label for this gene is pepPI [H]

Identifier: 119715600

GI number: 119715600

Start: 1439299

End: 1440741

Strand: Reverse

Name: pepPI [H]

Synonym: Noca_1364

Alternate gene names: 119715600

Gene position: 1440741-1439299 (Counterclockwise)

Preceding gene: 119715606

Following gene: 119715599

Centisome position: 28.9

GC content: 73.18

Gene sequence:

>1443_bases
GTGAGCGAGCAGACCCCGCCCGAGGGCACCGACCCGTCCACCCAGCCCACGGCGCCGAAGACCGAGTCCCACGATCCTGC
CGTCCCGGCCGCCTACGCGGCGTTCATGCGCGAGGGCTGGGGCGACCGCGAGCTCGACCTGCCGGTCCAGCCGGTCGCGA
CCCCTGCAGCACTGCGGCGCGCGCGGCTCGCCGAGGCGTTCCCCGGCGAGCGCCTCGTGCTGCCGGCCGGTACCTTCAAG
GTCCGGGCCAACGACACCGACTACCGGTTCCGCCCGGACACCGCTCACACCTACTTCTCGGGCAACCAGACCAGTGACGC
CGTCCTCGTGGTCGCCGACGGCGAGTCCGTGCTCTACGCCCGGCCGCGCTCGTCGCGCGAGACCGACGAGTTCTTCCGGG
ACCGGCAGTACGGCGAGCTCTGGGCCGGGCGCCGCCCCTCGCTCAAGGAGATGTCGGACTCCCTCGGCCTCCCGGTGCGT
CACCTCGACGACCTCCCGGCCGCTCTGAGCGGTGGCGGCAAGACGCGGGTGCTGCGCGGGGTGTCCGCCAGCGTGGACAC
CGCCGTGAGCCCGGACGAGGCCCGCGACTCCGAGCTCGCTCGCGTCGTCTCGGAGATGCGGCTGGTCAAGGACGACTGGG
AGCTCGAGCAGCTCCAGGAGGCCTGCGACATCACCACGCTCGGGTTCGAGGACTCGGTGCGCGAGTGGGCCGACGTGCTG
CGCTACGGCGAGCGCTGGATCGAGGGCACCTTCTTCCGCCGCGCCCGGGCGATGGGCAACGACATCGGCTACGACTCGAT
CGTCGGCGGCGGCTCGCACGCCACCACGCTGCACTGGATCGAGAACTCCGGCGCGATCACGCCCGGTGAGCTGGTGCTGC
TGGACATGGGCGTGGAGAACCGGTCGCTCTACACCGCCGACGTGACCCGGACCCTGCCGGTCGACGGCCGCTTCACCGAC
CTGCAGCGCGAGCTCTACGACCTGGTGCACGCAGCCCAGGAGGCGGGCATCGCCGCGGCCGTCCCCGGCCAGCCGTTCCG
CTCGATCCACAACGCCGCGATGGCGGTGCTGGCGCACGGCCTCGAGGGCCTGGGGCTGCTGCCGGTCTCCGCGGAGGAGG
CGCTGGACCCCGAGAGCCGGGTCTATGCCCGCTGGACCCTCCACGGCACCAGCCACATGCTGGGGCTCGACGTGCACGAC
TGCGGCCAGGCCGCACCGGAGGCGTACGCCGACGGCACCCTCGCCGCGGGCATGGTGCTCACCGTGGAGCCCGGCCTGTA
CTTCCAGGAGGACGACCTGCTGGTGCCCGCGGAGCTGCGGGGCATCGGCATCCGCATCGAGGACGACATCCTCGTCACCG
CGGGCGCGCCCCGGAACCTCTCCGCGGCGCTCCCGCGGACCTCCGGGGACGTCGAGGAGTGGATGGGCGCGCTGCGCCGC
TGA

Upstream 100 bases:

>100_bases
GAGGTCGCACGGTCGCGGCGGGCTCCAGGCATGGACGCCAGCCTATCGGGGCAGGTCCGCGGGGCCGCGGTCCTGGCGGC
CCCCGGCGTACAGTGACCGC

Downstream 100 bases:

>100_bases
CGAGTGAGCTCTGGCGCGGCGGCCCGTCCCGCCCTCACCACCTGAGGGAGAAGGGGTCTCCCACCCGGGCCGAATCGCGC
CTACGCTCAGCAGGAGCCGA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase I; Aminopeptidase P I; APP; PEPP I; X-Pro aminopeptidase I; Xaa-Pro aminopeptidase I [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSEQTPPEGTDPSTQPTAPKTESHDPAVPAAYAAFMREGWGDRELDLPVQPVATPAALRRARLAEAFPGERLVLPAGTFK
VRANDTDYRFRPDTAHTYFSGNQTSDAVLVVADGESVLYARPRSSRETDEFFRDRQYGELWAGRRPSLKEMSDSLGLPVR
HLDDLPAALSGGGKTRVLRGVSASVDTAVSPDEARDSELARVVSEMRLVKDDWELEQLQEACDITTLGFEDSVREWADVL
RYGERWIEGTFFRRARAMGNDIGYDSIVGGGSHATTLHWIENSGAITPGELVLLDMGVENRSLYTADVTRTLPVDGRFTD
LQRELYDLVHAAQEAGIAAAVPGQPFRSIHNAAMAVLAHGLEGLGLLPVSAEEALDPESRVYARWTLHGTSHMLGLDVHD
CGQAAPEAYADGTLAAGMVLTVEPGLYFQEDDLLVPAELRGIGIRIEDDILVTAGAPRNLSAALPRTSGDVEEWMGALRR

Sequences:

>Translated_480_residues
MSEQTPPEGTDPSTQPTAPKTESHDPAVPAAYAAFMREGWGDRELDLPVQPVATPAALRRARLAEAFPGERLVLPAGTFK
VRANDTDYRFRPDTAHTYFSGNQTSDAVLVVADGESVLYARPRSSRETDEFFRDRQYGELWAGRRPSLKEMSDSLGLPVR
HLDDLPAALSGGGKTRVLRGVSASVDTAVSPDEARDSELARVVSEMRLVKDDWELEQLQEACDITTLGFEDSVREWADVL
RYGERWIEGTFFRRARAMGNDIGYDSIVGGGSHATTLHWIENSGAITPGELVLLDMGVENRSLYTADVTRTLPVDGRFTD
LQRELYDLVHAAQEAGIAAAVPGQPFRSIHNAAMAVLAHGLEGLGLLPVSAEEALDPESRVYARWTLHGTSHMLGLDVHD
CGQAAPEAYADGTLAAGMVLTVEPGLYFQEDDLLVPAELRGIGIRIEDDILVTAGAPRNLSAALPRTSGDVEEWMGALRR
>Mature_479_residues
SEQTPPEGTDPSTQPTAPKTESHDPAVPAAYAAFMREGWGDRELDLPVQPVATPAALRRARLAEAFPGERLVLPAGTFKV
RANDTDYRFRPDTAHTYFSGNQTSDAVLVVADGESVLYARPRSSRETDEFFRDRQYGELWAGRRPSLKEMSDSLGLPVRH
LDDLPAALSGGGKTRVLRGVSASVDTAVSPDEARDSELARVVSEMRLVKDDWELEQLQEACDITTLGFEDSVREWADVLR
YGERWIEGTFFRRARAMGNDIGYDSIVGGGSHATTLHWIENSGAITPGELVLLDMGVENRSLYTADVTRTLPVDGRFTDL
QRELYDLVHAAQEAGIAAAVPGQPFRSIHNAAMAVLAHGLEGLGLLPVSAEEALDPESRVYARWTLHGTSHMLGLDVHDC
GQAAPEAYADGTLAAGMVLTVEPGLYFQEDDLLVPAELRGIGIRIEDDILVTAGAPRNLSAALPRTSGDVEEWMGALRR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=444, Percent_Identity=30.8558558558559, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI149589008, Length=504, Percent_Identity=26.984126984127, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI260593665, Length=348, Percent_Identity=29.5977011494253, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI260593663, Length=254, Percent_Identity=30.3149606299213, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789275, Length=449, Percent_Identity=31.6258351893096, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1788728, Length=281, Percent_Identity=29.8932384341637, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=28.0821917808219, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=479, Percent_Identity=27.9749478079332, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71989583, Length=375, Percent_Identity=27.4666666666667, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320922, Length=454, Percent_Identity=27.0925110132159, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321118, Length=420, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19920384, Length=397, Percent_Identity=29.9748110831234, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21357079, Length=475, Percent_Identity=28.2105263157895, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 52288; Mature: 52157

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTPPEGTDPSTQPTAPKTESHDPAVPAAYAAFMREGWGDRELDLPVQPVATPAALRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ARLAEAFPGERLVLPAGTFKVRANDTDYRFRPDTAHTYFSGNQTSDAVLVVADGESVLYA
HHHHHHCCCCEEEEECCEEEEEECCCCCEECCCCCCEEECCCCCCCEEEEEECCCEEEEE
RPRSSRETDEFFRDRQYGELWAGRRPSLKEMSDSLGLPVRHLDDLPAALSGGGKTRVLRG
CCCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCEEEEEC
VSASVDTAVSPDEARDSELARVVSEMRLVKDDWELEQLQEACDITTLGFEDSVREWADVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEECCHHHHHHHHHHH
RYGERWIEGTFFRRARAMGNDIGYDSIVGGGSHATTLHWIENSGAITPGELVLLDMGVEN
HHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEEECCCCCCCCCEEEEEECCCC
RSLYTADVTRTLPVDGRFTDLQRELYDLVHAAQEAGIAAAVPGQPFRSIHNAAMAVLAHG
CEEEEEECEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHC
LEGLGLLPVSAEEALDPESRVYARWTLHGTSHMLGLDVHDCGQAAPEAYADGTLAAGMVL
CCCCEEECCCHHHHCCCCCCEEEEEEECCCCEEEECCHHHHCCCCCHHHCCCCCCCCEEE
TVEPGLYFQEDDLLVPAELRGIGIRIEDDILVTAGAPRNLSAALPRTSGDVEEWMGALRR
EECCCCEECCCCEECCHHHCEEEEEEECCEEEECCCCCCCHHCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SEQTPPEGTDPSTQPTAPKTESHDPAVPAAYAAFMREGWGDRELDLPVQPVATPAALRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
ARLAEAFPGERLVLPAGTFKVRANDTDYRFRPDTAHTYFSGNQTSDAVLVVADGESVLYA
HHHHHHCCCCEEEEECCEEEEEECCCCCEECCCCCCEEECCCCCCCEEEEEECCCEEEEE
RPRSSRETDEFFRDRQYGELWAGRRPSLKEMSDSLGLPVRHLDDLPAALSGGGKTRVLRG
CCCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCEEEEEC
VSASVDTAVSPDEARDSELARVVSEMRLVKDDWELEQLQEACDITTLGFEDSVREWADVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEECCHHHHHHHHHHH
RYGERWIEGTFFRRARAMGNDIGYDSIVGGGSHATTLHWIENSGAITPGELVLLDMGVEN
HHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCEEEEEEECCCCCCCCCEEEEEECCCC
RSLYTADVTRTLPVDGRFTDLQRELYDLVHAAQEAGIAAAVPGQPFRSIHNAAMAVLAHG
CEEEEEECEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHC
LEGLGLLPVSAEEALDPESRVYARWTLHGTSHMLGLDVHDCGQAAPEAYADGTLAAGMVL
CCCCEEECCCHHHHCCCCCCEEEEEEECCCCEEEECCHHHHCCCCCHHHCCCCCCCCEEE
TVEPGLYFQEDDLLVPAELRGIGIRIEDDILVTAGAPRNLSAALPRTSGDVEEWMGALRR
EECCCCEECCCCEECCHHHCEEEEEEECCEEEECCCCCCCHHCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]