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The map label for this gene is cobB [H]

Identifier: 119387125

GI number: 119387125

Start: 1622162

End: 1622842

Strand: Direct

Name: cobB [H]

Synonym: Pden_4420

Alternate gene names: 119387125

Gene position: 1622162-1622842 (Clockwise)

Preceding gene: 119387124

Following gene: 119387126

Centisome position: 93.76

GC content: 70.34

Gene sequence:

>681_bases
ATGCGCATCACCGTGCTGACGGGGGCCGGCATTTCGGCCGAAAGCGGGATCAGGACGTTCCGCGCCACTGACGGGCTGTG
GGAATCCCACCGGATCGAGGACGTCGCCACGCCCCAGGGCTTTCAGCGCGACCCGGCACTGGTGCATCGCTTCTACAACC
AGCGCCGCGCCGATGCCGCCCGCGCCCAGCCCAACCTTGCGCATCGGGCGCTTGCACGGCTTGCGGAACATCACCGGGTG
ACGCTGGTCACGCAGAACGTGGACGACCTGCACGAACGCGGCGGCTCGCCCGAGGTGATCCACATGCATGGCAGCCTGCT
CGGCGCGCTCTGCGCCGGCTGCGGGCATCGCTGGCCGGCGGCGCTGGTGATGCGGGCGCTGGACCCCTGCCCCAGTTGCG
GCAAGCCGCAGACACGGCCCGACATCGTCTGGTTCGGCGAGATCCCCTATCACATGGAGCGGATATGGGAGGCGGTCGAA
CAGGCCGACCTCTTCGCCGCCATCGGCACCTCGGGCCTCGTCTATCCGGCGGCGGGGCTGGCGCAGCACGCCCGCCGCAA
CGGTGCCGAAACGGTCGAACTGAACCTGGCCGCCTCGGCCGTCAGCCGCGATTTCACCGATCGCCGCACCGGCCCCGCGA
CCGAGGTGGTGCCGCAATGGGTGGCCGCGCTCTGCAACTGA

Upstream 100 bases:

>100_bases
GAGGTGCGCATGTCGAAAAGCGATGCCGACAACGCCTTCTGGGCGCGCTACAAGAACTTCGCCGCAGCAGCCGAGGCCTA
TTGCGCGCGCTGAGGATCTC

Downstream 100 bases:

>100_bases
CCGCTCCTGCGCCCTTTCCGTTGCCGAAATACCCCGGGGGAACGCCGGACAGGCCCCGCCAAGGGGCCTGTCCGGCGTGG
GGGCAGCGCCCCCGCCCCCG

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRITVLTGAGISAESGIRTFRATDGLWESHRIEDVATPQGFQRDPALVHRFYNQRRADAARAQPNLAHRALARLAEHHRV
TLVTQNVDDLHERGGSPEVIHMHGSLLGALCAGCGHRWPAALVMRALDPCPSCGKPQTRPDIVWFGEIPYHMERIWEAVE
QADLFAAIGTSGLVYPAAGLAQHARRNGAETVELNLAASAVSRDFTDRRTGPATEVVPQWVAALCN

Sequences:

>Translated_226_residues
MRITVLTGAGISAESGIRTFRATDGLWESHRIEDVATPQGFQRDPALVHRFYNQRRADAARAQPNLAHRALARLAEHHRV
TLVTQNVDDLHERGGSPEVIHMHGSLLGALCAGCGHRWPAALVMRALDPCPSCGKPQTRPDIVWFGEIPYHMERIWEAVE
QADLFAAIGTSGLVYPAAGLAQHARRNGAETVELNLAASAVSRDFTDRRTGPATEVVPQWVAALCN
>Mature_226_residues
MRITVLTGAGISAESGIRTFRATDGLWESHRIEDVATPQGFQRDPALVHRFYNQRRADAARAQPNLAHRALARLAEHHRV
TLVTQNVDDLHERGGSPEVIHMHGSLLGALCAGCGHRWPAALVMRALDPCPSCGKPQTRPDIVWFGEIPYHMERIWEAVE
QADLFAAIGTSGLVYPAAGLAQHARRNGAETVELNLAASAVSRDFTDRRTGPATEVVPQWVAALCN

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=234, Percent_Identity=35.042735042735, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI6912664, Length=251, Percent_Identity=33.0677290836653, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI13787215, Length=235, Percent_Identity=33.6170212765957, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI6912660, Length=201, Percent_Identity=32.3383084577114, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI7657575, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI63054862, Length=197, Percent_Identity=31.9796954314721, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7706712, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI308199517, Length=228, Percent_Identity=55.2631578947368, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17541892, Length=204, Percent_Identity=31.8627450980392, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17567771, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17505510, Length=215, Percent_Identity=26.046511627907, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137536, Length=217, Percent_Identity=30.8755760368664, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=161, Percent_Identity=33.5403726708075, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 24705; Mature: 24705

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITVLTGAGISAESGIRTFRATDGLWESHRIEDVATPQGFQRDPALVHRFYNQRRADAA
CEEEEEECCCCCHHHCCHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RAQPNLAHRALARLAEHHRVTLVTQNVDDLHERGGSPEVIHMHGSLLGALCAGCGHRWPA
HCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCHH
ALVMRALDPCPSCGKPQTRPDIVWFGEIPYHMERIWEAVEQADLFAAIGTSGLVYPAAGL
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AQHARRNGAETVELNLAASAVSRDFTDRRTGPATEVVPQWVAALCN
HHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRITVLTGAGISAESGIRTFRATDGLWESHRIEDVATPQGFQRDPALVHRFYNQRRADAA
CEEEEEECCCCCHHHCCHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RAQPNLAHRALARLAEHHRVTLVTQNVDDLHERGGSPEVIHMHGSLLGALCAGCGHRWPA
HCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCHH
ALVMRALDPCPSCGKPQTRPDIVWFGEIPYHMERIWEAVEQADLFAAIGTSGLVYPAAGL
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AQHARRNGAETVELNLAASAVSRDFTDRRTGPATEVVPQWVAALCN
HHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]