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The map label for this gene is menA [H]

Identifier: 119714771

GI number: 119714771

Start: 537409

End: 538302

Strand: Reverse

Name: menA [H]

Synonym: Noca_0507

Alternate gene names: 119714771

Gene position: 538302-537409 (Counterclockwise)

Preceding gene: 119714776

Following gene: 119714769

Centisome position: 10.8

GC content: 75.28

Gene sequence:

>894_bases
ATGCTTGAATCTCCGGTCGTGGCAACTCCCGACCAGTGGCTCGCCGGCGCGCGGCCTCGGACCCTGCCCGCGGCCGTCTC
CCCGGTGCTGGCGGGCACCGGTGTCGCGGCGTACGCCGACGGCCTGGTGTGGTGGAAGGCGCTGCTCGCCCTCGTCGTGG
CGCTCGCCCTGCAGGTCGCGGTCAACTACGCCAACGACTACTCCGACGGCATCCGCGGCACCGACGCGGACCGGGTCGGG
CCGATGCGCCTGGTCGGGTCCGGCGCCGCCAGGCCCGCGGCCGTGAAGCGGGCCGCGTTCCTGGCGTTCGGGGTCGCCGC
CGGCGCCGGGCTGGTGCTGGCGGCGACCACCGCGTGGTGGCTCGTCGCGGTCGGGCTGGTGTCGGTGCTGGCCGCCTGGT
TCTACACCGGCGGGTCGAAGCCCTACGGTTACCTCGGGCTCGGCGAGGTGATGGTCTTCGTGTTCTTCGGGCTGGTCGCG
GTGCTGGGGACGGCGTACGTCCAGACCGAGGCCTGGGAGTGGGCAGCCCTGTACGCAGCCGTCGGCGTGGGCACGCTGGC
CTGCGCGATCCTGGTGGCCAACAACCTGCGCGACATCCCCACCGACGCCGTCGCCGGCAAGCGGACCCTCGCGGTGGTCC
TCGGGGACCGGCGCACGCGCAGCCTCTTCCTGCTCCTGGTCGTGCTCGCCGCCGCCGCGGTGGTCGCGGTGGCAGCCACC
ACCACGTGGTGGGCCCTGGCCGGTCTCGGCTTCCTGGTGCTCGCCGGGCCCGCTGCGCGGACCGTGCTCGGTGGCGCCGC
CGGGCCCGGGCTGATCCCGGTGCTGCAGCAGACCGGCCTGGCCGAGCTGCTCTGGGCGGTGCTGGTCGCGGCCGCGCTGG
TGGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
ACCACCCACGGTTCCGGGTCGTCGGCCGCCAGCCACCCGGCGACTGGTTCGACCACCGTGTCCACTCGGTCCACCTGGCT
GAGGCTAGACGGTGCGATTG

Downstream 100 bases:

>100_bases
TCGGGCCGGGGCGCCGGCCGGGTCGCCAGCCAGCACCGGCGTACCCTGGCGGCATGCTCTGGATCATCCTGCTGCTCGTC
GTGGTGGCCGTCCTCGCCTA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLESPVVATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVAVNYANDYSDGIRGTDADRVG
PMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWWLVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVA
VLGTAYVQTEAWEWAALYAAVGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAAT
TTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG

Sequences:

>Translated_297_residues
MLESPVVATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVAVNYANDYSDGIRGTDADRVG
PMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWWLVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVA
VLGTAYVQTEAWEWAALYAAVGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAAT
TTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG
>Mature_297_residues
MLESPVVATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVAVNYANDYSDGIRGTDADRVG
PMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWWLVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVA
VLGTAYVQTEAWEWAALYAAVGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAAT
TTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=233, Percent_Identity=28.3261802575107, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790365, Length=297, Percent_Identity=36.026936026936, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17737429, Length=220, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 30118; Mature: 30118

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESPVVATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVA
CCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNYANDYSDGIRGTDADRVGPMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWW
HHHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVAVLGTAYVQTEAWEWAALYAA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAAT
HHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLESPVVATPDQWLAGARPRTLPAAVSPVLAGTGVAAYADGLVWWKALLALVVALALQVA
CCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VNYANDYSDGIRGTDADRVGPMRLVGSGAARPAAVKRAAFLAFGVAAGAGLVLAATTAWW
HHHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVAVGLVSVLAAWFYTGGSKPYGYLGLGEVMVFVFFGLVAVLGTAYVQTEAWEWAALYAA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVGTLACAILVANNLRDIPTDAVAGKRTLAVVLGDRRTRSLFLLLVVLAAAAVVAVAAT
HHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTWWALAGLGFLVLAGPAARTVLGGAAGPGLIPVLQQTGLAELLWAVLVAAALVAGG
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]