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The map label for this gene is panC

Identifier: 119714724

GI number: 119714724

Start: 490048

End: 491052

Strand: Direct

Name: panC

Synonym: Noca_0460

Alternate gene names: 119714724

Gene position: 490048-491052 (Clockwise)

Preceding gene: 119714723

Following gene: 119714725

Centisome position: 9.83

GC content: 73.33

Gene sequence:

>1005_bases
ATGAGCTCCGCTCCCGTCCTCGCGCACACCCGTGAGGAGCTCGCCACGCTGCTCGCTGCCGCCCGCGCCCGGGGCGAGCA
GGTGGGCCTCGTGCCCACGATGGGCGCCCTCCACGAGGGGCACGCCAGCCTGGTCCGCGCCGCTCGGGAGCGGGTGACCG
ACGACGGACGGATGGGGCCGGTCGTCGTCTCGGTGTTCGTCAACCCCCTGCAGTTCGGCGCGAACGAGGACCTCGACCGC
TATCCACGCACCCTGGAGGCGGACCTGGAGGTCTGCGCGCGCGAGGGCGCCGACATCGTCTTCGCGCCGAGCGTCGACGA
GGTCTACCCCGGGGGACCCCCTCAGGTCACCGTGCGCCCCGGGCCGCTCGGCAAGATCCTCGAGGGCAAGGTCCGGCCCG
GCCACTTCCGTGGGGTGCTCACGGTCGTCGCCAAGCTGTTCGGCCTGGTGCGGCCCGACGTCGCGGTCTTCGGCCAGAAG
GACTACCAGCAGCTGGCGCTGATCCGCCGGATGGTGCTCGACCTCGCCCTCGGGGTCGAGATCGTCGCCGCGGAGACGGT
CCGCGAGGACGACGGCCTCGCGCTCTCCAGCCGCAACCGCTACCTCGAGCCGGAGCAGCGTGAACAGGCCGTCGCGTTGA
GCCGGGCGCTGCTCGCCGCCCAGGAGAACGCGGGCTACGGCGCCGAGGTCGCGCTCGACGAGGCGCGCGCCGAGCTGCGG
GCGGCGCCGGGCGTCGACCTGGACTACCTCGTGATCACCGACCCCGACCTCGACGAGCTGCCCGCCGTCGTACCGCCCGG
AACGCCCGCGCGGATCCTCGTCGCCGCCCGCGTCGGCGGCACCCGCCTGATCGACAACCTGCCCCTGATGCTCGGCACCA
GAGGACCCGCTGGCGAAGCCAGTCCGCCGAACCGCGAGCGAAGCGAGCCTGGTTCGGCGGAACAGAACAAGAGCCCGGGC
GAAGCCCGGACCACGCCCTCCGGCACGAGCGAAGCGAGTGAGTGA

Upstream 100 bases:

>100_bases
TGGTGACCGACGGCCGGGTGCTGCCGATCCGTGCGGCCGCGATCAAGCGGGCGCTGGAGCAGGCCGAGCAGGCCGCGCCC
AGGACGACCGCGCCCCGTCG

Downstream 100 bases:

>100_bases
TGTTGCGCACCATGATGAAGAGCAAGATCCACCGGGCCACGGTGACCCAGGCCGACCTGCACTACGTCGGCTCGGTGACG
GTCGACGAGGACCTCCTCGA

Product: pantothenate synthetase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGPVVVSVFVNPLQFGANEDLDR
YPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRPGPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQK
DYQQLALIRRMVLDLALGVEIVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELR
AAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEASPPNRERSEPGSAEQNKSPG
EARTTPSGTSEASE

Sequences:

>Translated_334_residues
MSSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGPVVVSVFVNPLQFGANEDLDR
YPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRPGPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQK
DYQQLALIRRMVLDLALGVEIVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELR
AAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEASPPNRERSEPGSAEQNKSPG
EARTTPSGTSEASE
>Mature_333_residues
SSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGPVVVSVFVNPLQFGANEDLDRY
PRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRPGPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQKD
YQQLALIRRMVLDLALGVEIVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELRA
APGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEASPPNRERSEPGSAEQNKSPGE
ARTTPSGTSEASE

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=270, Percent_Identity=50, Blast_Score=220, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6322046, Length=314, Percent_Identity=39.8089171974522, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_NOCSJ (A1SDW7)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921689.1
- ProteinModelPortal:   A1SDW7
- SMR:   A1SDW7
- STRING:   A1SDW7
- GeneID:   4597359
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0460
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   GGEPQVR
- PhylomeDB:   A1SDW7
- BioCyc:   NSP35761:NOCA_0460-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 35429; Mature: 35297

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: ACT_SITE 41-41 BINDING 71-71 BINDING 71-71 BINDING 164-164 BINDING 187-187

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGP
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
VVVSVFVNPLQFGANEDLDRYPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRP
HHHEEHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECC
GPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQKDYQQLALIRRMVLDLALGVE
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCHH
IVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELR
EEEHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEA
CCCCCCEEEEEEECCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCCCCCCC
SPPNRERSEPGSAEQNKSPGEARTTPSGTSEASE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSAPVLAHTREELATLLAAARARGEQVGLVPTMGALHEGHASLVRAARERVTDDGRMGP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
VVVSVFVNPLQFGANEDLDRYPRTLEADLEVCAREGADIVFAPSVDEVYPGGPPQVTVRP
HHHEEHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECC
GPLGKILEGKVRPGHFRGVLTVVAKLFGLVRPDVAVFGQKDYQQLALIRRMVLDLALGVE
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCHH
IVAAETVREDDGLALSSRNRYLEPEQREQAVALSRALLAAQENAGYGAEVALDEARAELR
EEEHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AAPGVDLDYLVITDPDLDELPAVVPPGTPARILVAARVGGTRLIDNLPLMLGTRGPAGEA
CCCCCCEEEEEEECCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCCCCCCC
SPPNRERSEPGSAEQNKSPGEARTTPSGTSEASE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA