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The map label for this gene is moaA [H]

Identifier: 119714837

GI number: 119714837

Start: 603183

End: 604172

Strand: Direct

Name: moaA [H]

Synonym: Noca_0574

Alternate gene names: 119714837

Gene position: 603183-604172 (Clockwise)

Preceding gene: 119714836

Following gene: 119714839

Centisome position: 12.1

GC content: 68.18

Gene sequence:

>990_bases
GTGACGGCACCTCTGGCAGACCGCTTCGGCCGCGTGGCCGCGGACCTGCGTGTGTCCCTGACCGATCGGTGCAACCTGCG
TTGCAACTACTGCATGCCGGCTGAGGGCCTCGACTGGCTGCCGACAGAGCAGACTCTGACCGACGACGAGATCGTCCGGT
TGATCACCATCGGTGTGGAGATGCTCGGCATCCGCGAGGTTCGGTTCACGGGGGGCGAGCCGCTGCTGCGACGAGGGCTG
GTCGACATCGTGGCACGTACCCACGCGCTTGGGGTGGAAACCTCGCTTACCACCAACGCACTCGGCCTGGCCCGCACTGC
GCAGGCGCTCGCCGACGCCCGGCTCGATCGAATCAACGCCAGCATCGATACCGTCCGCCCGGACACCTTTGCCACCATCA
CCCGCCGCGACCGACTCCACGACGTAGTGGCCGGGCTCGAAGCAGCCAAGTCCGCCGGTTTGGGTCCCATCAAGCTCAAC
GCCGTCCTGCTGCGAGGCACCAACGATGACCAAGCCCCCGAGCTGCTGCGCTGGAGCATCGAACACGGCTACGAGCTTCG
CTTCATCGAGCAGATGCCCCTCGACGCGCAGCACGACTGGAGCCGCGCCGAGATGGTCACCGCCGACGAGATCTTCGACG
CGCTCTCCACCGAATTCAGCCTGACCCCGCACGGCGAGCCGCGCGGGAGCGCCCCCGCGGAGCTTTTCGACGTCGGCGGG
GGACCAGCCACCGTCGGCATCATCGCCTCGGTCACCCGTCCTTTTTGCGGAGACTGCGATCGTGTGCGCCTCACCGCCGA
CGGGCAGGTGCGCAACTGCCTTTTCGCCCGCGAGGAGTCCGACCTCCGCACGGCGCTGCGCTCCGGCGCCACGGACCAGG
AGATCGCCGAGCGCTGGGTCATTGCGATGCTCGGCAAGCGCGCGGGCCACGGGATCGACGACATGACGTTCTTGCAGCCC
GACCGCCCGATGTCCGCGATCGGCGGGTAG

Upstream 100 bases:

>100_bases
CGTCAGTGTCTTGCTGTTCTCGGCGCATATCGATCTCGCCCCGGACGACTCGTGCAAGAACGCGTCGGCTCGCTGAGCCT
GCCTCGATAGACTCGTATGC

Downstream 100 bases:

>100_bases
CGGCAACCAATCGGGCGCGGCGGGAGCCGCGCAAGCGTCGACAGGTAAGGGCCGCGTTGGACTGTCAAGACAGGGAGTGG
CTGTGCTTTGCAGGTGATGT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTAPLADRFGRVAADLRVSLTDRCNLRCNYCMPAEGLDWLPTEQTLTDDEIVRLITIGVEMLGIREVRFTGGEPLLRRGL
VDIVARTHALGVETSLTTNALGLARTAQALADARLDRINASIDTVRPDTFATITRRDRLHDVVAGLEAAKSAGLGPIKLN
AVLLRGTNDDQAPELLRWSIEHGYELRFIEQMPLDAQHDWSRAEMVTADEIFDALSTEFSLTPHGEPRGSAPAELFDVGG
GPATVGIIASVTRPFCGDCDRVRLTADGQVRNCLFAREESDLRTALRSGATDQEIAERWVIAMLGKRAGHGIDDMTFLQP
DRPMSAIGG

Sequences:

>Translated_329_residues
MTAPLADRFGRVAADLRVSLTDRCNLRCNYCMPAEGLDWLPTEQTLTDDEIVRLITIGVEMLGIREVRFTGGEPLLRRGL
VDIVARTHALGVETSLTTNALGLARTAQALADARLDRINASIDTVRPDTFATITRRDRLHDVVAGLEAAKSAGLGPIKLN
AVLLRGTNDDQAPELLRWSIEHGYELRFIEQMPLDAQHDWSRAEMVTADEIFDALSTEFSLTPHGEPRGSAPAELFDVGG
GPATVGIIASVTRPFCGDCDRVRLTADGQVRNCLFAREESDLRTALRSGATDQEIAERWVIAMLGKRAGHGIDDMTFLQP
DRPMSAIGG
>Mature_328_residues
TAPLADRFGRVAADLRVSLTDRCNLRCNYCMPAEGLDWLPTEQTLTDDEIVRLITIGVEMLGIREVRFTGGEPLLRRGLV
DIVARTHALGVETSLTTNALGLARTAQALADARLDRINASIDTVRPDTFATITRRDRLHDVVAGLEAAKSAGLGPIKLNA
VLLRGTNDDQAPELLRWSIEHGYELRFIEQMPLDAQHDWSRAEMVTADEIFDALSTEFSLTPHGEPRGSAPAELFDVGGG
PATVGIIASVTRPFCGDCDRVRLTADGQVRNCLFAREESDLRTALRSGATDQEIAERWVIAMLGKRAGHGIDDMTFLQPD
RPMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=333, Percent_Identity=39.3393393393393, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI22027536, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1786999, Length=340, Percent_Identity=32.9411764705882, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566329, Length=333, Percent_Identity=34.8348348348348, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=333, Percent_Identity=35.1351351351351, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=315, Percent_Identity=33.6507936507937, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI28574488, Length=339, Percent_Identity=38.9380530973451, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI28574490, Length=309, Percent_Identity=40.1294498381877, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35901; Mature: 35770

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLADRFGRVAADLRVSLTDRCNLRCNYCMPAEGLDWLPTEQTLTDDEIVRLITIGVE
CCCCHHHHHHHHHHHEEEEEECCCCCEECEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
MLGIREVRFTGGEPLLRRGLVDIVARTHALGVETSLTTNALGLARTAQALADARLDRINA
HHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SIDTVRPDTFATITRRDRLHDVVAGLEAAKSAGLGPIKLNAVLLRGTNDDQAPELLRWSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHH
EHGYELRFIEQMPLDAQHDWSRAEMVTADEIFDALSTEFSLTPHGEPRGSAPAELFDVGG
CCCCEEEEEECCCCCCCCCCCHHHEEEHHHHHHHHHCCEEECCCCCCCCCCCHHEEECCC
GPATVGIIASVTRPFCGDCDRVRLTADGQVRNCLFAREESDLRTALRSGATDQEIAERWV
CCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
IAMLGKRAGHGIDDMTFLQPDRPMSAIGG
HHHHHHHCCCCCCCCEEECCCCCHHHCCC
>Mature Secondary Structure 
TAPLADRFGRVAADLRVSLTDRCNLRCNYCMPAEGLDWLPTEQTLTDDEIVRLITIGVE
CCCHHHHHHHHHHHEEEEEECCCCCEECEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
MLGIREVRFTGGEPLLRRGLVDIVARTHALGVETSLTTNALGLARTAQALADARLDRINA
HHEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SIDTVRPDTFATITRRDRLHDVVAGLEAAKSAGLGPIKLNAVLLRGTNDDQAPELLRWSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHH
EHGYELRFIEQMPLDAQHDWSRAEMVTADEIFDALSTEFSLTPHGEPRGSAPAELFDVGG
CCCCEEEEEECCCCCCCCCCCHHHEEEHHHHHHHHHCCEEECCCCCCCCCCCHHEEECCC
GPATVGIIASVTRPFCGDCDRVRLTADGQVRNCLFAREESDLRTALRSGATDQEIAERWV
CCHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
IAMLGKRAGHGIDDMTFLQPDRPMSAIGG
HHHHHHHCCCCCCCCEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]