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The map label for this gene is hpd [H]

Identifier: 119715531

GI number: 119715531

Start: 1368677

End: 1369870

Strand: Direct

Name: hpd [H]

Synonym: Noca_1295

Alternate gene names: 119715531

Gene position: 1368677-1369870 (Clockwise)

Preceding gene: 119715528

Following gene: 119715534

Centisome position: 27.45

GC content: 68.26

Gene sequence:

>1194_bases
ATGACACTGACACCGGACGAGCTCAAGGCCGACCTGACCCTCGACCAGCTCAAGGAGCTGGTCGGCCTCGTGGAGTACGA
CGCCGCCAACGACCCCTTCCCGGTGATCGCCCAGGACGCCGTCTGCTTCGTGGTCGGCAACGCCACCCAGACCGCGTCCT
TCTACCAGCTCGCGCTCGGGATGGAGCTCGAGGCCTACCGTGGCCCGGAGAACGGGTGTCGCGAGTCCAAGTCCTACGTG
CTGCGCTCGGGCAGCGCCCGGTTCGTCTTCACCGGCGGGGTCACCCCGGACAGCCCGGTGCTCGACCACCACCGCAGGCA
CGGCGACGGGGTCGTCGACCTGGCGATGGAGGTGCCCGACGTCGACCGGTGCATCGAGCACGCCCGGGCGATGGGCGCCA
CGATCCTGGTGGAGCCCCACGACGAGACCGACGAGCACGGCACGGCCCGGCTCGCCGCGATCGCGACGTACGGCGAGACC
CGCCACACCCTGGTCGACCGCTCGCGCTACTCCGGCCCCTACCTGCCCGGCTACGCGCCGGCCACGACCACGGTGACCCG
CCGCGAGGGCCGGCCCAAGCGCCTGTTCCAGGCGATCGACCACTGCGTCGGGAACGTCGAGCTCGGCCGCATGGACGAGT
GGGTGACGTTCTACAACAGGGTGCTCGGCTTCACGAACATGGCCGAGTTCATCGGCGACGACATCGCGACCGACTACTCC
GCGCTGATGTCCAAGGTCGTCGCGAGCGGCAACCACCGGGTGAAGTTCCCGCTCAACGAGCCCGCCGTGGCGAAGAAGAA
GTCCCAGATCGACGAGTACCTCGAGTTCTACGACGGTGCCGGCTGCCAGCACATCGCGCTGGCGACCAACGACATCCTGC
GCAGCGTCGACGTCCTGCGCGAGAACGGCATCCAGTTCCTCGACACCCCGGACTCCTACTACGACGACCCCGAGCTGCGC
GCCCGGATCGGCGAGGTGCGGGTGCCGATCGAGGAGCTGAAGAAGCGCAAGATCCTCGTCGACCGCGACGAGGACGGCTA
CCTGCTGCAGATCTTCACCAAGCCGATGGGGGACCGGCCGACGGTCTTCTACGAGTTCATCGAACGGCACGGCTCGCTCG
GCTTCGGCAAGGGCAACTTCAAGGCGCTGTTCGAGGCGATCGAGCGCGAGCAGGAGCTCCGCGGCAACCTCTGA

Upstream 100 bases:

>100_bases
GCCGTCGAGGTCGTCCATCCTGATGCCTCCGACTGTACAAATTGCCCAGTGTGTCGGGTTAGTGTTGCACATCCTGTGTG
ACCCTGACCACGCTGCGGGC

Downstream 100 bases:

>100_bases
GGCTCGGGTCGTGTGCCTGACGACGCGCCATGGCGCGTGCTGAGGCACACGACCCCGCGGGTGCGCCTAGGCTGGGCGAC
GAGCGTTCCCCCGGGAGGGA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTLTPDELKADLTLDQLKELVGLVEYDAANDPFPVIAQDAVCFVVGNATQTASFYQLALGMELEAYRGPENGCRESKSYV
LRSGSARFVFTGGVTPDSPVLDHHRRHGDGVVDLAMEVPDVDRCIEHARAMGATILVEPHDETDEHGTARLAAIATYGET
RHTLVDRSRYSGPYLPGYAPATTTVTRREGRPKRLFQAIDHCVGNVELGRMDEWVTFYNRVLGFTNMAEFIGDDIATDYS
ALMSKVVASGNHRVKFPLNEPAVAKKKSQIDEYLEFYDGAGCQHIALATNDILRSVDVLRENGIQFLDTPDSYYDDPELR
ARIGEVRVPIEELKKRKILVDRDEDGYLLQIFTKPMGDRPTVFYEFIERHGSLGFGKGNFKALFEAIEREQELRGNL

Sequences:

>Translated_397_residues
MTLTPDELKADLTLDQLKELVGLVEYDAANDPFPVIAQDAVCFVVGNATQTASFYQLALGMELEAYRGPENGCRESKSYV
LRSGSARFVFTGGVTPDSPVLDHHRRHGDGVVDLAMEVPDVDRCIEHARAMGATILVEPHDETDEHGTARLAAIATYGET
RHTLVDRSRYSGPYLPGYAPATTTVTRREGRPKRLFQAIDHCVGNVELGRMDEWVTFYNRVLGFTNMAEFIGDDIATDYS
ALMSKVVASGNHRVKFPLNEPAVAKKKSQIDEYLEFYDGAGCQHIALATNDILRSVDVLRENGIQFLDTPDSYYDDPELR
ARIGEVRVPIEELKKRKILVDRDEDGYLLQIFTKPMGDRPTVFYEFIERHGSLGFGKGNFKALFEAIEREQELRGNL
>Mature_396_residues
TLTPDELKADLTLDQLKELVGLVEYDAANDPFPVIAQDAVCFVVGNATQTASFYQLALGMELEAYRGPENGCRESKSYVL
RSGSARFVFTGGVTPDSPVLDHHRRHGDGVVDLAMEVPDVDRCIEHARAMGATILVEPHDETDEHGTARLAAIATYGETR
HTLVDRSRYSGPYLPGYAPATTTVTRREGRPKRLFQAIDHCVGNVELGRMDEWVTFYNRVLGFTNMAEFIGDDIATDYSA
LMSKVVASGNHRVKFPLNEPAVAKKKSQIDEYLEFYDGAGCQHIALATNDILRSVDVLRENGIQFLDTPDSYYDDPELRA
RIGEVRVPIEELKKRKILVDRDEDGYLLQIFTKPMGDRPTVFYEFIERHGSLGFGKGNFKALFEAIEREQELRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=366, Percent_Identity=45.9016393442623, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI285002264, Length=347, Percent_Identity=45.2449567723343, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI14249394, Length=332, Percent_Identity=28.0120481927711, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17555220, Length=369, Percent_Identity=45.7994579945799, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17550752, Length=366, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24667510, Length=367, Percent_Identity=44.9591280653951, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI21356105, Length=296, Percent_Identity=46.9594594594595, Blast_Score=255, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 44432; Mature: 44300

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTPDELKADLTLDQLKELVGLVEYDAANDPFPVIAQDAVCFVVGNATQTASFYQLALG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHC
MELEAYRGPENGCRESKSYVLRSGSARFVFTGGVTPDSPVLDHHRRHGDGVVDLAMEVPD
CEEHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCC
VDRCIEHARAMGATILVEPHDETDEHGTARLAAIATYGETRHTLVDRSRYSGPYLPGYAP
HHHHHHHHHHCCCEEEECCCCCCCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCCCCCCC
ATTTVTRREGRPKRLFQAIDHCVGNVELGRMDEWVTFYNRVLGFTNMAEFIGDDIATDYS
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
ALMSKVVASGNHRVKFPLNEPAVAKKKSQIDEYLEFYDGAGCQHIALATNDILRSVDVLR
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
ENGIQFLDTPDSYYDDPELRARIGEVRVPIEELKKRKILVDRDEDGYLLQIFTKPMGDRP
HCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHCCCCEEEECCCCCEEEEEEECCCCCCC
TVFYEFIERHGSLGFGKGNFKALFEAIEREQELRGNL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLTPDELKADLTLDQLKELVGLVEYDAANDPFPVIAQDAVCFVVGNATQTASFYQLALG
CCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHC
MELEAYRGPENGCRESKSYVLRSGSARFVFTGGVTPDSPVLDHHRRHGDGVVDLAMEVPD
CEEHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCC
VDRCIEHARAMGATILVEPHDETDEHGTARLAAIATYGETRHTLVDRSRYSGPYLPGYAP
HHHHHHHHHHCCCEEEECCCCCCCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCCCCCCC
ATTTVTRREGRPKRLFQAIDHCVGNVELGRMDEWVTFYNRVLGFTNMAEFIGDDIATDYS
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
ALMSKVVASGNHRVKFPLNEPAVAKKKSQIDEYLEFYDGAGCQHIALATNDILRSVDVLR
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
ENGIQFLDTPDSYYDDPELRARIGEVRVPIEELKKRKILVDRDEDGYLLQIFTKPMGDRP
HCCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHCCCCEEEECCCCCEEEEEEECCCCCCC
TVFYEFIERHGSLGFGKGNFKALFEAIEREQELRGNL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]