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The map label for this gene is phoR [H]

Identifier: 119386645

GI number: 119386645

Start: 1074472

End: 1075524

Strand: Direct

Name: phoR [H]

Synonym: Pden_3938

Alternate gene names: 119386645

Gene position: 1074472-1075524 (Clockwise)

Preceding gene: 119386644

Following gene: 119386651

Centisome position: 62.1

GC content: 70.94

Gene sequence:

>1053_bases
ATGATCGAGGCGCGGCTGCATGCGCTTTTGCGGGCCGTGCCGGTGGCGATGCTGGTCGTCGACCGGCAGGCGCGCATCCT
GGGCGCCAACGAACCGGCCGAGGCGCTTCTGGGTGCGGTACCGGGCGGGCGACCCTTCGTCACCGTGCTGCGCCACCCCG
AGGTCAATGCCGCGCTGGATGCCGTGCTGGCCGGGCAGGAACGGGCGCGGCTGAACGTCACCTTGGGCGCGGCCGACCGA
CGGGTGTTTTGCGAGGTGACGGTGACGGCCTTGCAGGCGCCGGGGCTGCTGGGTGCGGCCGTGGTGATCGAGGACCGCTC
GCGCGATGAGGAAACCGAGCAGATGCGCCGCGACTTCGTCGCCAATGTCAGCCATGAATTGCGCACGCCGCTGACCGCAC
TGATGGGCTTTATCGAGACCTTGCGCGGTCCGGCCCGCAACGACCCCGCCGCGCGCGCGCGCTTTCTCGACATCATGGAG
CGCGAAGCGGGGCGGATGAACCGGCTGGTTGCCGACCTCTTGTCGCTGAGCCGCGTCGAGCAGGACGAGCGCCGCCGCCC
GGCGCAGAACCTGGACCTGGCCGGGCTGCTGCGCAGCGTCGTGGCAACGCTGACGCCCGCCGCCGCCGCGGCCGGGGTGC
GGCTGGAACTGCAGGGCGCAGCCGGCAAGGTGCCGGTGCCGGGCGACGCCGACCAACTGGTTCAGGTGTTTCACAACCTG
GTCGAGAACGCGCTGAAATACGGCGGCGGTGGCGGCGTGGCGACGGTGACGCTGGAACGGCTGGCGCATGAGCCGGTGCT
GCGCGGCCCGGCCTGGGCGGTTTCCGTCGCCGACCAGGGCGAGGGCATCGATCAGCAGCACCTGCCGCGCCTGACCGAGC
GGTTCTATCGCGTCGACACGCATCGCTCGCGCGAGCAGGGCGGCACCGGGCTGGGCCTGGCCATCGTCAAGCATATCGTG
AACCGGCATCGCGGCCGCCTGCGCATCGAAAGCGAGCGCGGAAAGGGCAGCCGCTTCACCGTCATCCTGCCCGAACAGAT
CGGCCGCATCTGA

Upstream 100 bases:

>100_bases
AGTTGGACGAGGCGGCGCGGGCGCAACTGCTGAAATCGGCCGAAGGCTATAACCGCAACGCCGCCCGCTTTCGGCAGGGG
CTGGTGCAGGCCGGCCGGGG

Downstream 100 bases:

>100_bases
ACCGGCAGGCCGCAGGTCGCGAAAGCGAAAAAAGCCGGGAGCATCGAGCCCCCGGCTTTTTTATGGCCCCGCGTCCCGGC
CGCGGACGGATCACTCTGCC

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIEARLHALLRAVPVAMLVVDRQARILGANEPAEALLGAVPGGRPFVTVLRHPEVNAALDAVLAGQERARLNVTLGAADR
RVFCEVTVTALQAPGLLGAAVVIEDRSRDEETEQMRRDFVANVSHELRTPLTALMGFIETLRGPARNDPAARARFLDIME
REAGRMNRLVADLLSLSRVEQDERRRPAQNLDLAGLLRSVVATLTPAAAAAGVRLELQGAAGKVPVPGDADQLVQVFHNL
VENALKYGGGGGVATVTLERLAHEPVLRGPAWAVSVADQGEGIDQQHLPRLTERFYRVDTHRSREQGGTGLGLAIVKHIV
NRHRGRLRIESERGKGSRFTVILPEQIGRI

Sequences:

>Translated_350_residues
MIEARLHALLRAVPVAMLVVDRQARILGANEPAEALLGAVPGGRPFVTVLRHPEVNAALDAVLAGQERARLNVTLGAADR
RVFCEVTVTALQAPGLLGAAVVIEDRSRDEETEQMRRDFVANVSHELRTPLTALMGFIETLRGPARNDPAARARFLDIME
REAGRMNRLVADLLSLSRVEQDERRRPAQNLDLAGLLRSVVATLTPAAAAAGVRLELQGAAGKVPVPGDADQLVQVFHNL
VENALKYGGGGGVATVTLERLAHEPVLRGPAWAVSVADQGEGIDQQHLPRLTERFYRVDTHRSREQGGTGLGLAIVKHIV
NRHRGRLRIESERGKGSRFTVILPEQIGRI
>Mature_350_residues
MIEARLHALLRAVPVAMLVVDRQARILGANEPAEALLGAVPGGRPFVTVLRHPEVNAALDAVLAGQERARLNVTLGAADR
RVFCEVTVTALQAPGLLGAAVVIEDRSRDEETEQMRRDFVANVSHELRTPLTALMGFIETLRGPARNDPAARARFLDIME
REAGRMNRLVADLLSLSRVEQDERRRPAQNLDLAGLLRSVVATLTPAAAAAGVRLELQGAAGKVPVPGDADQLVQVFHNL
VENALKYGGGGGVATVTLERLAHEPVLRGPAWAVSVADQGEGIDQQHLPRLTERFYRVDTHRSREQGGTGLGLAIVKHIV
NRHRGRLRIESERGKGSRFTVILPEQIGRI

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=343, Percent_Identity=35.8600583090379, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=35.1694915254237, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788549, Length=343, Percent_Identity=26.530612244898, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=31.9502074688797, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=29.957805907173, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=30.7086614173228, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=27.6859504132231, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=27.906976744186, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=30.0429184549356, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789403, Length=207, Percent_Identity=32.8502415458937, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=358, Percent_Identity=27.9329608938547, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=29.2372881355932, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=240, Percent_Identity=30, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=255, Percent_Identity=28.6274509803922, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=28.1385281385281, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=25.8474576271186, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789808, Length=223, Percent_Identity=30.9417040358744, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37979; Mature: 37979

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEARLHALLRAVPVAMLVVDRQARILGANEPAEALLGAVPGGRPFVTVLRHPEVNAALD
CCHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHH
AVLAGQERARLNVTLGAADRRVFCEVTVTALQAPGLLGAAVVIEDRSRDEETEQMRRDFV
HHHCCCCCCEEEEEEECCCCEEEEEEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ANVSHELRTPLTALMGFIETLRGPARNDPAARARFLDIMEREAGRMNRLVADLLSLSRVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDERRRPAQNLDLAGLLRSVVATLTPAAAAAGVRLELQGAAGKVPVPGDADQLVQVFHNL
HHHHHCCCCCCCHHHHHHHHHHHHCHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
VENALKYGGGGGVATVTLERLAHEPVLRGPAWAVSVADQGEGIDQQHLPRLTERFYRVDT
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HRSREQGGTGLGLAIVKHIVNRHRGRLRIESERGKGSRFTVILPEQIGRI
HCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHCCCC
>Mature Secondary Structure
MIEARLHALLRAVPVAMLVVDRQARILGANEPAEALLGAVPGGRPFVTVLRHPEVNAALD
CCHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHH
AVLAGQERARLNVTLGAADRRVFCEVTVTALQAPGLLGAAVVIEDRSRDEETEQMRRDFV
HHHCCCCCCEEEEEEECCCCEEEEEEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
ANVSHELRTPLTALMGFIETLRGPARNDPAARARFLDIMEREAGRMNRLVADLLSLSRVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDERRRPAQNLDLAGLLRSVVATLTPAAAAAGVRLELQGAAGKVPVPGDADQLVQVFHNL
HHHHHCCCCCCCHHHHHHHHHHHHCHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
VENALKYGGGGGVATVTLERLAHEPVLRGPAWAVSVADQGEGIDQQHLPRLTERFYRVDT
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HRSREQGGTGLGLAIVKHIVNRHRGRLRIESERGKGSRFTVILPEQIGRI
HCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]