Click here to switch to the map view.

The map label for this gene is lldD2 [H]

Identifier: 119714547

GI number: 119714547

Start: 301391

End: 302623

Strand: Direct

Name: lldD2 [H]

Synonym: Noca_0280

Alternate gene names: 119714547

Gene position: 301391-302623 (Clockwise)

Preceding gene: 119714545

Following gene: 119714548

Centisome position: 6.04

GC content: 70.88

Gene sequence:

>1233_bases
GTGAAACGTCAGCTCCCACGTCGACGCGACCTGGCTCCTCTGGTGCGGTTCCGTACCCCGGTGCTCTCCCCTCGCGGCCG
CCGGCTCCGGGACGCGCTCACCATCGAGGACCTGCGCCGGGCGGCTCGCCGGCGCACGCCCCGGGCGGCGTTCGACTACA
CCGACGGCGCCGCCGACGACGAGATTTCGCTGGCGCGGGCGCGGCAGGCGTTCCGCGACGTGCAGTTCAATCCGGGGGTG
CTCCGCGACGTCTCGTCGGTGGACACCTCCCGGGAGGTGCTGGGGGCTCGCGCGTCCCTCCCGTTCGGGATCGCGCCGAC
CGGGTTCACGCGGTTGATGCACACGGAGGGCGAGGTGGCCGGGGCAACAGCGGCAGCGGCGGCCGGCATCCCGTTCGCGC
TCTCGACGATGGGGACGACCTCGATCGAGGACGTCGCCGCGGCAGCACCGAGCGGTCGCCACTGGTTCCAGCTGTACATG
TGGAAGGACCGCGACCGCTCGATGGCACTGGTCGAGCGGGCGGCGCGAGCCGGGTTCGACGCCCTCCTCGTCACGGTCGA
CGTCCCGGTCGCGGGGGCCCGGCTGCGCGATGTCCGCAACGGGATGACGATCCCGCCGACCCTGACGCCTCGGACGGTGC
TCGACGCAATTCCCCGGATGCGGTGGTGGTTCGATCTGCTCACCACCGAGCCCCTCGCGTTCGCGACGCTCGACTCCTGG
TCCGGCACCGTCGCAGAACTGCTCGACACGATGTTCGACCCGACGGTGACGTTCGAGGACCTCGCCTGGATCAAGGAGCA
GTGGCCCGGTCGGCTCGTGGTGAAGGGCATCCAGACGGTCGACGACGCGAGACGGGTCGCCGACCTCGGCGCCGACGCAG
TCCTGTTGTCGAACCATGGCGGCCGACAGCTCGACCGTGCACCGATCCCGTTCCGCCTGCTGCCCGAGGTCGTCGCAGCG
GTCGGACAGGATGTCGAGGTCCACCTCGACACCGGGATCATGTCGGGGCAGGACATCGTCGCGGCCCTCGCACACGGAGC
CAGGTTCACCCTGGTCGGACGCGCCTATCTCTACGGGCTCATGGCCGGTGGCCGCGATGGCGTCGACCGCGCGGTCGAGA
TCCTCCGCAGCCAGGTGGAGCGGACCATGCGACTCCTCGGTGTTCGCTCGCTCGGCGATCTCGAGCCAGGTCATGTGACC
CAGCTCGACCGGCTGGAGCCGCGCCGCCGATAA

Upstream 100 bases:

>100_bases
CGGGGAGCGCGGCGAGCGTCGTCTTCCTCATGTCGGGGCAGTACCCAACCGGCAGCGGGCGAGTCGGGACCTCGGGAGCC
GCTTCGGCGATGATGTCGGG

Downstream 100 bases:

>100_bases
CCCCGAGTTGTGGTACGTCGTTGCGCCGGGCGTGAATCGGTACGCCGCTGCCCTGGTCGTCGCCCTCTCCGCGCTGGTCG
CACCGCCCGCCCATGCCGCA

Product: (S)-2-hydroxy-acid oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADDEISLARARQAFRDVQFNPGV
LRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVAGATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYM
WKDRDRSMALVERAARAGFDALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSW
SGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHGGRQLDRAPIPFRLLPEVVAA
VGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGLMAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVT
QLDRLEPRRR

Sequences:

>Translated_410_residues
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADDEISLARARQAFRDVQFNPGV
LRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVAGATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYM
WKDRDRSMALVERAARAGFDALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSW
SGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHGGRQLDRAPIPFRLLPEVVAA
VGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGLMAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVT
QLDRLEPRRR
>Mature_410_residues
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADDEISLARARQAFRDVQFNPGV
LRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVAGATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYM
WKDRDRSMALVERAARAGFDALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSW
SGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHGGRQLDRAPIPFRLLPEVVAA
VGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGLMAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVT
QLDRLEPRRR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=36.8421052631579, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI54234014, Length=377, Percent_Identity=34.7480106100796, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI7705393, Length=377, Percent_Identity=34.7480106100796, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=35.9249329758713, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI193208036, Length=377, Percent_Identity=34.2175066312997, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32566217, Length=287, Percent_Identity=33.4494773519164, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=31.6622691292876, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI281363140, Length=376, Percent_Identity=39.3617021276596, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI78707190, Length=376, Percent_Identity=39.3617021276596, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI78707188, Length=376, Percent_Identity=39.3617021276596, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 45169; Mature: 45169

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADD
CCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EISLARARQAFRDVQFNPGVLRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVA
HHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
GATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYMWKDRDRSMALVERAARAGFD
CHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCE
ALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSW
EEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHG
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCC
GRQLDRAPIPFRLLPEVVAAVGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGL
CCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEHHHHHHHHH
MAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVTQLDRLEPRRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MKRQLPRRRDLAPLVRFRTPVLSPRGRRLRDALTIEDLRRAARRRTPRAAFDYTDGAADD
CCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EISLARARQAFRDVQFNPGVLRDVSSVDTSREVLGARASLPFGIAPTGFTRLMHTEGEVA
HHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
GATAAAAAGIPFALSTMGTTSIEDVAAAAPSGRHWFQLYMWKDRDRSMALVERAARAGFD
CHHHHHHCCCCHHHHHCCCCCHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCE
ALLVTVDVPVAGARLRDVRNGMTIPPTLTPRTVLDAIPRMRWWFDLLTTEPLAFATLDSW
EEEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SGTVAELLDTMFDPTVTFEDLAWIKEQWPGRLVVKGIQTVDDARRVADLGADAVLLSNHG
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCC
GRQLDRAPIPFRLLPEVVAAVGQDVEVHLDTGIMSGQDIVAALAHGARFTLVGRAYLYGL
CCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEHHHHHHHHH
MAGGRDGVDRAVEILRSQVERTMRLLGVRSLGDLEPGHVTQLDRLEPRRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]