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The map label for this gene is proA

Identifier: 119387208

GI number: 119387208

Start: 1718596

End: 1719867

Strand: Direct

Name: proA

Synonym: Pden_4503

Alternate gene names: 119387208

Gene position: 1718596-1719867 (Clockwise)

Preceding gene: 119387207

Following gene: 119387210

Centisome position: 99.34

GC content: 68.55

Gene sequence:

>1272_bases
ATGAAAGACCTGACCTCTTCCGATGCCGATGCGCTGATCGCGGATCTGGGGCAAAAGGCCCGCGCCGCCGCAGCCGTGCT
GGCCGAGGCGAGCGCCGAGCGCAAGCATGCCGCCCTGATCGGCGCCGCCGATGCGATCCTCGAAGCCGAGGATGCCATCC
TCGACGCCAATGCCGAGGACATGCATTACGCCGAGGAAAAGGGCCTTTCGCCCGCCATGCTGGACCGGCTGAAGCTCGAT
CCCGCGCGCATCCGCGCCATGGCCGAGGGGCTGCGTTCGGTCGCGGCGCAGGCGGACCCGGTCGGCAAGGTGCTGGCCGA
ATGGGATCGGCCGAACGGGCTGAACATCCGGCGCGTGGCCACGCCCCTGGGCGTGATCGGCGTGGTCTACGAAAGCCGGC
CGAACGTCACCGCCGATGCGGCCGCACTGGCGCTGAAGGCCGGCAATGCGGTGATCCTGCGCGGCGGCTCGGAAAGCCTG
AACAGCTCGGCCGCGATCCATCGGGCGCTGGTCACCGGGCTGAAGCAGGCCGGCCTGCCCGAGACGGCGATCCAGATGGT
GCCGACCCGCGACCGAGAGGCGGTCGCCGCCATGCTGCGCGCGCAGGACTATATCGACGTGATCGTGCCGCGGGGCGGCA
AGGGGCTGGTCGGGCTGGTGCAGAAAGAGGCCCGCGTGCCGGTCTTTGCCCATCTGGAAGGCATCTGCCACGTCTATGCC
GACCGCGACGCCGACCTGGACAAGGCCCGCCGCGTGGTTCTGAACGCCAAGACGCGGCGCACCGGCATCTGCGGCGCCGC
CGAATGCCTGTTGATCGACTGGCAGTTCTATACGAAACACGGTCCCGTGCTGGTCCAGGACCTGCTGGACGCAGGCGTCG
AGGTGCGGGCCGAGGGCGAGCTTGCCAAGGTGCCGGGCACCGTGCCGGCCGAGCCCTCGGATTTCGGGCAGGAGTTCCTG
GACAAGATCATCGCCGTCAAGCTGGTCGATGGCGTCGAAGAGGCGATCGCCCATATCCGCCGCCATGGCTCGGGCCATAC
CGAATCGATCCTGACCGAAAACGACGCCACGGCCGAGCGCTTCTTCAGCGGGCTCGACAGCGCCATCCTGATGCGCAATG
CCTCGACGCAATTCGCCGATGGCGGCGAGTTCGGCATGGGCGCCGAGATCGGCATCGCCACCGGCAAGATGCATGCGCGC
GGGCCGGTCGGTGCCGAGCAGCTGACCAGCTTCAAGTATCTGGTCACCGGCGACGGCACCATCCGGCCCTGA

Upstream 100 bases:

>100_bases
CCGCAGGAGCCTGGCAACAGAATCCTGCACCTTACCCCTTTCCATCTGGTTTTTCGGCGCGCCCGGGCCTATCTCAGGCG
TCATGCAAGGGAATGCCGCC

Downstream 100 bases:

>100_bases
TCGGACCAAGGCCCGAGCGGCGAAACCCGGCGGGATCCGAGCCTCAGAACGCGATCTCGCCGCCGGTCCCGTCCAGCTCC
CATGCCAGCGGTCGGCCTGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAEDMHYAEEKGLSPAMLDRLKLD
PARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVATPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESL
NSSAAIHRALVTGLKQAGLPETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYA
DRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGELAKVPGTVPAEPSDFGQEFL
DKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAERFFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGAEQLTSFKYLVTGDGTIRP

Sequences:

>Translated_423_residues
MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAEDMHYAEEKGLSPAMLDRLKLD
PARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVATPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESL
NSSAAIHRALVTGLKQAGLPETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYA
DRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGELAKVPGTVPAEPSDFGQEFL
DKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAERFFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGAEQLTSFKYLVTGDGTIRP
>Mature_423_residues
MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAEDMHYAEEKGLSPAMLDRLKLD
PARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVATPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESL
NSSAAIHRALVTGLKQAGLPETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYA
DRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGELAKVPGTVPAEPSDFGQEFL
DKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAERFFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHAR
GPVGAEQLTSFKYLVTGDGTIRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=406, Percent_Identity=38.6699507389163, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI62912457, Length=406, Percent_Identity=38.6699507389163, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=41.8269230769231, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=39.4673123486683, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=39.4673123486683, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=39.2523364485981, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=36.8550368550369, Blast_Score=265, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PARDP (A1BAM3)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_918263.1
- ProteinModelPortal:   A1BAM3
- SMR:   A1BAM3
- STRING:   A1BAM3
- GeneID:   4583053
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_4503
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   A1BAM3
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44707; Mature: 44707

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAED
CCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MHYAEEKGLSPAMLDRLKLDPARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVA
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEHHHH
TPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESLNSSAAIHRALVTGLKQAGLP
CCHHEEEEEEECCCCCCHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
ETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYA
HHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHEEC
DRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGE
CCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEECCC
LAKVPGTVPAEPSDFGQEFLDKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAER
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHH
FFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHARGPVGAEQLTSFKYLVTGDGT
HHHCCCHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCEEEEEECCCC
IRP
CCC
>Mature Secondary Structure
MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAED
CCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MHYAEEKGLSPAMLDRLKLDPARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVA
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEHHHH
TPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESLNSSAAIHRALVTGLKQAGLP
CCHHEEEEEEECCCCCCHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
ETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYA
HHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHEEC
DRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGE
CCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEECCC
LAKVPGTVPAEPSDFGQEFLDKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAER
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHH
FFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHARGPVGAEQLTSFKYLVTGDGT
HHHCCCHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCEEEEEECCCC
IRP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA