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The map label for this gene is cvrA [H]

Identifier: 119714565

GI number: 119714565

Start: 316905

End: 318422

Strand: Direct

Name: cvrA [H]

Synonym: Noca_0298

Alternate gene names: 119714565

Gene position: 316905-318422 (Clockwise)

Preceding gene: 119714564

Following gene: 119714569

Centisome position: 6.36

GC content: 73.19

Gene sequence:

>1518_bases
GTGTCGTTCGACGTCCACGATCTCGACACGTTCATCCTCGTGGGCTCGGCGGTCACGCTCCTGGCGATCCTGGCCGTCCG
GGTCTCCACCGGCGCCGGACTGCCCAGCCTGCTGATCTACCTGCTCATGGGTGCCGCACTGGGCGAGTCGGGCGTCGGCA
TCCAGTTCGAGAACTACGAGGTCGCGCACGCGGTCGGCTTCGCCGCGCTGGCGATGATCCTCGCCGAGGGTGGCCTGACC
ACGAACTGGCCCGAGATGCGCGGCTGCATCCGGCTCGGCGTCTCGCTGGCGACGCTCGGCGTCGCGGTGTCGGTCACCGT
GGTCGCCGTCGGCGCGCACTACCTGCTCGGCATGCCGTGGCAGCTGGCGGTCCTGCTCGGGGCGGTCACGTCGCCGACCG
ACGCGGCGGCGGTGTTCTCGGTGCTCCGGGTGGTGCCGCTGCCCAAGCGGCTGACCGGGACGCTCGAGGCCGAGTCGGGT
CTCAACGACGCACCCACCGTCGTCCTGGTCACGCTGATCTCGAGCGGGGCGGTCGAGGACAACGGCGCGCTCGCCATGGT
CGGCATCGTCGGCTACGAGCTCGCGATCGGGGTCGCGCTCGGCCTGGCCGCCGGGTACGGCGGCGCCTGGGTGATGCGCC
GGGCCGCGCTGCCCTCCTCCGGCCTCTACCCGCTCGCGGTGATGACCCTCGCCTTCCTGGGGTACGGCGCCGCCGCGTTC
GTGCACGGGTCCGGCTTCGCCGCGGTGTACGTCGCGGCCCTGGTCCTCGGCAACTCCGAGCTCCCCCACCGGGCGGCGAC
CCGGTCCTTCGCCGAGGGGCTGGCCTGGCTGTCCCAGATCGGCCTGTTCGTCACCCTGGGCCTGCTGCTCTCGCCGGGGC
GGATCAGCCTCTCGACCGTGGGCCTGGCGATCGTCGCCGGCCTGGTCCTCACCTTCGTCGCGCGGCCGCTGTCGGTGCTG
GCCAGTGCGGTCGTGCAGCCACTGCCGTGGCGCGAGCTCTCGTTCGTGTCCTGGGCCGGTCTGCGCGGGGCGGTGCCGAT
CGTGCTCACGACGATCCCGCTCGCCGAGGGCGTCGACGATGCGGAGCGGCTCTTCGACCTGGTCTTCGTGATGGTCGTGC
TCTACACGGTGCTGACCGGGCCGACGCTGCCACTCGTCGCCCGGGTCCTGCGGGTCGCCCGGCGCTCCGAGCCGCGCGGG
CTCGAGGTCGAGGCCGCGCCCCTGGAGCGGATCGCGGCCGACCTGCTGCAGGTCTCGATCGCGCCCGGATCGCGGATGCA
CGGCGTCGAGGTCGGCGAGCTCCGGCTGCCGCGCGGTGCCTCGGTGTCGATGGTGATCCGGGACGGCAACACGCTGGTGC
CCGAGCGGCGTACCGTCCTCCGGCAGGGCGACGACCTCCTGGTGGTGACTCCTCGCAAGCTGCGTTGGCAGACCGAGGAG
CGACTGCGCCAGGTCAGTGCGCGCGGCCGGCTCGCCCAGTGGCTGGTCGAGAAGCCCGCCCGCCGGCCCCAGCCCTGA

Upstream 100 bases:

>100_bases
GGCGCCCCGGCTACACACCCACCGGCTGACGCGCCTGGCAGGCGGGGGTGGGCGCACCGATAGACTGCGGTCCCGCCCCG
CGACGAGGCCGAGGTGATCC

Downstream 100 bases:

>100_bases
GCATCGGGGGGCCTGGGCGCCCCTCAGCCGACCGGCGGGCTGCAGATCGTGGCGTCGTCCTCGGCCTGCACCGAGCGGCG
GCCCTCGACCAGGTCCTGGA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSFDVHDLDTFILVGSAVTLLAILAVRVSTGAGLPSLLIYLLMGAALGESGVGIQFENYEVAHAVGFAALAMILAEGGLT
TNWPEMRGCIRLGVSLATLGVAVSVTVVAVGAHYLLGMPWQLAVLLGAVTSPTDAAAVFSVLRVVPLPKRLTGTLEAESG
LNDAPTVVLVTLISSGAVEDNGALAMVGIVGYELAIGVALGLAAGYGGAWVMRRAALPSSGLYPLAVMTLAFLGYGAAAF
VHGSGFAAVYVAALVLGNSELPHRAATRSFAEGLAWLSQIGLFVTLGLLLSPGRISLSTVGLAIVAGLVLTFVARPLSVL
ASAVVQPLPWRELSFVSWAGLRGAVPIVLTTIPLAEGVDDAERLFDLVFVMVVLYTVLTGPTLPLVARVLRVARRSEPRG
LEVEAAPLERIAADLLQVSIAPGSRMHGVEVGELRLPRGASVSMVIRDGNTLVPERRTVLRQGDDLLVVTPRKLRWQTEE
RLRQVSARGRLAQWLVEKPARRPQP

Sequences:

>Translated_505_residues
MSFDVHDLDTFILVGSAVTLLAILAVRVSTGAGLPSLLIYLLMGAALGESGVGIQFENYEVAHAVGFAALAMILAEGGLT
TNWPEMRGCIRLGVSLATLGVAVSVTVVAVGAHYLLGMPWQLAVLLGAVTSPTDAAAVFSVLRVVPLPKRLTGTLEAESG
LNDAPTVVLVTLISSGAVEDNGALAMVGIVGYELAIGVALGLAAGYGGAWVMRRAALPSSGLYPLAVMTLAFLGYGAAAF
VHGSGFAAVYVAALVLGNSELPHRAATRSFAEGLAWLSQIGLFVTLGLLLSPGRISLSTVGLAIVAGLVLTFVARPLSVL
ASAVVQPLPWRELSFVSWAGLRGAVPIVLTTIPLAEGVDDAERLFDLVFVMVVLYTVLTGPTLPLVARVLRVARRSEPRG
LEVEAAPLERIAADLLQVSIAPGSRMHGVEVGELRLPRGASVSMVIRDGNTLVPERRTVLRQGDDLLVVTPRKLRWQTEE
RLRQVSARGRLAQWLVEKPARRPQP
>Mature_504_residues
SFDVHDLDTFILVGSAVTLLAILAVRVSTGAGLPSLLIYLLMGAALGESGVGIQFENYEVAHAVGFAALAMILAEGGLTT
NWPEMRGCIRLGVSLATLGVAVSVTVVAVGAHYLLGMPWQLAVLLGAVTSPTDAAAVFSVLRVVPLPKRLTGTLEAESGL
NDAPTVVLVTLISSGAVEDNGALAMVGIVGYELAIGVALGLAAGYGGAWVMRRAALPSSGLYPLAVMTLAFLGYGAAAFV
HGSGFAAVYVAALVLGNSELPHRAATRSFAEGLAWLSQIGLFVTLGLLLSPGRISLSTVGLAIVAGLVLTFVARPLSVLA
SAVVQPLPWRELSFVSWAGLRGAVPIVLTTIPLAEGVDDAERLFDLVFVMVVLYTVLTGPTLPLVARVLRVARRSEPRGL
EVEAAPLERIAADLLQVSIAPGSRMHGVEVGELRLPRGASVSMVIRDGNTLVPERRTVLRQGDDLLVVTPRKLRWQTEER
LRQVSARGRLAQWLVEKPARRPQP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=476, Percent_Identity=34.0336134453782, Blast_Score=194, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52990; Mature: 52859

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDVHDLDTFILVGSAVTLLAILAVRVSTGAGLPSLLIYLLMGAALGESGVGIQFENYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCH
VAHAVGFAALAMILAEGGLTTNWPEMRGCIRLGVSLATLGVAVSVTVVAVGAHYLLGMPW
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLAVLLGAVTSPTDAAAVFSVLRVVPLPKRLTGTLEAESGLNDAPTVVLVTLISSGAVED
HHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCHHHHHHHHHCCCCCC
NGALAMVGIVGYELAIGVALGLAAGYGGAWVMRRAALPSSGLYPLAVMTLAFLGYGAAAF
CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHEE
VHGSGFAAVYVAALVLGNSELPHRAATRSFAEGLAWLSQIGLFVTLGLLLSPGRISLSTV
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GLAIVAGLVLTFVARPLSVLASAVVQPLPWRELSFVSWAGLRGAVPIVLTTIPLAEGVDD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCH
AERLFDLVFVMVVLYTVLTGPTLPLVARVLRVARRSEPRGLEVEAAPLERIAADLLQVSI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHEEC
APGSRMHGVEVGELRLPRGASVSMVIRDGNTLVPERRTVLRQGDDLLVVTPRKLRWQTEE
CCCCCCCCCEECCEECCCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCHHHCCCHHH
RLRQVSARGRLAQWLVEKPARRPQP
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SFDVHDLDTFILVGSAVTLLAILAVRVSTGAGLPSLLIYLLMGAALGESGVGIQFENYE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCH
VAHAVGFAALAMILAEGGLTTNWPEMRGCIRLGVSLATLGVAVSVTVVAVGAHYLLGMPW
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLAVLLGAVTSPTDAAAVFSVLRVVPLPKRLTGTLEAESGLNDAPTVVLVTLISSGAVED
HHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCHHHHHHHHHCCCCCC
NGALAMVGIVGYELAIGVALGLAAGYGGAWVMRRAALPSSGLYPLAVMTLAFLGYGAAAF
CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHEE
VHGSGFAAVYVAALVLGNSELPHRAATRSFAEGLAWLSQIGLFVTLGLLLSPGRISLSTV
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GLAIVAGLVLTFVARPLSVLASAVVQPLPWRELSFVSWAGLRGAVPIVLTTIPLAEGVDD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCH
AERLFDLVFVMVVLYTVLTGPTLPLVARVLRVARRSEPRGLEVEAAPLERIAADLLQVSI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHEEC
APGSRMHGVEVGELRLPRGASVSMVIRDGNTLVPERRTVLRQGDDLLVVTPRKLRWQTEE
CCCCCCCCCEECCEECCCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCHHHCCCHHH
RLRQVSARGRLAQWLVEKPARRPQP
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA