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The map label for this gene is pntA [H]

Identifier: 119714527

GI number: 119714527

Start: 278976

End: 280460

Strand: Direct

Name: pntA [H]

Synonym: Noca_0260

Alternate gene names: 119714527

Gene position: 278976-280460 (Clockwise)

Preceding gene: 119714526

Following gene: 119714528

Centisome position: 5.6

GC content: 72.05

Gene sequence:

>1485_bases
GTGGCCGCGACCGCCCAGACGGCGTCACGGCTGGTCAAGCTCGGCTACGACGTCGTCGTCGAGTCCGGCGCCGGGGGTCC
GGCCAGCCAGCCCGACGAGGCGTATGCCGAGGCCGGCGTCACGGTGAGCAGCGCCGAGGAGGTGTGGTCCAGCGACGTCG
TCGTCAAGATCAACGCTCCCACCGACGACGAGGTCGCGCGCCTGGGCCGCGGCGCCACGGTGGTGTCGCTGATGGCGCCG
GCGCGCTCGCCCGAGCTCGTCGAGCGGCTCGCCGCCGCGGGCGTGACCGCGCTGGCGATGGACGCGGTGCCGCGGATCTC
GCGGGCACAGTCGATGGACGTGCTCTCGTCGATGGCCAACGTCGCCGGCTACCGGGCGGTCGTCGAGGCCGCGCACGCCT
TCGGCCGCCAGTTCACCGGCCAGGTCACCGCGGCCGGCAAGATCCCGCCGGCGCGGGTGTTCGTCGTCGGCGCCGGCGTC
GCCGGGCTCGCGGCGATCGGCGCGGCTGGCTCGATGGGCGCGATCGTCCGCGCCTTCGACGTACGACCCGAGGTCGCCGA
GCAGGTCGAGTCGATGGGGGCGGAGTTCGTCACCGTCGACATGCAGTCCGAGGTCAGCTCCGACGGCTACGCCAAGGAGA
TGACCGCGGAGCAGGAGAAGGCGACGGCCGTCATGTACGACGAGGAGGCGCGCGCGGCCGACATCGTCATCACCACCGCT
CTGATCCCGGGGCGCCCGGCGCCGCGACTGATCGGCGAGGAGACGGTGGCCGGCATGCGCCCCGGCAGCGTGATCGTCGA
CATGGCCGCGGCCAACGGCGGCAACGTCGCGATGACGGTCGCGGACGAGGAGGTCGTCACCGACAACGGTGTCCGGATCC
TCGGCTACACCGACCTCGCGGGCCGCCTGGCGGCGCAGACCTCCCAGCTCTACGGCACCAACGTCGTCAACCTGCTGACG
CTGATGACGCCCGAGAAGGATGGTGCCCTCACCCTCGACCTCGACGACCCGGTCCAGCGCGGGCTGACGGTCGTGCGCGA
GGGGGAGGTGCTCTGGCCGCCGCCGCCGGTGCAGGTGTCCGCCGCGCCCAAGGCTCCGGCGCCGACCGCACCGGCCGAGC
CACCGCCGCCGAAGAAGAAGCGGCCGATGTGGCTGGTGTTCGCCGCGGCGTCCGTCCTGCTGTTCCTCGTGGCCACGACG
GCCCCGGCCCCGCTGCCGGAGCACTTCTTCGTGCTCACGCTCGCGATCGTGATCGGCTACTACGTGATCGGCCACGTGCA
CCACGCGCTGCACACGCCCTTGATGAGCGTCACCAACGCGATCTCGGGGATCATCGTCGTCGGAGCGATGCTCCAGCTCG
GGGTCGATGACGCCGCCGTACGCACCCTGTCCTTCGTCGCAGTGCTCCTGGCCAGCATCAACGTGTTCGGCGGCTTCGCC
GTGACCCGCCGGATGCTCGGCATGTTCCGGAAGGCGGACCAGTGA

Upstream 100 bases:

>100_bases
GGTTCGAGTCCGGCTGGTGAGGTGTCTCCGGCCGTCAGCGTCCTCAGGAGGTTTTGTGCGTATCGGTGTTCCGCGCGAGT
CGCGAGCGGGTGAGACCCTC

Downstream 100 bases:

>100_bases
TGAGTGCCGTAAGCATCTCCGTCGGCGCCTACCTGGTCGCCTCGCTCCTGTTCATCCTCAGCCTCGCCGGCCTGTCGCGC
CACGAGAGCGCCCGCAACGG

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha; Pyridine nucleotide transhydrogenase subunit alpha [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MAATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAPTDDEVARLGRGATVVSLMAP
ARSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMANVAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGV
AGLAAIGAAGSMGAIVRAFDVRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTA
LIPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLAGRLAAQTSQLYGTNVVNLLT
LMTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVSAAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATT
APAPLPEHFFVLTLAIVIGYYVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFA
VTRRMLGMFRKADQ

Sequences:

>Translated_494_residues
MAATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAPTDDEVARLGRGATVVSLMAP
ARSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMANVAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGV
AGLAAIGAAGSMGAIVRAFDVRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTA
LIPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLAGRLAAQTSQLYGTNVVNLLT
LMTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVSAAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATT
APAPLPEHFFVLTLAIVIGYYVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFA
VTRRMLGMFRKADQ
>Mature_493_residues
AATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAPTDDEVARLGRGATVVSLMAPA
RSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMANVAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGVA
GLAAIGAAGSMGAIVRAFDVRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTAL
IPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLAGRLAAQTSQLYGTNVVNLLTL
MTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVSAAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATTA
PAPLPEHFFVLTLAIVIGYYVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFAV
TRRMLGMFRKADQ

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=510, Percent_Identity=41.9607843137255, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI122939153, Length=510, Percent_Identity=41.9607843137255, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1787887, Length=495, Percent_Identity=59.1919191919192, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17550456, Length=494, Percent_Identity=43.7246963562753, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR004571 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 51225; Mature: 51094

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAP
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHCCCEECCHHHHCCCCEEEEEECC
TDDEVARLGRGATVVSLMAPARSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMAN
CCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGVAGLAAIGAAGSMGAIVRAFD
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHC
VRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTA
CCHHHHHHHHHCCCEEEEEEEHHHCCCCCCHHHHHHHHHHCEEEEECCCCCCEEEEEEEE
LIPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLA
ECCCCCCCCHHCHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEECCCCEEEEEEHHHH
GRLAAQTSQLYGTNVVNLLTLMTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVS
HHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEECCCHHHHCCEEEECCCEECCCCCCEEE
AAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATTAPAPLPEHFFVLTLAIVIGY
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTRRMLGMFRKADQ
HHHHHHHHHHHCCC
>Mature Secondary Structure 
AATAQTASRLVKLGYDVVVESGAGGPASQPDEAYAEAGVTVSSAEEVWSSDVVVKINAP
CCCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHCCCEECCHHHHCCCCEEEEEECC
TDDEVARLGRGATVVSLMAPARSPELVERLAAAGVTALAMDAVPRISRAQSMDVLSSMAN
CCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGYRAVVEAAHAFGRQFTGQVTAAGKIPPARVFVVGAGVAGLAAIGAAGSMGAIVRAFD
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCHHHHHHC
VRPEVAEQVESMGAEFVTVDMQSEVSSDGYAKEMTAEQEKATAVMYDEEARAADIVITTA
CCHHHHHHHHHCCCEEEEEEEHHHCCCCCCHHHHHHHHHHCEEEEECCCCCCEEEEEEEE
LIPGRPAPRLIGEETVAGMRPGSVIVDMAAANGGNVAMTVADEEVVTDNGVRILGYTDLA
ECCCCCCCCHHCHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEECCCCEEEEEEHHHH
GRLAAQTSQLYGTNVVNLLTLMTPEKDGALTLDLDDPVQRGLTVVREGEVLWPPPPVQVS
HHHHHHHHHHCCCCHHHHHHEECCCCCCCEEEECCCHHHHCCEEEECCCEECCCCCCEEE
AAPKAPAPTAPAEPPPPKKKRPMWLVFAAASVLLFLVATTAPAPLPEHFFVLTLAIVIGY
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YVIGHVHHALHTPLMSVTNAISGIIVVGAMLQLGVDDAAVRTLSFVAVLLASINVFGGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTRRMLGMFRKADQ
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3525165; 1633824; 9097039; 9278503; 1932078 [H]