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The map label for this gene is mtnAB [H]

Identifier: 119714668

GI number: 119714668

Start: 433600

End: 434634

Strand: Direct

Name: mtnAB [H]

Synonym: Noca_0403

Alternate gene names: 119714668

Gene position: 433600-434634 (Clockwise)

Preceding gene: 119714662

Following gene: 119714669

Centisome position: 8.7

GC content: 71.79

Gene sequence:

>1035_bases
ATGGTCCTGGCATTGCAATGGCAGGAGGACGCGCAGACGATCCGGCTGCTCGACCAGACCCTTCTGCCCGTCGAGGAGCG
CTACCTGGACGTCGACACCGTCGACGCCCTGGTCGCCGCGATCCAGAGCCTGGCGGTCCGGGGAGCGCCTGCGCTCGGGG
CCGTGGGTGCGCTCGGTGTGGTCGTCGCCATGCGGCAGGCCGAGCGCGAGGGCTGGGATGACGAGCGGCTGCAGGTCGAG
GTCGACCGGATCCGACTGGCACGTCCGACGGCCGTGAACCTCGCCTGGGGCGTGGACCAGGTCCGCGCCGCGATGCCGTC
GGGGCCGGAGACGGTGCTGAAGATGGCCAAGGCCGTCGTGGAGGAGGACGAGGCGGCCAACCGGACCCTCTCCCGGCTCG
GTGCCGACTGGATCCTGGGTCGCACCGGCAGGGAACGCGTGCGCGTCGTCACGCACTGCAACACCGGCGCGCTGGCCACC
TCGGCCTGGGGGACCGCCTACGGGATCATCCACGAGCTCCACGACCGTGGCGCCTTGGAGGTCGTGTACGTCGACGAGAC
CCGCCCGCTGCTCCAAGGTGCCCGGCTGACCAGCTGGGAGCTGACGCGGGACGAGATCCCGCATCTGCTCGAGGTGGACG
GCGCGGCGTCGAGCACGATCGTGCGCGGCCTCGTGGACGTCGCGATCATCGGCGCGGACCGGATCACCGCCAACGGCGAC
ACTGCGAACAAGGTCGGCTCGCTGGCCCTGGCCCTGGCCTGCCAACGAGCCGGGATCCCGTTCGTGGTCGCGGCGCCGAG
CTCCACTGTCGACCTGGCGACGGCCCATGGCGACGACATCGCGATCGAGGAGCGGGACGCCGCGGAGGTGCTCAGTCTCG
GGGGCCACCCGACGGCGTTGCCGTCGACCCGGGTCTACAACCCCGCCTTCGACGTGACTCCGCACGACCTGATCAGCGCG
ATCGTGACGGACCGGGGGGTGGTCGAGCCGGCCGCCCGTCCCGCCCCGAACCTGCTCGCATCGGTGGCGAGCTGA

Upstream 100 bases:

>100_bases
CGGCCGTGTGTTCACTCGAATCCGTTGACAACTGCCTAAGTCATATCTACTCTCCCAAGCAGTTGTAAAACAACCGGCAG
TATATCGGGAGGCGAACCAC

Downstream 100 bases:

>100_bases
CACATGAGGCAGACCGGAGCCCCGGCTGCACCTACGAGAGGAACCCCATGAGGATGAACAAACTCATCGTGGCCGGTGTC
GCCGCGGTGTCTGCCTTGAG

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: Methylthioribose-1-phosphate isomerase; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Methylthioribulose-1-phosphate dehydratase; MTRu-1-P dehydratase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MVLALQWQEDAQTIRLLDQTLLPVEERYLDVDTVDALVAAIQSLAVRGAPALGAVGALGVVVAMRQAEREGWDDERLQVE
VDRIRLARPTAVNLAWGVDQVRAAMPSGPETVLKMAKAVVEEDEAANRTLSRLGADWILGRTGRERVRVVTHCNTGALAT
SAWGTAYGIIHELHDRGALEVVYVDETRPLLQGARLTSWELTRDEIPHLLEVDGAASSTIVRGLVDVAIIGADRITANGD
TANKVGSLALALACQRAGIPFVVAAPSSTVDLATAHGDDIAIEERDAAEVLSLGGHPTALPSTRVYNPAFDVTPHDLISA
IVTDRGVVEPAARPAPNLLASVAS

Sequences:

>Translated_344_residues
MVLALQWQEDAQTIRLLDQTLLPVEERYLDVDTVDALVAAIQSLAVRGAPALGAVGALGVVVAMRQAEREGWDDERLQVE
VDRIRLARPTAVNLAWGVDQVRAAMPSGPETVLKMAKAVVEEDEAANRTLSRLGADWILGRTGRERVRVVTHCNTGALAT
SAWGTAYGIIHELHDRGALEVVYVDETRPLLQGARLTSWELTRDEIPHLLEVDGAASSTIVRGLVDVAIIGADRITANGD
TANKVGSLALALACQRAGIPFVVAAPSSTVDLATAHGDDIAIEERDAAEVLSLGGHPTALPSTRVYNPAFDVTPHDLISA
IVTDRGVVEPAARPAPNLLASVAS
>Mature_344_residues
MVLALQWQEDAQTIRLLDQTLLPVEERYLDVDTVDALVAAIQSLAVRGAPALGAVGALGVVVAMRQAEREGWDDERLQVE
VDRIRLARPTAVNLAWGVDQVRAAMPSGPETVLKMAKAVVEEDEAANRTLSRLGADWILGRTGRERVRVVTHCNTGALAT
SAWGTAYGIIHELHDRGALEVVYVDETRPLLQGARLTSWELTRDEIPHLLEVDGAASSTIVRGLVDVAIIGADRITANGD
TANKVGSLALALACQRAGIPFVVAAPSSTVDLATAHGDDIAIEERDAAEVLSLGGHPTALPSTRVYNPAFDVTPHDLISA
IVTDRGVVEPAARPAPNLLASVAS

Specific function: Bifunctional protein that catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose- 1-phosphate (MTRu-1-P), and the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5- methylthiopentyl-1-phosp

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the aldolase class II family. MtnB subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=335, Percent_Identity=41.7910447761194, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI23943880, Length=322, Percent_Identity=37.888198757764, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17557462, Length=325, Percent_Identity=38.7692307692308, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325375, Length=381, Percent_Identity=34.1207349081365, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21357667, Length=343, Percent_Identity=38.7755102040816, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24651647, Length=343, Percent_Identity=38.7755102040816, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- InterPro:   IPR017714 [H]

Pfam domain/function: PF00596 Aldolase_II; PF01008 IF-2B [H]

EC number: =5.3.1.23; =4.2.1.109 [H]

Molecular weight: Translated: 36529; Mature: 36529

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLALQWQEDAQTIRLLDQTLLPVEERYLDVDTVDALVAAIQSLAVRGAPALGAVGALGV
CEEEEEECHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VVAMRQAEREGWDDERLQVEVDRIRLARPTAVNLAWGVDQVRAAMPSGPETVLKMAKAVV
HHHHHHHHHCCCCCCCEEEEEEHEEECCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHH
EEDEAANRTLSRLGADWILGRTGRERVRVVTHCNTGALATSAWGTAYGIIHELHDRGALE
HCHHHHHHHHHHHCCHHEECCCCCCEEEEEEECCCCCEECCCCHHHHHHHHHHCCCCCEE
VVYVDETRPLLQGARLTSWELTRDEIPHLLEVDGAASSTIVRGLVDVAIIGADRITANGD
EEEECCCCHHHHCCCCCEEECCHHHCCCEEEECCCCHHHHHHHHHHHEEECCCEEECCCC
TANKVGSLALALACQRAGIPFVVAAPSSTVDLATAHGDDIAIEERDAAEVLSLGGHPTAL
CHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCEEECCCCHHHHHHCCCCCCCC
PSTRVYNPAFDVTPHDLISAIVTDRGVVEPAARPAPNLLASVAS
CCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MVLALQWQEDAQTIRLLDQTLLPVEERYLDVDTVDALVAAIQSLAVRGAPALGAVGALGV
CEEEEEECHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VVAMRQAEREGWDDERLQVEVDRIRLARPTAVNLAWGVDQVRAAMPSGPETVLKMAKAVV
HHHHHHHHHCCCCCCCEEEEEEHEEECCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHH
EEDEAANRTLSRLGADWILGRTGRERVRVVTHCNTGALATSAWGTAYGIIHELHDRGALE
HCHHHHHHHHHHHCCHHEECCCCCCEEEEEEECCCCCEECCCCHHHHHHHHHHCCCCCEE
VVYVDETRPLLQGARLTSWELTRDEIPHLLEVDGAASSTIVRGLVDVAIIGADRITANGD
EEEECCCCHHHHCCCCCEEECCHHHCCCEEEECCCCHHHHHHHHHHHEEECCCEEECCCC
TANKVGSLALALACQRAGIPFVVAAPSSTVDLATAHGDDIAIEERDAAEVLSLGGHPTAL
CHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCEEECCCCHHHHHHCCCCCCCC
PSTRVYNPAFDVTPHDLISAIVTDRGVVEPAARPAPNLLASVAS
CCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA