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The map label for this gene is typA [H]

Identifier: 119386732

GI number: 119386732

Start: 1172479

End: 1174299

Strand: Direct

Name: typA [H]

Synonym: Pden_4025

Alternate gene names: 119386732

Gene position: 1172479-1174299 (Clockwise)

Preceding gene: 119386731

Following gene: 119386733

Centisome position: 67.77

GC content: 66.39

Gene sequence:

>1821_bases
ATGGACATCCGCAATATCGCGATCATCGCCCACGTCGACCATGGCAAGACCACGCTGGTCGACCAGCTATTGAAGCAGTC
GGGCAGTTTCCGCGAAAACCAGGCCGTGGCCGAGCGCGTGATGGACAGCAACGACATCGAGCGCGAGCGCGGCATCACCA
TCCTGGCCAAGGCGACCTCGGTCGAGTGGAAGGGCACCCGCATCAACATCGTGGACACCCCCGGCCACGCCGATTTCGGC
GGCGAGGTCGAGCGCATCCTGAGCATGGTGGACGGAGTCTGCCTGCTGGTCGATGCGGCGGAAGGTCCCATGCCGCAGAC
CAAGTTCGTGACCTCCAAGGCGCTGGCCCTGGGGCTGCGGCCCATCGTGGTCCTGAACAAGGTCGACAAGCCCGCCGCCG
ACCCGGACAAGGCGCTGGACGAGGTGTTCGACCTGTTCGCGAACCTGGGGGCCAGCGACGAACAGCTTGATTTCCCGCAT
CTTTACGCCTCGGGCATCGGCGGCTGGGCCGACGAGACGCTGGAGGGACCGCGCAAGGACATGTCGGCGCTTTTCGACCT
GGTGCTGCGCCATGTCGAGGCGCCCCGGCAGATCTCGCGCCAGGACGAACCCTTCCAGATGCTGGCGACCACGCTGGGCG
CCGACCCCTTCATCGGCCGCATCCTGACCGGCCGGGTCGAGGCCGGCCGCGCCAAGGCCGGCGACACGATCAAGGCGCTG
TCGCGCGACGGCGAGCGCATCGAGCAGTTCCGCGTCTCGAAGGTTCTGGCCTTCCGCGGCCTGACCCAGCAGCCGATCGA
CGAAGCGGTGGCGGGTGATATCGTCACCATCGCCGGCATGTCCAAGGCCACGGTGGCCGACACGCTCTGCGCGCTCGAGG
TCGAGACCGCCCTGCCCGCCCAGCCCATCGACCCGCCGACGATCAGCGTCACCTTTGGCATCAACGACAGCCCGCTGGCC
GGCCGCGACGGCAACAAGGTGCAGTCGCGGGTGATTCGCGAGCGGTTGATGAAAGAGGCCGAGACCAATGTCGCGATCAA
GGTCGAGGACACGCCGGGCGGCGACGCCTTCGTCGTCTCGGGCCGCGGCGAATTGCAGATGGGCGTGCTGATCGAGAACA
TGCGTCGCGAGGGATTCGAGCTGTCGATCTCGCGCCCGCGGGTAATCTTCCGCGATATCGACGGCGTGCGCCACGAGCCG
ATCGAGGAAGCCATCATCGATGTCGACGACGAATATACCGGCGCGGTGATCGACAAGCTGACCGGGACCCGTAAGGGCGA
CCTGGTCGAGATGAAGCCCGCCGGCCACGGCAAGACCCGCATCGTCGCCCATGTCCCCTCGCGCGGGTTGATCGGCTACC
AGGGCGAGTTCATGACCGACACCCGCGGCAACGGCGTGCTGAACCGCATCTTCCACAGCTGGGCGCCCTACAAGGGCGCG
ATCCAGGGTCGGCGCCAGGGCGTTCTGATCTCGATGGAGGACGGGGTTTCCGTGGCCTATGCGCTGTGGAACCTGGAAGA
GCGCGGCAAGATGTTCATCGGCGCGCAGGAGCAGGTCTACCAGGGCATGATCATCGGCGAGCATTCGCGCGACAACGACC
TGGAGGTGAACCCGCTCAAGGGCAAGAAGCTGACCAACGTGCGTGCCTCGGGCACGGACGAGGCGGTGCGCCTGACGCCC
CCGGTGCGCATGTCGCTGGAAGAGGCCATCGCCTATATCGACGATGACGAACTGGTCGAGGTGACGCCCAAAAGCATCCG
CCTGCGCAAGCGCTATCTGGACCCGCACGAGCGCAAGCGCCAGTCCCGCAGCGAAGGCTGA

Upstream 100 bases:

>100_bases
CCTGGGCCTTCTGGGCCTGCGCTGACGTCATTTGCGATTGACGCTGGCCTTTCGCGCCCCTCTGCGTTACCGGAGGCGCA
AATTCTGAAAAAGGCCCCAT

Downstream 100 bases:

>100_bases
ACTAATTTCAACGCCGATGGATTGCAGACTTTCGCATTGGCGAAACTCTGCTAGGCTTGGGACGAATTGGCTTTGGGAGC
GGCTGATGGAAGGCCGGGGA

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MDIRNIAIIAHVDHGKTTLVDQLLKQSGSFRENQAVAERVMDSNDIERERGITILAKATSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVCLLVDAAEGPMPQTKFVTSKALALGLRPIVVLNKVDKPAADPDKALDEVFDLFANLGASDEQLDFPH
LYASGIGGWADETLEGPRKDMSALFDLVLRHVEAPRQISRQDEPFQMLATTLGADPFIGRILTGRVEAGRAKAGDTIKAL
SRDGERIEQFRVSKVLAFRGLTQQPIDEAVAGDIVTIAGMSKATVADTLCALEVETALPAQPIDPPTISVTFGINDSPLA
GRDGNKVQSRVIRERLMKEAETNVAIKVEDTPGGDAFVVSGRGELQMGVLIENMRREGFELSISRPRVIFRDIDGVRHEP
IEEAIIDVDDEYTGAVIDKLTGTRKGDLVEMKPAGHGKTRIVAHVPSRGLIGYQGEFMTDTRGNGVLNRIFHSWAPYKGA
IQGRRQGVLISMEDGVSVAYALWNLEERGKMFIGAQEQVYQGMIIGEHSRDNDLEVNPLKGKKLTNVRASGTDEAVRLTP
PVRMSLEEAIAYIDDDELVEVTPKSIRLRKRYLDPHERKRQSRSEG

Sequences:

>Translated_606_residues
MDIRNIAIIAHVDHGKTTLVDQLLKQSGSFRENQAVAERVMDSNDIERERGITILAKATSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVCLLVDAAEGPMPQTKFVTSKALALGLRPIVVLNKVDKPAADPDKALDEVFDLFANLGASDEQLDFPH
LYASGIGGWADETLEGPRKDMSALFDLVLRHVEAPRQISRQDEPFQMLATTLGADPFIGRILTGRVEAGRAKAGDTIKAL
SRDGERIEQFRVSKVLAFRGLTQQPIDEAVAGDIVTIAGMSKATVADTLCALEVETALPAQPIDPPTISVTFGINDSPLA
GRDGNKVQSRVIRERLMKEAETNVAIKVEDTPGGDAFVVSGRGELQMGVLIENMRREGFELSISRPRVIFRDIDGVRHEP
IEEAIIDVDDEYTGAVIDKLTGTRKGDLVEMKPAGHGKTRIVAHVPSRGLIGYQGEFMTDTRGNGVLNRIFHSWAPYKGA
IQGRRQGVLISMEDGVSVAYALWNLEERGKMFIGAQEQVYQGMIIGEHSRDNDLEVNPLKGKKLTNVRASGTDEAVRLTP
PVRMSLEEAIAYIDDDELVEVTPKSIRLRKRYLDPHERKRQSRSEG
>Mature_606_residues
MDIRNIAIIAHVDHGKTTLVDQLLKQSGSFRENQAVAERVMDSNDIERERGITILAKATSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVCLLVDAAEGPMPQTKFVTSKALALGLRPIVVLNKVDKPAADPDKALDEVFDLFANLGASDEQLDFPH
LYASGIGGWADETLEGPRKDMSALFDLVLRHVEAPRQISRQDEPFQMLATTLGADPFIGRILTGRVEAGRAKAGDTIKAL
SRDGERIEQFRVSKVLAFRGLTQQPIDEAVAGDIVTIAGMSKATVADTLCALEVETALPAQPIDPPTISVTFGINDSPLA
GRDGNKVQSRVIRERLMKEAETNVAIKVEDTPGGDAFVVSGRGELQMGVLIENMRREGFELSISRPRVIFRDIDGVRHEP
IEEAIIDVDDEYTGAVIDKLTGTRKGDLVEMKPAGHGKTRIVAHVPSRGLIGYQGEFMTDTRGNGVLNRIFHSWAPYKGA
IQGRRQGVLISMEDGVSVAYALWNLEERGKMFIGAQEQVYQGMIIGEHSRDNDLEVNPLKGKKLTNVRASGTDEAVRLTP
PVRMSLEEAIAYIDDDELVEVTPKSIRLRKRYLDPHERKRQSRSEG

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=315, Percent_Identity=32.3809523809524, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI94966754, Length=152, Percent_Identity=38.8157894736842, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=41.3793103448276, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI25306287, Length=142, Percent_Identity=42.2535211267606, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19923640, Length=142, Percent_Identity=42.2535211267606, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI25306283, Length=142, Percent_Identity=42.2535211267606, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503483, Length=145, Percent_Identity=36.551724137931, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=41.4414414414414, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=41.4414414414414, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=41.4414414414414, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI34147630, Length=246, Percent_Identity=29.2682926829268, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI223555963, Length=324, Percent_Identity=24.6913580246914, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI5729864, Length=324, Percent_Identity=24.6913580246914, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=29.4573643410853, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=34.0579710144928, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=34.0579710144928, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=54.8922056384743, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=404, Percent_Identity=29.7029702970297, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1789738, Length=151, Percent_Identity=37.7483443708609, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=30.3448275862069, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790412, Length=277, Percent_Identity=28.8808664259928, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789737, Length=277, Percent_Identity=28.8808664259928, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789559, Length=137, Percent_Identity=36.4963503649635, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=241, Percent_Identity=35.2697095435685, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=43.6619718309859, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=45.8333333333333, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506493, Length=176, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=39.0625, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=39.0625, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=172, Percent_Identity=31.9767441860465, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=281, Percent_Identity=27.4021352313167, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994658, Length=140, Percent_Identity=36.4285714285714, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=505, Percent_Identity=26.5346534653465, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=202, Percent_Identity=33.6633663366337, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=202, Percent_Identity=33.6633663366337, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=38.255033557047, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=35.8108108108108, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=34.4444444444444, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=274, Percent_Identity=28.8321167883212, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI78706572, Length=405, Percent_Identity=29.8765432098765, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582462, Length=145, Percent_Identity=41.3793103448276, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585711, Length=168, Percent_Identity=34.5238095238095, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585713, Length=168, Percent_Identity=34.5238095238095, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585709, Length=168, Percent_Identity=34.5238095238095, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574573, Length=156, Percent_Identity=37.8205128205128, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221458488, Length=144, Percent_Identity=43.0555555555556, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357743, Length=171, Percent_Identity=35.672514619883, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363316, Length=273, Percent_Identity=28.9377289377289, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17864358, Length=273, Percent_Identity=28.9377289377289, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28572034, Length=303, Percent_Identity=27.0627062706271, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66535; Mature: 66535

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRNIAIIAHVDHGKTTLVDQLLKQSGSFRENQAVAERVMDSNDIERERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCEEEEEEECE
VEWKGTRINIVDTPGHADFGGEVERILSMVDGVCLLVDAAEGPMPQTKFVTSKALALGLR
EEECCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVVLNKVDKPAADPDKALDEVFDLFANLGASDEQLDFPHLYASGIGGWADETLEGPRKD
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHCCHHHH
MSALFDLVLRHVEAPRQISRQDEPFQMLATTLGADPFIGRILTGRVEAGRAKAGDTIKAL
HHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHH
SRDGERIEQFRVSKVLAFRGLTQQPIDEAVAGDIVTIAGMSKATVADTLCALEVETALPA
HCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHEEEHHCCCC
QPIDPPTISVTFGINDSPLAGRDGNKVQSRVIRERLMKEAETNVAIKVEDTPGGDAFVVS
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEE
GRGELQMGVLIENMRREGFELSISRPRVIFRDIDGVRHEPIEEAIIDVDDEYTGAVIDKL
CCCCEEHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHH
TGTRKGDLVEMKPAGHGKTRIVAHVPSRGLIGYQGEFMTDTRGNGVLNRIFHSWAPYKGA
CCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCHH
IQGRRQGVLISMEDGVSVAYALWNLEERGKMFIGAQEQVYQGMIIGEHSRDNDLEVNPLK
HCCCCCCEEEEECCCCEEEHEECCHHHCCCEEECCHHHHHCCEEEECCCCCCCCEECCCC
GKKLTNVRASGTDEAVRLTPPVRMSLEEAIAYIDDDELVEVTPKSIRLRKRYLDPHERKR
CCEECEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCHHHHHH
QSRSEG
HHCCCC
>Mature Secondary Structure
MDIRNIAIIAHVDHGKTTLVDQLLKQSGSFRENQAVAERVMDSNDIERERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCEEEEEEECE
VEWKGTRINIVDTPGHADFGGEVERILSMVDGVCLLVDAAEGPMPQTKFVTSKALALGLR
EEECCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVVLNKVDKPAADPDKALDEVFDLFANLGASDEQLDFPHLYASGIGGWADETLEGPRKD
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHCCHHHH
MSALFDLVLRHVEAPRQISRQDEPFQMLATTLGADPFIGRILTGRVEAGRAKAGDTIKAL
HHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHH
SRDGERIEQFRVSKVLAFRGLTQQPIDEAVAGDIVTIAGMSKATVADTLCALEVETALPA
HCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCCHHHHHHHHHHEEEHHCCCC
QPIDPPTISVTFGINDSPLAGRDGNKVQSRVIRERLMKEAETNVAIKVEDTPGGDAFVVS
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEE
GRGELQMGVLIENMRREGFELSISRPRVIFRDIDGVRHEPIEEAIIDVDDEYTGAVIDKL
CCCCEEHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHH
TGTRKGDLVEMKPAGHGKTRIVAHVPSRGLIGYQGEFMTDTRGNGVLNRIFHSWAPYKGA
CCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCHH
IQGRRQGVLISMEDGVSVAYALWNLEERGKMFIGAQEQVYQGMIIGEHSRDNDLEVNPLK
HCCCCCCEEEEECCCCEEEHEECCHHHCCCEEECCHHHHHCCEEEECCCCCCCCEECCCC
GKKLTNVRASGTDEAVRLTPPVRMSLEEAIAYIDDDELVEVTPKSIRLRKRYLDPHERKR
CCEECEEECCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCHHHHHH
QSRSEG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]