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The map label for this gene is adhA [H]

Identifier: 119386911

GI number: 119386911

Start: 1366192

End: 1367175

Strand: Direct

Name: adhA [H]

Synonym: Pden_4206

Alternate gene names: 119386911

Gene position: 1366192-1367175 (Clockwise)

Preceding gene: 119386910

Following gene: 119386912

Centisome position: 78.97

GC content: 72.05

Gene sequence:

>984_bases
ATGCATGCCATGGTGCTGGAACGGATCGGCGCGCCGCTGGTCTGGACCGAACTTCCCGACCGCGAGCCCGGCCCGGCCCA
GATCCGGGTCGCCGTCTCGGCCTGCGGCGTCTGCCGCACCGACCTGCATGTGGTCGACGGAGAGTTGCCCGACCCGGTGC
TGCCGATCATCCCGGGGCATGAGGTCGTCGGCCGGATCGAGGCGCTTGGCCCCGGCGTCGCCGGCCTTGCCCTGGGCCAG
CGGGTCGGCATCCCCTGGCTGGGCCATAGCTGCGGCGCCTGCCCCTATTGCCGCGAGGGGCGCGAGAACCTGTGCGATGC
GCCGGGCTTCACCGGCTATACCCGCGACGGCGGCTATGCGACCTCGGTGATCGCCGACGCGCGTTTCGCCTTTCCCCTGG
GCGAGACGGGCGAGGACGTGGCGCTGGCGCCGCTGCTTTGCGCCGGGCTGATCGGCTGGCGCGCGCTGGTGATCGCGGGC
AAGGCGCCTCGGCTGGGACTTTACGGCTTTGGCGCCGCGGCCCATATCGTCGCGCAGGTGGCGGCATGGCAGGGCCGTGC
GGTCCATGCCTTCACCCGCCCCGGCGACCTGCGCTCGCAGGACTTCGCGCACAGCCTGGGCGCGGTCTGGGCAGGCGGCT
CGGACCAGGCGCCGCCCGAACCCCTGGATGCGGCGATCATCTTCGCCCCGGTTGGCGATCTGGTGCCCCTGGCGTTGAAA
GCGGTGCGCAAGGGCGGCCGCGTGGTCTGCGCCGGCATCCATATGAGCGACATCCCCGCCTTTCCCTATGCCCTGCTCTG
GCATGAACGCCAGATCGCCTCGGTCGCCAACCTGACGCGGCAGGACGGGCTGGACTTCCTGTCGCTCGCGCCCCGCATCG
GGATCGCGACCGAAACCACGACCTATCCGCTGCGCGAGGCCAATCGCGCGCTGGACGACCTGCGCGCCGGCCGTTTCGAC
GGCGCGGCCGTGCTGGTGCCCTGA

Upstream 100 bases:

>100_bases
CCGGCAAGCGCGAAAACTCCGCGACCTAAAGCCGCGCCCATTTGCAAGCCGGGCCCGCCGCCCGCATATTGGGCATGACC
CCGGCGATGGGAGAAGGCGG

Downstream 100 bases:

>100_bases
GCCGCCCGCCGGGCGCGGTGGCGCCCGGCCCATGCCTTTCCTGCCGGGATCCCTGCCATGACGCATAAGGTGAACACCCC
CGAAGCCGGCCCCGCCGGGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MHAMVLERIGAPLVWTELPDREPGPAQIRVAVSACGVCRTDLHVVDGELPDPVLPIIPGHEVVGRIEALGPGVAGLALGQ
RVGIPWLGHSCGACPYCREGRENLCDAPGFTGYTRDGGYATSVIADARFAFPLGETGEDVALAPLLCAGLIGWRALVIAG
KAPRLGLYGFGAAAHIVAQVAAWQGRAVHAFTRPGDLRSQDFAHSLGAVWAGGSDQAPPEPLDAAIIFAPVGDLVPLALK
AVRKGGRVVCAGIHMSDIPAFPYALLWHERQIASVANLTRQDGLDFLSLAPRIGIATETTTYPLREANRALDDLRAGRFD
GAAVLVP

Sequences:

>Translated_327_residues
MHAMVLERIGAPLVWTELPDREPGPAQIRVAVSACGVCRTDLHVVDGELPDPVLPIIPGHEVVGRIEALGPGVAGLALGQ
RVGIPWLGHSCGACPYCREGRENLCDAPGFTGYTRDGGYATSVIADARFAFPLGETGEDVALAPLLCAGLIGWRALVIAG
KAPRLGLYGFGAAAHIVAQVAAWQGRAVHAFTRPGDLRSQDFAHSLGAVWAGGSDQAPPEPLDAAIIFAPVGDLVPLALK
AVRKGGRVVCAGIHMSDIPAFPYALLWHERQIASVANLTRQDGLDFLSLAPRIGIATETTTYPLREANRALDDLRAGRFD
GAAVLVP
>Mature_327_residues
MHAMVLERIGAPLVWTELPDREPGPAQIRVAVSACGVCRTDLHVVDGELPDPVLPIIPGHEVVGRIEALGPGVAGLALGQ
RVGIPWLGHSCGACPYCREGRENLCDAPGFTGYTRDGGYATSVIADARFAFPLGETGEDVALAPLLCAGLIGWRALVIAG
KAPRLGLYGFGAAAHIVAQVAAWQGRAVHAFTRPGDLRSQDFAHSLGAVWAGGSDQAPPEPLDAAIIFAPVGDLVPLALK
AVRKGGRVVCAGIHMSDIPAFPYALLWHERQIASVANLTRQDGLDFLSLAPRIGIATETTTYPLREANRALDDLRAGRFD
GAAVLVP

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=104, Percent_Identity=37.5, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=36.5384615384615, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501929, Length=119, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI71743840, Length=111, Percent_Identity=35.1351351351351, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI71565154, Length=97, Percent_Identity=36.0824742268041, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073058, Length=111, Percent_Identity=35.1351351351351, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI71565152, Length=96, Percent_Identity=34.375, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082401, Length=320, Percent_Identity=28.75, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786518, Length=222, Percent_Identity=35.1351351351351, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87081918, Length=343, Percent_Identity=27.4052478134111, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI226510992, Length=109, Percent_Identity=35.7798165137615, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=223, Percent_Identity=26.9058295964126, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790045, Length=181, Percent_Identity=29.2817679558011, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=162, Percent_Identity=31.4814814814815, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=304, Percent_Identity=25.9868421052632, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=329, Percent_Identity=23.7082066869301, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=124, Percent_Identity=31.4516129032258, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=125, Percent_Identity=32.8, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=145, Percent_Identity=39.3103448275862, Blast_Score=108, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323961, Length=155, Percent_Identity=36.1290322580645, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=146, Percent_Identity=37.6712328767123, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=162, Percent_Identity=35.8024691358025, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=310, Percent_Identity=26.7741935483871, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319949, Length=244, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17737895, Length=94, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34325; Mature: 34325

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAMVLERIGAPLVWTELPDREPGPAQIRVAVSACGVCRTDLHVVDGELPDPVLPIIPGH
CCHHHHHHCCCCEEEECCCCCCCCCCEEEEEEHHCCCHHCCCEEECCCCCCCCCCCCCCH
EVVGRIEALGPGVAGLALGQRVGIPWLGHSCGACPYCREGRENLCDAPGFTGYTRDGGYA
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
TSVIADARFAFPLGETGEDVALAPLLCAGLIGWRALVIAGKAPRLGLYGFGAAAHIVAQV
HHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEECCHHHHHHHHH
AAWQGRAVHAFTRPGDLRSQDFAHSLGAVWAGGSDQAPPEPLDAAIIFAPVGDLVPLALK
HHHCCCEEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCHHHHHHHHH
AVRKGGRVVCAGIHMSDIPAFPYALLWHERQIASVANLTRQDGLDFLSLAPRIGIATETT
HHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
TYPLREANRALDDLRAGRFDGAAVLVP
CCCHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MHAMVLERIGAPLVWTELPDREPGPAQIRVAVSACGVCRTDLHVVDGELPDPVLPIIPGH
CCHHHHHHCCCCEEEECCCCCCCCCCEEEEEEHHCCCHHCCCEEECCCCCCCCCCCCCCH
EVVGRIEALGPGVAGLALGQRVGIPWLGHSCGACPYCREGRENLCDAPGFTGYTRDGGYA
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
TSVIADARFAFPLGETGEDVALAPLLCAGLIGWRALVIAGKAPRLGLYGFGAAAHIVAQV
HHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEECCHHHHHHHHH
AAWQGRAVHAFTRPGDLRSQDFAHSLGAVWAGGSDQAPPEPLDAAIIFAPVGDLVPLALK
HHHCCCEEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCEEEEECCHHHHHHHHH
AVRKGGRVVCAGIHMSDIPAFPYALLWHERQIASVANLTRQDGLDFLSLAPRIGIATETT
HHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
TYPLREANRALDDLRAGRFDGAAVLVP
CCCHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]