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The map label for this gene is kynA

Identifier: 119715460

GI number: 119715460

Start: 1295671

End: 1296474

Strand: Direct

Name: kynA

Synonym: Noca_1224

Alternate gene names: 119715460

Gene position: 1295671-1296474 (Clockwise)

Preceding gene: 119715457

Following gene: 119715461

Centisome position: 25.99

GC content: 70.15

Gene sequence:

>804_bases
ATGAGCGACAACTTCGTGTCCTTCGGTGAGCAGGGCGCCCAGCTCACCTACGGGAGCTACCTGCGACTGCCGCAGCTGCT
GGAGGCCCAGCACCTGGAGTCGGACCCACCCGCGCACGACGAGCTGCTGTTCATCACGATCCACCAGGTCTACGAGCTGT
GGTTCAAGCAGCTGCTGCACGAGGTCTCCGCCGCGCGCGATGCGATGCTCGGGGGCGAGGCCGGCGGCCGGCTGTGGTGG
GCCCAGCACCTGCTCACGCGGGTGCACGTCATCGAGCGGGTGCTGGTCCAGCAGATCGACGTCCTGGAGACGATGACGCC
CCAGGAGTTCCTGGAGTTCCGGCAACGGCTCGCTCCGGCCAGCGGGTTCCAGTCGGTGCAGTTCCGCGAGCTGGAGTTCC
TCTCCGGCGCGAAGGACCCGGCGTACCTCGAGCGGTTCCGGGGGATCACCCCTGCCGAGAAGGCGCGGCTCGACGCGCGG
CTGTCGGAGCCGACGCTCTGGGACGCGTTCCTCGCGATGCTGCGCTCCTTCGGCTTCGCCGCCGACTCCGACGCCGAGGT
CTCCGCGGCGCTGCGCACCGCCGCCCACGACCGGACCCGGTACGCCGTGGTGTGGGCCCTGTCCGAGGGATTGCTCCAGC
ACGACGAGCTCGCCGCCAACTGGCGCGCCCGGCACGTCGTCATGGTCGAGCGGATGATCGGCAGCAAGTCCGGGACCGGC
GGGTCGAGCGGCTCGTCGTACCTCCGCTCCCGGCTGCCGGTCCAGTACTACCCGCTCCTATGGGGACTGCGCAGCGAGCT
GTAG

Upstream 100 bases:

>100_bases
GTCTCGCGTGTCGGCTTCGCCGCCACGCAGGCCGCGGAGTCGCTCCCGGGGCGGCCGCACCGCGCGGTGGTACAGGTCGT
GGAGCCCTAGGGTCGGGCCT

Downstream 100 bases:

>100_bases
GAGCCCCGAAACGCCGACTCGGCGGGGCGGTGTTGGTGGACGGACGACGGCGTCCTAATGTCGGACCCGTGTCAACGACG
ACGCGTGAGCAGGACCTGTC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAMLGGEAGGRLWW
AQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDAR
LSEPTLWDAFLAMLRSFGFAADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTG
GSSGSSYLRSRLPVQYYPLLWGLRSEL

Sequences:

>Translated_267_residues
MSDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAMLGGEAGGRLWW
AQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDAR
LSEPTLWDAFLAMLRSFGFAADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTG
GSSGSSYLRSRLPVQYYPLLWGLRSEL
>Mature_266_residues
SDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLHEVSAARDAMLGGEAGGRLWWA
QHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPASGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDARL
SEPTLWDAFLAMLRSFGFAADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTGG
SSGSSYLRSRLPVQYYPLLWGLRSEL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=123, Percent_Identity=47.9674796747967, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564651, Length=138, Percent_Identity=40.5797101449275, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17552370, Length=138, Percent_Identity=40.5797101449275, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17530891, Length=160, Percent_Identity=44.375, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_NOCSJ (A1SG03)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_922425.1
- ProteinModelPortal:   A1SG03
- SMR:   A1SG03
- STRING:   A1SG03
- GeneID:   4599273
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_1224
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   QWSVLAT
- ProtClustDB:   CLSK2533163
- BioCyc:   NSP35761:NOCA_1224-MONOMER
- InterPro:   IPR004981
- PANTHER:   PTHR10138

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 30218; Mature: 30086

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 114-114 BINDING 121-121 BINDING 239-239

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLH
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
EVSAARDAMLGGEAGGRLWWAQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
SGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDARLSEPTLWDAFLAMLRSFGFA
CCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
ADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTG
CCCCHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GSSGSSYLRSRLPVQYYPLLWGLRSEL
CCCCHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SDNFVSFGEQGAQLTYGSYLRLPQLLEAQHLESDPPAHDELLFITIHQVYELWFKQLLH
CCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHH
EVSAARDAMLGGEAGGRLWWAQHLLTRVHVIERVLVQQIDVLETMTPQEFLEFRQRLAPA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
SGFQSVQFRELEFLSGAKDPAYLERFRGITPAEKARLDARLSEPTLWDAFLAMLRSFGFA
CCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
ADSDAEVSAALRTAAHDRTRYAVVWALSEGLLQHDELAANWRARHVVMVERMIGSKSGTG
CCCCHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GSSGSSYLRSRLPVQYYPLLWGLRSEL
CCCCHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA