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The map label for this gene is gmk [H]

Identifier: 119386643

GI number: 119386643

Start: 1073313

End: 1073951

Strand: Direct

Name: gmk [H]

Synonym: Pden_3936

Alternate gene names: 119386643

Gene position: 1073313-1073951 (Clockwise)

Preceding gene: 119386641

Following gene: 119386644

Centisome position: 62.04

GC content: 68.54

Gene sequence:

>639_bases
ATGGAGATGGAGCGCAGCGGACTTCTGGTGATCCTGTCCTCGCCCTCGGGGGCGGGCAAATCGACGCTGGCGCGGCAGCT
GATGGACTGGGATCCGGGCCTGCGCTTTTCCGTCTCGGCCACCACCCGCAGGCCGCGCCCCGGCGAGGTCGAGGGCGAGC
ATTACTATTTCCGCACCGCCGAGCAGTTCCGCGCCATGGTCGCGGCGGGCGAGATGCTGGAACATGCCGAGGTCTTCGGC
AATTTCTACGGCACCCCGCGCGGCCCGGTCGAGGAGGCGATGCGCGCCGGCCGCGACACTCTGTTCGACGTGGACTGGCA
GGGCGGCCAGCAGATCCGCGCGTCTAGCCTTGGCGGACATGTCATCTCGATCTTCGTGCTGCCGCCCAGCCTGGCCGAGC
TGGAGCGCCGGCTGATCTCGCGCCAGCAGGACGCGCCGGAGGTGATCGCCGGCCGCATGCGCAAAAGCCGGGACGAAATC
AGCCATTGGGCGGAGTACGATTATGTCATCGTCAACGACGACCTGGACCGCAGCGCCGAGGCGCTGAAGACCATCCTGCG
GGCCGAGCGGATGCGCCGCGCCCGGCAGGTGGGGCTTGGCCCCTTCGTTCGGGCGCTCATGGAGGAGGAAAGCGCATGA

Upstream 100 bases:

>100_bases
TTGACCAATGGTTAAAACCCCGCCCGCCGCCGGGCGGGGCTTGACCCTGCTGGCGGGCAGGGCCATTCAGGCGGCGCTGG
AACGGCAGGGGACAAGGCGG

Downstream 100 bases:

>100_bases
TCTGGGAACTGGACGGTATCGCGCCGCAAATCGCCGAGGACGCCTGGGTGGCGCCGGATGCGCAGCTGATGGGCAAGGTC
GTGCTGGAGCCGGGCGCCAG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MEMERSGLLVILSSPSGAGKSTLARQLMDWDPGLRFSVSATTRRPRPGEVEGEHYYFRTAEQFRAMVAAGEMLEHAEVFG
NFYGTPRGPVEEAMRAGRDTLFDVDWQGGQQIRASSLGGHVISIFVLPPSLAELERRLISRQQDAPEVIAGRMRKSRDEI
SHWAEYDYVIVNDDLDRSAEALKTILRAERMRRARQVGLGPFVRALMEEESA

Sequences:

>Translated_212_residues
MEMERSGLLVILSSPSGAGKSTLARQLMDWDPGLRFSVSATTRRPRPGEVEGEHYYFRTAEQFRAMVAAGEMLEHAEVFG
NFYGTPRGPVEEAMRAGRDTLFDVDWQGGQQIRASSLGGHVISIFVLPPSLAELERRLISRQQDAPEVIAGRMRKSRDEI
SHWAEYDYVIVNDDLDRSAEALKTILRAERMRRARQVGLGPFVRALMEEESA
>Mature_212_residues
MEMERSGLLVILSSPSGAGKSTLARQLMDWDPGLRFSVSATTRRPRPGEVEGEHYYFRTAEQFRAMVAAGEMLEHAEVFG
NFYGTPRGPVEEAMRAGRDTLFDVDWQGGQQIRASSLGGHVISIFVLPPSLAELERRLISRQQDAPEVIAGRMRKSRDEI
SHWAEYDYVIVNDDLDRSAEALKTILRAERMRRARQVGLGPFVRALMEEESA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=193, Percent_Identity=42.4870466321244, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4504221, Length=193, Percent_Identity=42.4870466321244, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI226874831, Length=193, Percent_Identity=42.4870466321244, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI21361598, Length=194, Percent_Identity=28.8659793814433, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=33.1460674157303, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI52630447, Length=199, Percent_Identity=28.643216080402, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=24.5714285714286, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=24.5714285714286, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=24.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=24.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=54.6875, Blast_Score=213, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI193203132, Length=192, Percent_Identity=35.4166666666667, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=192, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71988041, Length=186, Percent_Identity=26.8817204301075, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=36.2162162162162, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356141, Length=191, Percent_Identity=35.6020942408377, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=27.9329608938547, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=27.9329608938547, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=27.9329608938547, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330164, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330162, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330166, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23854; Mature: 23854

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMERSGLLVILSSPSGAGKSTLARQLMDWDPGLRFSVSATTRRPRPGEVEGEHYYFRTA
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEECH
EQFRAMVAAGEMLEHAEVFGNFYGTPRGPVEEAMRAGRDTLFDVDWQGGQQIRASSLGGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCHHHHHCCCCE
VISIFVLPPSLAELERRLISRQQDAPEVIAGRMRKSRDEISHWAEYDYVIVNDDLDRSAE
EEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
ALKTILRAERMRRARQVGLGPFVRALMEEESA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEMERSGLLVILSSPSGAGKSTLARQLMDWDPGLRFSVSATTRRPRPGEVEGEHYYFRTA
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEECH
EQFRAMVAAGEMLEHAEVFGNFYGTPRGPVEEAMRAGRDTLFDVDWQGGQQIRASSLGGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCHHHHHCCCCE
VISIFVLPPSLAELERRLISRQQDAPEVIAGRMRKSRDEISHWAEYDYVIVNDDLDRSAE
EEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHH
ALKTILRAERMRRARQVGLGPFVRALMEEESA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA