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The map label for this gene is tcmA [H]

Identifier: 119714391

GI number: 119714391

Start: 137752

End: 139167

Strand: Direct

Name: tcmA [H]

Synonym: Noca_0124

Alternate gene names: 119714391

Gene position: 137752-139167 (Clockwise)

Preceding gene: 119714390

Following gene: 119714392

Centisome position: 2.76

GC content: 74.93

Gene sequence:

>1416_bases
TTGGCCGGACCCGATGGCGTCCGGCTCGGTACGGCGACCGGCCGCGCCGTCGTCCTCGCGGCGGTCCTCGGCTCGGGGAT
GACGATGCTCGACGGCACCGTCGTGAACGTCGCGCTGCGCACGATCGGCGCGGACCTGGACGCCTCGCTCCCCGAGCTGC
AGTGGATCACCAACGGCTACCTGCTCTCGATGGCCAGCCTGATCCTGCTGGGCGGGTCGCTGGGCGACCGGTTCGGCCGG
CGCCGGGTGTTCGTGGTGGGCACGGTGTGGTTCGCCGTCGCCTCGCTCGCGTGCGGCTCGGCGCCGACGCCGGAGGTCCT
GATCGTCGCGCGGATCCTCCAGGGCGTCGGCGCGGCCCTGCTCACGCCGGGCAGCCTCGCGATGATCCAGGGTGCCTTCG
TCCGCGACGACCGGGCCCAGGCGATCGGCTCCTGGTCCGGGTTGACGAGCATCGCGGCCGCCGTCGGGCCGCTCGTCGGC
GGCGCACTGGTGCAGTACGCCAGCTGGCGCTGGATCTTCCTGGTCAACCTGCCGATCGCGACGCTCACCGTCGTCGTCGC
CCGCCGCGCGGTCCCGGAGACGCGGGACCCGAACGCCCCCCGGCGCTTCGACGCCCTCGGCGCGGTGCTGGCCGCGCTCG
CCCTCGGCGGCCTGACCTACGCGCTGATCGAGTGGGGTGGCGCCCTCGCGCCCTGGGCCGTGGTCGTCACCGTCCTCGCG
GCTGCGGCGTACCTCGTCGACGAGCGCCGCAGCGACCACCCGATGCTGCCGCTCGGCATCTTCGCCGACCGCACCTTCAC
CGCCGCCAACGCGATGACGATGGTCGTCTACGCCGCGCTCGGTGCCGTGTTGTTCTTCCTCGTCCTGCAGCTGCAGACGG
TGAGCGGGTACGGCGCGCTCGGCGCCGGCCTGGCCACTCTGCCGATCACGTTCTGCATGCTGCTGCTCGCCTCGCAGGGC
GGCCGGCTGGGCGCCCGGATCGGCCCTCGCGTCCCGATGAGCCTCGGCCCGCTGGTGATGGCCGCGGGCACCCTGCTGCT
GCTGCGCGTCGGCGCCGGGACGACGTACTGGACCGACGTGCTGCCCGGGCTGGTCGTCTTCGGGCTGGGGCTGGCACTGC
TGGTCGCGCCGCTGACCGCCACCGTCCTGGCCGCCGTGGCCGACGAGCACGCCGGGATCGCCAGCGGCGTCAACAACGCG
GTCGCCCGCGCCGGCTCGCTGCTGGCGGTGGCCGCGCTCCCGGCCGCGGTCGGGCTGCGCGGCGAGGAGTACGCCGACCC
GGTGGCGTTCGACGCCGCCTACGGCTCGGCGATCCTCGCGTGCGCCGCGCTGCTCGCGCTGGGCGGCGTCGTCTCGTGGC
TGAGCATCCGCGACCCGGGCATCGGCCGGACCGCCGCGCCACCGATCGGAAGGTAG

Upstream 100 bases:

>100_bases
GACGCCGAGCGTGTGCAGCACCGCGCCGAAGTCCAGGGTTGCCTTCATCAGGGATTCCCCTGAGTTCACTATCGTGTTCG
TCGTGGGCGACCCCGCCGGA

Downstream 100 bases:

>100_bases
GTCGTCCCTCGGGACGCACCGCCGCGAACGGGCGGCTCTCCTGCCGCGATCCCGGGGTGCTCGCACCCGCCACGGCCGCT
TCCCGGTAGGCCTCAGGAGG

Product: EmrB/QacA family drug resistance transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MAGPDGVRLGTATGRAVVLAAVLGSGMTMLDGTVVNVALRTIGADLDASLPELQWITNGYLLSMASLILLGGSLGDRFGR
RRVFVVGTVWFAVASLACGSAPTPEVLIVARILQGVGAALLTPGSLAMIQGAFVRDDRAQAIGSWSGLTSIAAAVGPLVG
GALVQYASWRWIFLVNLPIATLTVVVARRAVPETRDPNAPRRFDALGAVLAALALGGLTYALIEWGGALAPWAVVVTVLA
AAAYLVDERRSDHPMLPLGIFADRTFTAANAMTMVVYAALGAVLFFLVLQLQTVSGYGALGAGLATLPITFCMLLLASQG
GRLGARIGPRVPMSLGPLVMAAGTLLLLRVGAGTTYWTDVLPGLVVFGLGLALLVAPLTATVLAAVADEHAGIASGVNNA
VARAGSLLAVAALPAAVGLRGEEYADPVAFDAAYGSAILACAALLALGGVVSWLSIRDPGIGRTAAPPIGR

Sequences:

>Translated_471_residues
MAGPDGVRLGTATGRAVVLAAVLGSGMTMLDGTVVNVALRTIGADLDASLPELQWITNGYLLSMASLILLGGSLGDRFGR
RRVFVVGTVWFAVASLACGSAPTPEVLIVARILQGVGAALLTPGSLAMIQGAFVRDDRAQAIGSWSGLTSIAAAVGPLVG
GALVQYASWRWIFLVNLPIATLTVVVARRAVPETRDPNAPRRFDALGAVLAALALGGLTYALIEWGGALAPWAVVVTVLA
AAAYLVDERRSDHPMLPLGIFADRTFTAANAMTMVVYAALGAVLFFLVLQLQTVSGYGALGAGLATLPITFCMLLLASQG
GRLGARIGPRVPMSLGPLVMAAGTLLLLRVGAGTTYWTDVLPGLVVFGLGLALLVAPLTATVLAAVADEHAGIASGVNNA
VARAGSLLAVAALPAAVGLRGEEYADPVAFDAAYGSAILACAALLALGGVVSWLSIRDPGIGRTAAPPIGR
>Mature_470_residues
AGPDGVRLGTATGRAVVLAAVLGSGMTMLDGTVVNVALRTIGADLDASLPELQWITNGYLLSMASLILLGGSLGDRFGRR
RVFVVGTVWFAVASLACGSAPTPEVLIVARILQGVGAALLTPGSLAMIQGAFVRDDRAQAIGSWSGLTSIAAAVGPLVGG
ALVQYASWRWIFLVNLPIATLTVVVARRAVPETRDPNAPRRFDALGAVLAALALGGLTYALIEWGGALAPWAVVVTVLAA
AAYLVDERRSDHPMLPLGIFADRTFTAANAMTMVVYAALGAVLFFLVLQLQTVSGYGALGAGLATLPITFCMLLLASQGG
RLGARIGPRVPMSLGPLVMAAGTLLLLRVGAGTTYWTDVLPGLVVFGLGLALLVAPLTATVLAAVADEHAGIASGVNNAV
ARAGSLLAVAALPAAVGLRGEEYADPVAFDAAYGSAILACAALLALGGVVSWLSIRDPGIGRTAAPPIGR

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=397, Percent_Identity=29.7229219143577, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790195, Length=381, Percent_Identity=28.6089238845144, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1788710, Length=390, Percent_Identity=28.4615384615385, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789042, Length=393, Percent_Identity=28.2442748091603, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788392, Length=296, Percent_Identity=31.4189189189189, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790146, Length=168, Percent_Identity=29.7619047619048, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787065, Length=123, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=374, Percent_Identity=24.331550802139, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325455, Length=158, Percent_Identity=31.0126582278481, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323520, Length=391, Percent_Identity=23.0179028132992, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=412, Percent_Identity=23.7864077669903, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319770, Length=326, Percent_Identity=23.6196319018405, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=153, Percent_Identity=30.718954248366, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47856; Mature: 47725

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPDGVRLGTATGRAVVLAAVLGSGMTMLDGTVVNVALRTIGADLDASLPELQWITNGY
CCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHH
LLSMASLILLGGSLGDRFGRRRVFVVGTVWFAVASLACGSAPTPEVLIVARILQGVGAAL
HHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
LTPGSLAMIQGAFVRDDRAQAIGSWSGLTSIAAAVGPLVGGALVQYASWRWIFLVNLPIA
CCCCCHHHHHCHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
TLTVVVARRAVPETRDPNAPRRFDALGAVLAALALGGLTYALIEWGGALAPWAVVVTVLA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AAAYLVDERRSDHPMLPLGIFADRTFTAANAMTMVVYAALGAVLFFLVLQLQTVSGYGAL
HHHHHHHHCCCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GAGLATLPITFCMLLLASQGGRLGARIGPRVPMSLGPLVMAAGTLLLLRVGAGTTYWTDV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHH
LPGLVVFGLGLALLVAPLTATVLAAVADEHAGIASGVNNAVARAGSLLAVAALPAAVGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEEYADPVAFDAAYGSAILACAALLALGGVVSWLSIRDPGIGRTAAPPIGR
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGPDGVRLGTATGRAVVLAAVLGSGMTMLDGTVVNVALRTIGADLDASLPELQWITNGY
CCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHH
LLSMASLILLGGSLGDRFGRRRVFVVGTVWFAVASLACGSAPTPEVLIVARILQGVGAAL
HHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
LTPGSLAMIQGAFVRDDRAQAIGSWSGLTSIAAAVGPLVGGALVQYASWRWIFLVNLPIA
CCCCCHHHHHCHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHH
TLTVVVARRAVPETRDPNAPRRFDALGAVLAALALGGLTYALIEWGGALAPWAVVVTVLA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AAAYLVDERRSDHPMLPLGIFADRTFTAANAMTMVVYAALGAVLFFLVLQLQTVSGYGAL
HHHHHHHHCCCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GAGLATLPITFCMLLLASQGGRLGARIGPRVPMSLGPLVMAAGTLLLLRVGAGTTYWTDV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHH
LPGLVVFGLGLALLVAPLTATVLAAVADEHAGIASGVNNAVARAGSLLAVAALPAAVGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEEYADPVAFDAAYGSAILACAALLALGGVVSWLSIRDPGIGRTAAPPIGR
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]