Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 119714712

GI number: 119714712

Start: 479166

End: 479735

Strand: Direct

Name: folK [H]

Synonym: Noca_0448

Alternate gene names: 119714712

Gene position: 479166-479735 (Clockwise)

Preceding gene: 119714711

Following gene: 119714713

Centisome position: 9.61

GC content: 71.4

Gene sequence:

>570_bases
GTGACTGAGACCCCGAACCCGAACATCATCGACGCGGACACGCTGACCGGCGAGATGCGGCCGATCCGCCGTGCGGTGCT
GGCACTCGGGTCCAACCTGGGTGAGCGGATGGGGAACCTCCAGGGCGCGCTGAACGCGCTGGCCGACACCCCAGACGTCT
GGATCACCGCCGTGTCCCCGGTCTACGAGACCGACCCCGTCGACTGCCCGCCCGAGGCGAAGACGTTCCTCAACGCCGTC
GTGCTGATCGACACCACGCTGGCCGCGAGCCGGCTGATGGACCGGGCGCTGGCGATCGAGGACGCCTTCGAGCGGGAGCG
CGGTGAGCAGCGCAACGCGCCGCGGACCCTCGACGTCGACCTGATCGTCGTCGGCGACCGGCGCAGCAACGAGGAGTTCC
TGCGGCTGCCGCACCCGCGGGCCGCCGAACGGGCCTTCGTGCTGCGCCCGTGGTTCGACGTCGACCCGGCGGCCGAGGTG
CCCGACCGGGGTCCGGTCGCGGACCTGCTCGATGGGACCGACCAGAGCGGGCTGAAGCTGCGCGACGACCTGGTCCTCGA
GATCCAGTGA

Upstream 100 bases:

>100_bases
GTTGAATGGGCGAGGGTGACGGTCCACAAGCCGGACGCACCCATCGAAGCGACGTTCGCGGACGTCACGCTGACGATCAC
CCGGAGACGTGAGGGCACCC

Downstream 100 bases:

>100_bases
CCGGTCGGTGAGCGCCGGACCCTCCGGCGAGGAGCCGCAGCCGACCGGTCGCCTGCGGCCGACCTCTGGTGGTGCGCTCA
CGGCGTGGGCCGTCGCGGGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MTETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSPVYETDPVDCPPEAKTFLNAV
VLIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVDLIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEV
PDRGPVADLLDGTDQSGLKLRDDLVLEIQ

Sequences:

>Translated_189_residues
MTETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSPVYETDPVDCPPEAKTFLNAV
VLIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVDLIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEV
PDRGPVADLLDGTDQSGLKLRDDLVLEIQ
>Mature_188_residues
TETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSPVYETDPVDCPPEAKTFLNAVV
LIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVDLIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEVP
DRGPVADLLDGTDQSGLKLRDDLVLEIQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=37.6811594202899, Blast_Score=90, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20821; Mature: 20690

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSP
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
VYETDPVDCPPEAKTFLNAVVLIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEVPDRGPVADLLDGTDQSGLKL
EEEECCCCCCCHHEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEE
RDDLVLEIQ
CCCEEEEEC
>Mature Secondary Structure 
TETPNPNIIDADTLTGEMRPIRRAVLALGSNLGERMGNLQGALNALADTPDVWITAVSP
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
VYETDPVDCPPEAKTFLNAVVLIDTTLAASRLMDRALAIEDAFERERGEQRNAPRTLDVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LIVVGDRRSNEEFLRLPHPRAAERAFVLRPWFDVDPAAEVPDRGPVADLLDGTDQSGLKL
EEEECCCCCCCHHEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEE
RDDLVLEIQ
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]