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The map label for this gene is sufS [H]

Identifier: 119386677

GI number: 119386677

Start: 1107420

End: 1108631

Strand: Direct

Name: sufS [H]

Synonym: Pden_3970

Alternate gene names: 119386677

Gene position: 1107420-1108631 (Clockwise)

Preceding gene: 119386676

Following gene: 119386680

Centisome position: 64.01

GC content: 66.83

Gene sequence:

>1212_bases
ATGAACTTCGACGTCGAAAAGGTCCGCGCCGATTTCCCGATCCTGTCGCGGCAGGTGAACGGCCGGCCGCTGGTCTATCT
GGACAACGGCGCCTCGGCGCAGAAACCGCGCGTGGTGATCGACGCCATCACCCGCGCCTATGAGGCGGAATATGCCAATG
TCCATCGCGGGCTGCATTTCCTGTCCAACCTCGCGACCGAGAATTACGAGCGCGTGCGCGCCATCATCGCCCGCTTCCTG
AACGCCCCGCGCGAGAACGAGGTGATCTTCACCTCGGGCGCGACCGAAGGAATCAACCTCGTCTCCTATGGCTGGGCCGC
GCCCCGCCTGCAGGCCGGCGACGAGATCGTGCTGTCGGTGCTGGAGCATCACGCCAATATCGTGCCCTGGCATTTCCTGC
GCGAGCGCCAGGGCGTGGTGCTGAAATGGGTCGAGCCCGAGCCCGACGGCTCGCTGCCGCCCGAAAAGGTGCTGGCGGCG
GTGGGCCCGCGCACCCGGCTGATCGCCGTCACGCATATGTCGAACGTGACCGGCACCGTGGTCGATGTCGGCGCCATCGC
ACGCGGCACCTCGGTGCCGGTTCTGGCCGACGGGTCGCAGGCCGCCGTGCATATGCCGGTGGACCTGTCCGCGCTCGGCG
TCGATTTCTACTGCATTACCGGGCACAAGCTCTATGGCCCTTCGGGCTCGGGTGCGATCTGGATCCGGGCCGAGCGCCAG
GCCGAGATGCGCCCCTTCATGGGCGGCGGCGACATGATCCGCACCGTCACCCGCGAAAGCATCGACTATGCCGACCCGCC
GCTGCGCTTCGAGGCCGGCACGCCCGGCATCGCCAACCAGATCGGGCTGGGTGCGGCGCTGGAATACCTGATGGCGCTTG
GCATGGAGAATGTCGCCGCGCATGAACGCGACCTACGCGACTATGCCCGCGACCGGCTGCGCAGCCTGAACTGGCTGTCG
GTGCAGGGCGACGCGGCGGACAAGGGCGCGATCTTCTCGATGACGATGCAGGGCGCACATGCGCATGACATCTCGACCAT
CCTCGACAAGCGCGGCATCGCGGTGCGGGCGGGCACGCATTGCGCCATGCCATTGCTGGATTTCTTCGGCGTCAGCGCCA
CGGCGCGCGCCAGTTTCGCGATGTACAACACCCGCGCCGAAGTCGATGCGCTGATCGACGGGCTGACCTTCTGCCGCGAG
CTTTTTGCCTGA

Upstream 100 bases:

>100_bases
CCGGCAAGGTGGTGGTGGGGCTGATCGGCAGCGTCTTCCTGCTTGGCTTCGTGCTGTCGCTGATCGCGGCGGCATTCGGC
ATCGTCCCCGAGGTGACACC

Downstream 100 bases:

>100_bases
ACCCCATTGCAGAGCCGCGCATTTGCGGCTATGCAGCCCATGCGTTGCACCCGTAGCTCAGCTGGATAGAGCGTTGCCCT
CCGAAGGCAAAGGCCACACG

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNFDVEKVRADFPILSRQVNGRPLVYLDNGASAQKPRVVIDAITRAYEAEYANVHRGLHFLSNLATENYERVRAIIARFL
NAPRENEVIFTSGATEGINLVSYGWAAPRLQAGDEIVLSVLEHHANIVPWHFLRERQGVVLKWVEPEPDGSLPPEKVLAA
VGPRTRLIAVTHMSNVTGTVVDVGAIARGTSVPVLADGSQAAVHMPVDLSALGVDFYCITGHKLYGPSGSGAIWIRAERQ
AEMRPFMGGGDMIRTVTRESIDYADPPLRFEAGTPGIANQIGLGAALEYLMALGMENVAAHERDLRDYARDRLRSLNWLS
VQGDAADKGAIFSMTMQGAHAHDISTILDKRGIAVRAGTHCAMPLLDFFGVSATARASFAMYNTRAEVDALIDGLTFCRE
LFA

Sequences:

>Translated_403_residues
MNFDVEKVRADFPILSRQVNGRPLVYLDNGASAQKPRVVIDAITRAYEAEYANVHRGLHFLSNLATENYERVRAIIARFL
NAPRENEVIFTSGATEGINLVSYGWAAPRLQAGDEIVLSVLEHHANIVPWHFLRERQGVVLKWVEPEPDGSLPPEKVLAA
VGPRTRLIAVTHMSNVTGTVVDVGAIARGTSVPVLADGSQAAVHMPVDLSALGVDFYCITGHKLYGPSGSGAIWIRAERQ
AEMRPFMGGGDMIRTVTRESIDYADPPLRFEAGTPGIANQIGLGAALEYLMALGMENVAAHERDLRDYARDRLRSLNWLS
VQGDAADKGAIFSMTMQGAHAHDISTILDKRGIAVRAGTHCAMPLLDFFGVSATARASFAMYNTRAEVDALIDGLTFCRE
LFA
>Mature_403_residues
MNFDVEKVRADFPILSRQVNGRPLVYLDNGASAQKPRVVIDAITRAYEAEYANVHRGLHFLSNLATENYERVRAIIARFL
NAPRENEVIFTSGATEGINLVSYGWAAPRLQAGDEIVLSVLEHHANIVPWHFLRERQGVVLKWVEPEPDGSLPPEKVLAA
VGPRTRLIAVTHMSNVTGTVVDVGAIARGTSVPVLADGSQAAVHMPVDLSALGVDFYCITGHKLYGPSGSGAIWIRAERQ
AEMRPFMGGGDMIRTVTRESIDYADPPLRFEAGTPGIANQIGLGAALEYLMALGMENVAAHERDLRDYARDRLRSLNWLS
VQGDAADKGAIFSMTMQGAHAHDISTILDKRGIAVRAGTHCAMPLLDFFGVSATARASFAMYNTRAEVDALIDGLTFCRE
LFA

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=271, Percent_Identity=29.1512915129151, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156713448, Length=421, Percent_Identity=26.8408551068884, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI157388923, Length=320, Percent_Identity=26.875, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=48.5221674876847, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789175, Length=411, Percent_Identity=40.1459854014599, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994898, Length=389, Percent_Identity=27.2493573264781, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=234, Percent_Identity=28.2051282051282, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533177, Length=343, Percent_Identity=26.8221574344023, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=26.7990074441687, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129463, Length=290, Percent_Identity=28.2758620689655, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43936; Mature: 43936

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDVEKVRADFPILSRQVNGRPLVYLDNGASAQKPRVVIDAITRAYEAEYANVHRGLHF
CCCCHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSNLATENYERVRAIIARFLNAPRENEVIFTSGATEGINLVSYGWAAPRLQAGDEIVLSV
HHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHH
LEHHANIVPWHFLRERQGVVLKWVEPEPDGSLPPEKVLAAVGPRTRLIAVTHMSNVTGTV
HHHCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCEE
VDVGAIARGTSVPVLADGSQAAVHMPVDLSALGVDFYCITGHKLYGPSGSGAIWIRAERQ
EECCHHCCCCCCCEEECCCCCEEECCCCHHHHCEEEEEEECCEEECCCCCCEEEEEECCC
AEMRPFMGGGDMIRTVTRESIDYADPPLRFEAGTPGIANQIGLGAALEYLMALGMENVAA
CCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHH
HERDLRDYARDRLRSLNWLSVQGDAADKGAIFSMTMQGAHAHDISTILDKRGIAVRAGTH
HHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCC
CAMPLLDFFGVSATARASFAMYNTRAEVDALIDGLTFCRELFA
HHHHHHHHHCCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFDVEKVRADFPILSRQVNGRPLVYLDNGASAQKPRVVIDAITRAYEAEYANVHRGLHF
CCCCHHHHHCCCCHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSNLATENYERVRAIIARFLNAPRENEVIFTSGATEGINLVSYGWAAPRLQAGDEIVLSV
HHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHH
LEHHANIVPWHFLRERQGVVLKWVEPEPDGSLPPEKVLAAVGPRTRLIAVTHMSNVTGTV
HHHCCCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCEE
VDVGAIARGTSVPVLADGSQAAVHMPVDLSALGVDFYCITGHKLYGPSGSGAIWIRAERQ
EECCHHCCCCCCCEEECCCCCEEECCCCHHHHCEEEEEEECCEEECCCCCCEEEEEECCC
AEMRPFMGGGDMIRTVTRESIDYADPPLRFEAGTPGIANQIGLGAALEYLMALGMENVAA
CCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHH
HERDLRDYARDRLRSLNWLSVQGDAADKGAIFSMTMQGAHAHDISTILDKRGIAVRAGTH
HHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCC
CAMPLLDFFGVSATARASFAMYNTRAEVDALIDGLTFCRELFA
HHHHHHHHHCCCHHHHHHEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA