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The map label for this gene is hpt [H]

Identifier: 119714707

GI number: 119714707

Start: 474309

End: 474860

Strand: Direct

Name: hpt [H]

Synonym: Noca_0443

Alternate gene names: 119714707

Gene position: 474309-474860 (Clockwise)

Preceding gene: 119714706

Following gene: 119714708

Centisome position: 9.51

GC content: 65.76

Gene sequence:

>552_bases
ATGCACGCATCCGACGTGGAGAACGACCTGGTCAACGTCCTCTTCACCGAGGAGCAGATCCAGCAACGGCTGGCCGAGCT
GGCCAAGGACATCGAGGCCGACTACGAAGGCAAGGACCTCCTCATCGTCGGCATCCTCCGGGGCGCGGTGATGGTGATGG
CCGACCTGGCCCGCAGCTTCACTCGGCACCTGGAGATGGACTGGATGGCGGTGTCGTCGTACGGCTCGGGCACCAAGTCC
AGCGGCGTGGTCCGGATCCTCAAGGACCTCGACACCGACATCTCCGGGCGGCACGTGGTCATCGTCGACGAGATCATCGA
CACCGGCCTGACCCTGTCCTGGCTGACCTCGAACCTGTCCTCGCGCAGCCCCGCGAGCGTCGAGATCTGCACGCTGCTGC
GCAAGCCCGACGCGCTCACCATGCCGGTCGAGGTGAAGTACGTCGGGTGGGACATCCCCAACGAGTTCGTGGTCGGCTAC
GGCTTGGACTACCGCGAGCGGTACCGCAACCTGCGCGACATCGGCACCCTCGCCCCCCACGTCTACTCCTAG

Upstream 100 bases:

>100_bases
CAAGGCCTACTACCTCGGCTCCCCGGACCTGAAGGTGTCGGCGTCCACGTCCTTCACCCTGACCGTCACCAGGGGGCGGC
ACTGACCTAGAGTCTGCGCC

Downstream 100 bases:

>100_bases
CGGGGAAGCGTCGGCGGACCCGCTGATGGTGGTCGAGCGAGGCCCGCGACCGAGCCTGCGAGGTCGCCACGGCCGTGTCG
AGACCCGGTGAGCGCAGAGT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSFTRHLEMDWMAVSSYGSGTKS
SGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLSSRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGY
GLDYRERYRNLRDIGTLAPHVYS

Sequences:

>Translated_183_residues
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSFTRHLEMDWMAVSSYGSGTKS
SGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLSSRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGY
GLDYRERYRNLRDIGTLAPHVYS
>Mature_183_residues
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSFTRHLEMDWMAVSSYGSGTKS
SGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLSSRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGY
GLDYRERYRNLRDIGTLAPHVYS

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=183, Percent_Identity=33.879781420765, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4504483, Length=181, Percent_Identity=31.4917127071823, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=49.7041420118343, Blast_Score=164, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17510817, Length=182, Percent_Identity=31.8681318681319, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20476; Mature: 20476

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSF
CCCCHHHHHHHHHEECHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
TRHLEMDWMAVSSYGSGTKSSGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLS
HHHHHHHHEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCHHHHHHCCC
SRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGYGLDYRERYRNLRDIGTLAPH
CCCCCCCHHHHHHCCCCCEECCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
VYS
CCC
>Mature Secondary Structure
MHASDVENDLVNVLFTEEQIQQRLAELAKDIEADYEGKDLLIVGILRGAVMVMADLARSF
CCCCHHHHHHHHHEECHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
TRHLEMDWMAVSSYGSGTKSSGVVRILKDLDTDISGRHVVIVDEIIDTGLTLSWLTSNLS
HHHHHHHHEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHHHHCCCCHHHHHHCCC
SRSPASVEICTLLRKPDALTMPVEVKYVGWDIPNEFVVGYGLDYRERYRNLRDIGTLAPH
CCCCCCCHHHHHHCCCCCEECCEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
VYS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]